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3M employee and church chorister Art Fry needed something to temporarily mark pages in his hymnal. He was in luck because his colleague, Spencer Silver, accidentally developed a glue that was too weak for other purposes. After initially discouraging consumer response, Post-it Notes became a hit in 1979.
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| Number | Title | Issue Date |
| 8187841 | Method for evaluating or selecting agent for preventing or curing photodamage of skin A method for evaluating or selecting a substance capable of preventing or curing photodamage of skin is provided. Provided is a method for evaluating or selecting an agent for preventing or curing photodamage of skin, the method including: (A) contacting cells that ... | 05/29/2012 |
| 8183015 | Biological reagents and methods to verify the efficiency of sample preparation and nucleic acid amplification and/or detection This invention relates to reagent comprising: any one of cells, viral particles, organelles, parasites, cells comprising organelles, cells comprising viral particles, cells comprising parasites, cells comprising bacterial cells and any combination thereof, the cells... | 05/22/2012 |
| 8173400 | Method of detecting or quantitating endogenous wheat DNA and method of determining contamination rate of genetically modified wheat in test sample An object of the present invention is to discover an endogenous wheat sequence satisfying the conditions of: a) it is universally present in varieties of wheat, b) the amount present (detected amount) is not affected by the wheat variety, c) even if other grains are... | 05/08/2012 |
| 8158388 | Repair of nucleic acids for improved amplification Methods and compositions are provided for repairing a polynucleotide so that it can be copied with improved fidelity and/or yield in, for example, an amplification reaction. This involves the use of a reaction mixture that includes a ligase and a cofactor selected f... | 04/17/2012 |
| 8153403 | Process for identifying existence of single nucleotide polymorphism without DNA sequencing A process for detecting the presence of a mutation in an oligonucleotide strand such as a DNA strand from a gene without the need for DNA sequencing is provided. The inventive process provides a rapid pre-test to screen for the presence or absence of a mutation in a... | 04/10/2012 |
| 8143030 | Intermittent detection during analytical reactions Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one... | 03/27/2012 |
| 8137911 | Preparation and use of single-stranded transcription substrates for synthesis of transcription products corresponding to target sequences The present invention provides methods, compositions and kits for using an RNA polymerase for making transcription products corresponding to a target sequence by obtaining single-stranded DNA transcription substrates that comprise a single-stranded promoter that is ... | 03/20/2012 |
| 8124382 | Methods, microarray, and kits for detection of drug resistance genes in gram-negative bacteria The present invention provides kits and microarrays containing primer pairs for amplifying drug resistance genes and/or probes for detection of drug resistance genes. Also provided are methods of detecting drug resistance genes using kits and microarrays described h... | 02/28/2012 |
| 8124383 | Methods and kits for diagnosis, prognosis or monitoring of epstein-barr virus (EBV)—associated cancer Disclosed is a non-invasive method for diagnosis, prognosis or monitoring of Epstein-Barr virus (EBV)-associated cancer by detecting and/or quantifying EBV associated nucleic acid fragments in a urine sample from an individual. Kits for diagnosis, prognosis or monit... | 02/28/2012 |
| 8093003 | Fluorescence energy transfer by competitive hybridization A method is provided for detecting the presence of nucleotides or monitoring nucleotide amplification. It utilizes fluorescence energy transfer by competitive hybridization. Competitive hybridization is achieved by using unequal length complementary probes which hav... | 01/10/2012 |
| 8093020 | Allelic discrimination analysis using an efficiency related value (EFR) In various embodiments this invention provides novel methods for discriminating two or more different target nucleic acids. In certain embodiments the methods comprise providing data amplification reactions comprising reagents to amplify two or more different target... | 01/10/2012 |
| 8088603 | Compositions and methods for diagnosing, treating, and preventing prostate conditions Disclosed are compositions and methods for diagnosing, preventing, and treating prostate cancer and prostate intraepithelial neoplasia (PIN). ... | 01/03/2012 |
| 8084206 | High speed, high fidelity, high sensitivity nucleic acid detection The present invention provides methods, compositions, and kits for nucleic acid detection. ... | 12/27/2011 |
| 8080394 | Method for determining predisposition to pulmonary infection Provided herein are methods and materials for diagnosing a subject's predisposition for pulmonary infection in a CF subject by detecting a pulmonary infection genetic marker. Pulmonary infection markers have been identified in the IL-1 gene cluster and may be useful... | 12/20/2011 |
| 8076104 | Rapid and comprehensive identification of prokaryotic organisms An improved method for rapid identification of microorganisms is disclosed, along with sequences of PCR primers optimized for this purpose. The primers are designed based on information analysis of sequences from a large number of organism to amplify certain segment... | 12/13/2011 |
| 8071301 | Method of isolating nucleic acids from a biological sample Method of preparing a biological sample appropriate for use in a subsequent in vitro nucleic acid amplification reaction. The method involves a rapid, transient exposure to alkaline conditions which can be achieved by mixing an alkaline solution with a pH-buffered s... | 12/06/2011 |
| 8071296 | Nucleic acid interaction analysis The present invention provides an isolated oligonucleotide and a method using the isolated oligonucleotide to detect and/or identify at least two polynucleotides from a nucleic acid-protein complex. The oligonucleotide comprises at least one first tag and at least o... | 12/06/2011 |
| 8071337 | Method for detecting viable cells in a sample by using a virus A method for detecting viable cells such as bacterial cells, within a sample, said method comprising (i) incubating said sample with a virus which is able to infect said cells under conditions which allow said virus to infect and replicate within any such cells whic... | 12/06/2011 |
| 8067208 | Probes and methods for hepatitis C virus typing using multidimensional probe analysis This invention provides compositions and methods for HCV typing, e.g., genotyping and/or subtyping. The compositions and methods of the invention can be used to assign an HCV isolate to one of at least five HCV types (for example, selected from types 1, 2, 3, 4, 5 o... | 11/29/2011 |
| 8067205 | Method of synthesizing cDNA A method for synthesizing cDNA possessing a consecutive sequence starting with a nucleotide adjacent to a cap structure of mRNA, which comprises (i) a process for annealing a double-stranded DNA primer and an RNA mixture containing mRNA possessing a cap structure, (... | 11/29/2011 |
| 8053214 | Apparatus and method of extracting and optically analyzing an analyte from a fluid-based sample An extraction and analysis device includes a microfluidic based collection system that extracts one or more different analytes from a fluid-based sample and an optical analysis system directly coupled to the collection system to perform optical analysis on the one o... | 11/08/2011 |
| 8043834 | Universal reagents for rolling circle amplification and methods of use Disclosed are compositions and methods useful for labeling and detection of analytes. The compositions generally are associations of three components: reporter binding agents, amplification target circles, and DNA polymerase. The compositions are assembled prior to ... | 10/25/2011 |
| 8034563 | Activated joining of nucleic acid probes A process is provided to generate fluorescent molecules in the presence of target nucleic acids, but not in the absence of that target. Two probes, one bearing moiety A and the other bearing moiety B, bind to the target in a way that brings A and B together. A photo... | 10/11/2011 |
| 8030032 | Methods and compositions related thereto for detecting and identifying distinct species of nucleic acids from causative agents Methods are described herein for detecting and identifying distinct species of nucleic acids, in a single container, for example, from a certain genus of infectious agents or otherwise causative agents comprising, for example, providing a forward PCR primer common t... | 10/04/2011 |
| 8030465 | Nucleic acid ligands to complex targets The present invention relates to a nucleic acid ligands capable of binding to one or more target molecules in a complex mixture. ... | 10/04/2011 |
| 8030033 | Polymorphisms in ABCB1 associated with a lack of clinical response to medicaments The present invention relates to methods, compositions and kits for determining the prognosis of a clinical response in a human patient to a medicament which acts in the central nervous system and which is a substrate of the ABCB1 protein. Further, the invention rel... | 10/04/2011 |
| 8026084 | Methods for rapid identification and quantitation of nucleic acid variants There is a need for nucleic acid analysis which is both specific and rapid, and in which no nucleic acid sequencing is required. The present invention addresses this need, among others by providing a method of nucleic acid amplification of overlapping sub-segments o... | 09/27/2011 |
| 8012718 | Physiogenomic method for predicting diabetes and metabolic syndromes induced by psychotropic drugs The invention is generally directed to a physiogenomic method for predicting diabetes and metabolic syndromes induced by psychotropic drugs. In one embodiment, the invention relates to the use of genetic variants of marker genes to predict the likelihood that an ind... | 09/06/2011 |
| 8012719 | Method for the quantitative detection of nucleic acids Provided herein is a method for the quantitative detection of HHV-6 subtypes A and/or B based on the use of a calibrator, suitable primers and probes, and a nucleic acid polymerase with 5′-3′ nuclease activity. ... | 09/06/2011 |
| 8012720 | Protein detecting device A protein detecting device, which comprises: (1) a detecting unit having a bonding section, which has properties for specifically bonding to a protein to be detected, a detecting section for detecting the bonding of the protein to be detected to the bonding section,... | 09/06/2011 |
| 7998707 | Quantitative measurement of gene expression from fixed paraffin embedded tissue Methods are disclosed for rapid, reliable and simple isolation of RNA, DNA and proteins from formalin-fixed paraffin-embedded tissue samples. RNA purified in this manner can be used to monitor gene expression levels. The tissue sample can be a tumor or other patholo... | 08/16/2011 |
| 7989186 | Compositions and methods for detecting cryptococcus neoformans Disclosed are oligonucleotides useful in methods for determining whether a sample contains Cryptococcus neoformans, a causative agent for human cryptococcosis. These oligonucleotides, which have nucleotide sequences derived from a coding segment of the gene e... | 08/02/2011 |
| 7960147 | Quantitative measurement of gene expression based on isolation of RNA from formalin-fixed paraffin-embedded tissue specimens Methods are disclosed for rapid, reliable and simple isolation of RNA from formalin-fixed paraffin-embedded tissue samples. RNA purified in this manner can be used for quantitative measurement gene expression levels. The tissue sample can be a tumor or other patholo... | 06/14/2011 |
| 7955822 | Detection of nucleic acids and proteins The invention generally relates to methods for detecting a target nucleic acid and a target protein in a single assay. ... | 06/07/2011 |
| 7951563 | Methods and nucleic acids for analysis of cellular proliferative disorders Aspects of the invention provide methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferati... | 05/31/2011 |
| 7943347 | Nucleic acid amplification method Provided is a simple and highly sensitive nucleic acid amplification method including hybridizing two types of oligonucleotide probes with a target gene and ligating the oligonucleotide probes with DNA ligase and amplifying the resultant single-stranded oligonucleot... | 05/17/2011 |
| 7939264 | DNA sequencing method The present invention pertains to a method for determining the sequence of a polynucleotide, the method relying on the detection of a conformational change in an enzyme that interacts with and processes along the polynucleotide. The detection of a conformational cha... | 05/10/2011 |
| 7932037 | DNA assays using amplicon probes on encoded particles Encoded bead multiplex assays for chromosomal gains and losses are provided that provide the benefits of complex, large template DNA sources, such as BAC DNA, as the probe material without bead networking or other assay performance problems. Reagents for assaying DN... | 04/26/2011 |
| 7919280 | Method for isolation of DNA, RNA and proteins from formalin-fixed paraffin-embedded tissue specimens Methods are disclosed for rapid, reliable and simple isolation of RNA from formalin-fixed paraffin-embedded tissue samples. RNA purified in this manner can be used to monitor gene expression levels. The tissue sample can be a tumor or other pathological tissue. ... | 04/05/2011 |
| 7919238 | Method for rapid identification of alternative splicing Alternatively spliced RNA, along with their normally-spliced counterparts, can be rapidly identified by hybridizing cDNA from normal tissue to cDNA from an abnormal or test tissue. The two cDNA populations are separately tagged prior to hybridization, which allows i... | 04/05/2011 |
