Celebrity Inventors
Mark Twain (Samuel L. Clemens) received Patent No. 121,992 for "An Improvement in Adjustable and Detachable Straps for Garments." He later received two more patents: one for a self-pasting scrapbook and one for a game to help players remember important historical dates.
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| Number | Title | Issue Date |
| 5527538 | Liposomal targeting of ischemic tissue Liposomes of a size of less than 200 nanometers target ischemic myocardial tissue and preferentially deliver active agents to infarcted areas in the absence of antibodies bound to the liposomes to effect the delivery.... | 06/18/1996 |
| 5458873 | Carboxyvinyl polymer having Newtonian viscosity A carboxyvinyl polymer having Newtonian viscosity, ophthalmic preparations containing the polymer, a process for preparing the polymer, and a vehicle for ophthalmic preparations containing the polymer. By using the polymer in a vehicle, an ophthalmic prep... | 10/17/1995 |
| 5441725 | Cosmetic compositions containing a polyethoxylated vitamin E The present invention relates to cosmetic compositions containing at least one polyethoxylated vitamin E species, which may be prepared by reacting a vitamin E with ethylene oxide, and exhibit an excellent cell protecting activity in the living body. The ... | 08/15/1995 |
| 5403590 | Method of pulsatile drug infusion A method of pulsatile infusion of a drug or other therapeutic agent is described. The pulsatile infusion method minimizes tachyphylaxis, while enabling the target cell, tissue, or organ to benefit from the administered drug or other therapeutic agent. The... | 04/04/1995 |
| 5401511 | Binding of protein and non-protein recognizing substances to liposomes Methodologies have been developed and certain recognizing substances and crosslinking reagents have been identified to modify liposomes. Crosslinking reagents link residues on the liposomal surface to the residues offered by certain recognizing substances... | 03/28/1995 |
| 5399352 | Device for local drug delivery and methods for using the same A device for the local delivery of a substance into a natural tissue conduit in the mammalian body, having a first clement capable of contacting the lumen of the conduit and a second element which overlays first element, a reservoir being formed between t... | 03/21/1995 |
| 5395620 | Biodegradable microcapsules having walls composed of crosslinked atelocollagen and polyholoside The invention relates to microcapsules with a mixed wall of crosslinked atelocollagen and polyholosides, for example glycosaminoglycans, and to processes for the manufacture of the said microcapsules. According to the invention, the microcapsules comprise... | 03/07/1995 |
| 5395619 | Lipid-polymer conjugates and liposomes A lipid-polymer conjugate for use in forming long-circulating liposomes is disclosed. The conjugate includes a vesicle-forming lipid having covalently attached to its polar head group, one of the polymers: polyvinylpyrrolidone, polyvinylmethylether, polyh... | 03/07/1995 |
| 5393505 | Process for increasing the acid gas absorption capacity of contaminated alkanolamine solutions The present invention includes a process for rejuvenating a spent aqueous alkanolamine solution comprising use of alkyl-substituted ammonium-containing organic base treatment to remove inorganic ions.... | 02/28/1995 |
| 5393792 | High dosage topical forms of collagenase High concentrations of collagenase as active ingredient in non-aqueous topical pharmaceutical formulations.... | 02/28/1995 |
| 5391580 | Poly(sulfone-alpha-olefin) composite permselective membrane article for use in blood oxygenation A biocompatable multi-layer article suitable for use in blood oxygenation is disclosed. The article is made up of a microporous polypropylene tube, a perm-selective, water vapor impermeable, carbon dioxide and oxygen permeable, homogeneous layer directly ... | 02/21/1995 |
| 5391376 | Method for preventing and treating cachexia The present invention relates to method for preventing or treating cachexia in a mammal based on the administration of a therapeutically effective amount of an anti-cachexia agent. Suitable agents include ADP-ribose-polymerase inhibitors, ADP-ribose-trans... | 02/21/1995 |
| 5391373 | Skin cream composition A skin cream composition according to the present invention provides significant retexturization of the skin, producing significantly improved smoothness, as well as significantly minimizing age spots and improving color of the skin, together with increas... | 02/21/1995 |
| 5391726 | Preparation of giant ring compounds The invention concenrs giant ring compounds containing about 20 to about 160 atoms in the backbone of the ring and methods for preparing the giant ring compounds.... | 02/21/1995 |
| 5389378 | Benzoporphyrin vesicles and their use in photodynamic therapy This invention relates to benzoporphyrin containing vesicles which are suitable for pharmaceutical application. In particular, the present invention relates to a liposomal preparation of benzoporphyrin (BPD) incorporated into vesicles comprising a liposom... | 02/14/1995 |
| 5389366 | Neocarzinostatin derivative composition for oral administration A composition for oral administration to cancer patients includes a neocarzinostatin derivative and from 0.1 and 100 ml per mg of the neocarzinostatin derivative of at least one fatty acid glyceride which has from 6 to 20 carbon atoms and which is noniodi... | 02/14/1995 |
| 5389379 | Process for the preparation of biologically active material containing polymeric microcapsules A process for the preparation of microcapsules containing biologically active material is disclosed. The process involves dissolving a polymer into a solvent into which the active material is also introduced; atomizing the resulting suspension or solution... | 02/14/1995 |
| 5389377 | Solid care therapeutic compositions and methods for making same A liposome composition which comprises a substantially uniform sized inorganic core coated with an amphipathic organic compound and further coated with a second amphipathic vesicle forming lipid. Also disclosed are novel phenyl lipid compounds which serve... | 02/14/1995 |
| 5389115 | Pills or pellets containing genetic material and inert carrier material and method for their preparation Pills or pellets containing genetic material and inert carrier material, characterized in that the inert carrier material forms the core of the pills or pellets, while the genetic material is distributed in a multitude around the core, adhering to that co... | 02/14/1995 |
| 5389364 | Conditioning hair with aminosilane reaction products with lactones or carbonates Hair is conditioned by applying to the hair an effective amount of a composition which includes as the hair conditioning agent, from 0.5 to 5.0 percent by weight of a derivatized amine functional organosilicon compound which is one of (i) a reaction produ... | 02/14/1995 |
| 5389373 | Preparation of oil-in-water emulsions of drugs A process for preparing an oil-in-water emulsion of a drug which is poorly soluble in water wherein the drug (e.g. amphotericin B) is dissolved in a solution of high or low pH prior to the formation of the drug emulsion. The solution of high pH is prefera... | 02/14/1995 |
| 5387421 | Multi stage drug delivery system A drug delivery system includes a first capsule half having an inner chamber for containing a drug therein. A plug is disposed in a passageway of the capsule half for plugging the opening thereof. The plug is releasable from the passageway opening upon th... | 02/07/1995 |
| 5385738 | Sustained-release injection The present invention relates to a sustained-release injection, which comprises a suspension of a powder comprising an active ingredient and a pharmaceutically acceptable biodegradable carrier (e.g. proteins, polysaccharides and synthetic high molecular c... | 01/31/1995 |
| 5385739 | Stable compositions of gastroprotected omerprazole microgranules and process for the production thereof The present invention relates to a stable formulation of omeprazole microgranules containing a neutral core consisting of sugar and starch, characterized in that it contains an active layer consisting of a dilution of omeprazole in mannitol in substantial... | 01/31/1995 |
| 5384132 | Stabilized gonadotropin containing preparations Disclosed are lyophilized gonadotropin containing preparations containing a dicarboxylic acid salt stabilizer. The particular proteins (e.g. LH, TSH, FSH, or HCG) are in admixture with, and at least partially capable of stabilization by, the particular st... | 01/24/1995 |
| 5384126 | Composition based upon hydrated lipidic lamellar phases or liposomes containing at least one derivative of labdane The present invention relates to a novel composition based on hydrated lipidic lamelar phases or on liposomes and to a cosmetic or pharmaceutical, particularly dermatological composition incorporating it. According to the invention, the hydrated lipidic lamela... | 01/24/1995 |
| 5380530 | Oral care composition coated gum Disclosed are several oral hygiene preparations including plaque disrupting and gingivitis control preparations in the form of chewing gums, wherein a chewing gum is coated with a plaque disrupting emulsion containing an ingestible surfactant and a polydi... | 01/10/1995 |
| 5378475 | Sustained release drug delivery devices A method and device for treating a mammalian organism to obtain a desired local or systemic physiological or pharmacological effect is provided. The method includes administering a sustained release drug delivery system to a mammalian organism in need of ... | 01/03/1995 |
| 5378469 | Collagen threads The present invention provides improved collagen threads and methods of making and using such threads, including the production of yarn, as well as braided, knitted, and woven articles of manufacture, comprising such threads.... | 01/03/1995 |
| 5378474 | Sustained release pharmaceutical composition The present invention relates to a pharmaceutical pellet composition having a core element including at least one highly soluble active ingredient and a core coating which is partially soluble at a highly acidic pH. The pharmaceutical composition provides... | 01/03/1995 |
| 5376379 | Liposomes of thermal waters stabilized in a DNA gel The present invention relates to compositions based on thermal water containing liposomes of thermal water stabilized in a deoxyribonucleic acid (DNA) gel and a process for preparing thereof. The composition is useful in dermatology and cosmetology.... | 12/27/1994 |
| 5376380 | Method of producing liposomal products from freeze or spray-dried preparations of liposomes A method of producing liposomal products which comprises treating a positively or negatively charged, freeze- or spray-dried liposomal preparation with an aqueous solution of a drug charged oppositely to the charge of the liposomes.... | 12/27/1994 |
| 5376382 | Tablets, granulates and pellets with a high active substance content for highly concentrated, solid dosage forms of thioctic acid A solid medicinal form having an active substance content of over 45 weight % and processes for its preparation by granulating with large amounts of water, drying and optionally conventional tableting and/or pelleting.... | 12/27/1994 |
| 5376385 | Releasably bound active materials A process for binding water-sensitive active materials in essentially non-aqueous systems.... | 12/27/1994 |
| 5374429 | Medical adhesive sheet and medical preparation A medical adhesive sheet comprising a support comprising a laminate of a polyester film having a thickness of from 0.5 to 6 μm and a polyester nonwoven fabric having a basis weight of from 5 to 20 g/m2, and a pressure-sensitive adhesive layer ... | 12/20/1994 |
| 5370877 | Method for improving delivery and reducing toxicity of biologically active substances using novel -amino dicarboxylic acid derivatives -Aminocarboxylic acid derivatives of the formula: ##STR1## where n, X, Y and Z have the meanings stated in the description, and their preparation are described. The compounds are used in a method for improving delivery and reducing toxicity of... | 12/06/1994 |
| 5369130 | Paste composition for skin barrier Skin barrier paste compositions free from organic solvents comprised of at least a rubber component and a filler component wherein the rubber component includes a liquid rubber having an average molecular weight of about 1,000 to about 80,000 and a viscos... | 11/29/1994 |
| 5369119 | Use of imexon as an immune suppressive and pharmaceutical compositions containing imexon The subject of the present invention is the use of imexon for the production of pharmaceutical compositions with an immunosuppressive action. The present invention also provides pharmaceutical compositions containing imexon and further active materials.... | 11/29/1994 |
| 5366732 | Method of milking cows A method of preparing, treating and then milking cows includes the use of a flexible wipe (A) constructed of hydrophilic material containing a moisture-activated antimicrobial composition. The process includes washing teats and udder of a milk-bearing cow... | 11/22/1994 |
| 5366733 | Method for the treatment of periodontal disease by sustained delivery of a therapeutic agent to the periodontal pocket, and composition of matter therefor Oral compositions for the local administration of a therapeutic agent to a periodontal pocket of a patient for alleviating dental disease comprise a plurality of dry, discrete microparticles each of which comprise an effective amount of at least one thera... | 11/22/1994 |
