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| Number | Title | Issue Date |
| 5380531 | Accumulations of amino acids and peptides into liposomes The present invention relates to liposomal compositions having a concentration gradient which load amino acids and peptides exhibiting weak acid or base characteristics into liposomes. Specifically loaded into liposomes by the methods of the present inven... | 01/10/1995 |
| 5332575 | Method of targeting melanocytes with a compound containing a fucose residue The invention concerns a method of binding a product to the membrane of a melanocyte by means of a ligand-receptor bond, which comprises using a product consisting of a basic structure coupled to at least one ligand consisting of an oside residue accessib... | 07/26/1994 |
| 5314695 | Tissue factor based prothrombin time reagent Prothrombin time reagents are provided which comprise novel liposome compositions in which tissue factor is associated with an inserted into the phospholipid bilayer of the liposomes. Methods for their preparation are also provided. The liposome compositi... | 05/24/1994 |
| 5304382 | Ferritin analogs Ferritin analogs comprising an apoferritin protein shell and a core substantially devoid of ferrihydrite, e.g. of inorganic composition such as aluminum hydroxide or organic composition such as acetaminophen. The protein shell can be removed from ferritin... | 04/19/1994 |
| 5300303 | Spray granules or microgranules of pure riboflavin which contain no binder are non-dusting and free-flowing, and the preparation thereof A process for preparing spray granules or microgranules, which contain no binder, are non-dusting and free-flowing, from finely divided pure riboflavin, comprises subjecting an aqueous or water-containing suspension of the pure finely divided riboflavin t... | 04/05/1994 |
| 5294446 | Composition and method of promoting hard tissue healing Osteoprogenitor cells encapsulated in alginate and alternatively, additionally encapsulated in poly-L-lysine and/or agarose promote regeneration of bone at the site of implantation. The present invention provides a composition comprising osteoprogenitor c... | 03/15/1994 |
| 5290565 | Composition for promoting healing Composition for promoting healing containing, as a healing agent, nonionic vesicles obtained from a lipid mixture containing at least one nonionic lipid having the formula; ##STR1## wherein R is either at least one C16 -C18 radi... | 03/01/1994 |
| 5290562 | Compositions and methods employing liposomes including tyrosine or a tyrosine derivative Compositions, for example cosmetic or pharmaceutical compositions, and methods of increasing melanin formation on the skin or scalp employ liposomes including between 0.001 and 10 weight percent, with respect to the total weight of the composition, of tyr... | 03/01/1994 |
| 5288495 | Method for controlling pests using stabilized thiocarbonate solutions Aqueous thiocarbonate solutions are stabilized by the addition of base, sulfide and/or polysulfide, and the stability and safety of the more concentrated solutions containing 1 weight percent or more equivalent CS2 as a thiocarbonate are achiev... | 02/22/1994 |
| 5284934 | Synthesis and utilization of carbohydrate-binding polymer-lectin conjugates The present invention provides a process for preparing a carbohydrate-binding lectin derivative for use as immune modulators or immunoconjugates. The polymer-lectin conjugate produced in accordance with the process is polyethylene glycol Ricinus communis ... | 02/08/1994 |
| 5281662 | Anthraquinone dye treated materials Disclosed is a treated material including a base material such as an extrudate, a woven fabric, or unwoven fibers, a disperse dye-type molecule such as a dye or antibiotic dispersed within and non-covalently adhered to the base material, and a molecule-of... | 01/25/1994 |
| 5279834 | Pharmaceutical or cosmetic composition containing hydroquinone and kojic acid The invention relates to a cosmetic or pharmaceutical composition, containing hydroquinone and kojic acid or a derivative thereof, especially the salts or esters thereof. The hydroquinone and/or kojic acid component is in a form which is at least partiall... | 01/18/1994 |
| 5277913 | Liposomal delivery system with photoactivatable triggered release A triggered release liposomal delivery system is disclosed that selectively releases its contents in response to illumination or reduction in pH. The liposomes contain an amphipathic lipid, such as a phospholipid, having two chains derived from fatty acid... | 01/11/1994 |
| 5271939 | Pharmaceutical compositions and methods of treatment to prevent and treat corneal scar formation produced by laser irradiation Methods for preventing and treating corneal haze resulting from exposure of the eye to laser irradiation are disclosed. The methods include administration of compositions of wound healing modulators to the eye. Compositions for use in preventing and treat... | 12/21/1993 |
| 5270057 | Stabilized gonadotropin containing preparations Disclosed are lyophilized gonadotropin containing preparations containing a dicarboxylic acid salt stabilizer. The particular proteins (e.g. LH, TSH, FSH, or HCG) are in admixture with, and at least partially capable of stabilization by, the particular st... | 12/14/1993 |
| 5270046 | Heparin bound anti-thrombotic material Disclosed is an anticoagulant material comprising a polymer obtained from an ionically bonded composite synthesized from i) a basic compound having a copolymerizable functional group and ii) a heparin salt. Disclosed is also a process for preparing the an... | 12/14/1993 |
| 5270052 | Methods and compositions for treatment of infection by intracellular parasites A method for treating an infection caused by an intracellular parasite in a patient. The method includes administering to the patient liposomes coated with C-reactive protein, wherein the liposomes include phosphatidylcholine or phosphorylcholine.... | 12/14/1993 |
| 5270053 | Parenterally administerable liposome formulation comprising synthetic lipid The invention relates to pharmaceutical compositions in the form of parenterally, especially intravenously, administrable liposome dispersions or dry preparations, especially lyophilisates, that can be used therefor, comprising the zinc-phthalocyanine com... | 12/14/1993 |
| 5268180 | Cosmetic pharmaceutical or foodstuff composition comprising an aqueous dispersion of lipidic vesicles This composition consists in an aqueous dispersion D, lamellar structure lipid vesicles encapsulating an aqueous phase E; it is characterised by the fact that the lipid phase forming the layers of the said vesicles is at least partly made up of a compound... | 12/07/1993 |
| 5266322 | Cosmetic film forming compositions This invention relates to a cosmetic film forming composition which is especially useful as a nail coating composition which upon drying forms a film which will adhere to keratin of a nail. More particularly, the present invention relates to cosmetic film... | 11/30/1993 |
| 5266303 | Aerosol hair spray formulations This invention relates to aerosol hair spray formulations based on (1) a sulfonate-containing, water-dispersible or water-dissipatible, linear polyester having a glass transition temperature of about 36° C. to about 40° C. and (2) a water-soluble, polyv... | 11/30/1993 |
| 5264221 | Drug-containing protein-bonded liposome A drug-containing protein-bonded liposome comprising a liposome containing a drug and having maleimide residues on its surface, and a protein and residues of a compound having a polyalkylene glycol moiety, bonded via respective thiol groups to the maleimi... | 11/23/1993 |
| 5264220 | Method of extending the vascular dwell-time of particulate therapeutic and particulate diagnostic agents The present invention relates to a composition for increasing the vascular dwell-time of a particulate therapeutic or diagnostic agent in a mammal through the adjunct administration of an effective amount of the particulate therapeutic or diagnostic agent... | 11/23/1993 |
| 5262425 | -mannosidase inhibitors [4S-(4,4aଲ,5ଲ,6,7,7a)]-Octahydro-1H-1 -pyrindine-4,5,6,7-tetrols and [4R-(4,4a,5,6ଲ,7ଲ,7aଲ)]-octahydro-1H-1 -pyrindine-4,5,6,7-tetrols are useful as inhibitors of alpha-mannosida... | 11/16/1993 |
| 5260292 | Topical treatment of acne with aminopenicillins A method and composition for topically treating acne and acneiform dermal disorders includes applying an amount of an antibiotic selected from the group consisting of ampicillin, amoxicillin, other aminopenicillins, and cephalosporin, and derivatives and ... | 11/09/1993 |
| 5260065 | Blended lipid vesicles A new class of lipid vesicles having a blend of two lipids, a primary lipid and a secondary lipid, has been developed. The primary lipid, which forms the greatest proportion of lipid by weight, will not form vesicles nor preferably, even a lamellar phase,... | 11/09/1993 |
| 5256422 | Lipid vesicle containing water-in-oil emulsions The present invention features water-in-oil emulsions having intact lipid vesicles dispersed in the water or aqueous phase. Methods of making the emulsions are also disclosed. The preferred vesicles for use in the emulsions are paucilamellar lipid vesicle... | 10/26/1993 |
| 5254330 | Aerosol carriers Pharmaceutical excipients useful in dry powder inhalents comprise particles having a rugosity (measured by air permeametry) of less than 1.75. The use of these carriers increases the amount of drug injested by the patient using a dry powder inhaler. The p... | 10/19/1993 |
| 5252339 | Pharmaceutical compositions containing orally absorbable glycosamimoglycans Pharmaceutical compositions for oral use, preferably selected from capsules, tablets or sugar coated tablets, coated by an enterosoluble gastroresistant film, containing a lyophilizate consisting of therapeutically effective amounts of a glycosaminoglycan... | 10/12/1993 |
| 5252336 | Liposome composition whose liposome membrane contains a polyoxyethylene derivative A liposome composition is obtained by using as constituent components of the liposome membrane a polyoxyethylene derivative represented by the general formula: X--O--(CH2 CH2 O)n --Y (I) wherein X represents an alkanoyl group o... | 10/12/1993 |
| 5252348 | Artificial viral envelopes The production of artificial viral envelopes by a novel double-detergent dialysis technique is disclosed. Specifically exemplified is the production of HIV-1 and RSV viral envelopes. The resulting artificial viral envelopes are essentially identical to th... | 10/12/1993 |
| 5246707 | Sustained release delivery of water-soluble bio-molecules and drugs using phospholipid-coated microcrystals, microdroplets and high-concentration liposomes The novel uses of the phospholipid-coated microcrystal in the delivery of water-soluble biomolecules such as polypeptides and proteins. The proteins are rendered insoluble by complexation and the resulting material forms the solid core of the phospholipid... | 09/21/1993 |
| 5246698 | Biocompatible viscoelastic gel slurries, their preparation and use Disclosed are biocompatible viscoelastic gel slurries formed from a polymeric gel, preferably a hyaluronan or a derivative thereof such as hylan swollen in an aqueous medium and a fluid phase which is an aqueous solution of a polymer which may also but no... | 09/21/1993 |
| 5244672 | Composition containing liposomes stabilized by a stabilizing support based on atelocollagen and glycosaminoglycans The invention relates to a composition containing liposomes, stabilized by a stabilizing support comprising a mixture of atelocollagen and glycosaminoglycans in a relative proportion preferably ranging between 18 and 25% by weight of the atelocollagen. Th... | 09/14/1993 |
| 5242690 | Inert granular carrier for chemicals A granular substrate, and method for preparation thereof, is provided for use with herbicide, fungicide, and/or insecticide formulations, the substrate comprising an agglomerated grain dust and/or hulls in combination with a binder, particularly a lignosu... | 09/07/1993 |
| 5238683 | Aerosol preparation of glutathione and a method for augmenting glutathione level in lungs An aerosol preparation of reduced glutathione (GSH) is provided to augment the level of GSH in the lungs. Treatment of pulmonary conditions, where reduced level of GSH is found, by the aerosol preparation of the present invention is taught.... | 08/24/1993 |
| 5229506 | Preparation of cellulose aminomethanate An improvement to the process for synthesizing cellulose aminomethanate is disclosed which comprises slurring cellulose in low concentrations of aqueous caustic solutions, in the presence of urea, and steeping the slurried mixture, at from about 2° C. to... | 07/20/1993 |
| 5227165 | Liposphere delivery systems for local anesthetics A local anesthetic microsuspension system is disclosed that includes lipospheres, that are solid, water-insoluble microparticles that have a layer of a phospholipid embedded on their surface. The core of the liposphere is a solid anesthetic such as lidoca... | 07/13/1993 |
| 5221535 | Sustained release formulations of insect repellent A microsuspension system containing insect repellent is disclosed that includes lipospheres, that are solid, water-insoluble microparticles that have a layer of a phospholipid embedded on their surface. The core of the liposphere is a solid insect repelle... | 06/22/1993 |
| 5219576 | Collagen wound healing matrices and process for their production Collagen implants that are useful as wound healing matrices are characterized by being formed of collagen fibrils that are not chemically cross-linked, and having a bulk density of 0.01 to 0.3 g/cm3 and a pore population in which at least about... | 06/15/1993 |
