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| Number | Title | Issue Date |
| 6514759 | Plant growth factor The present invention relates to a peptide of the formula: ##STR1## wherein R1 and R2 are the same or different and each represents SO3 H or H; X represents an -amino acid or a single bond; Z1 and Z2... | 02/04/2003 |
| 6479523 | Pharmacologic drug combination in vagal-induced asystole Controlled cessation of heart beat during coronary bypass surgery and other cardiac surgeries on a beating heart improves surgical technique, and is achieved typically by electrical stimulation of the vagus nerve and administration of a combination of dru... | 11/12/2002 |
| 6410694 | Method for solubilization and naturation of somatotropins A method for the solubilization and/or naturation of a somatotropin involves contacting a somatotropin with a detergent composition and water under conditions effective to obtain a naturated somatotropin, wherein the detergent composition may be a C1... | 06/25/2002 |
| 6388054 | Anti-cancer compounds The present invention provides compounds useful to inhibit tumor growth and to induce apoptosis. In general, the anti-cancer agents (ACA) are described by the formula: [ACA]n -X [Formula I] wherein X is a linker group having 2-5 functional groups o... | 05/14/2002 |
| 6380357 | Glucagon-like peptide-1 crystals The invention provides individual tetragonal flat rod shaped or plate-like crystals of glucagon-like peptide-1 related molecules, processes for their preparation, compositions and methods of use. The crystal preparations exhibit extended time action in vi... | 04/30/2002 |
| 6358921 | Antimicrobial peptide compositions and method The invention concerns antimicrobial cyclic peptides and peptide analogs having relatively low hemolytic activity. Peptides of the invention are effective in killing and/or inhibiting growth of a number of microorganisms, including gram-positive bacteria,... | 03/19/2002 |
| 6352997 | Method of improving in-vitro fertilization The present invention provides for a method of treating polycystic ovary syndrome in a subject in need of such treatment comprising the administration of a therapeutically effective amount of a compound of structural formula I: ##STR1## to the subjec... | 03/05/2002 |
| 6352974 | Oral calcitonin pharmaceutical compositions and methods of making the same The present invention relates to novel compositions, in particular to compositions comprising calcitonin or a fragment or conjugate thereof and to methods for preparing such compositions. It also relates to oral formulations comprising the compositions an... | 03/05/2002 |
| 6350430 | Melanocortin receptor ligands and methods of using same The invention provides ligands for melanocortin receptors. For example, the invention provides the melanocortin receptor peptide ligand Ac-Nlc-Gln-His-(p(I)-D-Phe)-Arg-(D-Trp)-Cly-NH2, (SEQ ID NO: 1), where the iodo group is unlabeled or radioa... | 02/26/2002 |
| 6346512 | Compounds and methods for modulating cell adhesion Cyclic peptides and compositions comprising such cyclic peptides are provided. The cyclic peptides comprise a cadherin cell adhesion recognition sequence HAV. Methods for using such peptides and compositions for modulating cadherin-mediated cell adhesion ... | 02/12/2002 |
| 6342477 | Remedies for thrombocytopenia Agents for preventing and treating thrombocytopenia, thrombocytopenic purpura and various diseases that tend to cause bleeding due, presumably, to thrombocytopenia contain a parathyroid hormone (PTH) or at least one PTH derivative as an active ingredient.... | 01/29/2002 |
| 6337318 | Sustained GnRH peptide-release formulation A pharmaceutical and/or veterinary formulation for sustained release of a peptide agonist or analogue, comprising about 2-15% (w/w) of at least one peptide agonist or analogue other than deslorelin (on an active basis), about 0.5-3.5% (w/w) lecithin and t... | 01/08/2002 |
| 6335317 | Use of gut-trophic growth factors to improve oxidative status The present disclosure describes methods for minimizing oxidative damage in an animal or human during or after malnutrition, underfeeding or fasting, especially during refeeding after undernutrition or malnutrition, and for minimizing oxidant damage durin... | 01/01/2002 |
| 6333307 | Compounds and method for modulating neurite outgrowth Modulating agents comprising cyclic peptides, and compositions comprising such modulating agents are provided. The cyclic peptides comprise a cadherin cell adhesion recognition sequence HAV. Methods for using such peptides and compositions for modulating ... | 12/25/2001 |
| 6331520 | Pharmaceutical compositions of peptides having low solubility in physiological medium Pharmaceutical compositions are described, which comprise: a) a peptide poorly soluble in aqueous physiological saline solution, as active ingredient; b) a non-ionic aromatic hydrotropic pharmaceutically acceptable agent; and c) a physiological aqueous solution.... | 12/18/2001 |
| 6306822 | Phosphopeptides and methods of treating bone diseases Phosphopeptides which significantly reduce bone loss or weakening are provided by the invention. Also provided is a method for treating or preventing any condition associated with bone loss or weakening by administering the phosphopeptides by oral or inje... | 10/23/2001 |
| 6306450 | Storage stable, citrus-flavored compositions comprising plant extracts Storage-stable, citrus-flavored compositions comprising citral or a citral derivative as the flavoring agent and a plant extract as the stabilizing agent. The plant extract inhibits the formation of p-methylacetophenone, thereby preventing the development... | 10/23/2001 |
| 6268344 | Methods for treating hypercoagulable states or acquired protein C deficiency A method of treatment for human patients with an acquired hypercoagulable state or acquired protein C deficiency associated with sepsis, purpura fulminans, meningococcal sepsis, bone marrow and other transplantations, severe burns, pregnancy, major surger... | 07/31/2001 |
| 6255286 | Depsipeptides and drugs containing the same as the active ingredient Depsipeptides represented by the formula (1): ##STR1## (wherein: R1 is a straight or branched alkyl group of 5-20 carbon atoms or a straight or branched alkoxymethyl group of 5-15 carbon atoms; R2 is --A--B, --A--B--W, --A--B--W--D o... | 07/03/2001 |
| 6255344 | Histidine derivatives, preparation, process, and their use as free antiradical agents The invention relates to novel histidine derivatives corresponding to the general formula (I) below: ##STR1## in which: R denotes a linear or branched, saturated or unsaturated alkyl radical containing from 6 to 22 carbon atoms, n is an integer ranging fr... | 07/03/2001 |
| 6250469 | Formulations for protection of peg-interferon alpha conjugates The present invention provides formulations that prevent loss and damage of PEG-interferon alpha conjugates during and following lyophilization. The formulations of the present invention protect PEG-interferon alpha conjugates from loss and degradation du... | 06/26/2001 |
| 6251868 | Method for treating a human immunodeficiency virus infection The present invention provides a method for preventing or treating a human immunodeficiency virus (HIV) infection, including a new or an asymptomatic infection as well as AIDS, comprising administering to a mammal in need thereof a HIV infection preventin... | 06/26/2001 |
| 6248717 | Tartrate salt of a substituted dipeptide as growth hormone secretagogue This invention is directed to the (L)-tartaric acid salt of 2-amino-N-{1-(2,4-difluoro-benzyloxymethyl)-2-oxo-2-[3-oxo-3a-pyridin-2-yl methyl-2-(2,2,2-trifluoro-ethyl)-2,3,3a,4,6,7-hexahydro-pyrazolo{4,3-c}pyri din-5-yl]-ethyl]-2-methyl-propionamide which i... | 06/19/2001 |
| 6245743 | Inhibitors of factor Xa Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.... | 06/12/2001 |
| 6245740 | Polyol:oil suspensions for the sustained release of proteins The present invention relates to the preparation of polyol/thickened oil suspensions containing a biologically active agent, for the sustained delivery of the biologically active agent. The described protein/glycerol/oil suspensions show sustained release... | 06/12/2001 |
| 6242040 | Functional sodium chloride compositions Novel functional sodium chloride compositions containing sodium gluconate as a substitute for the conventionally employed sodium chloride and being efficacious in preventing hypertension and the onset of complications thereof in the brain, heart, kidney; ... | 06/05/2001 |
| 6241997 | Chewable calcium supplement and method A chewable calcium composition and its associated method of manufacturing are disclosed. The chewable composition includes a lipid base and a micronized calcium salt substantially uniformly mixed with the lipid base such that the lipid base forms a contin... | 06/05/2001 |
| 6239105 | Homeopathic preparations of purified growth hormone The present invention comprises homeopathic preparations of purified growth hormone, as well as methods and systems for delivery of such preparations and treatment of disorders and conditions by administering such preparations.... | 05/29/2001 |
| 6239111 | In vivo method of improving survival rate of brain neurons The present invention discloses the use, in the manufacture of a preventive and therapeutic drug of a brain disease, of a compound represented by formula (1): [wherein R represents a hydrogen atom, an alkyl group, an alkenyl group, a substituted alkyl gro... | 05/29/2001 |
| 6235876 | Liquid phase process for the preparation of GNRH peptides A liquid phase process for preparing GnRH peptide analogs of the formula: G-AA1 -(A)D-Phe-AA3 -AA4 -(R2 -AA5 -AA6 -AA7 -AA8 -Pro-AA10 -NH2 Formula 1 whic... | 05/22/2001 |
| 6225300 | TNF receptor and steroid hormone in a combined therapy The present invention relates to the use of a TNF Receptor together with a steroid hormone to produce a pharmaceutical composition for the treatment of lethal bacterial and viral infections as well as autoimmune and inflammatory diseases. It also relates ... | 05/01/2001 |
| 6224895 | Method for promoting ovulation, parturition, and lactation in mammals The present invention generally relates to various methods for promoting ovulation, parturition and lactation in female mammals. These benefits are obtained by administering to the mammals a composition containing a D2 receptor antagonist that ... | 05/01/2001 |
| 6224871 | Dietary supplement for nutritionally promoting healthy joint function A dietary supplement for nutritionally promoting healthy joint function in human subjects is disclosed. The supplement includes as a major ingredient a protein derived from the enzymatic hydrolysis of collagen in combination with lesser proportions of glu... | 05/01/2001 |
| 6211152 | Formulations for peptide release A pharmaceutical and/or veterinary formulation comprising deslorelin and an excipient, the formulation being characterised in that, in vitro, it releases deslorelin into phosphate buffered saline, as hereinbefore described, at 37° C. at a rate of about 2... | 04/03/2001 |
| 6211155 | Peptide conjugates derived from thymic hormones, their use as a medicament and compositions containing them The invention relates to peptide conjugates comprising a sequence of at least 3 amino acids derived from a thymic hormone selected amongst thymuline and thymopoietine, the amino acids being independently in the form D, L or DL, said sequence being chemica... | 04/03/2001 |
| 6207681 | Methods and compositions for treating urinary incontinence using enantiomerically enriched (R)-trihexyphenidyl A method for treating urinary incontinence, such as incontinence resulting from bladder detrusor muscle instability, using enantiomerically enriched (R)-trihexyphenidyl. The method comprises administering a therapeutically effective amount of enantiomeric... | 03/27/2001 |
| 6207639 | Compounds and methods for modulating neurite outgrowth Modulating agents comprising cyclic peptides, and compositions comprising such modulating agents are provided. The cyclic peptides comprise a cadherin cell adhesion recognition sequence HAV. Methods for using such peptides and compositions for modulating ... | 03/27/2001 |
| 6204247 | Chemical modification of proteins to improve biocompatibility and bioactivity The present invention broadly relates to chemical modification of biologically active proteins or analogs thereof. More specifically, the present invention describes novel methods for site-specific chemical modification of various proteins, and resultant ... | 03/20/2001 |
| 6204285 | Methods and compositions for treating urinary incontinence using enantiomerically enriched (R,R)-glycopyrrolate A method for treating urinary incontinence, such as incontinence resulting from bladder detrusor muscle instability, using enantiomerically enriched (R, R)-glycopyrrolate. The method comprises administering a therapeutically effective amount of enantiomer... | 03/20/2001 |
| 6200954 | Small peptides having potent anti-angiogenic activity The present invention provides peptides having potent anti-angiogenic activity. The peptides can be administered as pharmaceutical compositions for prevention or treatment of undesired angiogenesis, for instance for prevention of tumor metastasis or inhib... | 03/13/2001 |
