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| Number | Title | Issue Date |
| 6642000 | PCR amplification on microarrays of gel immobilized oligonucleotides The invention relates two general methods for performing PCR amplification, combined with the detection and analysis of the PCR products on a microchip. In the first method, the amplification occurs both outside and within a plurality of gel pads on a mic... | 11/04/2003 |
| 6613517 | Nucleic acid binding assay and selection method The invention provides a novel nucleic acid binding assay, which is useful for assessing the sequence-dependence of the binding of ligands to nucleic acid molecules, as well as for determining the affinity of the binding interaction. The invention also pr... | 09/02/2003 |
| 6610482 | Support bound probes and methods of analysis using the same The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used ... | 08/26/2003 |
| 6573042 | Detection of bladder cancer Cells collected from bladder washings or urine may be analyzed by in situ hybridization. Such analysis includes detection of bladder cancer or carcinoma-in-situ.... | 06/03/2003 |
| 6569618 | Diagnosis of diseases associated with coronary twitching The present invention relates to a process for screening for a gene involving a coronary artery spasm-associated disease, which comprises detecting the presence of the relevant nucleotide substituents in the endothelial nitric oxide synthase (eNOS) gene. ... | 05/27/2003 |
| 6569622 | Nucleic acids encoding a protein conferring an inducible resistance to glycopeptide, particularly in gram-positive bacteria The invention relates to a protein VanB involved, in Gram-positive bacteria, in resistance to glycopeptides, particularly to vancomycine, said resistance being of the type inducible by the vancomycine and non-inducible by teicoplanine. The invention also ... | 05/27/2003 |
| 6489145 | Method of DNA shuffling Disclosed is a method of producing random polynucleotides by introducing two or more related polynucleotides into a suitable host cell such that a hybrid polynucleotide is generated by recombination and reductive reassortment. Also provided are vector and... | 12/03/2002 |
| 6479243 | Method for generating libraries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules Disclosed is an in vitro process for synthesizing DNA encoding a family of antigen-combining proteins. This process involves obtaining DNA containing genes encoding antigen-combining proteins and then combining these genes with sequence specific primers. ... | 11/12/2002 |
| 6479242 | Method for genotyping of single nucleotide polymorphism The VSET method comprises: providing a polynucleotide acid sample comprising at least one target site, and a first region of nucleotides immediately adjacent to the target site; preferably genomic DNA; preferably amplifying the polynucleotide; then combin... | 11/12/2002 |
| 6458534 | Gene associated with Nijmegen breakage syndrome, it's gene product and methods for their use The present invention relates to a novel gene, NBS1, and its gene product, nibrin. In addition, it relates to methods for detecting mutations or polymorphisms of the gene that are associated with Nijmegen breakage syndrome in patients. Such mutations may ... | 10/01/2002 |
| 6455279 | Process for the production of naturally folded and secreted proteins by co-secretion of molecular chaperones A process for the production of a naturally folded eukaryotic polypeptide containing two or several cysteines linked by disulfide bridges by a) culturing prokaryotic cells in which the said prokaryotic cells contain an expression vector which codes for th... | 09/24/2002 |
| 6455249 | Method of amplifying DNA and RNA mismatch cleavage products Detection of probe fragment products of basepair mismatch cleavage indicate the presence and sequence of target DNA. Detection of the target is enhanced by amplification through recycling targets by maintaining an assay temperature between the melting poi... | 09/24/2002 |
| 6436647 | Method for detecting chemical interactions between naturally occurring biological analyte molecules that are non-identical binding partners A method of using micromechanical devices as sensors for detecting chemical interactions between naturally occurring bio-polymers which are non-identical binding partners is provided. The method is useful whether the reactions occur through electrostatic ... | 08/20/2002 |
| 6432650 | Amplification of chromosomal DNA in situ Amplification of chromosomal DNA in situ to increase the amount of DNA associated with a chromosome or chromosome region is described. The amplification of chromosomal DNA in situ provides for the synthesis of Fluorescence in situ Hybridization (FISH) pai... | 08/13/2002 |
| 6428955 | DNA diagnostics based on mass spectrometry The invention provides fast and highly accurate mass spectrometer based processes for detecting a particular nucleic acid sequence in a biological sample. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a gene... | 08/06/2002 |
| 6423516 | Process and agent for instabilizing viral quasi-species-distributions avoiding resistance phenomena A process for instabilizing viral quasi-species-distributions under avoidance of resistance phenomena by replication of the nucleic acids of the viruses present in the quasi-species-distribution by of a defective replication system, a) whereby the defecti... | 07/23/2002 |
| 6420116 | Antimicrobial peptide The present invention relates to a novel human antimicrobial peptide which is a member of the defensin superfamily. In particular, isolated nucleic acid molecules are provided encoding the human antimicrobial peptide. Antimicrobial peptide are also provid... | 07/16/2002 |
| 6416952 | Photolithographic and other means for manufacturing arrays The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used ... | 07/09/2002 |
| 6413723 | Methods and compositions for identifying nucleic acids containing cis acting elements The invention provides a method of identifying nucleic acid molecules that contain cis acting nucleic acid elements. Also provided is a method of isolating nucleic acid binding factors. The invention also provides methods of identifying compounds that are... | 07/02/2002 |
| 6413717 | Methods for indentifying anti-cancer agents Methods are provided for identifying agents that modulate the expression of genes, such as genes encoding tumor suppressor or tumor-promoting proteins. The methods generally comprise screening candidate agents for the ability to enhance expression of a tu... | 07/02/2002 |
| 6413718 | Method for sequencing of nucleic acid polymers Sequencing of a selected region of a target nucleic acid polymer in a natural abundance DNA sample can be performed in a single vessel by combining the sample with a sequencing mixture containing a primer pair, a thermally stable polymerase such as Thermo... | 07/02/2002 |
| 6410277 | DNA polymersases with enhanced length of primer extension A formulation and kit of thermostable or other DNA polymerases comprising at least one thermostable or other DNA polymerase which lacks 3'-exonuclease activity, and at least one thermostable DNA polymerase exhibiting 3'-exonuclease activity. Also provided... | 06/25/2002 |
| 6410239 | Identification and comparison of protein--protein interactions that occur in populations and identification of inhibitors of these interactors Methods are described for detecting protein-protein interactions, among two populations of proteins, each having a complexity of at least 100. Encoded proteins are fused either to the DNA-binding domain of a transcriptional activator or to the activation ... | 06/25/2002 |
| 6410232 | Molecules of the follistatin-related protein family and uses thereof Novel FMCP polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length FMCP proteins, the invention further provides isolated FMCP fussion proteins, antigenic peptides and anti-FMCP antibodies. The invention also... | 06/25/2002 |
| 6406854 | Method and compositions for evaluating resolution of nucleic acid separation systems Disclosed are methods and compositions for estimating the crossover point of a molecular separation system.... | 06/18/2002 |
| 6403320 | Support bound probes and methods of analysis using the same The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used ... | 06/11/2002 |
| 6401267 | Methods and compositions for efficient nucleic acid sequencing Disclosed are novel methods and compositions for rapid and highly efficient nucleic acid sequencing based upon hybridization with two sets of small oligonucleotide probes of known sequences. Extremely large nucleic acid molecules, including chromosomes an... | 06/11/2002 |
| 6403308 | Methods for detecting and reversing resistance to macrocyclic lactone compounds This invention describes novel purified and isolated nucleic acid molecules or the fragments thereof, extracted from nematode or arthropod pests or recombinant, which encode P-glycoprotein homologs and regulate resistance to the macrocyclic lactone compou... | 06/11/2002 |
| 6399755 | Products for inhibiting expression of human MDM2 A human gene has been discovered which is genetically altered in human tumor cells. The genetic alteration is gene amplification and leads to a corresponding increase in gene products. Detecting that the gene, designated hMDM2, has become amplified or det... | 06/04/2002 |
| 6399334 | Normalized nucleic acid libraries and methods of production thereof The present invention relates generally to methods for producing normalized nucleic acid libraries in which each member of the library can be isolated with approximately equivalent probability. In particular, the present methods comprise subtractive hybri... | 06/04/2002 |
| 6391548 | Circular site-directed mutagenesis The invention provides improved methods of introducing site-directed mutations into circular DNA molecules of interest by means of mutagenic primer pairs. The mutagenic primer pairs are also selected so as to be either completely complementary or partiall... | 05/21/2002 |
| 6391539 | Immunogenic compositions of human papillomavirus The invention concerns human papillomavirus (HPV) DNA and more particularly the probes derived from these papillomaviruses, as well as the methods of detecting HPV using these probes. These human papillomaviruses are designated as HPV-2d, HPV-10b, HPV-14a... | 05/21/2002 |
| 6387623 | Screening of drugs from chemical combinatorial libraries employing transponders Materials and methods are disclosed for identifying chemical compounds having desired binding properties towards a binding partner of pharmaceutical interest. The method employs transponders associated with the solid phase material used in the assay and a... | 05/14/2002 |
| 6387628 | Mass spectrometric detection of polypeptides A process for determining the identity of a target polypeptide using mass spectroscopy is provided. Depending on the target polypeptide to be identified, a process as disclosed can be used, for example, to diagnose a genetic disease or chromosomal abnorma... | 05/14/2002 |
| 6383784 | Construction of nucleoprotein based assemblies comprising addressable components for nanoscale assembly and nanoprocessors A nucleoprotein based nanoprocessor is described. The nanoprocessor includes one or more chimelic fusion proteins linked to a DNA scaffold. Both components of the fusion protein are enzymes.... | 05/07/2002 |
| 6379895 | Photolithographic and other means for manufacturing arrays The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used ... | 04/30/2002 |
| 6379898 | Nucleic acid detection This invention discloses methods, compositions and kits for the detection of extremely low levels of nucleic acid, cells and cellular material in biological samples. The nucleic acid detection systems utilize either the pyrophosphorolysis reaction catalyz... | 04/30/2002 |
| 6380370 | Nucleic acid and amino acid sequences relating to Staphylococcus epidermidis for diagnostics and therapeutics The invention provides isolated polypeptide and nucleic acid sequences derived from Staphylococcus epidermidis that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the ... | 04/30/2002 |
| 6379891 | Method of detecting HEV infection Viral proteins derived from an enterically transmitted non-A/non-B viral hepatitis agent (HEV) are disclosed. In one embodiment, the protein is immunologically reactive with antibodies present in individuals infected with the viral hepatitis agent. This p... | 04/30/2002 |
| 6379899 | Isothermal exponential RNA amplification in complex mixtures Methods and compositions are provided for performing isothermal amplification of a nucleic acid target employing probes characterized by having a masked RNA polymer promoter unable to bind to a complementary initiator oligonucleotide and RNA polymerase an... | 04/30/2002 |
