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"The abolishment of pain in surgery is a chimera. It is absurd to go on seeking it...knife and pain are two words in surgery that must forever be associated in the consciousness of the patient."
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| Number | Title | Issue Date |
| 5869236 | Mutation detecting method using photobridging-stabilized double-stranded DNA denaturing gradient electrophoresis A method for the detection of nucleic acid sequence variants is disclosed which method comprises the stabilization of a portion of the sequence by a covalent bond with a photoactivatable intercalating agent and compositions.... | 02/09/1999 |
| 5807717 | Coupled isothermal polynucleotide amplification and translation system A cell-free system for polynucleotide amplification and translation is disclosed. Also disclosed are methods for using the system and a composition which allows the various components of the system to function under a common set of reaction conditions.... | 09/15/1998 |
| 5763165 | Method for determining lung adenocarcinomas by assaying for one or more of MAGE-1, MAGE-2 and MAGE-3 A method for determining lung adenocarcinomas is described. The method involves assaying for expression of a gene coding for at least one of tumor rejection antigen precursors MAGE-1, 2 and 3, or their expression product.... | 06/09/1998 |
| 5731171 | Sequence independent amplification of DNA The present invention is a rapid sequence-independent amplification procedure (SIA). Even minute amounts of DNA from various sources can be amplified independent of any sequence requirements of the DNA or any a priori knowledge of any sequence characteris... | 03/24/1998 |
| 5679512 | Method for introducing defined sequences at the 3'end of polynucleotides A method is disclosed for extending a primer to produce a single stranded polydeoxynucleotide that has two or more defined sequences. A combination is provided which comprises a template polynucleotide, a blocker polynucleotide, a primer polynucleotide an... | 10/21/1997 |
| 5663048 | Y-chromosome specific polynucleotide probes for prenatal sexing Y-chromosome specific hybridization probes for prenatal sexing are provided capable of hybridizing only to Y-chromosome specific DNA sequences of bovine and other ruminants and are suitable for sexing embryos at or before the time of embryo transfer with ... | 09/02/1997 |
| 5652095 | Interferon regulatory factors 1 and 2 in the diagnosis of tumorigenicity The present invention relates, in general, to a method of diagnosing tumorigenic mammalian cells or the propensity of a mammalian cell to become tumorigenetic. Additionally, the present invention relates to a cloned cDNA or genomic DNA for reducing the pr... | 07/29/1997 |
| 5648211 | Strand displacement amplification using thermophilic enzymes Strand Displacement Amplification methods (thermophilic SDA) which can be performed over a broad temperature range (37° C. to 70° C.). The preferred temperature range for thermophilic SDA is 50° C. to 70° C. It has been found that certain thermophilic... | 07/15/1997 |
| 5646264 | DNA complexes with dyes designed for energy transfer as fluorescent markers Heteromultimeric fluorophores are provided for binding to DNA, which allow for the detection of DNA in electrical separations and preparation of probes having high-fluorescent efficiencies and large Stokes shifts. In addition, by appropriate choice of flu... | 07/08/1997 |
| 5644047 | Compositions for diagnosing rochalimaea henselae and rochalimaea quintana infection A method of diagnosing cat scratch disease and a method of diagnosing bacillary angiomatosis in a subject by detecting the presence of Rochalimaea henselae or an immunogenically specific determinant thereof in the subject is provided. Also provided is a v... | 07/01/1997 |
| 5627275 | Detection and identification of enteric pathogens The present invention is directed to methods and reagents for the specific detection and presumptive identification of various bacteria associated with waterborne infectious disease. In particular, this invention relates to methods and reagents for the sp... | 05/06/1997 |
| 5625049 | Nucleic acids encoding human astrovirus serotype 2 The present invention provides a nucleic acid encoding human Astrovirus serotype 2, or a unique fragment thereof. The sequence, a genomic RNA of human astrovirus serotype 2 contains 6,797 nucleotides, and is organized into three open reading frames. Also ... | 04/29/1997 |
| 5616459 | Selection of ribozymes that efficiently cleave target RNA Mutant ribozymes are screened by culturing cells whose survival is dependant upon cleavage of RNA by a ribozyme, which cleavage causes the cells to survive in the presence of an agent which otherwise would kill the cells, and selecting cells which survive... | 04/01/1997 |
| 5616478 | Method for amplification of nucleic acids in solid media Amplification and/or expression of nucleic acids is carried out in a medium immobilized by using an organic and/or inorganic solid matrix penetrating the medium and having a porous, fibrous, reticulated, coiled, capillary, lamellar or folded texture and w... | 04/01/1997 |
| 5616463 | Methods for determining the presence of functional p53 in mammalian cells The dependence of ionizing radiation-induced GADD45 mRNA expression on the presence of functional p53 in mammalian cells is disclosed. First and second oligonucleotide sequences are provided which can form a double-stranded oligomer capable of binding to ... | 04/01/1997 |
| 5606045 | Nucleic acid probes and methods The present invention is directed to compositions comprising an oligonucleotide linked to a detectably labeled marker component comprising a fluorophore moiety which comprises a substantially planar, multidentate macrocyclic ligand coordinated to a centra... | 02/25/1997 |
| 5606044 | Kits for detecting amplification of human MDM2 A human gene has been discovered which is genetically altered in human tumor cells. The genetic alteration is gene amplification and leads to a corresponding increase in gene products. Detecting that the gene, designated hMDM2, has become amplified or det... | 02/25/1997 |
| 5591839 | Polynucleotides encoding 댒-3 neuraminidase Polynucleotide sequences encoding enzymes that possess 댒-3 neuraminidase activity are provided. Of particular interest are polynucleotide sequences encoding an enzyme having 댒-3 neuraminidase activity and naturally produced by the bacteria ... | 01/07/1997 |
| 5585477 | Poliovirus specific primers The ability to rapidly detect wild polioviruses in clinical specimens is a major concern for the world-wide eradication of polioviruses. This report describes a method of detecting polioviruses of all three serotypes from viral isolates of clinical specim... | 12/17/1996 |
| 5582985 | Detection of mycobacteria The invention provides a method, compositions, and kits useful for detecting mycobacteria in a sample. The method includes contacting the sample with a formaldehyde solution, an organic solvent, and a protein-degrading agent prior to hybridizing a mycobac... | 12/10/1996 |
| 5582988 | Methods for capture and selective release of nucleic acids using weakly basic polymer and amplification of same Nucleic acids can be made available for amplification or other treatment after lysis by contacting the lysate with specific weakly basic polymers to form a precipitate with the nucleic acids at acidic pH. After removing non-precipitated materials, the pH ... | 12/10/1996 |
| 5580726 | Method and Kit for enhanced differential display An improved method for detecting and isolating differentially expressed mRNAs which comprises using first oligonucleotide primers for reverse transcription of mRNAs and both the first oligonucleotide primers and second oligonucleotide primers for amplific... | 12/03/1996 |
| 5576178 | Method of detecting genetic deletions and mutations associated with DiGeorge syndrome, Velocardiofacial syndrome, charge association, conotruncal cardiac defect, and cleft palate and probes useful therefor There is provided by this invention methods of detecting genetic deletions and mutations associated with at least one condition selected from the group consisting of DiGeorge syndrome, Velocardiofacial syndrome, CHARGE association, conotruncal cardiac def... | 11/19/1996 |
| 5573908 | Adrenergic receptor as a proto-oncogene A recombinant cell comprising a host cell containing a recombinant DNA sequence is disclosed. The recombinant DNA sequence comprises vector DNA and DNA which encodes a mammalian adrenergic receptor. The host cell is one capable of undergoing proliferation... | 11/12/1996 |
| 5573905 | Encoded combinatorial chemical libraries The present invention describes an encoded combinatorial chemical library comprised of a plurality of bifunctional molecules having both a chemical polymer and an identifier oligonucleotide sequence that defines the structure of the chemical polymer. Also... | 11/12/1996 |
| 5573914 | DNA/RNA target and signal amplification A process for detecting the presence or absence of a specific nucleic acid sequence or antibody in a sample using an oligonucleotide to bind to the nucleic acid sequence or antibody to be detected, forming double-stranded nucleic acid sequence using the b... | 11/12/1996 |
| 5569754 | RNA import elements for transport into mitochondria The invention relates to small RNAs encoded within the nucleus of mammalian cells that specifically import to the mitochondria. The RNAs bind to several nucleolar peptides and thus provide potential carriers for import of biological molecules, including m... | 10/29/1996 |
| 5567585 | Method and kit for silver staining, developing an image and visualizing biological materials A silver staining method is provided for staining an organic molecule capable of binding silver. An improved image is developed and visualized. A kit useful in practicing the method is described. A permanent record of the image of the profile of the stain... | 10/22/1996 |
| 5565554 | Dimeric fluorescent energy transfer dyes comprising asymmetric cyanine azole-indolenine chromophores Novel fluorescent DNA-staining dyes are provided combining asymmetric cyanine azole-indolenine dyes, which provide for strong DNA affinity, large Stokes shifts and emission in the red region of the spectrum. The dyes find particular application in gel ele... | 10/15/1996 |
| 5556772 | Polymerase compositions and uses thereof The subject invention provides novel compositions containing a mixture of (a) an enzyme that possesses substantial 3'-5' exonuclease activity (b) a DNA polymerase with less 3'-5' exonuclease activity than the enzyme with substantial 3'-5' exonuclease acti... | 09/17/1996 |
| 5543509 | Method for quantifying laminin and ଲ-actin messenger RNA A method for the quantifying of human and murine laminin mRNA transcripts of the A, B1 and B2 chains, and of human and murine ଲ-actin mRNA, entails utilizing particular types of PCR primers and control cRNA.... | 08/06/1996 |
| 5543292 | Process for the measurement of nucleic acids A process for detecting the existence of at least one sequence of oligonucleotide in a nucleic acid sample includes at least one performance of a step of mixing the sample with a labeled common polynucleotide, and a polynucleotide probe comprising a sequence c... | 08/06/1996 |
| 5539096 | Genes differentially expressed in metastatic and non-metastatic rat rhabdomyosarcoma cell lines The present invention relates to polynucleotide sequences and proteins that are differentially expressed in invasive or metastasis cancer cells during malignant tumor progression of cancer, for example in rhabdomyosarcoma and which may thus serve as gener... | 07/23/1996 |
| 5529900 | Direct genetic test for glucocorticoid-remediable aldosteronism A method of screening for glucocorticoid remediable aldosteronism (GRA) in a mammal by detecting the presence or absence of a chimaeric gene duplication resulting from unequal crossing over of the 11, ଲ-hydroxylase and aldosterone synthase genes, or... | 06/25/1996 |
| 5525492 | Process for amplifying HLA sequences The present invention is directed to a process for HLA typing in polymorphic systems by polymerase chain reaction of the nucleic acids. More specifically, the oligonucleotide primers and probes are drawn to the alpha domain of the HLA gene.... | 06/11/1996 |
| 5525714 | Mutated form of the ଲ-amyloid precursor protein gene The invention relates to a polypeptide containing a sequence of contiguous amino acids of the polypeptide sequence coded by exon 17 of the cDNA of the APP 770 gene, with said sequence of contiguous amino acids being such that: it has from 5 to the total n... | 06/11/1996 |
| 5523206 | Non-radioactive DNA sequencing A new process and kit are described that combines methods for generating the nucleotide base sequence of a DNA molecule with an ultra-sensitive silver staining protocol. This new combination of technologies allows for a direct, non-instrument based visual... | 06/04/1996 |
| 5523388 | Methods of synthesizing oligonucleotides with random codons The invention provides a method of synthesizing oligonucleotides having random tuplets using individual monomers. The steps consist of: (1) sequentially coupling monomers on separate supports to form at least two different tuplets, the coupling is perform... | 06/04/1996 |
| 5516630 | Methods of detecting hepatitis A virus Methods for producing HAV cDNA, products thereof, and uses thereof, are described. HAV cDNA is produced, for example, by reverse transcribing HAV RNA and subsequently inserting the HAV cDNA into bacterial plasmids by genetic-engineering techniques. Transf... | 05/14/1996 |
| 5512436 | Enhancement of polynucleotide hybridization Hybridization buffers, for hybridizing complementary polynucleotides, contain polyvinyl alcohol (MW 1000-20000) and/or polystyrene sulphonic acid (e.g. MW 60000-80000) as a rate enhancer, generally at a concentration of 1-10%. Dextran sulphate, polyethyle... | 04/30/1996 |
