Did You Know...
...that Thomas Edison's patent application on his phonograph was approved by the Patent Office in just seven weeks? In contrast, it took Gordon Gould, the inventor of the laser, 30 years to obtain his patent -- finally awarded in 1988!
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| Number | Title | Issue Date |
| 6720410 | Nucleic acids encoding enamel matrix related polypeptides The invention relates to novel nucleic acid fragments encoding polypeptides which are capable of mediating contact between enamel and cell surface. The invention also relates to expression vectors containing the nucleic acid fragments according to the invention for ... | 04/13/2004 |
| 6100025 | Cloning by complementation and related processes Disclosed are methods for detecting mammalian genes encoding proteins which can function in microorganisms, particularly yeast, to modify, complement, or suppress a genetic defect associated with an identifiable phenotypic alteration or characteristic in ... | 08/08/2000 |
| 5985550 | Double receptor polynucleotide assay method A method for the detection of a polynucleotide target sequence is described. The method involves the formation of a covalent or non-covalent bonded pair of nucleotide sequences formed in response to a target polynucleotide sequence, adding nucleotide sequ... | 11/16/1999 |
| 5985548 | Amplification of assay reporters by nucleic acid replication A method for the amplified detection of an analyte, wherein amplification is achieved by replication of a target nucleic acid sequence which has been immobilized in response to analyte.... | 11/16/1999 |
| 5955125 | Confectionary holder The present invention relates to a confectionary holder which simulates the sound of rain as the holder is vertically positioned. The holder comprises a transparent tube having ends, two sides, and at least two sets of indents directed inward toward the c... | 09/21/1999 |
| 5914228 | Direct detection of hepatitis C virus RNA The methods and compositions of this invention provide a fast, accurate means for directly determining the presence and quantity of HCV in a sample, and thus in a patient, through hybridization to patient samples using a probe specific for HCV. They allow... | 06/22/1999 |
| 5885772 | Method for the detection of anencephaly The invention includes methods and materials, including probes, to be used as diagnostic tools for detecting anencephaly. Such methods may be practiced by both manual and automated means, and in the instance of the latter, suitable equipment for such auto... | 03/23/1999 |
| 5882857 | Internal positive controls for nucleic acid amplification The present invention relates to an improvement in a method for amplifying a target sequence of a target polynucleotide. The method comprises combining a sample suspected of containing the target polynucleotide with reagents for amplifying the target sequ... | 03/16/1999 |
| 5874217 | Microsatellite sequences for canine genotyping Methods of genotyping canines by analysis of polymorphisms in the number of microsatellite DNA repeats are provided. The internal repeat sequence is amplified by the use of specific primers. The number of repeats, and therefore the distance between the pr... | 02/23/1999 |
| 5871920 | Daz: a gene associated with azoospermia Novel gene present in interval 6E of the distal portion of the long arm of the human Y chromosome, whose alteration is associated with reduced sperm count. Methods of diagnosis and treatment utilizing said gene, and antibodies that bind to the protein enc... | 02/16/1999 |
| 5871697 | Method and apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing This invention provides methods by which biologically derived DNA sequences in a mixed sample or in an arrayed single sequence clone can be determined and classified without sequencing. The methods make use of information on the presence of carefully chos... | 02/16/1999 |
| 5871917 | Identification of differentially methylated and mutated nucleic acids The present invention provides Methyl- (or Mutant-) Differential Display (MDD) methods and nucleic acid probes for detecting mutations and the methylation patterns of nucleic acids. The methods of the present invention are particularly useful for detectin... | 02/16/1999 |
| 5869240 | Methods and apparatus for sequencing polymers with a statistical certainty using mass spectrometry Integrated methods and apparatus for sequencing or identifying polymers by mass spectrometry with a statistical certainty. The methods involve integrating data obtained by mass spectrometry analysis of a series of polymer fragments and statistically compa... | 02/09/1999 |
| 5866325 | Methods and materials relating to the functional domains of DNA binding proteins Disclosed are DNA sequences encoding novel DNA binding proteins implicated in regulation of early stages of cell growth. Illustratively provided are human and mouse origin DNA sequences encoding early growth regulatory ("Egr") proteins which include "zinc... | 02/02/1999 |
| 5863717 | Use of conserved oligonucleotide primers to amplify human papillomavirus DNA sequences Two oligonucleotides are provided which function as amplifying primers when used in tandem in the polymerase chain reaction with HPV DNA. The primers are of the formulae: IU: 5'-TIIN1 IN1 IIN2 TAAAACGAAAGT-3' and IWDO: 5'-N | 01/26/1999 |
| 5861287 | Alternative dye-labeled primers for automated DNA sequencing Methods for the use of a class of dyes for improved DNA sequencing are provided. A new class of dyes, BODIPY.RTM. fluorophores, has been described recently. The parent heterocyclic molecule of the BODIPY.RTM. fluorophores is a dipyrrometheneboron difluori... | 01/19/1999 |
| 5861124 | Method and apparatus for detecting denaturation of nucleic acid An apparatus for detecting denaturation of a nucleic acid, including: denaturation condition controlling means for controlling condition of denaturation under which a double-stranded nucleic acid is separated into a first single-stranded nucleic acid and ... | 01/19/1999 |
| 5858987 | E6AP antisense constructs and methods of use The present invention relates to the discovery that antisense nucleic acids complimentary to an E6AP gene can be used to regulate cellular p53 levels. In general the invention features E6AP antisense constructs which, by inhibiting E6AP activity, can modu... | 01/12/1999 |
| 5856096 | Rapid and sensitive assays for detecting and distinguishing between processive and non-processive telomerase activities Improved telomerase activity assays are provided in which a ligation sequential reaction (LSR) or BrdUTP are used to identify a telomerase specific product. These assays are useful in diagnosing various cancers and determining the clinical prospects for c... | 01/05/1999 |
| 5856442 | Transcripts of the MHC class I HLA-G gene and their applications Transcripts of the major histocompatibility complex (MHC) Class I HLA-G gene which are present in foetal trophoblasts and/or in adult circulating mono-nuclear cells, as well as methods of using these. Either the said transcripts comprise, in succession in... | 01/05/1999 |
| 5856089 | Method for the detection of chromosome structural abnormalities by in situ hybridization to fixed tissue The present invention is directed to in situ hybridization methods using nucleic acid probes for single copy sequences for detecting chromosomal structural abnormalities in fixed tissue obtained from a patient suspected of having a chromosomal structural ... | 01/05/1999 |
| 5853663 | Pressure distributor and multi-macrocarrier assembly for ballistic transfer transfection apparatus The ballistic transfer transfection technology employs a cold gas shock wave to accelerate microprojectiles that carry matter into cells by mechanical force. The present invention relates to a device that splits the cold gas shock wave into several indivi... | 12/29/1998 |
| 5851768 | Method for diagnosis of ovarian dysgenesis Methods are provided for diagnosing ovarian dysgenesis, comprising analysis of DNA from a patient which encodes a portion of the receptor for follicle-stimulating hormone.... | 12/22/1998 |
| 5849488 | DNA-sequence-based diagnosis of mastitis from a milk sample A rapid method for diagnosing mastitis is described. The method is based on DNA sequence identification comprising the steps of determining the presence of the following DNA sequences in a milk sample: a DNA sequence specific for somatic cells for indicat... | 12/15/1998 |
| 5846723 | Methods for detecting the RNA component of telomerase Methods of detecting the RNA component of telomerase, diagnosing cancer, and determining its prognosis using polynucleotides that hybridize to the RNA component of mammalian telomerase in a sample.... | 12/08/1998 |
| 5847088 | Antibodies specific for platelet-activating factor acetylhydrolase The present invention provides purified and isolated polynucleotide sequences encoding human plasma platelet-activating factor acetylhydrolase. Also provided are materials and methods for the recombinant production of platelet-activating factor acetylhydr... | 12/08/1998 |
| 5846705 | Nucleotide sequence of two circular SSDNA associated with banana bunchy top virus and method for detection of banana bunchy top virus Nucleotide sequences of two circular single-stranded DNAs associated with Banana Bunchy Top Virus and the proteins encoded by the open reading frames in the nucleotide sequences are provided. A method for detecting Banana Bunchy Top Virus using the PCR te... | 12/08/1998 |
| 5843648 | P15 and tyrosinase melanoma antigens and their use in diagnostic and therapeutic methods The present invention provides a nucleic acid sequence encoding a melanoma antigen recognized by T lymphocytes, designated p15. This invention further relates to bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnos... | 12/01/1998 |
| 5843651 | Light scattering optical waveguide method for detecting specific binding events A waveguide binding assay method involves detecting the scattering of light directed into the waveguide, the scattering being the result of scattering labels specifically bound to the waveguide within the penetration depth of an evanescent wave. The waveg... | 12/01/1998 |
| 5843652 | Isolation and characterization of Agouti: a diabetes/obesity related gene The present invention relates to the cloning and expression of the Agouti gene and analogous genes in transformed, transfected and transgenic mice. The present invention provides an animal model for the study of diabetes, obesity and tumors for the testin... | 12/01/1998 |
| 5844072 | Antibiotic cryptdin peptides and methods of their use The present invention provides substantially purified cryptdin peptides having a consensus amino acid sequence: X1 -C-X2 -C-R-X3 -C-X4 -E-X5 -C-X6 -C-C-X7 or having a consensus amino ... | 12/01/1998 |
| 5843643 | Site-specific transfection of eukaryotic cells using polypeptide-linked recombinant nucleic acid A method and composition are disclosed for transfecting eukaryotic cells using a DNA segment coupled to a site-specific chromosome-binding polypeptide. The polypeptide-DNA conjugate is referred to herein as a polypeptide-linked-rDNA (PLR) molecule. One ex... | 12/01/1998 |
| 5837453 | Telomerase activity assays Telomerase activity in a sample can be measured using a two reaction protocol involving telomerase substrate and primer extension steps. The presence of telomerase activity in a human somatic tissue or cell sample is positively correlated with the presenc... | 11/17/1998 |
| 5837450 | Detection of target nucleic acid molecules using thermostable 5' nuclease A means for cleaving a nucleic acid cleavage structure in a site-specific manner is disclosed. A cleaving enzyme having 5' nuclease activity without interfering nucleic acid synthetic ability is employed as the basis of a novel method of detection of spec... | 11/17/1998 |
| 5834187 | Sequence and analysis of LKP pilin structural genes and the LKP pili operon of nontypable Haemophilus influenzae The invention relates to the isolation and cloning of the structural gene, hipP, for the NTHi pili serotype 5 and the LKP operon. The invention relates to DNA molecules capable of hybridizing to the DNA sequences of the Haemophilus influenzae genome relat... | 11/10/1998 |
| 5830658 | Convergent synthesis of branched and multiply connected macromolecular structures The invention provides methods and compositons for convergent synthesis of branched polymers useful as molecular probes. The invention also includes several novel branched polymeric structures particularly useful for detecting target polynucleotides. Bran... | 11/03/1998 |
| 5830645 | Comparative fluorescence hybridization to nucleic acid arrays The present invention provides methods of determining relative copy number of target nucleic acids and precise mapping of chromosomal abnormalities associated with disease. The methods of the invention use target nucleic acids immobilized on a solid surfa... | 11/03/1998 |
| 5830664 | Method for the detection of target nucleic acid Method for the sensitive detection of a target nucleic acid by hybridization with a probe nucleic acid. The latter contains a part which can hybridize with the target nucleic acid and a nucleic acid-specific part which does not hybridize with the target n... | 11/03/1998 |
| 5827659 | Methods and apparatus for sequencing polymers using mass spectrometry The methods and apparatus disclosed herein are useful for sequencing polymers using mass spectrometry. The methods involve differing ratios of hydrolyzing agent to polymer disposed upon a reaction surface adapted for use with a mass spectrometer. The meth... | 10/27/1998 |
| 5827660 | Caged fluorochrome-labeled probes and subtraction of autoflourescence background Disclosed are methods for removing autofluorescence background from microscopic images or from flow cytometer measurements. The microscopic images can be fluorescent in situ hybridization images or images of living cells. The methods involve the steps of:... | 10/27/1998 |
