Did You Know...
...that on Dec. 15, 1836, the Patent Office was completely destroyed by fire? Lost were some 7,000 models, 9,000 drawings, and 230 books plus all records of patent applications and grants.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 4925848 | Derivative of codeine useful as an agonist and process for the preparation of it A compound of the formula: ##STR1## A process for its preparation and pharmaceutical compositions comprising the compound or a pharmaceutically acceptable salt thereof with a pharmaceutically acceptable diluent or carrier. The compound exhibits ... | 05/15/1990 |
| 4916224 | Dideoxycarbocyclic nucleosides Antiviral and antitumor compounds are disclosed of general formula: ##STR1## wherein Z is H, OH or NH2, Y is CH or N, the bond indicated by C1 '--C2 ' is absent or, in combination with the C1 '--C2 | 04/10/1990 |
| 4916225 | 9-substituted guanines Novel compounds, 9-substituted guanines, with the following general formula ##STR1## where R' is acetyl; R" is 2-tetrahydrofuryl or 2-tetrahydropyranyl. The proposed compounds have antiviral activity.... | 04/10/1990 |
| 4912216 | Method for production of perfluoro-(N-vinylamine) compounds A perfluoro-(N-vinylamine) compound containing a >NCF.dbd.CF2 group is produced from a perfluoro-compound containing a group of the general formula: ##STR1## (wherein X stands for a fluorine atom or a --OM group having an alkali or al... | 03/27/1990 |
| 4912104 | Tricyclic fused pryimidine derivatives, and their use as pharmaceuticals Novel tricyclic fused pyrimidine derivatives represented by the formula (I): ##STR1## wherein R1 and R2 are independently C1-8 alkyl or C2-8 alkenyl; R3 is hydrogen, C1-3 alkyl, C... | 03/27/1990 |
| 4912114 | Morphinan derivatives Compounds of formula I ##STR1## wherein X and Y each denotes hydrogen or together denote -0-, R1 denotes allyl optionally substituted by 1 to 3 alkyl groups, the substituent or substituents having in total a maximum of 3 carbon atoms, cycl... | 03/27/1990 |
| 4904811 | (Z)-2-cyano-2-oximino-acetyl chlorides A Z compound, substantially free of the E-isomers, of the formula ##STR1## in which Q represents Cl or OM, M represents hydrogen or an alkali metal atom, R represents optionally substituted cycloalkyl or the ##STR2## group, R1 represents ... | 02/27/1990 |
| 4904658 | Substituted-6H,8H-pyrimido-[1,2,3-cd]purine-8,10-(9H)-diones and substituted-6H,10H-pyrimido[1,2-cd]purin-10-ones Substituted-6H,8H-pyrimido[1,2,3-cd]purine-8,10(9H)-diones and substituted-6H,10H-pyrimido[1,2-cd]purin-10-ones which are useful as cognition enhancing agents, anxiolytic agents and/or antihypertensive agents in the treatment of cognitive and relative neu... | 02/27/1990 |
| 4904667 | 1H-1,2,4-thiadiazolo(3,4-b)quinazolin-5-one-2,2-dioxides, and a method for increasing the cardiac output of a mammal with them 1H-1,2,4-thiadiazolo[3,4-b]quinazolin-5-one-2,2-dioxides are disclosed. These compounds are useful as caridotonic agents. A preferred compound is 7-(n-cyclohexyl-N-methyl-4-amino-4-oxobutyloxy)-1H-1,2,4-thiadiazolo[3,4-b ]quinazolin-5-one-2,2-dioxide.... | 02/27/1990 |
| 4902798 | Anthrapyridone compounds An anthrapyridone compound of the following formula (I) and which is useful for coloring resins: ##STR1## wherein X1 is hydrogen, --NHCOR1, --CONR2 R3, --COR4, --SO2 R5 or -... | 02/20/1990 |
| 4900737 | Isoquinoline derivatives Compounds of formula (I) ##STR1## (wherein R1 is a hydrogen atom or a methyl group; R2 is a hydrogen atom or a hydroxyl, C1-4 alkoxy or C2-4 alkanoyloxy group; R3 is a hydrogen atom, or (when R2 | 02/13/1990 |
| 4898942 | Process for manufacturing diazinon An improved process for the production of Diazinon substantially free of toxic by-products in high yield and very high purity which involves mixing 2-isopropyl-4-methyl-6-hydroxypyrimidine with solid sodium or potassium hydroxide in a ketone or ether solv... | 02/06/1990 |
| 4898941 | Process for preparing diphenylalkene derivatives A process for preparing a diphenylalkene derivative of the formula [II] ##STR1## which comprises oxidizing a diphenylalkanoic acid derivative of the formula [I] ##STR2## wherein R1 and R2 are each substituted or unsubstitut... | 02/06/1990 |
| 4898943 | Tricyclic triazolopyrimidine derivatives Novel tricyclic triazolopyrimidine compounds represented by formula (I) shown in the specification and physiologically acceptable salts thereof are disclosed. These compounds have an excellent anti-allergic activity and are useful for treatment and prophy... | 02/06/1990 |
| 4897477 | Synthesis of vinblastine and vincristine type compounds A new process for the stereospecific synthesis of alkaloids of the vinblastine and vincristine type including the synthesis of vinblastine and vincristine as well novel alkaloids which are active as anti-tumor agents.... | 01/30/1990 |
| 4897479 | Arylsulfonyloxy purine intermediates Compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof are disclosed. In these compounds, R1 is halogen, --SR4 wherein R4 is H or alkyl of 1 to 4 carbon atoms, --OCH3, --OSO | 01/30/1990 |
| 4895853 | Antitumor alkaloids This invention relates to antitumor alkaloid compositions, a process of producing the compositions and a method for inhibiting tumors utilizing the compositions. More particularly, the compositions are antitumor alkaloids which are derived from marine org... | 01/23/1990 |
| 4895852 | Antitumor alkaloids This invention relates to antitumor alkaloid compositions, a process of producing the compositions and a method for inhibiting tumors utilizing the compositions. More particularly, the compositions are antitumor alkaloids which are derived from marine org... | 01/23/1990 |
| 4894456 | Synthesis of camptothecin and analogs thereof A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase I and show an... | 01/16/1990 |
| 4889860 | Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists A potent, selective opioid receptor agonist or antagonist exhibiting properties useful for a longacting analgesic or opiate abuse treatment agent or appetite suppressant having the general formula: ##STR1## wherein R is methyl, cyclopropylmethyl or a... | 12/26/1989 |
| 4886798 | Optical isomers of sulfonyldecahydro-8H-isoquino-(2,1-G)(1,6) naphthyridines and related compounds useful as 2 -blockers Compounds of the formula (1): ##STR1## in which: X and Y are independently hydrogen, hydroxy, lower alkyl, lower alkoxy or halo, or X and Y taken together is methylenedioxy or ethylene-1,2-dioxy, and R is lower alkyl, optionally substituted phenyl, -... | 12/12/1989 |
| 4885301 | Purinone derivatives which have bronchodilator, vasodilator and anti-allergic activities This invention relates to purinone derivatives which have bronchodilator, vasodilator and anti-allergic activities. A compound of the invention is 2-(2-propoxyphenyl)-6-purinone.... | 12/05/1989 |
| 4883796 | Oxime ethers of 2,6-dioxabicyclo(3.3.0)octanones, and compositions and methods for treatment of a cardiac disease or circulatory with them Oxime ethers of 2,6-dioxabicyclo[3.3.0]octanones of the formula I ##STR1## have pharmacological activity and are especially applicable as drugs for the prophylaxis and therapy of cardiac and circulatory diseases.... | 11/28/1989 |
| 4883876 | Acylated vincaminic acid derivatives Vincaminic acid derivatives represented by the formula ##STR1## wherein R1 is a hydrogen atom, an alkyl group having 1 to 8 carbon atoms or an alkoxyalkyl group having 2 to 6 carbon atoms, R2 is a hydrogen atom, an alkyl group h... | 11/28/1989 |
| 4882321 | Thionophosphonic acid ester arthropodicides Arthropodicidally active O-(6-alkoxy-2-tert-butylpyrimidin-4-yl)-O-methyl-thionoethanephosphonic acid diesters of the formula ##STR1## in which R represents alkyl with 1 to 4 carbon atoms or cycloalkyl with 3 or 4 carbon atoms. The intermediate ... | 11/21/1989 |
| 4882320 | Pesticidal pyrimidinyl (thiono)(thio)-phosphates Pesticidally active pyrimidinyl (thiono)(thio)-phosphates of the formula ##STR1## in which R1 stands for alkoxy, R2 stands for alkoxy or alkylthio and X stands for oxygen or sulphur, with the proviso that the two radicals R1 an... | 11/21/1989 |
| 4880929 | Process for preparing a 2-alkyl-1,4,5,6-tetrahydropyrimidine The invention relates to a process for preparing a 2-alkyl-1,4,5,6-tetrahydropyrimidine with the formula ##STR1## where R represents a straight or branched chain with 1-8 C-atoms or a phenyl group from 1,3-diaminopropane and an alkanecarboxylic acid,... | 11/14/1989 |
| 4880800 | Aminocyclopentyl ethers and pharmaceutical formulation Compounds are described of the formula ##STR1## where: R1 is --H or --CH3, n is 1, m is 2-4 and X is --CH.dbd.CH-- or --CH2 CH2 --; Y is a saturated heterocyclic amino group, R2 is (i) substituted or unsub... | 11/14/1989 |
| 4877631 | Process for recovering caffeine absorbed in activated carbon, and a process for decaffeinating coffee A process for recovering from caffeine-loaded activated carbon by treatment f the loaded carbon with an acid. According to the present invention, activated carbon is treated with a compound having the formula ##STR1## wherein R1 is methyl, ... | 10/31/1989 |
| 4876257 | 6-Substituted purinyl piperazine derivatives useful as cardiotonic and antiarrhythmic agents 6-Substituted purinyl piperazine derivatives and a method of synthesis for the derivatives are described. The 6-substituted purinyl piperazine derivatives are useful as cardiotonic agents and antiarrhythmic agents.... | 10/24/1989 |
| 4871720 | Aromatically substituted azacycloalkyl-alkanediphosphonic acids useful for the treatment of illnesses that can be attributed to calcium metabolism disorders Aromatically substituted azacycloalkylalkanediphosphonic acids of the formula ##STR1## in which R represents an aromatically substituted azacycloaliphatyl radical that is bonded to the group alk by way of a nitrogen atom and that optionally cont... | 10/03/1989 |
| 4871848 | Compositions prepared from hydrocarbyl substituted nitrogen-containing aromatic heterocyclic compounds, an aldehyde and/or ketone and an amine Novel compositions are prepared by reacting hydrocarbyl substituted nitrogen-containing aromatic heterocyclic compounds such as 2,5-dimethylpyridine or 2,4,6-collidine, an aldehyde such as formaldehyde, or a ketone such as acetone, or mixtures thereof and... | 10/03/1989 |
| 4868186 | Theophyllinemethyldithiolan and theophyllinemethyldithianyl derivatives having antibronchospastic antitussive and mucolytic activity New derivatives of theophylline are described, which have the general formula: ##STR1## in which R is selected from the group consisting of 2'-(1'-oxy-1', 3'-dithiolanyl), 2'-(1', 3'-dithiolanyl) and 2'-(1',3'-dithianyl), possibly substituted in... | 09/19/1989 |
| 4868191 | Alkaloid compounds, and pharmaceutical compositions containing them Novel alkaloid compounds that are derivatives of methaniminoetheno[d,e]acridine are derived from marine sponges of the genus Dercitus. These compounds and pharmaceutical compositions containing therapeutic effective amounts thereof are useful as antitumor... | 09/19/1989 |
| 4866065 | Imidazothienopyrimidines useful in psychopharmaceutical preparations New heterocyclic compounds having the general formula ##STR1## wherein ##STR2## wherein R' is C1-6 -alkyl, C3-7 -cycloalkyl or C1-6 -alkoxymethyl; R4 is C1-6 -alkyl; --S-- is ##STR3## ... | 09/12/1989 |
| 4866073 | Acridinylmethylamino derivatives and pharmaceutical compositions containing them The present invention relates to compounds of formula (I) or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29 carbon atoms in total); ethers, esters thereof; acid addition salts thereof; wh... | 09/12/1989 |
| 4866070 | Acenaphtho[1,2b]quinolinylmethylamino derivatives and pharmaceutical compositions containing them The present invention relates to compounds of formula (I) or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29 carbon atoms in total); ethers, esters thereof; acid addition salts thereof; wh... | 09/12/1989 |
| 4863948 | Isoindolinone sulfonamide anti-arrhythmic agents A series of novel alkanesulphonamidophenyl-N-alkyl-N-(heterocyclic-alkyl)alkylamine derivatives have been prepared, including their pharmaceutically acceptable salts, wherein the heterocyclic moiety is a 5- or 6-membered nitrogen-containing heterocyc... | 09/05/1989 |
| 4861896 | Preparation of halo substituted isothiazolones This invention relates to an improved preparation of halo substituted isothiazolones by a single-step synthesis. The products are useful as biocides.... | 08/29/1989 |
| 4859681 | 17 -Acyl-4-aza-5a-androst-1-en-3-ones as 5 alpha-reductase inhibitors 17ଲ-Acyl-4-aza-5-androst-1-en-3-ones of the formula: ##STR1## wherein R is selected from hydrogen, methyl and ethyl and R2 is a monovalent radical selected from straight carbons, or monocyclic aryl optionally containing 1 or more l... | 08/22/1989 |
