Did You Know...
...that in the early 1940s GE engineer James Wright was charged with a task of utmost importance to the war effort: develop a cheap substitute for rubber that could be used to produce tires, gas masks and a whole host of military gear. Wright tackled the task diligently -- and wound up inventing Silly Putty.
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| Number | Title | Issue Date |
| 7459298 | Purification, cloning and biochemical characterization of XendoU, endoribonucleasic activity involved in small nuclear RNA splicing-independent biosynthesis in Xenopus laevis Cloning and characterization of the gene for Mn++ dependent RNA-sc endoribonucleasic activity able to generate 2′-3′ cyclic phosphate and 5′OH ends. ... | 12/02/2008 |
| 7452983 | Protein which binds to Akt2 A novel polypeptide, a polynucleotide, an expression vector, a cell transfected with the expression vector, a method for screening an insulin resistance improving agent and a carbohydrate metabolism improving agent, and a method for producing a pharmaceutical compos... | 11/18/2008 |
| 7452706 | Recombinant bacterial phytases and uses thereof A purified recombinant phytase enzyme derived from Escherichia coli B. The enzyme has a molecular weight of about 47.1 kilodaltons and has phytase activity. The enzyme can be produced from native or recombinant host cells and can be used to aid in the digesti... | 11/18/2008 |
| 7445922 | -derived endoglucanase enzyme lacking cellulose-binding domain This invention relates to a protein that is a Zygomycetes-derived endoglucanase lacking the cellulose-binding domain and exhibits endoglucanase activity, and a method for using the same. This invention can enhance effects of an endoglucanase enzyme on fabric ... | 11/04/2008 |
| 7442535 | Fusion protein incorporating a cysteinized ribonuclease A fusion protein contains a cysteinized variant of an RNase disclosed in U.S. Pat. No. 6,239,257 B1. ... | 10/28/2008 |
| 7442536 | Cysteinized ribonuclease and targeting moiety conjugated thereto A cysteinized variant of an RNase disclosed in U.S. Pat. No. 6,239,257 B1 is disclosed. A targeting moiety can be conjugated to the cysteine residue. ... | 10/28/2008 |
| 7435556 | Method for increasing the ratio of p-hydroxybenzoic acid ester glucoside to total p-hydroxybenzoic acid glucose conjugates in p-hydroxybenzoic acid-producing microorganisms and green plant cells This invention pertains to a method for increasing the ratio of the pHBA ester glucoside to total pHBA glucose conjugates in pHBA-producing microorganisms and green plant cells using nucleic acid fragments encoding plant glucosyltransferases that exhibit catalytic a... | 10/14/2008 |
| 7432098 | Phytases and methods for making and using them The invention provides isolated and recombinant phytase enzymes. In one aspect, the phytases are produced by modification of the wild type appA of E. coli. The enzyme can be produced from recombinant host cells. The phytases of the invention can be used to ai... | 10/07/2008 |
| 7432097 | Phytases, nucleic acids encoding them and methods of making and using them In one aspect, the invention provides a purified and modified phytase enzyme from Escherichia coli K12 appA phytase. The enzyme has phytase activity and improved thermal tolerance as compared with the wild-type enzyme. In addition, the enzyme has improved pro... | 10/07/2008 |
| 7427498 | Composition, methods and reagents for the synthesis of a soluble form of human PHEX This invention relates to a soluble form of PHEX, PHEX being a type II integral membrane glycoprotein. This enzyme is the gene product of a phosphate-regulating gene with homologies to endopeptidases on the X chromosome. To produce a soluble form of PHEX, the transm... | 09/23/2008 |
| 7416874 | Recombinant bacterial phytases and uses thereof A purified recombinant phytase enzyme derived from Escherichia coli B. The enzyme has a molecular weight of about 47.1 kilodaltons and has phytase activity. The enzyme can be produced from native or recombinant host cells and can be used to aid in the digesti... | 08/26/2008 |
| 7416875 | Cytotoxic ribonuclease variants This invention relates to altered forms of members of the RNase A superfamily. An RNase A can be modified to be cytotoxic by altering its amino acid sequence so that it is not bound easily by the ribonuclease inhibitor while still retaining catalytic properties. Whi... | 08/26/2008 |
| 7410789 | Process for the fermentative production of S-adenosylmethionine A microorganism strain secreting S-adenosylmethionine having increased activity of the cmr (mdfA) gene product is provided. ... | 08/12/2008 |
| 7407785 | Human DNase I hyperactive variants The present invention relates to amino acid sequence variants of human DNase I that have increased DNA-hydrolytic activity. The invention provides nucleic acid sequences encoding such hyperactive variants, thereby enabling the production of these variants in quantit... | 08/05/2008 |
| 7407791 | Production of secreted polypeptides Described herein are methods and compositions for the production and secretion of polypeptides. Included herein is the use of interrupting peptide transport activity for an increase in polypeptide production and/or secretion. ... | 08/05/2008 |
| 7402309 | Phage-associated lytic enzymes for treatment of and related conditions The present disclosure relates to methods, compositions and articles of manufacture useful for the treatment of Bacillus anthracis and B. cereus bacteria and spores, and related conditions. The disclosure further relates to methods and compositions for... | 07/22/2008 |
| 7402387 | Methods and compositions for detecting dihydropyrimidine dehydrogenase splicing mutations The present invention provides compositions, methods, and kits for the detection of genetic polymorphisms or mutations of the dihydropyrimidine dehydrogenase deficiency (DPDD). The polymorphisms or mutations generally occur in the dihydropyrimidine dehydrogenase (DP... | 07/22/2008 |
| 7402310 | Deoxyribonuclease, gene encoding same and use thereof This invention provides a novel acid DNase (DLAD) which is an endonuclease capable of cleaving DNA independently from divalent cations, under acidic conditions, which retains its activity in acidic to even neutral pH range, and which is not inhibited by G-actin. Thi... | 07/22/2008 |
| 7399617 | Method for producing an L-amino acid in an bacterium via altering expression levels of target proteins A bacterium belonging to the genus Escherichia which has an ability to produce an L-amino acid, wherein the ability to produce the L-amino acid is increased by increasing expression of an L-amino acid excretion protein is described. A method for producing the... | 07/15/2008 |
| 7399625 | Scytalone dehydrogenase gene showing tolerance to agricultural pesticide The present invention provides a gene that can be used extensively in studies relating to resistant rice blast fungi. The gene codes for either one of the following proteins (a) or (b): (a) a protein consisting of the amino acid sequence shown in SEQ ID NO:2; or (b)... | 07/15/2008 |
| 7396669 | Mammalian endonucleases and methods of use Isolated mammalian Mus81-Eme endonuclease complexes comprise an Mus81 protein portion and an Eme protein portion. A method of identifying a chemical compound that modulates mammalian cellular response to DNA damage comprises contacting a chemical compound to be test... | 07/08/2008 |
| 7393671 | Mutant carotenoid ketolases CrtW carotenoid ketolases are provided that are useful for the production of astaxanthin and other cyclic ketocarotenoids. The mutant ketolase genes of the present invention encode polypeptides characterized by an improvement in astaxanthin synthesis activity when c... | 07/01/2008 |
| 7393679 | Whole cell catalyst A whole cell catalyst is described comprising a hydantoinase, a racemase and a carbamoylase. Thus this catalyst is able to degrade hydantoins directly into the amino acids. Additionally, a process for the production of this catalysts and for the production of... | 07/01/2008 |
| 7390643 | Geranyl diphosphate synthase molecules, and nucleic acid molecules encoding same In one aspect, the present invention provides isolated nucleic acid molecules that each encode a geranyl diphosphate synthase protein, wherein each isolated nucleic acid molecule hybridizes to a nucleic acid molecule consisting of the sequence set forth in SEQ ID NO... | 06/24/2008 |
| 7390894 | Glutathione S-transferase sequence variants Isolated GSTO2 nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as GSTO2 allozymes. Methods for determining if a subject contains a GSTO2 sequence variant also are described. ... | 06/24/2008 |
| 7387893 | Vectors, cells and processes for pyrimidine deoxyribonucleosides production Novel DNA constructs and host cells comprising the same are disclosed. DNA constructs comprise a transcription unit (e.g. operon) comprising DNA sequences encoding for ribonucleotide reductase and thioredoxin or a uridine kinase gene and/or a dCTP deaminase gene. In... | 06/17/2008 |
| 7378261 | Method for preparing para-hydroxystyrene by biocatalytic decarboxylation of para-hydroxycinnamic acid in a biphasic reaction medium A biocatalytic method for preparing para-hydroxystyrene from para-hydroxycinnamic acid is described. The method uses an enzyme source having para-hydroxycinnamic acid decarboxylase activity to catalyze the decarboxylation of para-hydroxycinnamic acid in a biphasic r... | 05/27/2008 |
| 7371571 | Recombinant mycobacteria overexpressing D-alanine ligase gene and uses therefore Recombinant mycobacterial strains which overproduce essential biosynthetic enzymes of pathogenic mycobateria are provided. These strains overproduce enzymes involved in the synthesis and incorporation of D-alanine into mycobacterial peptidogly... | 05/13/2008 |
| 7361507 | Method for modulating nitrilase selectivity, nitrilases obtained by said method and use thereof The invention concerns a modified nitrilase with modulated selectivity, characterized in that it comprises in position 162 an amino acid residue different from the original amino acid residue. ... | 04/22/2008 |
| 7361484 | GSK3 polypeptides The invention provides truncated GSK3 polypeptides capable of crystallization, including GSK3α and GSK3β polypeptides, and use of these polypeptides to identify and optimize GSK3 inhibitors. Also provided are GSK3 polypeptides having at least one substituted amino... | 04/22/2008 |
| 7344870 | 3-phosphoinositide-dependent protein kinase The present invention provides for a substantially pure human or rabbit 3-phosphoinositide-dependent protein kinase. ... | 03/18/2008 |
| 7338793 | Methods and compositions for cyclizing diterpenes An enzyme having diterpene cyclase activity has been purified from P. elisabethae using a series of chromatography steps. The purified enzyme has an apparent molecular weight of about 47 kilodaltons and an isoelectric point of about 5.1. The purifed enzyme ca... | 03/04/2008 |
| 7335506 | Method for producing L-lysine or L-arginine by using methanol-assimilating bacterium A DNA encoding a variant of a protein, the protein having a loop region and six hydrophobic helices and involved in secretion of L-lysine to the outside of a cell, wherein the DNA encodes a variant of a protein not containing the loop region and facilitates secretio... | 02/26/2008 |
| 7335475 | PR/SET-domain containing nucleic acids, polypeptides, antibodies and methods of use The present invention provides an isolated nucleic acid molecule encoding a PFM/SET polypeptide. Also provided is an isolated nucleic acid molecule encoding a functional fragment of a PFM/SET polypeptide that contains a PR, SET, PRAZ or PKZL domain of a PFM/SET poly... | 02/26/2008 |
| 7332311 | Fatty acyl-CoA: fatty alcohol acyltransferases By this invention, nucleic acid sequences encoding for fatty acyl-CoA:fatty alcohol acyltransferase (wax synthase) are provided, wherein said wax synthase is active in the formation of a wax ester from fatty alcohol and fatty acyl-CoA substrates. Of special interest... | 02/19/2008 |
| 7332304 | Process and materials for production of glucosamine and N-acetylglucosamine A biosynthetic method for producing glucosamine and N-acetylglucosamine is disclosed. Such a method includes the fermentation of a genetically modified microorganism to produce glucosamine and/or N-acetylglucosamine. Also disclosed are genetically modified microorga... | 02/19/2008 |
| 7329529 | Ubiqutin proteases The invention provides isolated nucleic acids molecules that encode novel ubiquitin protease polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the ubiquitin protease nucleic acid molecules of the in... | 02/12/2008 |
| 7314730 | Regulation of human transmembrane serine protease Reagents that regulate human transmembrane serine protease activity and reagents that bind to human transmembrane serine protease gene products can be used to regulate extracellular matrix degradation. Such regulation is particularly useful for treating COPD, metast... | 01/01/2008 |
| 7303903 | Production of weakly active or inactive mutants of alkaline phosphatase and their expression in yeast The invention concerns a method for the recombinant production or expression of eukaryotic alkaline phosphatase mutants in yeast cells wherein the specifically introduced mutations result in a reduction of the specific AP activity by at least a factor 1:100. The inv... | 12/04/2007 |
| 7303894 | Detection of phenols using engineered bacteria Detection of phenols using engineered bacteria. A biosensor can be created by placing a reporter gene under control of an inducible promoter. The reporter gene produces a signal when a cognate transcriptional activator senses the inducing chemical. Creation of bacte... | 12/04/2007 |
