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| Number | Title | Issue Date |
| 5240844 | Test kit for determining the presence of organic materials and method of utilizing same A test card incorporates a colorimetric indicator test to determine the presence of a minute amount of a specific substance in a liquid medium. The test card includes top and bottom sheets adhesively secured to an intermediate frame member which, together... | 08/31/1993 |
| 5006459 | Therapeutic and diagnostic methods using soluble T cell surface molecules The present invention is directed to the measurement of soluble T cell growth factor receptors, soluble T cell differentiation antigens, or related soluble molecules or fragments thereof, and the use of such measurements in the diagnosis and therapy of di... | 04/09/1991 |
| 4983530 | Sandwich immunoassay for determination of total monoclonal IGG A sandwich immunoassay for determining total monoclonal IgG content in samples of purified IgG, cell culture medium and ascites fluid is provided based on the utilization of anti-light-chain IgG antibodies as both capture and label antibodies.... | 01/08/1991 |
| 4980299 | Carrier for coating with immunologically-active material The present invention provides a carrier for coating with immunologically-active material, wherein it consists of an injection molded synthetic resin with a content of adjuvant and additional materials of less than 1% by weight. The present invention also... | 12/25/1990 |
| 4978625 | Fluorescence immunoassay using water insoluble dyes In a method for fluorescence immunoassay of an analyte, an antianalyte attached to the surface of a solid support is contacted with the analyte and a tracer which includes a substantially water insoluble fluorescent dye occluded in the nonaqueous portion ... | 12/18/1990 |
| 4977079 | Method for the determination of anti-P. falciparum sporozoite antibodies in human blood An immunoenzimatic method is disclosed for the detection and the measurement of anti-P. falciparum sporzoite antibodies in human blood and/or in its derivatives, which operates with a synthetic antigen-enzyme conjugate capable of forming with the antispor... | 12/11/1990 |
| 4975367 | Catalytic test composition intended to produce a range of colors Test compositions, indicators, and test device are provided which are capable of generating different hues at different analyte concentrations. The compositions are capable of generating a yellow hue in situ. Visual tests for clinically important analytes... | 12/04/1990 |
| 4971916 | Liposome based homogeneous immunoassay for diagnostic tests The present invention provides for novel homogeneous immunoassay systems involving complement-mediated lysis of marker-encapsulating lipid vesicles (liposomes) for detection of analyte in a fluid sample. These systems do not require the separation of unbo... | 11/20/1990 |
| 4971905 | Diagnosis of cancerous or precancerous conditions in human secretory epithelia by enzyme activity of ଲ-1-3N-acetylglucosaminyltransferase A method for diagnostic or prognostic monitoring of premalignant or malignant conditions of human secretory epithelia, particularly colonic epithelia, by determining the extent of expression of a 댡-3N-acetylglucosaminyltransferase is described. Ass... | 11/20/1990 |
| 4965069 | Oxidized viruses or viral antigens and utilization for diagnostic prophylactic and/or therapeutic applications Novel and improved methods for diagnosis, prognosis, prophylaxis and therapy of viral infections are described. The novel methods employ a virus, viral antigen or fragment thereof in which "perturbation" of an oligosaccharide moiety renders the virus, vir... | 10/23/1990 |
| 4963468 | Immunoseparating strip A method and device for determining the presence of an analyte in a sample suspected of containing the analyte is disclosed. The method involves contacting a test solution containing the sample, an antibody for the analyte, and a conjugate of the analyte ... | 10/16/1990 |
| 4963478 | Article for preforming immunological assays utilizing organic dyes and method for producing and utilizing same An article for performing solid-phase immunological assays and method for performing assays utilizing the article of the invention. A solid-phase support suitable for immunological assays is stained with an organic dye that has a net-positive charge and a... | 10/16/1990 |
| 4960691 | Chromatographic test strip for determining ligands or receptors A test strip for analysis of analytes such as antigens, antibodies or polynucleotides employs a chromatographic medium and a solvent capable of transporting reagents and/or sample. Reagents are selected and disposed on the medium such that a labeled (firs... | 10/02/1990 |
| 4960693 | System of reactants involving an apo-enzyme useful in immunological analysis and a method for carrying out immuoassays with this system A quick and simple immunoassay technique applicable to the determination of large molecules like proteins, polynucleotides and others involves labelling competitive immunospecies with an enzyme as signal generator. This enzyme can be converted to the corr... | 10/02/1990 |
| 4959308 | Immunoassay for antibodies binding platelets The present invention involves a method for producing a substrate useful in a system for the detection of antibodies directed against platelet antigens. This method comprises several steps. A platelet sample of interest is initially treated with an aqueou... | 09/25/1990 |
| 4959302 | Method of evaluating immune system response to allografts, viral infection and immunosuppressive therapy Detection of solublen Interleukin-2 (IL-2) and Interleukin-2 receptor (IL-2R) levels in the serum, plasma, urine and bile of kidney and liver transplant patients using sensitive immunoassays provides valuable prognostic, monitoring and diagnostic informat... | 09/25/1990 |
| 4959307 | Immunoseparating strip A method and device for determining the presence of an analyte in a sample suspected of containing the analyte are disclosed. The method involves contacting a test solution containing the sample, an antibody for the analyte, and a conjugate of the analyte... | 09/25/1990 |
| 4957735 | Target-sensitive immunoliposomes- preparation and characterization Novel target-sensitive immunoliposomes were prepared and characterized. In this invention, target specific binding of antibody-coated liposomes was sufficient to induce bilayer destabilization, resulting in a site-specific release of liposome contents. Un... | 09/18/1990 |
| 4950589 | Genus-specific listeria antigen identified by monoclonal antibodies Antigens characteristic of all species of Listeria except L. denitrificans comprising proteins found in Listeria heat extracts, the major antigen having a molecular weight of from about 30 to about 38KD and comprising three immunogenically different epito... | 08/21/1990 |
| 4945039 | Standard materials for measurement of immune complexes and method for measurement of immune complexes A standard material for measuring immune complexes which is prepared by chemically binding immunoglobulin and/or its fragment with a complement and/or its derivative through the medium of a bifunctional reagent. By using the standard material, the standar... | 07/31/1990 |
| 4940670 | Method for compounding and testing patient specific monoclonal antibodies and monoclonal antibody fragments for in vivo use A kit for compounding radiolabeled monoclonal antibodies or antibody fragments for in vivo cancer diagnosis and therapy, which provides reagents for: (1) the selection of monoclonal antibodies or antibody fragments which are specific to a tumor specimen; ... | 07/10/1990 |
| 4935344 | Method for characterizing types of renal carcinoma and prognosis Antigenic profiles of renal carcinoma specimans developed with panels of monoclonal antibodies derived from several different tissues serve as useful clinical indicators for cancer type, cancer subset as well as histiogenesis and prognosis indicators.... | 06/19/1990 |
| 4935339 | Delayed solid phase immunologic assay A method for the determination of a substance present in a sample, which comprises: (a) contacting a sample containing a substance with: (i) a first immunological binding partner to the substance, wherein the first immunological binding partner is a monoclonal... | 06/19/1990 |
| 4923813 | Monoclonal antibody-based immunoassay for cyclic DNA adducts resulting from exposure to crotonaldehyde or acrolein Monoclonal antibodies specific for the 8R,6R- and 8S,6S-stereoisomers of 3-(2-deoxy-ଲ-D-erythropentofuransyl)-5,6,7,8-tetrahydro-8-hydroxy-6-m ethylpyrimido[1,2-a]purine-10(3H)one were produced. These cyclic 1,N2 -propanodeoxyguanosines ar... | 05/08/1990 |
| 4918004 | Method of calibrating a flow cytometer or fluorescence microscope for quantitating binding antibodies on a selected sample, and microbead calibration kit therefor A method for calibrating a flow cytometer or fluorescence microscope in terms of number of binding antibodies as a function of fluorescence intensity value measured on the flow cytometer or fluorescence microscope, and subsequent measuring of a sample to ... | 04/17/1990 |
| 4914022 | Method for preparing multiple tissue samples for microscopic investigation and testing A flexible, efficient and rapid method is shown whereby many different tissues samples may be stained or reacted and examined simultaneously, on one standard glass slide. This method is based on the preparation of "cores" of paraffin embedded tissue from ... | 04/03/1990 |
| 4900659 | Nucleotide sequence composition and method for detection of Neisseria gonorrhoeae and method for screening for a nucleotide sequence that is specific for a genetically distinct group This invention relates to specific discrete nucleotide sequences. More precisely, this invention relates to a composition comprising discrete nucleotide sequences that are specific for Neisseria gonorrhoeae, as defined hereinbelow, i.e. the compositions o... | 02/13/1990 |
| 4900663 | Test kit for determining the presence of organic materials and method of utilizing same A test card incorporates a colorimetric indicator test to determine the presence of a minute amount of a specific substance in a liquid medium. The test card includes top and bottom sheets adhesively secured to an intermediate frame member which, together... | 02/13/1990 |
| 4898813 | Catalytic test composition intended to produce a range of colors Test compositions and test devices are provided which are capable of generating different hues at different analyte concentrations. Visual results for clinically important analytes, such as glucose and cholesterol, are provided by use of compositions cont... | 02/06/1990 |
| 4895796 | Identification of NK cells and cytotoxic T lymphocytes A method for distinguishing between NK cells and T lymphocytes is provided, which comprises contacting a sample containing lymphocytes with a first reagent comprising anti-CD3 and a first detectable label and a second reagent comprising a mixture of anti-... | 01/23/1990 |
| 4894326 | Monoclonal antibody defining oncofetal structure of fibronectin Antibody defining structure present in fibronectins from tumors and fetal tissues but absent in fibronectins from normal adult tissues and plasma; useful for diagnosing and treating human cancers.... | 01/16/1990 |
| 4894329 | Method of assaying the bioactivity of a thymic extract A method of assaying the bioactivity of a thymic extract is disclosed. The disclosed method measures the chemiluminescence of macrophage derived from an immune-deficient mouse after stimulation with the sample thymic extract, phagocytic stimulator, and lu... | 01/16/1990 |
| 4889815 | Nephelometric method for determination of an antigen or antibody content in whole blood A method and apparatus for use in quantifying, in a whole blood sample in which the red cells are lysed, a component which will react with a reagent to form an antigen-antibody complex, the method comprising mixing the sample with the reagent to obtain th... | 12/26/1989 |
| 4888275 | Diagnosing and monitoring cancer This invention relates to the use of a specific carcinoma associated antigen/hapten of carbohydrate nature, fucosylsialosylgangliotetraose-IV2 -Fuc-II3 NeuAc-GgOse4 (Lipid Document, 1977) and defined derivati... | 12/19/1989 |
| 4885256 | Monoclonal antibodies to cholesterol and methods Monoclonal antibodies which demonstrate specific reactivity to cholesterol and methods for the detection of high levels of cholesterol by contacting biological specimens containing cholesterol with the monoclonal antibodies and measuring the formation of ... | 12/05/1989 |
| 4883751 | Specific immunoassay for heparin Disclosed herein are assays for measuring the amount of heparin present in a biological sample. The assays use a positively charged polycarbodiimide heparin-inhibitor compound and antibodies which recognize heparin when bound to the carbodiimide inhibitor... | 11/28/1989 |
| 4880750 | Individual-specific antibody identification methods An identification method, applicable to the identification of animals or inanimate objects, is described. The method takes advantage of a hithertofore unknown set of individual-specific, or IS antibodies, that are part of the unique antibody repertoire pr... | 11/14/1989 |
| 4876189 | Process for the quantification of cell populations or subpopulations and a reagent suitable therefor A process for quantification of cell populations or subpopulations, by incubating a sample with labelled antibodies directed against characteristic surface antigens of the cell population to be quantified to form labelled antibody/antigen complexes. Stand... | 10/24/1989 |
| 4870006 | Antigenic material for a chagas' disease detection system T. Cruzi polypeptide antigens that react with serum from chagasic individuals and does not cross-react with serum from uninfected individuals or individuals infected with related parasites such as Leishmania is described. The DNA from T. Cruzi culture try... | 09/26/1989 |
| 4868106 | Analytical element and method for determining a component in a test sample Disclosed are an analytical element for determining a specific component A in a test sample, based on the specific reaction between said specific component A and a substance B capable of binding specifically to said specific component A, by the use of a l... | 09/19/1989 |
