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| Number | Title | Issue Date |
| 7553628 | Production of polyunsaturated fatty acids in oleaginous yeasts The present invention relates to methods for the production of ω-3 and/or ω-6 fatty acids in oleaginous yeast. Thus, desaturases and elongases able to catalyze the conversion of linoleic acid (LA) to γ-linolenic acid (GLA); α-linoleic acid (ALA) to stearidonic a... | 06/30/2009 |
| 7541189 | Transcription activation complex and utilization thereof The present invention provides a complex of the transcription coupling factor of any of ARNT 1 to 3 and the transcription regulatory factor comprising any of the amino acid sequence from the amino acid sequence group comprising for example the amino acid sequences r... | 06/02/2009 |
| 7531647 | Lentiviral vectors for site-specific gene insertion Murine leukemia virus (MLV) and lentivirus vectors have been used previously to deliver genes to hematopoietic stem cells (HSCs) in human gene therapy trials. However, these vectors integrate randomly into the host genome, leading to disruption or inactivation of vi... | 05/12/2009 |
| 7527970 | Method of identifying active chromatin domains The invention provides a method of mapping DNA-protein interactions within a genome by fixing living cells to cross-link DNA and proteins, lysing the cells, and isolating chromatin by immunoprecipitation. DNA is purified and a SAGE protocol is performed on the purif... | 05/05/2009 |
| 7528230 | Enhanced inserted yellow fluorescence protein and its application Disclosed are mutated genes for green fluorescence proteins and enhanced inserted YFPs expressed therefrom. The mutant proteins not only maintain their fluorescence even at 37° C., but also exhibit about 20 times stronger fluorescence intensities in comparison to t... | 05/05/2009 |
| 7524493 | Nucleic acid constructs cells transformed therewith and methods utilizing same for inducing liver regeneration and alleviation of portal hypertension A method of inducing liver regeneration in a damaged liver tissue region of an individual is provided. The method including the step of providing at least two distinct growth factors to the damaged liver tissue region of the individual, at least one of the at least ... | 04/28/2009 |
| 7525012 | Chemical inducible promoters used to obtain transgenic plants with a silent marker Chemically inducible promoters are described that may be used to transform plants, including tobacco and lettuce, with genes which are easily regulatable by adding the plants or plant cells to a medium containing an inducer of the promoter or by removing the plants ... | 04/28/2009 |
| 7521219 | Method of producing baculovirus The present invention is directed to a method for producing commercial quantities of baculovirus using a combination of methods involving producing occlusion bodies with infectious baculovirus in caterpillar larvae and large numbers of viral particles with serial pa... | 04/21/2009 |
| 7517670 | Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity The present invention relates to the field glycosylation engineering of proteins. More particular, the present invention is directed to the glycosylation engineering of proteins to provide proteins with improved therapeutic properties, e.g., antibodies, antibody fra... | 04/14/2009 |
| 7511128 | Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts The present invention relates to fatty acid desaturases and elongases able to catalyze the conversion of linoleic acid (LA) to γ-linolenic acid (GLA); α-linoleic acid (ALA) to stearidonic acid (STA); GLA to dihomo-γ-linoleic acid (DGLA); STA to eicosatetraenoic a... | 03/31/2009 |
| 7510831 | phytase enzymes, nucleic acids encoding such phytase enzymes, vectors and host cells incorporating same and methods of making and using same A novel DNA is provided which encodes an enzyme having phytase activity isolated from Trichoderma. Also provided for is a method of isolating DNA encoding an enzyme having phytase activity from organisms which possess such DNA, transformation of the DNA into ... | 03/31/2009 |
| 7504492 | RNA polymerase III promoter, process for producing the same and method of using the same The present invention provides an RNA polymerase III promoter characterized in that a part of its sequence is substituted with a sequence capable of undergoing specific DNA recombination by Cre recombinase in such a manner functions of PSE and a TATA box are not imp... | 03/17/2009 |
| 7501489 | cDNAs and proteins involved in hypoxia, circadian and orphan signal transduction pathways, and methods of use The present invention provides isolated nucleic acids and proteins that are new and distinct members of the bHLH-PAS superfamily of transcription regulators. These “MOPs” (members of PAS) are useful in a variety of research, diagnostic and therapeutic applicatio... | 03/10/2009 |
| 7498314 | Expression vectors and uses thereof The present invention relates to novel vectors, to DNA vaccines and gene therapeutics containing said vectors, to methods for the preparation of the vectors and DNA vaccines and gene therapeutics, and to therapeutic uses of said vectors. More specifically, the prese... | 03/03/2009 |
| 7494813 | VAC-BAC shuttle vector system The invention relates to a VAC-BAC shuttle vector system for creation of recombinant poxviruses from DNA cloned in a bacterial artificial chromosome. ... | 02/24/2009 |
| 7494806 | Retroviral vectors expressing exogenous gene or exogenous nucleic acid sequences Provided are novel vectors and viral vectors capable of expressing exogenous gene or exogenous nucleic acid sequences in a target cell of interest, such as T cells, bone marrow cells, epithelial cells, liver cells and the like. The nucleic acid components of the vec... | 02/24/2009 |
| 7491532 | Recombinant protein production in a human cell Methods and compositions for the production of recombinant proteins in a eukaryotic cell line are disclosed. The methods and compositions are particularly useful for generating stable expression of recombinant proteins of interest that are modified post-translationa... | 02/17/2009 |
| 7491508 | Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses A method for providing an adenovirus from a serotype which does not grow efficiently in a desired cell line with the ability to grow in that cell line is described. The method involves replacing the left and right termini of the adenovirus with the corresponding ter... | 02/17/2009 |
| 7482319 | Vault and vault-like carrier molecules A method of using vaults as carrier molecules to deliver one or more than one substance to an organism, or to a specific tissue or to specific cells, or to an environmental medium. A vault-like particle. A method of preventing damage by one or more than one substanc... | 01/27/2009 |
| 7479554 | AAV5 nucleic acids The present invention provides an adeno-associated virus 5 (AAV5) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the AAV5 vectors and particles. ... | 01/20/2009 |
| 7479374 | Triacylglycerol-deficient fission yeast and its uses A fission yeast having non-functional dga1 and plh1 genes, which is incapable of synthesizing triacylglycerols, is disclosed. The fission yeast is susceptible to lipotoxicity including lipoapoptosis, and is useful for screening of compounds that inhibit or prevent l... | 01/20/2009 |
| 7476728 | Flea GABA receptor subunit nucleic acid molecules The present invention relates to flea GABA receptor subunit nucleic acid molecules; to flea GABA receptor subunit proteins encoded by such nucleic acid molecules; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins... | 01/13/2009 |
| 7476539 | DNA containing variant FRT sequences To provide DNA comprising mutant FRT sequence which causes recombination reaction between two mutant FRT sequences having an identical sequence to each other but does not cause recombination reaction with a wild-type FRT sequence, in the presence of FLP recombinase;... | 01/13/2009 |
| 7476382 | Reovirus for the treatment of neoplasia Methods for treating neoplasia, by administering reovirus to a Ras-mediated neoplasm, are disclosed. The reovirus is administered so that it ultimately directly contacts cells of the neoplasm. Human reovirus, non-human mammalian reovirus, and/or avian reovirus can b... | 01/13/2009 |
| 7470770 | Gene encoding malic enzyme and method for preparing succinic acid using the same A nucleotide sequence encoding a malic enzyme and a method for preparing succinic acid using the same, more particularly, a maeB nucleotide sequence encoding a malic enzyme B having the activity of converting pyruvic acid or pyruvate to malic acid or malate, or vice... | 12/30/2008 |
| 7468275 | Synthetic internal ribosome entry sites and methods of identifying same Synthetic and isolated translational regulatory elements, including oligonucleotides that have translational enhancing activity, internal ribosome entry site (IRES) activity, or translational inhibitory activity, and multimers of such translational regulatory elemen... | 12/23/2008 |
| 7465541 | Vitamin D-responsive sequences located 5′-upstream of p27/gene and methods of screening for pharmaceutical agents using the sequences A 44-bp region that confers vitamin D3-responsiveness to the human p27Kip1 promoter in the human p27Kip1 transcriptional regulatory mechanism was revealed. This region also conferred vitamin D3-responsiveness to a heteroge... | 12/16/2008 |
| 7465792 | Fungi non-LTR retrotransposons and methods related thereto Retrotransposons and methods related thereto. The retrotransposon comprises a nucleotide sequence selected from a group consisting of a nucleotide sequence of SEQ ID NO: 1, a nucleotide sequence of SEQ ID NO: 2, a nucleotide sequence of SEQ ID NO: 3, and a nucleotid... | 12/16/2008 |
| 7465787 | Yeast cell surface display of proteins and uses thereof The present invention provides a genetic method for tethering polypeptides to the yeast cell wall in a form accessible for binding to macromolecules. Combining this method with fluorescence-activated cell sorting provides a means of selecting proteins with increased... | 12/16/2008 |
| 7459545 | Chemically synthesized artificial promoter for high level expression of transgenes and a method for its synthesis The invention relates to a chemically synthesized artificial promoter comprising a DNA sequence designed for the target level and pattern of gene expression, by strategically putting together several signature sequences identified by sequence alignment and statistic... | 12/02/2008 |
| 7459272 | Reduction in bacterial colonization by administering bacteriophage compositions The present invention provides a method for reducing the risk of bacterial infection or sepsis in a susceptible patient by treating the susceptible patient with a pharmaceutical composition containing bacteriophage of one or more strains which produce lytic infectio... | 12/02/2008 |
| 7459153 | Viral vectors for gene therapy Adenovirus types 11p and 4p show a higher binding affinity and infectivity than type 5 for endothelial and carcinoma cell lines. Adenovirus type 11p shows a stronger binding to cells for neural origin, such as glioblastoma, neuroblastoma and medulloblastoma. The fac... | 12/02/2008 |
| 7455978 | Protein/solubility folding assessed by structural complementation Many proteins, when produced recombinantly, suffer from improper processing, folding and lack normal solubility. Modified proteins, including those indicative of disease states, also can have such defects. The present invention is directed to methods of identifying ... | 11/25/2008 |
| 7449569 | Isolated fungal promoters and gene transcription terminators and methods of protein and chemical production in a fungus The present invention encompasses isolated gene regulatory elements and gene transcription terminators that are differentially expressed in a native fungus exhibiting a first morphology relative to the native fungus exhibiting a second morphology. The invention also... | 11/11/2008 |
| 7442551 | Lentiviral packaging constructs The present invention provides novel lentiviral packaging constructs that are useful for the establishment of stable packaging cell lines and producer cell lines. In particular, the present invention provides novel packaging cell lines that are capable of constituti... | 10/28/2008 |
| 7439065 | Helper virus-free AAV production A method for the production of adeno-associated virus stocks and recombinant adeno-associated virus stocks that are substantially free of contaminating helper virus is described. The method utilizes transfection with helper virus vectors to replace the infection wit... | 10/21/2008 |
| 7439066 | Methods for producing and using in vivo pseudotyped retroviruses using envelope glycoproteins from lymphocytic choriomeningitis virus (LCMV) The present invention provides novel pseudotyped retroviral vectors that can transduce human and other cells. Vectors are provided that are packaged efficiently in packaging cells and cell lines to generate high titer recombinant virus stocks expressing novel envelo... | 10/21/2008 |
| 7439060 | Independent helper virus packaging cell line for propagating viral vectors Provided are novel vectors and viral vectors capable of expressing exogenous gene or exogenous nucleic acid sequences in a target cell of interest, such as T cells, bone marrow cells, epithelial cells, liver cells and the like. The nucleic acid components of the vec... | 10/21/2008 |
| 7435546 | System to detect inducible translocation The present invention relates to a novel method for screening to identify/detect polypeptides capable of translocating into or out of the nucleus of a cell in response to induction by an external stimulus or stimuli. Kits for practicing the method of the invention a... | 10/14/2008 |
| 7432047 | Method for selective inactivation of viral replication Method for screening for an antiviral agent, by determining whether a potential agent interacts with a virus or cellular component which allows or prevents preferential translation of a virus RNA compared to a host RNA under virus infection conditions; and determini... | 10/07/2008 |
