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3M employee and church chorister Art Fry needed something to temporarily mark pages in his hymnal. He was in luck because his colleague, Spencer Silver, accidentally developed a glue that was too weak for other purposes. After initially discouraging consumer response, Post-it Notes became a hit in 1979.
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| Number | Title | Issue Date |
| 7955802 | Systems and methods for multiplex analysis of PCR in real time The present invention provides methods and systems for real-time measurements of PCR with multiplexing capability. Certain embodiments relate to methods and systems that use fluorescently encoded superparamagnetic microspheres for the immobilization of amplification... | 06/07/2011 |
| 7947452 | Oligonucleotides originating from sequences coding for the surface component of PTLV envelope proteins and their uses The invention relates to the use of oligonucleotides from the nucleotide sequences coding for the amino-terminal region of the surface component (SU) of envelope proteins of PTLV viruses in order to perform methods of detecting every PTLV strain or PTLV-related viru... | 05/24/2011 |
| 7939260 | Method for making available a priming oligonucleotide The present invention is directed to novel methods of synthesizing multiple copies of a target nucleic acid sequence which are autocatalytic (i.e., able to cycle automatically without the need to modify reaction conditions such as temperature, pH, or ionic strength ... | 05/10/2011 |
| 7931920 | Method for the isolation of nucleic acids from any starting material A composition suitable for the isolation of a nucleic acid from a material containing the nucleic acid contains at least one buffer with a chaotropic component; at least one proteolytic enzyme; at least one buffer with an non-chaotropic component; at least one alcoh... | 04/26/2011 |
| 7910354 | Efficient arrays of amplified polynucleotides The present invention is related generally to analysis of polynucleotides, particularly polynucleotides derived from genomic DNA. The invention provides methods, compositions and systems for such analysis. Encompassed by the invention are arrays of polynucleotides i... | 03/22/2011 |
| 7910302 | Efficient arrays of amplified polynucleotides The present invention is related generally to analysis of polynucleotides, particularly polynucleotides derived from genomic DNA. The invention provides methods, compositions and systems for such analysis. Encompassed by the invention are arrays of polynucleotides i... | 03/22/2011 |
| 7901890 | Methods and oligonucleotide designs for insertion of multiple adaptors employing selective methylation Aspects described and claimed herein provide methods to insert multiple DNA adaptors into a population of circular target DNAs at defined positions and orientations with respect to one another. The resulting multi-adaptor constructs are then used in massively-parall... | 03/08/2011 |
| 7897344 | Methods and oligonucleotide designs for insertion of multiple adaptors into library constructs Aspects described and claimed herein provide methods to insert multiple DNA adaptors into a population of circular target DNAs at defined positions and orientations with respect to one another. The resulting multi-adaptor constructs are then used in massively-parall... | 03/01/2011 |
| 7897747 | Method to produce single stranded DNA of defined length and sequence and DNA probes produced thereby A method for producing a single stranded DNA (ssDNA) molecule of a defined length and sequence is disclosed. This method enables the preparation of, inter alia, probes of greater length than can be chemically synthesized. The method starts with a double stranded mol... | 03/01/2011 |
| 7892732 | Method of performing PCR amplification on a microarray The present invention provides a method of amplifying target DNA by PCR or multiplex PCR on a microarray using array-immobilized DNA probes synthesized in a common area on the microarray by a maskless array synthesizer (MAS). The MAS constructed array-immobilized DN... | 02/22/2011 |
| 7892818 | Method and kit for the determination of cellular activation profiles A method for obtaining an activation profile of a biological sample by disposing onto a solid support in a pre-determined spatial arrangement a subset of capture molecules able to interact with one or more activated transcription factor(s) present in the biological ... | 02/22/2011 |
| 7888018 | Methods and kits for nucleic acid amplification Compositions and methods are provided for amplifying nucleic acid molecules. The nucleic acid molecules can be used in various research and diagnostic applications, such as gene expression studies involving nucleic acid microarrays. ... | 02/15/2011 |
| 7888109 | Apparatus and methods for detecting nucleic acid in biological samples There are disclosed apparatus and methods for the field-assisted acceleration of biological processes involving charged entities, including in particular the detection of target DNA in a biological sample. A reaction cell is provided with a dielectric surface, and a... | 02/15/2011 |
| 7862999 | Multiplex targeted amplification using flap nuclease Methods for multiplex amplification of a plurality of targets of distinct sequence from a complex mixture are disclosed. In one aspect targets are circularized using a single circularization probe that is complementary to two regions in the target that flank a regio... | 01/04/2011 |
| 7842457 | Bead emulsion nucleic acid amplification Disclosed are methods for nucleic acid amplification wherein nucleic acid templates, beads, and amplification reaction solution are emulsified and the nucleic acid templates are amplified to provide clonal copies of the nucleic acid templates attached to the beads. ... | 11/30/2010 |
| 7838237 | Screening methods and sequences relating thereto A screening method for identifying an individual having a pre-disposition towards having a cancer is disclosed, which screening method comprises the steps of: (a) obtaining a test sample comprising a nucleotide sequence comprised in the MYH gene of the ... | 11/23/2010 |
| 7838228 | Method of quantitative and/or comparative measurement of mRNA expression levels in small biological samples The present invention provides a method for quantitative and/or comparative assessment of the relative amounts of mRNA transcripts present in a cell or tissue sample. In the method reverse transcription of the mRNA contained in the sample is first carried out using ... | 11/23/2010 |
| 7833701 | Biomolecule substrate, and test and diagnosis methods and apparatuses using the same An object of the present invention is to provide a test apparatus for testing a DNA substrate on which a plurality of DNA fragments for testing are arranged, wherein absolute precision is not required. The above-described problem was solved by providing a substrate ... | 11/16/2010 |
| 7834168 | Herbicide tolerant cotton plants and methods for producing and identifying same The invention pertains to transgenic cotton plants, plant material and seeds, characterized by harboring a specific transformation event, particularly by the presence of a gene encoding a protein that confers herbicide tolerance, at a specific location in the cotton... | 11/16/2010 |
| 7833713 | Mitigation of Cot-1 DNA distortion in nucleic acid hybridization A novel method of suppressing non-specific cross-hybridization between repetitive elements present in nucleic acid probes and corresponding repetitive elements in the target nucleic acid by using DNA synthesized to contain a plurality of repetitive elements while av... | 11/16/2010 |
| 7799525 | Methods for genome amplification A method for whole genome amplification comprising (a) treating genomic DNA with a modifying agent which modifies cytosine bases but does not modify 5′-methyl-cytosine bases under conditions to form single stranded modified DNA; (b) providing a population of rando... | 09/21/2010 |
| 7790441 | Polymerase chain reaction kit and method of manufacturing the same The present invention provides a kit employed for polymerase chain reaction. The kit has a cavity and a flow channel on a substrate. The flow channel is separated from the cavity by at least a barrier formed along the cavity. Such a structure allows the cavity to be... | 09/07/2010 |
| 7790388 | Nucleic acid amplification method A nucleic acid amplification method, and probes for use within the method are described. ... | 09/07/2010 |
| 7790374 | Process for sequence saturation mutagenesis (SeSaM) A process for the mutagenesis of a double-stranded polynucleotide sequence (master sequence) of n base-pairs having a (+)-strand and a complementary (−)-strand comprising the steps (i) creation of a collection of single-stranded fragments of the (+)-strand of the ... | 09/07/2010 |
| 7785787 | Methods of isolating and amplifying nucleic acids using silanized solid support Provided are methods of isolating and amplifying nucleic acids from and in a nucleic acid-containing sample. The nucleic acid isolation method includes contacting a nucleic acid-containing sample to a silanized solid support to capture nucleic acids to the silanized... | 08/31/2010 |
| 7785777 | Diagnosis of Shwachman-Diamond Syndrome The SBDS gene has been identified as the site of mutations associated with SDS. Methods are provided for determining whether a subject is suffering from SDS. ... | 08/31/2010 |
| 7771935 | Evolving new molecular function Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The power of Nature and the flexibility of organic synthesis are combined in nucleic acid-templated synthesis. The present invention provid... | 08/10/2010 |
| 7767390 | Methods for evaluating drug-resistance gene expression in the cancer patient The methods of the invention detect in a qualitative or quantitative fashion drug-resistance RNA and DNA in blood plasma, serum, and other bodily fluids. The methods of the invention thereby enable the assessment of drug resistance in a neoplasm without the requirem... | 08/03/2010 |
| 7754423 | Methods for predicting the risk of diabetic nephropathy using genetic markers and arrays containing the same Disclosed is a method for detecting a Chinese diabetic subject suffering from, at risk for developing, or suspected of suffering from a nephropathy. The method includes determining whether a sample from the subject has at least one polymorphic sequence selected from... | 07/13/2010 |
| 7745122 | Analyzing messenger RNA and micro RNA in the same reaction mixture The present teachings provide methods, compositions, and kits for performing primer extension reactions on at least two target polynucleotides in the same reaction mixture. In some embodiments, a reverse transcription reaction is performed on a first target polynucl... | 06/29/2010 |
| 7741467 | Non-fluorescent energy transfer The present invention relates generally to the transfer of non-fluorescent energy between donor and acceptor moieties. In certain embodiments, the invention provides biomolecules that include substantially non-fluorescent donor moieties. Processes involving these do... | 06/22/2010 |
| 7741046 | Sequential analysis of biological samples Methods for probing multiple targets in a biological sample are provided. The methods include the steps of providing a biological sample containing multiple targets adhered to a solid support, binding at least one fluorescent probe to one or more target present in t... | 06/22/2010 |
| 7741045 | Sequential analysis of biological samples Methods for probing multiple targets in a biological sample are provided. The methods include the steps of providing a biological sample containing multiple targets, binding at least one fluorescent probe to one or more target present in the sample, and binding at l... | 06/22/2010 |
| 7732141 | Methods for evaluating drug-resistance gene expression in the cancer patient The methods of the invention detect in a qualitative or quantitative fashion drug-resistance RNA and DNA in blood plasma, serum, and other bodily fluids. The methods of the invention thereby enable the assessment of drug resistance in a neoplasm without the requirem... | 06/08/2010 |
| 7718354 | Methods for rapid identification of pathogens in humans and animals The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathoge... | 05/18/2010 |
| 7713697 | Methods and kits for amplifying DNA Novel methods of synthesizing multiple copies of a target nucleic acid sequence which are autocatalytic are disclosed (i.e., able to cycle automatically without the need to modify reaction conditions such as temperature, pH, or ionic strength and using the product o... | 05/11/2010 |
| 7709206 | Compositions, methods and systems for inferring bovine breed or trait Methods, compositions, and systems are provided for managing bovine subjects in order to maximize their individual potential performance and edible meat value, and to maximize profits obtained in marketing the bovine subjects. The methods and systems draw an inferen... | 05/04/2010 |
| 7704694 | Method for detecting target plant genus A method for detecting species in a target plant genus comprises the steps of conducting PCR using at least one member selected from the group consisting of primers (A) and (B), which can hybridize under stringent conditions to a nucleic acid molecule having a commo... | 04/27/2010 |
| 7700278 | Detection of red tide organisms by nucleic acid amplification A real-time reverse transcription-PCR, or NABSA, method targeting the rbcL gene developed for the detection and quantitation of the Florida red tide organism, Karenia brevis. ... | 04/20/2010 |
| 7695912 | Site-specific cleavage of nucleic acids by photoreactive conjugates A process of forming a double strand cleavage in DNA includes providing a reaction mixture containing double stranded DNA having a break in a first strand defining a target site in a second strand. The method continues by adding to the reaction mixture a photoreacti... | 04/13/2010 |
