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| Number | Title | Issue Date |
| 6037448 | Synthetic peptides for a rubella vaccine Synthetic peptides have an amino acids sequence corresponding to at least one antigenic determinant of at least one protein, usually a structural protein, particularly the E1, E2 or C proteins, of rubella virus (RV), are used as is, in hybrid or chimeric ... | 03/14/2000 |
| 6017542 | Nucleotide and amino acid sequences of canine herpesvirus GD and uses therefor Disclosed and claimed are nucleotides for genes encoding the canine herpesvirus (CHV) gB, gC and gD homologues. These genes encode polypeptides of 879, 459 and 345 amino acids, respectively, which are also disclosed and claimed. The genes are useful as DN... | 01/25/2000 |
| 5968775 | Hepatitis C virus infected cell systems The present invention is directed to extracorporeal cell systems infected with hepatitis C virus (HCV). The present invention also relates to products of such cell systems and their use as vaccines and in immunoassays. Methods whereby HCV-infected extraco... | 10/19/1999 |
| 5928862 | Competitive homogeneous assay Methods and compositions for performing assays for target polynucleotide strands include contacting a sample with a reagent which includes a first and a second polynucleotide probe. The first and second probes are capable of assuming a first position wher... | 07/27/1999 |
| 5849477 | Assays of coup transcription factor interactions in mammalian systems Multiple methods for measuring the COUP-TF system, including: a method to measure the level of COUP-TF by combining antibodies with biological samples and measuring the resultant antibody/COUP-TF complex; the binding of COUP-TF to promoters by combining b... | 12/15/1998 |
| 5846766 | Oxytocin receptor and DNA coding therefor The present invention relates to a receptor for a posterior pituitary hormone, oxytocin; a DNA sequence encoding for the receptor; a recombinant DNA molecule containing the DNA sequence and a transformant comprising the recombinant DNA molecule. The prese... | 12/08/1998 |
| 5840834 | Technique for joining amino acid sequences and novel composition useful in immunoassays Two amino acid sequences are joined together using an electron acceptor moiety and a linking moiety, such as a chelating agent. In particular, an amino acid sequence specific for binding to a material interest is linked to an enzyme which acts on an indic... | 11/24/1998 |
| 5833995 | Use of bluetongue virus proteins as vaccine components A protective effect against bluetongue infection in susceptible mammals which is obtained by innoculating said mammals with a polypeptide comprising at least an antigenic portion of bluetongue virus structural protein VP2 in antigenic form produced by tra... | 11/10/1998 |
| 5821108 | Enrichment for a thymocyte subset having progenitor cell activity using c-kit as a selection marker A subpopulation in the CD4+ 8+ (DP) thymic blast population is identified that is the precursor for thymic T cells. All such progenitors are c-kit+. The c-kit+ subset expresses lower levels of CD4 and CD8 than t... | 10/13/1998 |
| 5814611 | Pharmaceutical for the therapy of immune deficiency conditions A pharmaceutical preparation for the therapy of immune deficiency conditions comprising an active principle--a peptide of the structure: H--L--Glu--L--Trp--OH and a pharmaceutically acceptable vehicle.... | 09/29/1998 |
| 5811282 | Cell lines useful for detection of human immunodeficiency virus The present invention relates to a method for AIDS diagnosis and monitoring of anti-AIDS drug therapy, and more particularly to a method of assaying for human immunodeficiency virus. The present invention uses a focal immunoassay (FIA) which utilizes HIV-... | 09/22/1998 |
| 5811265 | Hybrid immunoglobulin-thrombolytic enzyme molecules which specifically bind a thrombus, and methods of their production and use Hybrid immunoglobulin-enzyme molecules are provided which are composed of antibodies, or derivatives or fragments thereof, which specifically bind an arterial or venous thrombus that are operably linked to the enzymatically active portions of thrombolytic... | 09/22/1998 |
| 5807992 | HIV-2 transmembrane glycoprotein homodimer (gp 80) Characterization of the envelope transmembrane protein of human immunodeficiency virus type 2 (HIV-2) was carried out using murine polyclonal and monoclonal antibodies or patient sera specific for HIV-2 proteins. A 80-Mr glycoprotein (gp80) was produced i... | 09/15/1998 |
| 5795741 | Coccidiosis poultry vaccine This invention relates to novel Eimeria proteins with immunogenic properties as well as to DNA sequences encoding these proteins. These proteins can be administered to poultry thereby protecting the birds against coccidiosis. In addition the DNA encoding ... | 08/18/1998 |
| 5786336 | Target-selective protocols based on mimics A method to potentiate the effect of a chemotherapeutic agent in a tumor cell, which method comprises administering to said tumor cell, along with said chemotherapeutic agent, a potentiating amount of a compound of the formula: ##STR1## or an am... | 07/28/1998 |
| 5783192 | Recombinant feline herpesvirus vaccine The present invention is concerned with a Feline herpesvirus (FHV) mutant comprising a heterologous gene introduced into an insertion-region of the FHV genome. The invention also relates to a vector vaccine comprising such an FHV mutant which expresses a ... | 07/21/1998 |
| 5736362 | Ryegrass pollen allergen The present invention provides nucleic acid sequences coding for two ryegrass pollen allergen Lol p Ib family members, purified Lol p Ib.1 and Lol p Ib.2 proteins and fragments thereof, methods of producing recombinant Lol p Ib.1 or Lol p Ib.2 or at least... | 04/07/1998 |
| 5736378 | Molecular cloning and characterization of the feline immunodeficiency virus isolate PPR Molecular clones of the feline immunodeficiency virus isolate PPR (FIVPPR) were obtained from a genomic library prepared from infected feline peripheral blood lymphocytes (PBLs). FIVPPR infected and replicated efficiently in feline P... | 04/07/1998 |
| 5721119 | Ryegrass pollen allergen The present invention provides nucleic acid sequences coding for two ryegrass pollen allergen Lol p Ib family members, purified Lol p Ib.1 and Lol p Ib.2 proteins and fragments thereof, methods of producing recombinant Lol p Ib.1 or Lol p Ib.2 or at least... | 02/24/1998 |
| 5709995 | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses The hepatitis C virus (HCV) is the major cause of non-A, non-B vital hepatitis. The most striking feature of HCV induced liver disease is its tendency toward chronicity and slowly progressive liver cell injury. HLA Class I-restricted cytotoxic T lymphocyt... | 01/20/1998 |
| 5708147 | Mononuclear leukocyte directed endothelial adhesion molecule associated with atherosclerosis The invention relates to novel endothelial cell-leukocyte adhesion molecules designated ATHERO-ELAM. ATHERO-ELAM molecules are expressed on cultured endothelial cells stimulated with bacterial LPS and selectively mediate the binding of monocytes to the en... | 01/13/1998 |
| 5705612 | NEF peptide encoded by human immunodefiency virus type 1 (HIV-1) The complete nucleotide sequence of a proviral molecular clone of the lymphadenopathy-associated virus, LAV, was ascertained. Recombinant phage clones were isolated from a genomic library of LAV-infected human T-lymphocyte DNA. The insert of recombinant p... | 01/06/1998 |
| 5705331 | HIV nucleocapsid protein capture assay and method of use An antigen capture method, and an antigen capture assay diagnostic kit, for detecting the presence or concentration of HIV in a biological sample without interference from antigen-antibody immune complexes is provided. The lysate of a biological sample ob... | 01/06/1998 |
| 5698671 | Metalloproteinase peptides Inappropriate degradation of extracellular matrix molecules by metalloproteinases plays an important role in a wide variety of pathologic conditions including neoplasia and arthritis. The present invention is an isolated protein of approximately 23,000 da... | 12/16/1997 |
| 5698448 | Immunosuppressive drug binding proteins and use Purified immunosuppressive drug binding proteins (immunophilins) of molecular mass 2.4-3.0 kDa, 4.5 kDa, 34-37 kDa, 50-54 kDa, 80-100 kDa, and greater than about 120 kDa are described. The 34-37 kDa immunophilin specifically binds FK-506 and rapamycin. Th... | 12/16/1997 |
| 5695956 | Clostridium perfingens type a enterotoxin toxoid and methods of preparation and use as a vaccine and therapeutic agent Escherichia coli strains that produce recombinant Clostridium perfringens type A enterotoxin toxoids from a Clostridium perfringens type A enterotoxin gene fragment encoding the Clostridium perfringens type A enterotoxin binding domain subcloned into an e... | 12/09/1997 |
| 5693508 | Retroviral expression vectors containing MoMLV/CMV-IE/HIV-TAR chimeric long terminal repeats Novel retroviral vectors were constructed by making modifications to the Moloney murine leukemia virus (MoMLV) long terminal repeat (LTR). A portion of the U3 region of the MoMLV LTR was replaced with a hybrid regulatory element consisting of the human cy... | 12/02/1997 |
| 5691135 | Immunoglobulin superantigen binding to gp 120 from HIV VH3 and VH4 type immunoglobulins display superantigen-type binding affinity for the HIV gp120 envelope glycoprotein. VH3 and VH4 type antibody molecules, including IgG and IgM, are shown to suppress HIV infection in vivo and in vitro. Determining the leve... | 11/25/1997 |
| 5690938 | Oral immunization with multiple particulate antigen delivery system Method of inducing a mucosal and or/systemic immune response in a host, comprising the step of administering to the host an effective amount of a Bluetongue antigen in the form of virus like and/or virus core like particles. Vaccines are also provided.... | 11/25/1997 |
| 5688920 | Nucleotide and amino acid sequences for canine herpesvirus GB, GC and GD and uses therefor Disclosed and claimed are nucleotides for genes encoding the canine herpesvirus (CHV) gB, gC and gD homologues. These genes encode polypeptides of 879, 459 and 345 amino acids, respectively, which are also disclosed and claimed. The genes are useful as DN... | 11/18/1997 |
| 5688504 | Anti-receptor and growth blocking antibodies to the vitamin B12 /transcobalamin II receptor and binding sites There is disclosed anti-receptor and growth blocking agents to the vitamin B12 /transcobalamin II receptor and binding sites. The anti-receptor and growth blocking agents antagonize or modulate the vitamin B12 /transcobalamin II rece... | 11/18/1997 |
| 5688511 | Cellular protein TDP-43 and regulation of HIV-1 gene expression Compositions including a polypeptide or nucleic acid sequence encoding a polypeptide that binds TAR DNA (particularly the region -18 to +28 of HIV-LTR DNA) and that does not bind to TAR RNA (particularly the region +1 to +80 of the TAR RNA) are disclosed.... | 11/18/1997 |
| 5683901 | Method of producing RNA viruses from cDNA The present invention relates to methods for producing RNA virus cDNA, methods for producing viable, RNA virus and viable, RNA virus produced by those methods. The invention also related to a novel RNA virus cDNA, recombinant DNA molecules containing that... | 11/04/1997 |
| 5681696 | Synthetic peptide compositions with immunoreactivities to antibodies to HTLV The present invention relates to a method for the detection HTLV-I and/or HTLV-II reactive antibodies and diagnosis of ATL (adult T cell leukemia/lymphoma) condition by the use of chemically synthesized peptide compositions. The peptide compositions compr... | 10/28/1997 |
| 5681695 | Method for increasing specificity in competitive immunoassays The invention is an improved immunoassay and method for detection of antibody to hepatitis B core antigen (anti-HBc). The improved assay comprises the addition of a reducing agent to decrease the number of false positive reactions in the assay.... | 10/28/1997 |
| 5679342 | Hepatitis C virus infected cell systems The present invention is directed to extracorporeal cell systems infected with hepatitis C virus (HCV). The present invention also relates to products of such cell systems and their use as vaccines and in immunoassays. Methods whereby HCV-infected extraco... | 10/21/1997 |
| 5677147 | HIV-2 virus variants HIV-2 virus variants, namely virus HIV D194 and virus HIV D205, which can be cloned from the corresponding virus isolate HIV D194 (ECACC V 87122303) or from the infected cell line HUT 194 (ECACC V 87122306) or from the virus isolate HIV D205 (ECACC V 8712... | 10/14/1997 |
| 5674677 | Immunoassay technique using histidine tags, metals, and chelating agents Two amino acid sequences are joined together using an electron acceptor moiety and a linking moiety, such as a chelating agent. In particular, an amino acid sequence specific for binding to a material interest is linked to an enzyme which acts on an indic... | 10/07/1997 |
| 5674700 | Method for the detection and/or assay of hormones, and antibodies which can be used in the said detection method An assay for detecting the presence and amount of a hormone in culture media or a biological sample includes the steps of preincubating two antibodies specific for the hormone to be assayed in a preincubation medium that is essentially free of the hormone... | 10/07/1997 |
| 5670311 | Peptides for detecting antibodies to HTLV-2 Peptides corresponding to epitopes of HTLV-2 proteins are provided. These peptides are immunologically reactive with HTLV-2 specific antibodies. Several of the peptides are sufficiently unreactive to antibodies to HTLV-1 to distinguish between antibodies ... | 09/23/1997 |
