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| Number | Title | Issue Date |
| 4323546 | Method and composition for cancer detection in humans Anti human chorionic gonadotropin (anti-hCG) and/or anti human chorionic gonadotropin- beta subunit (anti-hCG-ଲ) labeled with Technetium-99M are/is administered to a human. The biodistribution of the labeled composition is monitored in order to dete... | 04/06/1982 |
| 4323547 | Labeled fatty acids and method of making and using same Radioactive-halogen labeled fatty acids, especially fatty acids having as an ω-terminal or mid-chain substituent 18F as the labeling atom. The hydrocarbon has more than fifteen carbon atoms in the hydrocarbon chain and is purified by high pres... | 04/06/1982 |
| 4314987 | Method for diagnosing rheumatological diseases A process for differential diagnosis of various rheumatological and arthritic diseases, all of which may yield similar antinuclear antibody test results. The process comprises a continuous sequence of tests on a single serum specimen to minimize and elimi... | 02/09/1982 |
| 4313926 | Method for the preparation of a scintillographic agent The invention relates to a method for the preparation of a scintillographic agent which comprises preparing a derivative of iminodiacetic acid particularly an ω-chlor-2,4-dimethylacetanilide derivative, and chelating such derivative with a radiometal. Th... | 02/02/1982 |
| 4312854 | Immunoassay for thyroid stimulating hormone employing florisil adsorbent as separating agent An improved immunoassay method for determining thyroid stimulating hormone (TSH) in a liquid sample wherein the bound- and free-species of the labelled, preferably radio-labelled, TSH are separated by contacting the liquid reaction mixture with Florisil a... | 01/26/1982 |
| 4311689 | Method and container for production of diagnostic scanning A closed container for producing, on introduction of a solution of technetium-99m as pertechnetate, technetium in a form suitable for diagnostic scanning, contains under sterile conditions tin or a tin-containing alloy as a reducing agent for the pertechn... | 01/19/1982 |
| 4311790 | Radioenzymatic method for assaying 3,4-dihydroxyphenylglycol A method for assaying 3,4-dihydroxyphenylglycol in a sample containing other catechol compounds by forming tritiated O-methylated derivatives, extracting tritiated 3-methoxy-4-hydroxyphenylglycol at a pH of 5 or lower, isolating the tritiated 3-methoxy-4-... | 01/19/1982 |
| 4310504 | Dry radioimmunoassay test composition containing stabilized label/antibody mixture A dry radioimmunoassay test composition comprising a mixture of a radiolabelled form of a ligand, i.e., a hapten or an antigen, an antibody for the ligand, and a heavy metal cation, e.g., cupric ion, to inhibit the complex-forming reaction between the rad... | 01/12/1982 |
| 4307071 | Analytical reagent and method A reagent is disclosed for determining the concentration of a ligand in blood serum. The reagent includes a protenaceous, three-dimensional, serum-insoluble complex which is readily collected by centrifugation, the complex comprising non-specific immunogl... | 12/22/1981 |
| 4305922 | Labeling proteins with 99m-Tc by ligand exchange A new method for labeling proteins with 99m-technetium: (1) Start with any volume of technetium (pertechnetate and saline) solution and add 0.1 ml of stannous solution (stannous fluoride-acetate solution) per 15-20 ml of saline. The stannous ions will red... | 12/15/1981 |
| 4303636 | Cancer treatment A treatment of cancer by the application of external electromagnetic energy capable of the generation of heat in intracellular particles to induce selective thermal death of cancer cells in living tissue. This process allows for the selective treatment of... | 12/01/1981 |
| 4301140 | Radiopharmaceutical method for monitoring kidneys Complexes of technetium-99m with fructose 6-phosphate or fructose 1,6-diphosphate or salts thereof having utility as radiopharmaceutical agents for monitoring the activity of an organ, their preparation and a method employing such complexes for externally... | 11/17/1981 |
| 4301139 | Multilayer column chromatography specific binding assay method, test device and test kit A specific binding assay method, and a test device and test kit for use therein, for determining a liqand, such as an antigen or antibody, in, or the ligand binding capacity of, a liquid medium, particularly a body fluid such as serum, wherein the unknown... | 11/17/1981 |
| 4299815 | Carcinoembryonic antigen determination An improved process for the determination of carcinoembryonic antigen in a sample of serum or plasma is disclosed. The improved process, in essence, comprises negating potentially interfering substances in the sample by diluting the sample with water and ... | 11/10/1981 |
| 4299813 | Assay kit and method Method and kit for determining levels of tricyclic antidepressants in body fluid, the method including the step of measuring inhibition of the binding of radioactive muscarinic cholinergic or radioactive histamine H1 receptor binder to muscarin... | 11/10/1981 |
| 4299812 | Immunoassay of thyroxine in neonates using dried blood samples In the immunoassay of thyroxine using dried blood samples spotted on filter paper, the assay in this invention is run at a pH of 9.2 to 10.0, preferably at about 9.5, rather than the pH range of about 8.4 to 8.7 generally used in the art. The advantage of... | 11/10/1981 |
| 4299814 | Radioimmunoassay of MIF A method is disclosed for detecting the presence of migration inhibitory factor (MIF) which comprises reacting a test solution containing an unknown amount of MIF antigen, a known amount of MIF antigen which has been radiolabeled, a known amount of antibo... | 11/10/1981 |
| 4298593 | Reagents and methods utilizing labeled Fab bound to antigens This invention involves an improvement in a method for immunochemically assaying a member of an antigen-antibody binding pair in serum or plasma which utilizes labeled antigen having a plurality of antigenic binding sites as the indicating reagent, the im... | 11/03/1981 |
| 4298591 | Instantaneous radioiodination of rose bengal at room temperature and a cold kit therefor The disclosure relates to the radioiodination of rose bengal at room temperature and a cold-kit therefor. A purified rose bengal tablet is stirred into acidified ethanol at or near room temperature, until a suspension forms. Reductant-free 125 ... | 11/03/1981 |
| 4298592 | Double antibody separation method A double antibody radioimmunoassay method for determining antigens in a sample wherein polyethylene glycol is provided in a reaction medium to accelerate an immunoprecipitation reaction between water-soluble first antibodies bound to antigen and water-sol... | 11/03/1981 |
| 4298590 | Detection of malignant tumor cells Described herein is the utilization of anti-Malignin TAG products to detect the presence of cancerous or malignant tumor cells. These TAG products attach preferentially to cancerous or malignant tumor cells in cell collections in vitro or in vivo and thus... | 11/03/1981 |
| 4297337 | Solid-phase immunoassays using magnetic glass Solid-phase immunoassay procedures employing magnetic glass or crystal-containing material, or a superparamagnetic material formed of magnetic particles dispersed in a non-magnetic matrix, as particulate carrier.... | 10/27/1981 |
| 4293537 | Novel chemical method of labeling proteins with 99m Tc-Technetium at physiological condition A novel rapid chemical method of labeling exogenous and autologous plasma proteins, other compound and/or substance containing proteins with 99m Tc-Technetium at physiologic pH 7.4 condition, producing a sterile apyrogenic radioactive tracer ma... | 10/06/1981 |
| 4293538 | Assay for hepatitis A antigen Liquid containing hepatitis A antibody is adsorbed on a surface. The surface is then coated with a proteinaceous material and incubated in the presence of the sample to form a complex of hepatitis A antigen and hepatitis A antibody. The complex is incubat... | 10/06/1981 |
| 4293536 | Estrophilin detection Estrogen receptor protein, estrophilin, in a tissue sample is detected and quantified by radiochemical methods involving selective binding of the protein to controlled pore glass beads. Also disclosed are methods for selectively removing undesirable degra... | 10/06/1981 |
| 4292297 | Selenomethionine-75 Se-containing solution having a thiol as a stabilizer A selenomethionine-75 Se-solution, which is suitable for use as a radioactive diagnostic material in medical science applications, is stabilized with regard to maintaining its radiochemical purity by the addition of a thiol of the formula in wh... | 09/29/1981 |
| 4292296 | Diagnostic method Free analytes in samples containing free analytes and receptorbound analytes are determined by absorbing at least a portion of free analyte from the sample with insolubilized receptor or receptor which is then made insoluble, washing the insoluble recepto... | 09/29/1981 |
| 4291012 | Technetium-labelled diagnostic agent for the examination of the RES A process is disclosed for the preparation of a diagnositc agent for scanning the RES, in particular the liver, by mixing the sodium salt of 1-phenyl-2,3-dimethyl-pyrazolone-4-methylamino-methylsulfonic acid or 1-phenyl-2,3-dimethyl-pyrazolone in aqueous ... | 09/22/1981 |
| 4289747 | Immunological determination using lectin A method for the determination of one or more components of an immunological conjugate, e.g., antigens, of a fluid sample in a competitive or sandwich technique in which the conjugate is labelled and separated from its reactive mixture by reversible attac... | 09/15/1981 |
| 4289748 | Ultrasensitive enzymatic radioimmunoassay method A method of quantitatively measuring antigen or antibody concentration by selectively coupling an antigen to a solid substrate, coupling an enzyme-conjugated antibody to the antigen and reacting a radioindicator with the enzyme-conjugate producing a radio... | 09/15/1981 |
| 4288424 | Generator for ionic gallium-68 based on column chromatography A physiologically acceptable solution of gallium-68 fluorides, having an activity of 0.1 to 50 millicuries per milliliter of solution is provided. The solution is obtained from a generator comprising germanium-68 hexafluoride bound to a column of an anion... | 09/08/1981 |
| 4288425 | Method and apparatuses for electrophoretic immunoassay Methods and apparatuses are featured for preconcentrating immunological reactants prior to their contact and reaction, to greatly enhance the rate of reaction and the sensitivity. The preconcentration is accomplished within the reaction medium and is foll... | 09/08/1981 |
| 4284619 | Esters useful as brain imaging agents Certain radioiodine containing esters useful as brain imaging agents are disclosed. The compounds of the subject invention are represented by the formula ##STR1## wherein I is a radioisotope of iodine with iodine-123 being preferred and R is sel... | 08/18/1981 |
| 4280993 | Process for determining the concentration of benzodiazepines in a body fluid A process for determining the concentration of benzodiazepines in a body liquid comprising the steps of contacting freeze-dried brain tissue with tritium labelled flunitrazepam to bond labelled flunitrazepam to receptor sites of the brain tissue, determin... | 07/28/1981 |
| 4280991 | Diagnostic compositions The invention discloses diagnostic compositions for use in obtaining images of a patient's lungs. The basic components of the composition of the invention are sodium pertechnetate which is radioactive and ethanol. This composition may be combusted and the... | 07/28/1981 |
| 4280992 | Immunologically active substance-glass conjugates, process for producing the same and diagnostic reagents containing the same An immunologically active substance-glass conjugate comprising an immunologically active substance physically or chemically bound to the surface of a frosted glass makes it possible to assay physiologically active substances in body fluids with high sensi... | 07/28/1981 |
| 4279886 | Test for pancreatic exocrine function It has been determined that ingested vitamin B12 is bound by R protein in gastric juice, but that it is not capable of absorption in this form. In a system with a normally functioning exocrine pancreas, R protein is degraded by pancreatic prote... | 07/21/1981 |
| 4279859 | Simultaneous radioassay of folate and vitamin B12 A serum sample is heated at an alkaline pH to release folate and vitamin B12 from endogenous binders. A simultaneous radioassay for folate and vitamin B12 is effected by contacting the sample with binder for folate, binder for vitami... | 07/21/1981 |
| 4279885 | Solid phase assay An analyte, such as an antigen, is initially contacted with a receptor (antibody) bound to a solid support, in the absence of tracer, followed by removal of unbound analyte and contacting with tracer. By separately contacting the receptor with analyte and... | 07/21/1981 |
| 4279887 | Amides useful as brain imaging agents Certain radioiodine containing amides useful as brain imaging agents are disclosed. The compounds of the subject invention are represented by the formula ##STR1## wherein I is a radioisotope of iodine with I-123 being preferred, R1 an... | 07/21/1981 |
