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| Number | Title | Issue Date |
| 6204020 | DNA encoding N.gradient.2 CSF-1 (short form) and carboxy truncated fragment thereof A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system, is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombina... | 03/20/2001 |
| 6156300 | Point mutants of N.gradient.2 CSF-1 and carboxy truncated fragments thereof A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system. is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombina... | 12/05/2000 |
| 6156540 | Thrombin inhibitor There is provided a thrombin inhibitor polypeptide and DNA(RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. The anti-thrombin polypeptide is used to treat various diseases where prevent... | 12/05/2000 |
| 6153581 | Drug for recovering renal function Drug which contains human growth hormones capable of recovering the renal function when administered to a patient who has renal insufficiency but has not yet undergone kidney dialysis. By administrating the drug, the loss of renal function represented by ... | 11/28/2000 |
| 6146851 | DNA encoding NV2 (long form) and carboxy truncated fragments thereof A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinan... | 11/14/2000 |
| 6143523 | Human growth hormone variants Human growth hormone variants and their nucleic acids are disclosed wherein the amino acid residues at positions 10, 14, 18, 21, 167, 171, 174, 176 and 179 have been replaced with other amino acids. Also claimed are vectors and host cells comprising these... | 11/07/2000 |
| 6136563 | Human growth hormone variants comprising amino acid substitutions Human growth hormone variants are disclosed having enhanced affinity for the growth hormone receptor. Also disclosed are human growth hormone variants conjugated to one or more chemical groups, such as poly(ethylene glycol), which is believed to prolong t... | 10/24/2000 |
| 6127149 | Modified epimorphin Disclosed herein are a modified epimorphin obtained by adding a hydrophilic peptide composed of 5 to 99 amino acids to at least one terminus of a polypeptide containing the functional domain of epimorphin, and a modified epimorphin composed of a polypepti... | 10/03/2000 |
| 6117422 | N.gradient.2-CSF-1(long form) and carboxy truncated fragments thereof A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system. is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombina... | 09/12/2000 |
| 6114307 | Methods for stimulating pancreatic islet cell regeneration The present invention provides compositions for stimulating an increase in islet proliferation and ଲ-cell mass using an insulin homolog polypeptide. The present invention also includes methods for treating diabetes by stimulating islet proliferation... | 09/05/2000 |
| 6103224 | N.gradient.2 CSF-1 (short form) and carboxy truncated fragments thereof A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system. is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombina... | 08/15/2000 |
| 6096706 | Growth-promoting proteins and peptides for kidney epithelial cells Novel growth peptides derived from protein factors having molecular weights of about 22 and 45 kDa stimulate mitogenic activity of epithelial, but not fibroblastic cells, in particular, kidney epithelial cells. A source of the factors is scrape-wounded ki... | 08/01/2000 |
| 6077692 | Keratinocyte growth factor-2 This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypept... | 06/20/2000 |
| 6075008 | Method for promoting cell proliferation and growth A method is disclosed which provides for the proliferation and growth of cells, such as prostate cells, by contacting them with an effective amount of a placental-derived prostate growth factor.... | 06/13/2000 |
| 6069231 | PR domain peptides The present invention provides PR domain peptides, which are about 100 to about 120 amino acids in length and contain three highly conserved sequences of about 10 to about 12 amino acids, separated by less conserved sequences of about 20 to about 35 amino... | 05/30/2000 |
| 6057292 | Method for inhibiting growth hormone action Human growth hormone variants are disclosed having enhanced affinity for the growth hormone receptor. Also disclosed are human growth hormone variants conjugated to one or more chemical groups, such as poly(ethylene glycol), which is believed to prolong t... | 05/02/2000 |
| 6046035 | Polynucleotides encoding a cardiotrophin-like cytokine The present invention relates to a novel CLC protein which is a member of the IL-6 cytokine family. In particular, isolated nucleic acid molecules are provided encoding the human CLC protein. CLC polypeptides are also provided as are vectors, host cells a... | 04/04/2000 |
| 6040157 | Vascular endothelial growth factor 2 Disclosed are human VEGF2 polypeptides, biologically active, diagnostically or therapeuticall sefl fragments, analogs, or derivatives thereof, and DNA (RNA) enco such VEGF2 polypeptides. Also provided are procedures for producing such polypeptides by reco... | 03/21/2000 |
| 6030811 | Polynucleotides encoding a human mystrophin clone, HSABH01 A human cDNA encoding human myotrophin and the polypeptide encoded thereby and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing the human myotrophin polynucleotides and polypepti... | 02/29/2000 |
| 6028058 | Methods and compositions for regulating nuclear trafficking of proteins Methods are provided to regulate the trafficking of nuclear proteins, including the high molecular weight forms of FGF-2, to the nucleus. A nuclear trafficking component, which is approximately 29 kD, is identified as binding to and regulating nuclear loc... | 02/22/2000 |
| 6025204 | Diagnostic method for detection of placental-derived prostate growth factors A diagnostic method is described for the detection of placental-derived growth factors which involves contacting a biological tissue or fluid sample with a labeled antibody which is specific to the growth factors and detecting the labeled reaction product... | 02/15/2000 |
| 6022953 | Multifunctional M-CSF proteins and genes encoding therefor Multifunctional proteins having M-CSF activity and at least one other bioactivity not found together in a single naturally occuring molecule are described. These multifunctional M-CSF proteins can be produced by the expression of fused genes which are als... | 02/08/2000 |
| 6022711 | Human growth hormone variants having enhanced affinity for human growth hormone receptor at site 1 Growth hormone participates in the regulation of normal growth and development processes. The binding affinity of growth hormone for its target receptors is dependent upon the interaction of site 1 and site 2 domains of growth hormone with the target rece... | 02/08/2000 |
| 6020306 | Receptor-type tyrosine kinase and use thereof The present invention relates to an isolated receptor-type tyrosine kinase. The receptor-type tyrosine, in its naturally occurring form, is characterized by being reactive to monoclonal antibody III.A4, having an apparent molecular weight of approximately... | 02/01/2000 |
| 6010999 | Stabilization of fibroblast growth factors by modification of cysteine residues The present invention relates to physiologically-active derivatized natural and recombinant mammalian and human proteins and polypeptides. The invention provides chemical methods for derivatizing natural and recombinantly-derived proteins or polypeptides ... | 01/04/2000 |
| 6011007 | Acylated insulin The present invention relates to protracted human insulin derivatives in which the A21 and the B3 amino acid residues are, independently, any amino acid residue which can be coded for by the genetic code except Lys, Arg and Cys; PheB1 may be de... | 01/04/2000 |
| 6010882 | Production of biologically active recombinant insulin-like growth factor II polypeptides The present invention relates to the finding and construction of fish insulin-like growth factor II (IGF-II) cDNAs which can be cloned and expressed in cells. This invention also relates to the production of biologically active fish IGF-II polypeptides by... | 01/04/2000 |
| 6008328 | Method for purifying keratinocyte growth factors The present invention concerns the purification of keratinocyte growth factors.... | 12/28/1999 |
| 6004931 | Method for inhibiting growth hormone action Human growth hormone variants are disclosed having enhanced affinity for the growth hormone receptor. Also disclosed are human growth hormone variants conjugated to one or more chemical groups, such as poly(ethylene glycol), which is believed to prolong t... | 12/21/1999 |
| 6004780 | Growth factor HTTER36 The present invention discloses Growth Factor HTTER36 polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which includ... | 12/21/1999 |
| 5998170 | Polynucleotides encoding hepatocyte-specific members of the FGF family Nucleic acid molecules are described which are useful in vectors, transformed or transfected host cells, and methods for the recombinant expression of hepatocyte growth-specific polypeptide members of the FGF family.... | 12/07/1999 |
| 5994302 | Human vascular IBP-like growth factor A human Vascular IBP-like growth factor polypeptide (VIGF) and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for wound h... | 11/30/1999 |
| 5994103 | Human stanniocalcin-alpha A human stanniocalcin-alpha polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of electroly... | 11/30/1999 |
| 5994102 | Polynucleotides encoding prostatic growth factor and process for producing prostatic growth factor polypeptides The present invention relates to polynucleotides encoding human PGF polypeptides, variant polynucleotides encoding analog polypeptides, and variant polynucleotides useful as probes for polynucleotides encoding human PGF polypeptides. Also provided is a pr... | 11/30/1999 |
| 5994301 | Corpuscles of stannius protein, stanniocalcin The present invention relates to human Corpuscles of Stannius polypeptides and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and antagonists against such polypeptides. Also pro... | 11/30/1999 |
| 5989892 | Microorganisms, demulsifiers and processes for breaking an emulsion The present invention discloses a process for breaking an emulsion comprising water and oil, comprising the steps of mixing an emulsion consisting of water and oil with a culture, bacterial cells or a culture supernatant of a bacterium belonging to the ge... | 11/23/1999 |
| 5989866 | FGF homologs The present invention relates to polynucleotide and polypeptide molecules for zFGF-5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells and may be used for remodelling cardiac tissue a... | 11/23/1999 |
| 5986068 | Site-directed mutagenesis modified glycoprotein hormones and methods of use Described are new glycoprotein hormones capable of competing with natural hormones for the normal receptor binding sites but substantially incapable of effecting post receptor activities. The glycoprotein hormones of the present invention have had specifi... | 11/16/1999 |
| 5977338 | Probes and detection method for a human interferon-inducible protein The present invention provides a novel human interferon-inducible protein (HIFI) and the polynucleotides which identify and encode HIFI. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequen... | 11/02/1999 |
| 5962314 | Calcium receptor-active molecules The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can m... | 10/05/1999 |
