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| Number | Title | Issue Date |
| 7442817 | Process for the preparation of olefin oxides A process in continuous is described for the preparation of oxides of olefins by the direct epoxidation of an olefin with hydrogen peroxide, or compounds capable of producing hydrogen peroxide under the reaction conditions, in a solvent medium, in the presence of a ... | 10/28/2008 |
| 7235583 | Fatty acid-anticancer conjugates and uses thereof The invention provides conjugates of fatty acids and anticancer agents useful in treating cancer, and compositions and formulations thereof. Methods for using the conjugates also are provided. ... | 06/26/2007 |
| 7112685 | Labeled resiniferatoxin derivatives This invention relates resiniferatoxin derivatives useful in a vanilloid receptor binding assay and methods for production thereof. ... | 09/26/2006 |
| 7074945 | Metal alkoxide taxane derivatives A process for preparing N-acyl, N-sulfonyl and N-phosphoryl substituted isoserine esters in which a metal alkoxide is reached with a β-lactam. ... | 07/11/2006 |
| 7057057 | Histone deacetylase inhibitors based on alpha-ketoepoxide compounds Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, for example, an alpha-ketoepoxide group, such as an alpha-ketothio group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene e... | 06/06/2006 |
| 7030264 | Bis-β-hydroxyethyl terephthalate Bis-β-hydroxyethyl terephthalate having an optical density measured in a 10 wt % methanol solution at a measurement wavelength of 380 nm and a cell optical path length of 10 mm of 0.000 to 0.006. The present invention makes it clear that purified BHET having an opt... | 04/18/2006 |
| 6998494 | Preparation of trans-fused 3,3a,8,12b-tetrahydro-2h-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivatives The present invention concerns processes for the preparation of each of the 4 diastereomers of formula (I) in stereochemically pure form from either of two enantiomerically pure precursors. The tetracyclic ringsystem ha... | 02/14/2006 |
| 6995286 | Process for preparing isomers of salbutamol A process for making optically pure (R) and (S) salbutamol comprises obtaining the (R) or (S) isomer of either salbutamol or a salbutamol precursor in substantially optically pure form by resolving a racemic or optically impure mixture of enantiomers of salbutamol o... | 02/07/2006 |
| 6987194 | Insecticidal (dihalopropenyl) phenylalkyl substituted dihydrobenzofuran and dihydrobenzopyran derivatives Insecticidal (dihalopropenyl) phenylalkyl substituted dihydrobenzofuran and dihydrobenzopyran derivatives of Formula I are disclosed. These compounds provide unexpected insecticidal activity across a spectrum of insect pests combined with desirable physical properti... | 01/17/2006 |
| 6982346 | Process of making D-panthenyl triacetate A process of making D-panthenyl triacetate which includes reacting D-panthenol with acetic anhydride in the presence of the catalyst polymer bound dimethylaminopyridine to form an exothermic mixture. The so-produced acetic acid, and the catalyst are removed from the... | 01/03/2006 |
| 6974888 | Process for preparing organic hydroperoxide containing product Process for preparing alkylaryl hydroperoxide containing product, which process comprises: (a) oxidation of an alkylaryl compound to obtain reaction product containing alkylaryl hydroperoxide, (b) contacting with water at least part of the ... | 12/13/2005 |
| 6960671 | Process for direct oxidation of propylene to propylene oxide and large particle size titanium silicalite catalysts for use therein Large crystals of titanium silicalite or intergrowths of intergrown smaller crystals, having a mean particle size greater than 2 μm, have been found catalytically effective at commercially reasonable rates for the epoxidation of olefins in the presence of hydrogen ... | 11/01/2005 |
| 6956046 | 4-hydroxypiperidine derivatives having analgesic activity A compound represented by the following Formula (I): (wherein A represents oxygen atom or —NR3— (R3 represents hydrogen atom or lower alkyl group); R1 represents nitro group, lower ... | 10/18/2005 |
| 6949670 | Fluorocompound, silver halide photographic light-sensitive material, surfactant, and water-based coating composition employing same A fluorocompound denoted by general formula (1) below (wherein R1 denotes a substituted or unsubstituted alkyl group having a total of at least six carbon atoms, with R1 not being an alkyl group s... | 09/27/2005 |
| 6943259 | Halogenated triptolide derivatives as immunomodulators and anticancer agents Compounds having the structure I: are useful for inducing cell death (apoptosis) and in immunosuppression. In structure I, CR1R2 is selected from CHOH, C═O, CH... | 09/13/2005 |
| 6939978 | Production of taxol and taxanes A high yield, economical process for purifying taxanes from yew biomass is disclosed. The process does not require initial liquid:liquid portioning of the crude extract to separate highly polar substances. The organic solvent extract of the biomass is adsorbed onto ... | 09/06/2005 |
| 6933396 | Process to prepare psorospermin Psorospermin and analogs thereof are made using an enantiomerically selective process ... | 08/23/2005 |
| 6933395 | PROCESSING FOR PRODUCING OF DROSPIRENONE (6β, 7β, 15β, 16β-DIMETHYLENE-3-OXO-17α-PREGN-4-EN-21, 17-CARBOLACTONE, DRSP) AS WELL AS 7α-(3-HYDOXY-1-PROPLY)-6β, 7β; 15β, 16β-DIMETHYLENE-5β-ANDROSTANE-3β, 5,17β-TRIOL(ZK 92836) AND 6β, 7β; 15β, 16β-DIMETHYLENE-5β-HYDROXY Process for the production of drospirenone (6β,7β; 15β,16β-dimethylene-3-oxo-17α-pregn-4-ene-21,17-carbolactone, DRSP) (1) and 7α-(3-hydroxy-1-propyl)-6β,7β; 15β,16β-dimethylene-5β-androstane-3β,5,17β-triol (ZK 92836) and 6β,7β; 15β,16β-dimethylene-... | 08/23/2005 |
| 6924376 | Compounds, compositions and methods Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed. ... | 08/02/2005 |
| 6919464 | Synthetic derivatives of 21-butenyl and related spinosyns Macrolide compounds produced by synthetic modification of factors produced by NRRL 30141 have insecticidal and acaricidal activity and are useful intermediates for preparing additional insecticidal and acaricidal compounds ... | 07/19/2005 |
| 6916942 | Process for the preparation of C-4 carbonate taxanes A process for the preparation of novel C-4 carbonate taxanes useful as antitumor agents ... | 07/12/2005 |
| 6916941 | Crystalline composition containing escitalopram Crystalline particles of escitalopram oxalate with a particle size of at least 40 μm is disclosed. Method for the manufacture of said crystalline particles and pharmaceutical compositions comprising said crystalline particles are also disclosed. ... | 07/12/2005 |
| 6906209 | Purification of propylene oxide A process for purifying propylene oxide containing an unacceptable quantity of a poly (propylene oxide) polymer contaminant having a number average molecular weight of at least 50,000 and precursors having a number average molecular weight below 50,000. The process ... | 06/14/2005 |
| 6906208 | Mesoporous material and use thereof for the selective oxidation of organic compounds A material especially useful for the selective oxidation of hydrocarbons and other organic compounds includes a non-crystalline, porous inorganic oxide having at least 97 volume percent mesopores based on micropores and mesopores, and at least one catalytically acti... | 06/14/2005 |
| 6906205 | Spiro and dispiro 1,2,4-trioxolane antimalarials A means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side ... | 06/14/2005 |
| 6906088 | Taxanes having a C10 carbamoyloxy substituent Taxanes having a carbamoyloxy substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents. ... | 06/14/2005 |
| 6900326 | Method of producing N-alkoxycarbonylpiperidine derivative, new compound as raw material therefor, and method of producing the compound A method of producing an N-alkoxycarbonylpiperidine derivative, comprising reacting an N-aralkylpiperidine derivative represented by the following general formula (1): wherein R1 represents an aralkyl group ... | 05/31/2005 |
| 6900339 | Bryostatin composition and bryostatin acquisition methodologies Methods for obtaining bryostatins from the marine bryozoans of the Bugula neritina species complex are provided wherein the methods involve the extraction and purification of bryostatins from the larvae of Bugula neritina organisms. Further, the presen... | 05/31/2005 |
| 6900242 | Lactone formulations and method of use Compounds of Formula Ia and Ic having a lactone structure and an methylene group at the alpha-position of the lactone structure and methods for using and making the compounds have been disclosed. The lactone compounds can be reacted with an neucleaphilic agent to op... | 05/31/2005 |
| 6897324 | Process for the preparation of 11-oxaprostaglandins and intermediates therein For the preparation of an 11-oxaprostaglandin such as [2R,(1E,3R),3S,(4Z),4R)]-7-{tetrahydro-2-[4-(3-chlorophenoxy)-3-hydroxy-1-butenyl]-4-hydroxy-3-furanyl}-4-heptenoic acid and its ester derivatives, a novel process uses a novel enantiomerically enriched compound ... | 05/24/2005 |
| 6891050 | Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs A process for the preparation of taxanes including paclitaxel, docetaxel, and structurally similar analogs, as well as intermediates produced by the process. ... | 05/10/2005 |
| 6881850 | Heterocyclically annellated indenochromene derivatives The present invention relates to specific photochromic heterocyclically annellated indenochromene derivatives and the use thereof in plastics of all types, particularly for ophthalmic applications. In particular, the present invention relates to indeno[1,2-h]chromen... | 04/19/2005 |
| 6881846 | Antiproliferative agents This invention relates to certain dioxodihydropyridine derivatives and certain methacrylic acid and furan derivative precursors thereof, processes for their preparation, pharmaceutical compositions containing such compounds and their use as anti-proliferative agents... | 04/19/2005 |
| 6881853 | Method for producing propylene oxide A process for preparing propylene oxide comprises at least the following steps: (a) propene is reacted with a hydroperoxide in a solvent in the presence of a zeolite catalyst to give a mixture (M0), where the mixture (M0 | 04/19/2005 |
| 6881852 | Process of purification of paclitaxel and docetaxel A process for the purification of paclitaxel or docetaxel comprising: (a) mixing crude paclitaxel with a mixture of solvents such as alkane and chlorinated alkane, filtering the solid followed by drying to obtain paclitaxel or docetaxel of increased purity; (b) repe... | 04/19/2005 |
| 6878833 | Tetraalkylammonium alkoxides A process for preparing N-acyl, N-sulfonyl and N-phosphoryl substituted isoserine esters in which a metal or an ammonium alkoxide is reacted with a β-lactam. ... | 04/12/2005 |
| 6878832 | Isolation of taxanes An improved method for the isolation of taxanes of high purity from the crude extract of naturally occurring Taxus canadensis which comprises the steps of: a) filtering the crude extract by liquid column chromatography; b) enriching the taxanes obtained from step a)... | 04/12/2005 |
| 6878836 | Process for the epoxidation of propene A process for the continuous epoxidation of propene with hydrogen peroxide in the presence of a titanium silicalite catalyst and a methanol solvent, wherein the catalyst is periodically regenerated by washing with a methanol solvent at a temperature of at least 100... | 04/12/2005 |
| 6875888 | Method for the production of esters of unsaturated carboxylic acids In a process for preparing an ester of an unsaturated carboxylic acid by reacting an ester of the unsaturated carboxylic acid and a C1-C4-alkanol with an alcohol R3OH, where R3 is a C4-C20-alkyl radic... | 04/05/2005 |
| 6872837 | Taxanes having a c10 Heterosubstituted acetate substituent Taxanes having a heterosubstituted acetate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents. ... | 03/29/2005 |
