Did You Know...
...that to encourage use of his new invention, the shopping cart, market owner Sylvan Goldman hired fake shoppers to push the carts around his store in Oklahoma City? Seems his customers were reluctant to give up their hand-carried baskets.
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| Number | Title | Issue Date |
| 7462642 | Anti-cancer combinations The present invention relates to synergistic combinations of the compounds of formula I such as compounds of the xanthenone acetic acid class such as 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and NSAIDs, in particular diclofenac, which have anti-tumor activity. M... | 12/09/2008 |
| 7459474 | Modulators of the glucocorticoid receptor and method Novel non-steroidal compounds are provided which are glucocorticoid receptor modulators which are useful in treating diseases requiring glucocorticoid receptor agonist or antagonist therapy such as obesity, diabetes, inflammatory and immune disorders, and have the s... | 12/02/2008 |
| 7452910 | Indolyl-3-glyoxylic acid derivatives having therapeutically valuable properties The invention relates to the use of N-substituted indole-3-glyoxylamides of the general Formula I: and to pharmaceutical compositions having antitumor action. ... | 11/18/2008 |
| 7452548 | Conjugated linoleic acid compositions Novel compositions containing conjugated linoleic acids are efficacious as animal feed additives and human dietary supplements. Linoleic acid is converted to its conjugated forms in which the resulting composition is low in certain unusual isomers compared to conven... | 11/18/2008 |
| 7435755 | CDDO-compounds and combination therapies thereof CDDO-compounds in combination with other chemotherapeutic agents induce and potentiate cytotoxicity and apoptosis in cancer cell. One class of chemotherapeutic agents include retinoids. Cancer therapies based on these combination therapies are provided. Also provide... | 10/14/2008 |
| 7435745 | Methods and compositions for inhibition of angiogenesis The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, thalidomide and various related compounds such as thalidomide precursors, analogs, metabolites and hydrolysis products have been shown to inhibit angiogene... | 10/14/2008 |
| 7431959 | Method and system for irradiation of a drug eluting implantable medical device A method and system for modifying a drug eluting polymeric substrate for an implantable device, such as a stent, is disclosed. ... | 10/07/2008 |
| 7432300 | Gossypol co-crystals and the use thereof This invention relates to compositions comprising co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid which are useful as inhibitors of Bcl-2 family proteins. The invention also relates to the use of co-crystals of (... | 10/07/2008 |
| 7429378 | Transdiscal administration of high affinity anti-MMP inhibitors The present invention relates to injecting a high affinity antagonist of MMPs into a diseased intervertebral disc. ... | 09/30/2008 |
| 7425308 | Systems for the active electronic control of biological reactions A system useful in performing active biological reactions includes an array of unit cells arranged in rows and columns. Row lines are coupled to row contacts of unit cells of the array. A row selector is coupled to the row lines to provide a row select voltage. Colu... | 09/16/2008 |
| 7425559 | Medicine containing pyrimidine derivative A medicine for central diseases which contains as the active ingredient either a compound represented by the general formula (I): (I) (wherein R1 represents hydrogen or C1-6 alkyl; R2 represents C1-6 alkyl, etc.; A represe... | 09/16/2008 |
| 7425565 | Use of benzothiopenes to treat and prevent prostate cancer Disclosed herein is a method for treating and preventing prostate cancer, and particularly androgen-independent prostate cancer, the method including administering to a mammal a benzothiopene having the formula or pharmaceu... | 09/16/2008 |
| 7423063 | Calcium salts with cytotoxic activity Calcium salts, in particular calcium trifluoroacetate, are added to medicaments to provide cytotoxic and antitumoral activity. The medicaments can be administered to cancer patients as part of a method of treating a cancer patient. The medicaments can also be applie... | 09/09/2008 |
| 7416720 | Topical aqueous composition as nail hardener to decrease brittleness and increase strength The present invention is based upon the surprising discovery that the offering aqueous composition according to the invention is capable of being used as topical nail hardener. The present invention relates to a nail hardener that employs a composition of glycerin a... | 08/26/2008 |
| 7410955 | Therapeutic use of agonist ligands specific to G2A receptor The present invention relates to novel therapeutical use of agonist ligands specific to G2A receptor. More particularly, the present invention relates to methods for treating a disease or disorder associated with neutrophil accumulation and hyperactivity and/or exce... | 08/12/2008 |
| 7411005 | Compositions and methods for increasing milk production in animals The invention provides A composition for increasing milk production in an animal that includes an active compound chosen from calcium isopropyl cresol, calcium isopropyl-o-cresol, lactic acid, or combinations thereof, and calcium carbonate as a buffering agent. The ... | 08/12/2008 |
| 7405227 | Treatment of cancer Methods of treating ovarian cancer, endometrium cancer, cervical cancer, pancreatic cancer, bladder cancer, eve cancer, central nervous system cancer, thyroid cancer and lung cancer are disclosed. Specifically disclosed are methods of treating ovarian adenocarcinoma... | 07/29/2008 |
| 7405223 | Treating allergic and inflammatory conditions A method of treating and/or preventing allergic and inflammatory conditions of the skin or upper and lower airway passages, e.g. seasonal allergic rhinitis, perennial allergic rhinitis, or chronic idopathic urticaria, in a human more 12 years old, by administering a... | 07/29/2008 |
| 7402603 | Cyclooxygenase-2 inhibitor/histone deacetylase inhibitor combination The invention relates to a combination which comprises (a) a cyclooxygenase-2 inhibitor (“COX-2 inhibitor”) and (b) a histone deacetylase inhibitor (“HDAI”) for simultaneous, concurrent, separate or sequential use, especially for use in the treatment of pre-... | 07/22/2008 |
| 7399787 | Methods of treating cancer with HDAC inhibitors The present invention provides methods of treating cancers, chemoprevention, selectively inducing terminal differentiation, cell growth arrest and/or apoptosis of neoplastic cells, and/or inhibiting histone deacetylase (HDAC) by administration of pharmaceutical comp... | 07/15/2008 |
| 7393869 | Methods of using thiazolidine derivatives to treat cancer or inflammation Methods of using thiazolidine derivatives of formula (I) to treat cancer, inflammation, or other disorders related to the activities of protein phosphatases PTPN12 or PTPN2 in a mammal are disclosed. Pharmaceutical compositions containing such derivatives are disclo... | 07/01/2008 |
| 7393862 | Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias Methods of treating, preventing or managing leukemias are disclosed. The methods encompass the administration of an immunomodulatory compound of the invention known as Revlimid® or lenalidomide. The invention further relates to methods of treatment using this compo... | 07/01/2008 |
| 7390823 | Use of saredutant and of its pharmaceutically acceptable salts for the preparation of medicinal products that are useful in the treatment or prevention of all mood disorders, adaptation disorders or mixed anxiety-depression disorders The present invention relates to the use of saredutant and of its pharmaceutically acceptable salts for the preparation of medicinal products that are useful in the treatment or prevention of all mood disorders, adaptation disorders or mixed anxiety-depression disor... | 06/24/2008 |
| 7390833 | Method for treating ADAMTS-5-associated disease The present invention relates to methods of treating ADAMTS-5-associated diseases and particularly osteoarthritis comprising administering an agent capable of modulating ADMATS-5 activity to a subject afflicted with the disease. The agent is preferably a biaryl sulf... | 06/24/2008 |
| 7384956 | Anti-constipation composition An object of the present invention is to provide an anti-constipation composition containing a halogenated-bi-cyclic compound as an active ingredient in a ratio of bi-cyclic/mono-cyclic structure of at least 1:1. The halogenated-bi-cyclic compound is represented by ... | 06/10/2008 |
| 7381740 | Melatonin analogue prodrugs Disclosed are compounds that can serve as melatonin analogue prodrugs and that are soluble in aqueous solvents. Melatonin or melatonin analogues having modifications to the indole moiety are coupled to a tertiary amine to form a quaternary amine such that there is a... | 06/03/2008 |
| 7381546 | Polyketides and their synthesis and use The rapamycin gene cluster is an example of a gene cluster which includes a gene (rapL) leading to the formation of a precursor compound (pipecolic acid, in this case) which is required for inclusion in the larger product (rapamycin) produced by the enzymes encoded ... | 06/03/2008 |
| 7375137 | Methods of treating cancer with HDAC inhibitors The present invention provides methods of treating cancers, chemoprevention, selectively inducing terminal differentiation, cell growth arrest and/or apoptosis of neoplastic cells, and/or inhibiting histone deacetylase (HDAC) by administration of pharmaceutical comp... | 05/20/2008 |
| 7375124 | Use of α-phenylthiocarboxylic and α-phenyloxycarboxylic acids with serum-glucose-lowering and serum-lipid-lowering activity The use is described of derivatives of α-phenylthiocarboxylic and α-phenyloxycarboxylic acids with formula (i): in which the substituents have the meanings described in the text, for the preparation of a medicine for the prophylaxis and treatment of diabetes, part... | 05/20/2008 |
| 7371367 | Method of treating inflammatory acne vulgaris and rosacea with carbamide peroxide A method of treating inflammatory acne vulgaris or inflammatory acne rosacea comprises the topical application of a formulation incorporating carbamide peroxide in a pharmaceutically acceptable vehicle. Inflammatory acneform lesions that can be successfully treat wi... | 05/13/2008 |
| 7371744 | Biologically active methylene blue derivatives A phenothiazinium compound of Formula (I): wherein: A and B each independently is in which R′ and R″ each independently is a linear, branched or cyclic... | 05/13/2008 |
| 7371780 | Use of calphostin C to treat drug-resistant tumor cells Calphostin C is used to treat subjects for cancer which is resistant to treatment by other forms of chemotherapeutic drugs, for example breast or uterine cancer, or other cancers characterized by tumor cells that have a defect in an apoptotic regulatory pathway whic... | 05/13/2008 |
| 7365060 | Dinuclear copper-based compound and ligand for nucleic acid scission and anticancer treatment The present invention is related to a novel method for splitting nucleic acids at specific points on a complementary nucleic acid segment using a dinuclear copper-based compound of Formula I. Additionally, the present invention is related to a novel treatment of can... | 04/29/2008 |
| 7361683 | Paclitaxel aqueous injection solution and methods for preparing the same The present invention provides an injectable pharmaceutical composition containing, as an active ingredient, paclitaxel, an anti-cancer agent. The injectable pharmaceutical composition comprises an effective amount of paclitaxel, which is dissolved in polyoxyethylat... | 04/22/2008 |
| 7361687 | Arylsulphonamide derivatives and methods of preparing The present invention relates to novel arylsulphonamide compounds, defined by formula I and the description, as well as their method of preparation and their therapeutic use ... | 04/22/2008 |
| 7358222 | Preventing airway mucus production by administration of EGF-R antagonists Hypersecretion of mucus in the lungs is inhibited by the administration of an epidermal growth factor receptor (EGF-R) antagonist. The EGF-R antagonist may be in the form of a small organic molecule, an antibody, or portion of an antibody that binds to and blocks th... | 04/15/2008 |
| 7354954 | Use of GABA agonists for treatment of spastic disorders, convulsions, and epilepsy According to the subject invention, there is disclosed a method for treating a patient/subject having a spastic disorder, a convulsive disorder, pain or epilepsy which includes administering to the subject having any one of these conditions a therapeutically effecti... | 04/08/2008 |
| 7354948 | Methods for treatment of chronic uveitis using cyclopropyl-n-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindoline-4-yl}carboxamide Methods of treating, preventing and/or managing cancer as well as and diseases and disorders associated with, or characterized by, undesired angiogenesis are disclosed. Specific methods encompass the administration of a selective cytokine inhibitory drug alone or in... | 04/08/2008 |
| 7354955 | (2S)-amino(phenyl)acetic acid and derivatives as αδ voltage-gated calcium channel ligands The present invention relates to a method for treating pain, reflex sympathetic dystrophy, spasticity, and bipolar disorder using ligands of the α2δ voltage-gated calcium channel, wherein the ligand comprises (2s)-aminophenyl acetic acid and derivatives... | 04/08/2008 |
| 7351723 | Freeze-dried pantoprazole preparation and pantoprazole injection Lyophilized pantoprazole preparations which are obtainable by freeze-drying of an aqueous solution of pantoprazole, ethylenediamine tetraacetic acid and/or a suitable salt thereof, and sodium hydroxide and/or sodium carbonate are disclosed. The preparations have adv... | 04/01/2008 |
