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| Number | Title | Issue Date |
| 5849478 | Blocked-polymerase polynucleotide immunoassay method and kit An immunoassay method for detecting an analyte in a liquid sample is disclosed. The method includes first contacting the sample with a polynucleotide assay reagent composed of a analyte and an attached polynucleotide containing an initiation region adjace... | 12/15/1998 |
| 5834607 | Amines and methods of making and using the same Novel amine compounds are provided by the present invention. Methods of preparing and using said novel amine compounds are also provided.... | 11/10/1998 |
| 5709998 | Molecular diagnosis of familial adenomatous polyposis A two-pronged method for diagnosis of genetic diseases can detect mutations in about 87% of familial adenomatous polyposis (FAP) patients. One part of the diagnostic method employs in vitro protein synthesis from surrogate genes created by amplifying eith... | 01/20/1998 |
| 5656731 | Nucleic acid-amplified immunoassay probes In one aspect of this invention, various protein/nucleic acid hybrid probes are described which can be used to amplify the detectable signal in immunoassays. The protein moiety is capable of functioning either as an antibody or an antigen. The nucleic aci... | 08/12/1997 |
| 5654419 | Fluorescent labels and their use in separations Compositions are provided comprising sets of fluorescent labels carrying pairs of donor and acceptor dye molecules, designed for efficient excitation of the donors at a single wavelength and emission from the acceptor in each of the pairs at different wav... | 08/05/1997 |
| 5652096 | Identification of allele specific nucleic acid sequences by hybridization with crosslinkable oligonucleotide probes Hybridization method for discriminating between complementarity and partial complementarity of DNA base sequences. Kinetic covalent entrapment of PCR-amplified target DNA is achieved through the use of crosslinkable probes. A crosslinking site is introduc... | 07/29/1997 |
| 5650268 | Polymerase chain reaction assays for monitoring antiviral therapy and making therapeutic decisions in the treatment of acquired immunodeficiency syndrome The present invention relates to methods of monitoring, via polymerase chain reaction, the clinical progression of human immunodeficiency virus infection and its response to antiretroviral therapy. According to the invention, polymerase chain reaction ass... | 07/22/1997 |
| 5643761 | Method for generating a subtracted cDNA library and uses of the generated library This invention provides a method of generating a subtracted cDNA library of a cell comprising: a) generating a cDNA library of the cell; b) isolating double-stranded DNAs from the cDNA library; c) releasing the double-stranded cDNA inserts from the double... | 07/01/1997 |
| 5633131 | Rapid detection of isoniazid resistance in mycobacterium tuberculosis probes for selecting nucleic acid encoding isoniazid resistance, and methods and kits Multi-drug resistant strains of Mycobacterium tuberculosis represent a considerable threat to public health worldwide. Resistance to isoniazid (INH), a key component of anti-tuberculosis regimens, is often associated with loss of catalase activity and vir... | 05/27/1997 |
| 5605795 | Assays using chemiluminescent, enzymatically cleavable substituted 1,2-dioxetanes and kits therefor Dioxetane compounds reactable with an enzyme to release optically detectable eneregy are disclosed. These compounds have the formula: ##STR1## wherein T is a cycloalkyl group or a fused polycyclo-alkylidene group bonded to the dioxetane ring through ... | 02/25/1997 |
| 5597692 | Hybridization histochemistry method for determining the presence and location in animal or plant tissue of RNA A method for determining the presence and location in animal or plant tissue of a specific polynucleotide population comprising: (a) preparing a section of the tissue to be examined; (b) contacting the tissue section under hybridization conditions with a ... | 01/28/1997 |
| 5595874 | Nucleic acid probes for detection and/or quantitation of non-viral organisms A method for preparing probes, as well as several probes for use in qualitative or quantitative hybridization assays are disclosed. The method comprises constructing an oligonucleotide that is sufficiently complementary to hybridize to a region of rRNA se... | 01/21/1997 |
| 5596089 | Oligonucleotide probe and primers specific to bovine or porcine male genomic DNA The present invention relates to novel bovine (SEQ ID NO:1) and porcine (SEQ ID NO:2) genomic sequences for the SRY gene along with oligonucleotide primers. The present invention also relates to a method of sexing bovine or porcine tissue by descriminatin... | 01/21/1997 |
| 5595869 | Diagnostic methods for detecting lymphomas in humans The sequence of the protein coding regions of the bcl-2 gene are provided as well as bacterial clones which produce the proteins. Assays are provided for detecting a class of B-cell neoplasms associated with a chromosome translocation between chromosomes ... | 01/21/1997 |
| 5593841 | Nucleic acid probes for detection and/or quantitation of non-viral organisms A method for preparing probes, as well as several probes for use in qualitative or quantitative hybridization assays are disclosed. The method comprises constructing an oligonucleotide that is sufficiently complementary to hybridize to a region of rRNA se... | 01/14/1997 |
| 5591582 | Methods for detecting activated RAS oncogenes Molecules complementary to nucleotide sequences encoding mutant ras proteins which contain a single-base mutation in the codon encoding amino acids at position 13, 12 or 61 have been produced. These molecules are useful in methods of detecting specific si... | 01/07/1997 |
| 5589329 | Methods and compositions for detecting base pair mismatches The present invention discloses improved compositions and methods for detecting mutations, including single base changes, in nucleic acid sequences using RNase protection assays. The improvements include concomitant, dramatic reductions in the salt and RN... | 12/31/1996 |
| 5589342 | Kit for separating double-stranded nucleic acid from a single-stranded/double-stranded mixture of nucleic acids A method and a kit for separating double-stranded nucleic acid molecules from a mixture containing both single-stranded and double-stranded nucleic acid molecules. The method is particularly suitable for separating hybridized from unhybridized probe nucle... | 12/31/1996 |
| 5582989 | Multiplex genomic DNA amplification for deletion detection The present invention relates to a method for detecting multiple DNA sequences simultaneously. The method involves amplification of multiple sequences simultaneously by annealing a plurality of paired oligonucleotide primers to single stranded DNA. One me... | 12/10/1996 |
| 5580738 | Delta-like gene expressed in neuroendocrine tumors A polynucleotide molecule dlk is expressed in neuroendocrine tumors, including small cell lung carcinoma. A Dlk polypeptide encoded by dlk polynucleotide molecule can be used in detecting the existence of a primary or secondary neuroendocrine tumor. Monoc... | 12/03/1996 |
| 5571670 | Nucleic acid probes useful in detecting Chlamydia trachomatis and amplified nucleic acid hybridization assays using same Linear or branched oligonucleotide multimers useful as amplifiers in biochemical assays which comprise (1) at least one first single-stranded oligonucleotide unit that is complementary to a single-stranded oligonucleotide sequence of interest, and (2) a m... | 11/05/1996 |
| 5563033 | Detection of individual gene transcription In situ hybridization methods for assessing, determining or observing the RNA produced by transcriptionally active genes. In one embodiment, the methods allow simultaneous observation of the gene and its transcripts in a spatially correlated manner. As th... | 10/08/1996 |
| 5561071 | DNA and DNA technology for the construction of networks to be used in chip construction and chip production (DNA-chips) The invention relates to construction of specific molecular microcircuits by the use of double and single stranded nucleic acids and specific DNA-binding proteins.... | 10/01/1996 |
| 5556756 | Gold sol of less than 5 nm test method and reagent kit therefor A method for the qualitative or quantitative determination of an analyte in a test sample wherein a labelled reagent is caused to be immobilized in bound form on a solid phase to provide an indication of the presence or quantity of the analyte in the same... | 09/17/1996 |
| 5556958 | Inactivation of pathogens in clinical samples The present invention contemplates methods of decontaminating human fluids prior to processing in the clinical laboratory. The techniques handle large volumes of human serum without impairing the testing results. Novel compounds for photodecontaminating b... | 09/17/1996 |
| 5556748 | Methods of sandwich hybridization for the quantitative analysis of oligonucleotides The invention is directed to a sandwich hybridization assay wherein a nucleic acid capture probe is firstly immobilized on an assay plate via masked receptors on the plate. The capture probe is immobilized by the binding of receptor ligands on the capture... | 09/17/1996 |
| 5556750 | Methods and kits for fractionating a population of DNA molecules based on the presence or absence of a base-pair mismatch utilizing mismatch repair systems A diagnostic method for detecting a base pair mismatch in a DNA duplex, comprising the steps of contacting at least one strand of a first DNA molecule with the complementary strand of a second DNA molecule under conditions such that base pairing occurs co... | 09/17/1996 |
| 5554339 | Process for the manufacture of wholly microfabricated biosensors An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional feat... | 09/10/1996 |
| 5552541 | Haptenic probes for detecting capture polynucleotides Nucleic acid probes and protein probes are disclosed. The nucleic acid probe comprises a probe polynucleotide, a charged hapten label, and a binding moiety. The protein probe comprises a probe protein, a charged hapten label and a binding moiety. The char... | 09/03/1996 |
| 5550036 | Method for co-amplification of human protein C genes in human cells The present invention is a method of using the BK enhancer in tandem with a eukaryotic promoter to promote transcription of DNA that encodes a useful substance. The method of the present invention requires the presence of the E1A gene product for maximum ... | 08/27/1996 |
| 5550018 | Test for virulent genomic nucleotide 472 revertants in attenuated live poliovirus type 3 vaccines The present invention comprises the method of evaluation of the safety of live attenuated vaccines based on detection and measurement of the incidence of genetic changes associated with reversion to virulence in vaccine microorganisms. The method based on... | 08/27/1996 |
| 5547836 | Enhancement of chemiluminescent assays Chemiluminescent bioassays for the presence or concentration of an analyte in a sample use 1,2-dioxetanes as substrates for the enzyme of an enzyme complex that bind to the analyte. The chemiluminescence obtained from the decomposition of the dioxetane tr... | 08/20/1996 |
| 5545524 | Compositions and methods for chromosome region-specific probes The present invention provides a rapid reproducible method for generating chromosome region-specific probes for diagnostic and research applications. The method of the present invention comprises microdissecting a chromosome of interest to produce a DNA f... | 08/13/1996 |
| 5543302 | Proteases of altered stability to autolytic degradation Proteases are susceptible to autolytic degradation. The method of the invention provides a method to identify susceptible autolysis sites which are cleaved to produce a few discrete fragments. Once identified, amino acid(s) at or in the vicinity of the cl... | 08/06/1996 |
| 5543295 | Chemiluminescent 3--(Substituted adamant--2'--Ylidene) 1,2--Dioxetanes Enzymatically clearable chemiluminescent 1,2-dioxetane compounds capable of producing light energy when decomposed, substantially stable at room temperature before a bond by which an enzymatically clearable labile substituent thereof is intentionally clea... | 08/06/1996 |
| 5543305 | Methods of extracting deoxyribonucleic acids without using a proteolytic enzyme This invention provides a rapid and highly effective method for extracting nucleic acids from cells or virions without the use of proteolytic enzymes. Extraction is accomplished within a few minutes using a lysing composition comprising a buffer, a source... | 08/06/1996 |
| 5541308 | Nucleic acid probes for detection and/or quantitation of non-viral organisms A method for preparing probes, as well as several probes for use in qualitative or quantitative hybridization assays are disclosed. The method comprises constructing an oligonucleotide that is sufficiently complementary to hybridize to a region of rRNA se... | 07/30/1996 |
| 5532146 | Method for rendering ligase-based amplification products unamplifiable Methods for sterilization of ligase-based amplification products, including products of the Ligation Amplification Reaction (LAR), involving treatment of nucleic acid after amplification to render such nucleic acid incapable of serving as a template for f... | 07/02/1996 |
| 5532145 | Methods for treatment of enzyme preparations Method useful for solving the problem of contamination of protein with nucleic acid. Rendering amplifiable contaminating nucleic acid in enzyme preparations substantially unamplifiable prior to use of the enzyme.... | 07/02/1996 |
| 5527676 | Detection of loss of the wild-type P53 gene and kits therefor Methods and kits are provided for assessing mutations and/or loss of the p53 gene in human tumors. Both deletion mutations and point mutations in p53 are observed in the same human tumor cells and these mutations are clonal within the cells of the tumor. ... | 06/18/1996 |
