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| Number | Title | Issue Date |
| 8187586 | Methods of inducing apoptosis in hyperproliferative cells Methods of inducing apoptosis in hyperproliferative cells, particularly cancer cells are provided. Such method involves increasing the levels of a potassium channel modulatory protein in the cell. Examples of such proteins are native KChAP protein, a biologically ac... | 05/29/2012 |
| 8173427 | Method of producing a population of post-mitotic cells of the neutrophil lineage A method is provided for producing a population of post-mitotic cells of the neutrophil lineage, which method comprises the ex vivo steps of: (a) providing a population of cells comprising neutrophil progenitor cells; and (b) culturing the population of cells in an ... | 05/08/2012 |
| 8158416 | CDNA corresponding to the antigenome of nonsegmented negative strand RNA viruses, and process for the production of such viruses encoding additional antigenically active proteins The present invention relates, in general, to a methodology for the generation of nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued viruses are suitable for use as vaccines, or alternatively, as plasmids ... | 04/17/2012 |
| 8158119 | Cardiac targeted delivery of cells A method of delivering cardiac stem cell and treating damaged cardiac tissue is provided. The method involves isolation of subject's cardiac circulation from the subject's systemic circulation and perfusing a solution comprising stem cells into the cardiac circuit. | 04/17/2012 |
| 8153428 | Use of TGF beta superfamily antagonists and neurotrophins to make neurons from embryonic stem cells This invention provides a system for efficiently producing differentiated cells from pluripotent cells, such as human embryonic stem cells. Rather than permitting the cells to form embryoid bodies according to established techniques, differentiation is effected dire... | 04/10/2012 |
| 8148148 | Neural progenitor cell populations This invention provides populations of neural progenitor cells, differentiated neurons, glial cells, and astrocytes. The populations are obtained by culturing stem cell populations (such as embryonic stem cells) in a cocktail of growth conditions that initiates diff... | 04/03/2012 |
| 8124829 | Transgenic mice over-expressing receptor for advanced glycation endproduct (RAGE) in brain and uses thereof The present invention provides for a transgenic non-human animal whose cells contain a DNA sequence comprising: (a) a nerve tissue specific promoter; and (b) a DNA sequence which encodes a receptor for advanced glycation endproducts (RAGE), wherein the promoter and ... | 02/28/2012 |
| 8026346 | Tribonectins The invention features a tribonectin and a method of tribosupplementation carried out by administering tribonectins directly to an injured or arthritic joint. ... | 09/27/2011 |
| 8022268 | Transgenic animal model for alzheimer's disease Provided is a novel APP (amyloid precursor protein) transgenic non-human animal modeling in vivo the pathophysiological effects and effects on cognitive behavior of early intraneuronal and extracellular brain parenchymal amyloid-β (Aβ) deposition and cerebral amyl... | 09/20/2011 |
| 8012456 | Biological models capable of exhibiting secondary disease manifestations and useful for developing therapeutic drugs, diagnostic products and therapeutic or diagnostic procedures, methods of using same, and cells, tissues and organs derived therefrom This invention provides novel animal models for a human pathogen that is capable of exhibiting analogous secondary disease manifestation. Other animal models for a human pathogen are provided by this invention which are capable of exhibiting analogous secondary dise... | 09/06/2011 |
| 8008071 | Compositions and methods for detecting intracellular glucose and analogs thereof The subject invention pertains to nucleic acid constructs for post-transcriptional control of expression of a polynucleotide encoding a protein in a cell, wherein the constructs include a metabolite responsive instability element such as the glucose-regulated mRNA i... | 08/30/2011 |
| 8003315 | TAOJIKs as modifiers of the beta-catenin pathway and methods of use Human TAOJIK genes are identified as modulators of the beta-catenin pathway, and thus are therapeutic targets for disorders associated with defective beta-catenin function. Methods for identifying modulators of beta-catenin, comprising screening for agents that modu... | 08/23/2011 |
| 7993924 | cDNA corresponding to the antigenome of nonsegmented negative stranded RNA viruses and process for the production of such viruses The present invention relates, in general, to a methodology for the generation of nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued viruses are suitable for use as vaccines, or alternatively, as plasmids ... | 08/09/2011 |
| 7968337 | Neural precursor cells, method for the production and use thereof in neural defect therapy The invention relates to isolated and purified neural precursor cells, to methods for the generation of such precursor cells in unlimited quantities from embryonic stem cells, and to their use for the therapy of neural defects, particularly in mammals, preferably in... | 06/28/2011 |
| 7955595 | Glutamic acid decarboxylase (GAD) based delivery system The invention provide methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain that is overstimulated in neurodegenerative diseases. In particular, the invention provides methods and compositions us... | 06/07/2011 |
| 7935333 | Method and compositions for modifying target receptor function associated with neurological disorders A method of treating or preventing development of a neurological disorder has been developed wherein a subject with the disorder, or at risk of developing a disorder, is vaccinated against a brain protein or antigen. Alternatively, the antibodies can be directly adm... | 05/03/2011 |
| 7935531 | Methods for the early diagnosis of ovarian cancer The disclosed nucleic acid primer sets, used in combination with quantitative amplification (PCR) of tissue cDNA, can indicate the presence of specific proteases in a tissue sample. Specifically, the present invention relates to expression of hepsin protease. The de... | 05/03/2011 |
| 7932053 | Method for preparing modified collagen outside a host cell The present invention relates to a method for preparing a modified folded protein, comprising modifying unfolded a-chains comprising a collagenous amino acid sequence and thereafter folding at least part of the modified a-chains into a quaternary protein structure, ... | 04/26/2011 |
| 7928284 | Methods and animal model for analyzing age-related macular degeneration Methods for testing candidate drugs for treatment of age-related macular degeneration are provided. Ccl2-deficient, and Ccr2-deficient mice are used to determine the effect of candidate drugs and treatments on development of age-related macular degeneration. Also pr... | 04/19/2011 |
| 7919317 | Methods of differentiating and protecting cells by modulating the P38/MEF2 pathway The present invention provides a method of differentiating progenitor cells to produce a population containing protected neuronal cells. A method of the invention includes the steps of contacting the progenitor cells with a differentiating agent; and introducing int... | 04/05/2011 |
| 7919670 | Transgenic mice over-expressing receptor for advanced glycation endproduct (RAGE) in brain and uses thereof The present invention provides for a transgenic non-human animal whose cells contain a DNA sequence comprising: (a) a nerve tissue specific promoter; and (b) a DNA sequence which encodes a receptor for advanced glycation endproducts (RAGE), wherein the promoter and ... | 04/05/2011 |
| 7851214 | Infectious recombinant paramyxovirus from antigenomic cDNA The present invention relates, in general, to a methodology or the generation of nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued viruses are suitable for use as vaccines, or alternatively, as plasmids i... | 12/14/2010 |
| 7838291 | Entrapped stem cells and uses thereof The invention relates to the stem cells, embryonic stem cells in particular. It has been found that, when these stem cells are entrapped such that their proliferation is inhibited, they produce material which inhibits the proliferation of other, non-entrapped cells,... | 11/23/2010 |
| 7829330 | Stresscopins and their uses The invention provides novel nucleic acids and polypeptides, referred to herein as stresscopin 1 and stresscopin 2, which preferentially activate the CRH-R2 receptor over the R1 receptor. Stresscopins, analogs and mimetics, and related CRH-R2 agonists suppress food ... | 11/09/2010 |
| 7829335 | Method of differentiation induction to osteoblasts The invention offers a technique that selectively differentiation-induces mesenchymal stem cells, which can differentiate to cells that constitute various tissues and organs, to osteoblasts. In addition, the invention offers a technique that differentiation-induces ... | 11/09/2010 |
| 7829757 | SGRF gene-modified mouse A targeting vector was constructed by replacing exon regions in the SGRF gene with appropriate drug marker genes. This vector was transfected into mouse ES cell lines to obtain chimeric mice, which were then crossed with C57BL/6J mice to obtain mice comprising cells... | 11/09/2010 |
| 7825097 | Nucleotide vector vaccine for immunization against hepatitis Nucleotide vector comprising at least one gene or one complementary DNA coding for at least a portion of a virus, and a promoter providing for the expression of such gene in muscle cells. The gene may be the S gene of the hepatitis B virus. A vaccine preparat... | 11/02/2010 |
| 7820634 | Composition and method for production of transformed cells A composition useful for the production of transformed eukaryotic cells is described. The composition comprises submucosal tissue and a nucleic acid sequence. The nucleic acid sequence is typically recombinant DNA including gene(s) encoding for one or more biofuncti... | 10/26/2010 |
| 7820876 | Mouse mutant for expression of the alpha6 subunit of the nicotinic acetylcholine receptor The invention concerns a non-human mammal carrying a mutation in the gene coding for the alpha6 subunit of the nicotinic acetylcholine receptor (nAChR), said mutation preventing expression of said nAChR alpha6 subunit in a functional form in the mammal. The i... | 10/26/2010 |
| 7816497 | Compositions and methods for inhibiting drusen complement components C3a and C5a for the treatment of age-related macular degeneration Activated C3 (C3a) and its receptor (C3aR) and activated C5 (C5a) and its receptor (C5aR) have been shown to induce vascular endothelial growth factor (VEGF) expression in vitro and in vivo. Compositions and methods for inhibiting C3a, C3aR, C5a and C5aR for the tre... | 10/19/2010 |
| 7811557 | Methods for improving central nervous system functioning Methods of causing an improvement in central nervous system function are provided. The methods include administering an aliquot of stem cells to the patient, the cells being derived from blood, e.g., umbilical cord blood. In some cases a growth factor is administere... | 10/12/2010 |
| 7807618 | Methods and compositions for delivering enzymes and nucleic acid molecules to brain, bone and other tissues Disclosed are methods for delivering an enzyme to a subject's brain or bone. The methods include administering a hyaluronidase to the subject and administering the enzyme to the subject. The hyaluronidase and the enzyme are administered to the subject under conditio... | 10/05/2010 |
| 7795493 | Porcine animals lacking any expression of functional alpha 1, 3 galactosyltransferase The present invention is a porcine animal, tissue, organ, cells and cell lines, which lack any expression of functional alpha 1,3 galactosyltransferase (alpha1,3GT). These animals, tissues, organs and cells can be used in xenotransplantation and for other medical pu... | 09/14/2010 |
| 7786283 | BRI constructs and methods of using The invention provides constructs that feature a nucleic acid molecule encoding an amino terminal region of a BRI polypeptide. A construct of the invention can further include a multiple cloning site joined to the 3′ end of the BRI nucleic acid molecule or a nucle... | 08/31/2010 |
| 7785831 | Compositions and methods for non-targeted activation of endogenous genes The present invention is directed generally to activating gene expression or causing over-expression of a gene by recombination methods in situ. The invention also is directed generally to methods for expressing an endogenous gene in a cell at levels higher than tho... | 08/31/2010 |
| 7785882 | Neuronal progenitor cells from hippocampal tissue and a method for isolating and purifying them The present invention relates to an enriched or purified preparation of isolated hippocampal neural progenitor cells and progeny thereof. The present invention also relates to a method of separating neural progenitor cells from a mixed population of cell types from ... | 08/31/2010 |
| 7781208 | Methods and means for targeted gene delivery A method for producing viral gene delivery vehicles which can be transferred to pre-selected cell types by using targeting conjugates. The gene delivery vehicles comprise: 1) the gene of interest; and 2) a viral capsid or envelope carrying a member of a specific bin... | 08/24/2010 |
| 7780962 | Treatment of neoplasms with RNA viruses The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are us... | 08/24/2010 |
| 7776320 | Methods for therapeutic use of brain derived neurotrophic factor in the entorhinal cortex A protocol for use of growth factors to stimulate neuronal cell growth and activity in trkB receptor containing cortical tissues, including the entorhinal and hippocampal cortices. The method introduces exogenous growth factor, such as BDNF, NT-4/5 and NT-3, into th... | 08/17/2010 |
| 7772459 | Transgenic production in saliva The invention relates to the production of proteins and other substances of interest in saliva of transgenic animals, particularly in mammals that produce large quantities of saliva, particularly monogastric ruminants, and ovine, caprine and bovine mammals. Preferre... | 08/10/2010 |
