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Pet Toilet-Like Water Disk and Food Storage
One pet-friendly inventor patented "a device for watering pets, e.g., a dog or cat." The device, he helpfully noted, "has the general shape of a toilet."
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| Number | Title | Issue Date |
| 8173859 | Epilepsy model animal An epilepsy model animal (CHRNA4:S284L) developing spontaneous epileptic seizure during sleep, which is a nonhuman animal established by ontogenesis of a totipotent cell into which a polynucleotide encoding nonhuman mutant CHRNA4 is introduced and having said polynu... | 05/08/2012 |
| 8119854 | Role of proteoglycans in drug dependence The invention provides methods of preventing or treating drug addiction, or ameliorating the craving for an addictive drug, as well as compounds, peptides, and pharmaceutical compositions that may be used to prevent or treat drug addiction or ameliorate the craving ... | 02/21/2012 |
| 7973211 | Animal model for hyperpigmentation An animal model for hyperpigmentations in which the formation of hyperpigmentations in human skin is faithfully simulated is provided. An animal model for hyperpigmentations, wherein a black person's skin is grafted onto a non-human animal, is provided. ... | 07/05/2011 |
| 7960606 | Mouse model of chronic heart failure and coronary atherosclerosis regression An animal model has been developed where the animals can survive myocardial infarctions caused by diet-induced coronary atherosclerosis, and live with chronic heart failure. This animal model is a result of reduced activity of scavenger receptor class BI (SR-BI) and... | 06/14/2011 |
| 7902421 | Animal model for schizophrenia The invention is an animal model which exhibits neuropathological and behavioral features associated with human schizophrenia. The invention also encompasses an in vivo method of preparing an animal model of human schizophrenia. Such a model is useful for screening ... | 03/08/2011 |
| 7863499 | Model of infantile spasm syndrome Provided are non-human mammals treated with doxorubicin, lipopolysaccharide (LPS), and p-chlorophenylalanine (PCPA), where the mammal exhibits a symptom characteristic of infantile spasms. Also provided are methods of making a non-human mammal exhibit a symptom of i... | 01/04/2011 |
| 7847147 | Mouse developing visceral fat type obesity and diabetes An object of the present invention is to provide a mouse which has the characteristics of early developing visceral fat type obesity and also has concurrent diabetes and hyperlipemia and in which the trait is genetically established and recessively inherited. An ICR... | 12/07/2010 |
| 7667088 | Autoimmune disease model animal Pemphigus vulgaris (PV) is an autoimmune disease with a possible fatality of the skin and mucosae which is induced by an antibody against desmoglein 3 (Dsg3). Persistent production of anti-Dsg3 IgG can be induced by adoptively transferring spleen cells of a DSG3−/... | 02/23/2010 |
| 7638678 | Animal model for perimenopause and menopause and methods of inducing ovarian failure The present invention relates to an animal model for human perimenopause and menopause. Also provided by the present invention are methods of making the animal model and methods of screening using the model. Also provided are methods of inducing ovarian failure in a... | 12/29/2009 |
| 7560609 | Diabetic model The invention relates to an animal model for diabetes and a method for obtaining said animal model. The invention also relates to the uses of the animal model for screening for or testing compounds for treating or preventing diabetes symptoms. The invention further ... | 07/14/2009 |
| 7521589 | Developmental animal model of temporal lobe epilepsy Disclosed is a developmental animal model of temporal lobe epilepsy and other seizure-related disorders. In particular, the invention provides a method of inducing a permanent change in the neurological development of a rodent, such as a rat, comprising daily admini... | 04/21/2009 |
| 7514592 | Inducible heart attack animal model An animal model of coronary heart disease has been developed where myocardial infarct can be induced by altering the animal's diet. In all embodiments, this animal model is a result of reduced activity of scavenger receptor class BI (SR-BI) and apolipoprotein E (Apo... | 04/07/2009 |
| 7507871 | Rat model of diabetic nephropathy A rat model of diabetic nephropathy is disclosed. In another embodiment of the invention, a method of evaluating a test compound's effect of diabetic nephropathy is disclosed. In one embodiment, this method comprises the steps of (a) exposing the test compound to th... | 03/24/2009 |
| 7439415 | Population of Hoxb8 mutants and uses in identifying agents for treating repetitive behaviors This invention provides in vivo and in vitro methods of screening for an agent or a combination of agents that reduces one or more repetitive behaviors, comprising contacting neuronal cells of an animal with a HOXB8 gene mutation with the agent combination of agents... | 10/21/2008 |
| 7420100 | Methods and compositions relating to HDAC 4 and 5 regulation of cardiac gene expression The present invention relates to cardiac hypertrophy. More particularly, the present invention defines the molecular events linking calcium stimulation to cardiac hypertrophy. More specifically, the present invention shows that Ca2+ stimulation of the hyp... | 09/02/2008 |
| 7417175 | Interstitial prostatism model animal The present invention provides an animal model for prostatic stromal hyperplasia, and a method for screening for a substance effective for preventing/treating human benign prostatic hyperplasia using the animal model. The animal model for prostatic stromal hyperplas... | 08/26/2008 |
| 7414169 | Therapeutic and diagnostic tools for impaired glucose tolerance conditions Disclosed herein are novel genes and methods for the screening of therapeutics useful for treating impaired glucose tolerance conditions, as well as diagnostics and therapeutic compositions for identifying or treating such conditions. ... | 08/19/2008 |
| 7402728 | Transgenic mice expressing human CD20 and/or CD16 The present invention generally relates to non-human transgenic animals expressing human cellular markers, including CD20 and/or preferably CD16. ... | 07/22/2008 |
| 7402727 | Non-human animal exhibiting bone metastasis of tumor cells The present invention provides a non-human bone metastasis model animal in which tumor cells capable of inducing bone metastasis by peripheral administration have been introduced, and a method for producing the animal. The bone metastasis model animal in the ... | 07/22/2008 |
| 7399900 | Nematodes as model organisms for the investigation of neurodegenerative diseases, in particular parkinsons disease, uses and methods for the discovery of substances and genes which can used in the treatment of the above disease states and identification of anematode gene The invention relates to nematodes as model organisms for the investigation of neurodegenerative diseases in particular. Parkinsons disease, uses and methods for the discovery of substances and genes which can be used in the treatment of the above disease states and... | 07/15/2008 |
| 7388124 | Non-traumatic model for neurogenic pain A method for producing a non-human mammalian model for neurogenic pain is provided, which includes altering a peripheral nerve of a non-human mammal by non-surgically placing a gel substance into the fascial tunnel through which the peripheral nerve passes. The plac... | 06/17/2008 |
| 7355093 | Model animal with overexpression of regucalcin The present invention provides an animal model which overexpresses regucalcin, a calcium-binding protein that is inherently expressed in the liver and the like of the higher animal, and which is characterized by a showing of bone pathology typified by osteoporosis. ... | 04/08/2008 |
| 7342146 | Neurodegenerative non-human transgenic mammal expressing TrkA fusion protein The present invention provides a neurodegenerative, non-human transgenic mammal whose cells contain a TrkA-hFc transgene for encoding at least a TrkA fusion protein and the use thereof. ... | 03/11/2008 |
| 7339026 | mda-9 protein This invention provides a method for producing a temporally spaced subtracted cDNA library comprising: a) isolating temporally spaced RNAs from cells; b) generating cDNA inserts from the RNAs isolated from step (a); c) producing a temporally spaced cDNA library havi... | 03/04/2008 |
| 7332646 | Transgenic animal model for degenerative diseases of cartilage The present invention provides animal model systems for cartilage-degenerative disease, which comprise transgenic animals which can express recombinant matrix-degrading enzymes (MDEs), particularly matrix metalloproteinases (MMPs), in a temporally and spatially regu... | 02/19/2008 |
| 7332645 | IL-21 as a regulator of immunoglobin production A transgenic mouse is disclosed herein whose somatic and germ cells comprise a disrupted IL-21 receptor gene, the disruption being sufficient to inhibit the binding of IL-21 to an IL-21 receptor, and a disrupted IL-4 gene, the disruption being sufficient to inhibit ... | 02/19/2008 |
| 7332644 | Non-human animal model of oligodendrocyte developmental disorder The objects of the present invention is to provide a preventive method for the progress of neuropsychiatric disorders, a therapeutic agent for neuropsychiatric disorders, a screening method thereof, and a therapeutic method through the analysis of the mechanisms lea... | 02/19/2008 |
| 7323616 | Genetically altered mice deficient in functional caspase-9 The invention relates to genetically manipulated animals that are deficient in the expression of Caspase-9, a protein involved in programmed cell death. The invention further relates to methods for preventing specific types of cell death associated with Caspase-9 ac... | 01/29/2008 |
| 7309810 | Nonhuman model animal suffering from Guillain-Barré syndrome and/or fisher syndrome The present invention intends to provide a non-human animal model of Guillain-Barré syndrome, which can be obtained by immunizing FcγRIIB-gene-deficient non-human animal with ganglioside GQ1b, and a screening method of a therapeutic agent for Guillain-BarrÃ... | 12/18/2007 |
| 7309812 | Perlecan transgenic animals and methods of identifying compounds for the treatment of amyloidoses The invention provides a transgenic non-human animal expressing a perlecan encoding transgene. Also provided is a double-transgenic non-human animal expressing a perlecan and an amyloid encoding transgene. A method of screening for a compound which alters the rate o... | 12/18/2007 |
| 7276644 | Transgenic mouse comprising a myosin heavy chain atpase loop 1 mutation The invention provides a transgenic mouse that is a model for myocardial function. Also provided are methods for using the transgenic mouse model to study heart muscle, cardiac disease and identify compounds effective in treating or preventing cardiac disease. ... | 10/02/2007 |
| 7273963 | Malarial animal model having a chimeric human liver The present invention features a non-human animal model of malaria, e.g., Plasmodium, particularly Plasmodium falciparum. The model is based on a non-human, immunocompromised transgenic animal having a human-mouse chimeric liver, where the transgene pr... | 09/25/2007 |
| 7273964 | Non-human transgenic animals for the study of neurodegenerative syndromes A non-human transgenic animal that is transgenic for an antibody or fragments thereof and having a phenotype reminiscent of human pathology. The human pathology includes neurodegenerative syndromes, muscular atrophy/dystrophy and immune disorders. The animals may be... | 09/25/2007 |
| 7265259 | GSK-3β expressed in a transgenic mouse A transgenic animal in which GSK-3β protein is over-expressed is useful as a model for neurodegenerative disease. ... | 09/04/2007 |
| 7259289 | MCH1R deficient mice The present invention features viable MCH1R deficient mice. MCH1R deficient mice contain an alteration in one or both MCH1R alleles that substantially reduces expression of a functional MCH1R from the altered allele. Preferably, MCH1R deficient mice are MCH1R −/âˆ... | 08/21/2007 |
| 7253333 | Drosophila strain carrying bradeion gene(s) transferred thereinto Provided is a special Drosophila strain having a Bradeion gene artificially incorporated therein to exclusively express the gene in the compound eyes and thus to exhibit rough eye. The Drosophila strain has the following properties: (a) a ... | 08/07/2007 |
| 7244725 | Acetyl 2-hydroxy-1, 3-diaminoalkanes Disclosed are compounds of the formula: where variables Z, X, R15, R2, R3, and RC are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase en... | 07/17/2007 |
| 7235709 | Transgenic animals with increased slow-twitch muscle fibers and methods of using such animals Transgenic non-human mammals over-expressing MHCI in skeletal muscle are provided herein, as are methods of using these transgenic non-human mammals for screening candidate compounds for treating type 2 diabetes, and methods for altering the ratio of MHCI to MHCII i... | 06/26/2007 |
| 7220891 | Feline bronchioloalveolar lung carcinoma xenograft and cell line The present invention provides feline transplantable lung carcinoma xenografts and cell lines. Such xenografts and cell lines exhibit a number of unique characteristics which allows their use in experimental models of carcinoma in order to dissect out the molecular ... | 05/22/2007 |
| 7220890 | Chimeric mouse model for endometriosis A non-human animal model for endometriosis is provided as well as methods of making and using the animal. ... | 05/22/2007 |
