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| Number | Title | Issue Date |
| 8088969 | Swine population having low levels of porcine endogenous retrovirus and uses thereof The invention relates to methods of selecting and maintaining a population of pigs having a low copy number of porcine endogenous retrovirus, and the use of such pigs as a source of cells, tissue and/or organs suitable for xenotransplantation. The invention further ... | 01/03/2012 |
| 8013208 | Methods for producing antibodies This invention provides methods for producing antibodies, wherein the methods comprise the step of administering an immunogen comprising both a target antigen and a background antigen to transgenic animals, into which a gene coding for the background antigen has bee... | 09/06/2011 |
| 8003847 | Non-human mutant mammals deficient in Sigma receptors and their applications The genome of the non-human mutant mammal, deficient in an endogenous Sigma receptor, contains a mutation that comprises a disruption in an endogenous Sigma receptor gene, wherein said gene disruption gives rise to a mutant lacking detectable levels of endogenous Si... | 08/23/2011 |
| 7897833 | Animal model for pigment spots An animal model for pigment spots in which the formation of pigment spots in human skin is faithfully simulated is provided. An animal model for pigment spots, wherein a black person's skin is grafted onto a non-human animal, is provided. ... | 03/01/2011 |
| 7825292 | Desmin gene having novel point mutation causative of dilated cardiomyopathy The present invention is intended to elucidate the cause of severe cardiomyopathy in subline (T) not manifesting the macroscopic cardiac hypertrophy, which has been separated from a hamster (B) with hypertrophic cardiomyopathy and clarify the pathogenic cause of dil... | 11/02/2010 |
| 7671250 | Method of acquiring immunological tolerance The aim of the present invention is to provide a method of acquiring immunological tolerance to a foreign DNA or its expression product whereby the foreign DNA such as a vector carrying a foreign gene incorporated thereinto or its expression product can be recognize... | 03/02/2010 |
| 7663017 | Transgenic mice having a human major histocompatability complex (MHC) phenotype, experimental uses and applications The present invention relates to transgenic mice and isolated transgenic mouse cells, the mice and mouse cells comprising a disrupted H2 class I gene, a disrupted H2 class II gene, a functional HLA class I transgene, and a functional HLA class II transgene. In embod... | 02/16/2010 |
| 7626075 | Growth of foreign cells in fetal animals facilitated by conditional and selective destruction of native host cells Foreign cells can be grown in fetal non-mammalian hosts for the production of transplant organs and tissues, the development of new therapeutic agents, and the production of biological factors and drugs. Tissue-specific injury to fetal host target cells is carried w... | 12/01/2009 |
| 7586020 | Methods for determining effects of maternal treatments on offspring The present invention provides animal models and methods for the evaluation of maternal treatments that could improve or compromise the epigenetic state, the imprinting, or the DNA methylation and thus the health or disease propensity, of human or other mammalian of... | 09/08/2009 |
| 7554003 | Invertebrate animal model with neurodegenerative phenotype for screening and testing substances The present invention claims an invertebrate animal that has been modified to express a set of genes, the set comprising the gene coding for a modified version of the gamma subunit of AMP-activated protein kinase (AMPKg). According to the invention, the animal displ... | 06/30/2009 |
| 7550647 | Transfected shrimp as production systems for therapeutic proteins A crustacean or rotifer is infected with a recombinant infectious virus that expresses a protein exogenous to the virus. The genome of the crustacean or rotifer itself remains unaltered. Crustacean, rotifer, insect, or viral promoters drive the transcription of a ge... | 06/23/2009 |
| 7459600 | Isolation, selection and propagation of animal transgenic stem cells Animal stem cells are obtained and maintained by culturing cells containing, in the genome, a selectable marker. Differential expression of the selectable marker enables preferential survival and/or division of the desired stem cells compared to the non-stem cells. | 12/02/2008 |
| 7420100 | Methods and compositions relating to HDAC 4 and 5 regulation of cardiac gene expression The present invention relates to cardiac hypertrophy. More particularly, the present invention defines the molecular events linking calcium stimulation to cardiac hypertrophy. More specifically, the present invention shows that Ca2+ stimulation of the hyp... | 09/02/2008 |
| 7417175 | Interstitial prostatism model animal The present invention provides an animal model for prostatic stromal hyperplasia, and a method for screening for a substance effective for preventing/treating human benign prostatic hyperplasia using the animal model. The animal model for prostatic stromal hyperplas... | 08/26/2008 |
| 7416886 | Porcine uroplakin II promoter and the production method of useful proteins using said promoter The present invention relates to a porcine uroplakin II gene promoter, an expression vector containing the promoter, and a method for producing useful proteins using the vector. The promoter of the present invention promotes the bladder-specific expression of a targ... | 08/26/2008 |
| 7414169 | Therapeutic and diagnostic tools for impaired glucose tolerance conditions Disclosed herein are novel genes and methods for the screening of therapeutics useful for treating impaired glucose tolerance conditions, as well as diagnostics and therapeutic compositions for identifying or treating such conditions. ... | 08/19/2008 |
| 7405342 | Transgenic mice expressing heterologous complement receptor type 1 (CR1) molecules on erythrocytes and uses therefor The present invention is directed, at least in part, to mice which express exogenous complement receptor type 1 (CR1) on red blood cells. The invention also pertains to genetic constructs encoding heterologous CR1 for expression on red blood cells. Methods of using ... | 07/29/2008 |
| 7402726 | Methods and compositions for screening for modulators of Parkinson's disease Methods and compositions for identifying an agent (e.g., a gene product or small molecule compound) that modulates a Parkinson's disease phenotype are provided. In practicing the subject methods, a non-mammalian animal model, such as Drosophila melanogaster, ... | 07/22/2008 |
| 7402730 | Knockout animals manifesting hyperlipidemia Genetically engineered cells and animals are described that incorporate a mutated GHP1 allele. Animals that are homozygous for the mutated GHP1 allele are useful for the production of monoclonal antibodies against GHP1. ... | 07/22/2008 |
| 7402727 | Non-human animal exhibiting bone metastasis of tumor cells The present invention provides a non-human bone metastasis model animal in which tumor cells capable of inducing bone metastasis by peripheral administration have been introduced, and a method for producing the animal. The bone metastasis model animal in the ... | 07/22/2008 |
| 7399900 | Nematodes as model organisms for the investigation of neurodegenerative diseases, in particular parkinsons disease, uses and methods for the discovery of substances and genes which can used in the treatment of the above disease states and identification of anematode gene The invention relates to nematodes as model organisms for the investigation of neurodegenerative diseases in particular. Parkinsons disease, uses and methods for the discovery of substances and genes which can be used in the treatment of the above disease states and... | 07/15/2008 |
| 7393683 | Mammalian host cell modified by RNAi to inhibit α 1,6-fucosyltransferase The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region o... | 07/01/2008 |
| 7388124 | Non-traumatic model for neurogenic pain A method for producing a non-human mammalian model for neurogenic pain is provided, which includes altering a peripheral nerve of a non-human mammal by non-surgically placing a gel substance into the fascial tunnel through which the peripheral nerve passes. The plac... | 06/17/2008 |
| 7374889 | Human sphingosine-1-phosphate phosphatase and inhibition methods The present invention provides polynucleotides and polypeptides of a human sphingosine-1-phosphate phosphatase, referred to herein as hSPP1. The polynucleotides and polypeptides are used to further provide expression vectors, host cells comprising the vectors, probe... | 05/20/2008 |
| 7371920 | Transgenic mouse model of neurodegenerative disorders The present invention provides a transgenic animal model of Alzheimer's Disease designated TgCRND8 as well as a method for making such model, which allows for the characterization of the etiology of the disease as well as for provide a system for the development and... | 05/13/2008 |
| 7368270 | Human phospholipases The invention provides human lipid metabolism enzymes (LME) and polynucleotides which identify and encode LME. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, trea... | 05/06/2008 |
| 7361804 | Unactivated oocytes in nuclear transfer to produce ungulates A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to th... | 04/22/2008 |
| 7358416 | Transgenic mouse expressing human FcRn protein Disclosed is a transgenic knockout mouse whose genome comprises a homozygous disruption in its endogenous FcRn gene. The homozygous RcRn disruption prevents the expression of a functional FcRn protein, resulting in a transgenic knockout mouse in which exogenously ad... | 04/15/2008 |
| 7348314 | Compositions and methods for inhibiting viral replication The present invention relates to a double-stranded ribonucleic acid (dsRNA) having a nucleotide sequence which is less that 30 nucleotides in length and which is substantially identical to at least a part of a 3′-untranslated region (3′-UTR) of a (+) strand RNA ... | 03/25/2008 |
| 7335811 | Method for collecting cells in M phase or Gphase and method for nuclear transplantation using the cells Methods for collecting cells in M phase or G1 phase, by which the percentage of M phase or G1 phase cells is higher than that attained by the conventional methods are disclosed. ... | 02/26/2008 |
| 7332646 | Transgenic animal model for degenerative diseases of cartilage The present invention provides animal model systems for cartilage-degenerative disease, which comprise transgenic animals which can express recombinant matrix-degrading enzymes (MDEs), particularly matrix metalloproteinases (MMPs), in a temporally and spatially regu... | 02/19/2008 |
| 7329513 | High level constitutive production of anthrax protective antigen The present invention relates to a process for preparing anthrax protective antigen protein from E. coli using fed batch culture. This process creates a constitutively expressing system for rapid, efficient, cost-effective and high-level production of anthrax... | 02/12/2008 |
| 7326824 | Unactivated ungulate oocytes to produce a transgenic ungulate by nuclear transfer A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to th... | 02/05/2008 |
| 7323618 | Tissue specific expression of exogenous proteins in transgenic chickens Transgenes encoding exogenous proteins are stably integrated into embryonic stem cells and are present in the somatic tissue of transgenic or chimeric birds. The transgenes encode exogenous proteins and are expressed in any of endodermal, ectodermal, mesodermal, or ... | 01/29/2008 |
| 7323541 | Polypeptide DNA thereof and use of the same The present invention aims at providing a novel polypeptide, a receptor, a DNA thereof, and the like. Specifically, the present invention provides a polypeptide having a binding ability to the protein represented by SEQ ID NO: 1 or SEQ ID NO: 3, or its amide, its es... | 01/29/2008 |
| 7321076 | Unactivated ungulate oocytes to produce a cloned ungulate by nuclear transfer A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to th... | 01/22/2008 |
| 7314614 | Recombinant sendai virus vector for introducing exogenous genes to airway epithelia Provided are a recombinant Sendai virus vector for introducing exogenous genes to airway epithelia and a method for introducing exogenous genes using the vector. The recombinant Sendai virus vector enables efficient gene transfer to native mucus-layered airway epith... | 01/01/2008 |
| 7309811 | Transgenic mice knockouts of BACE-1 The invention provides transgenic animals that are heterozygous or homozygous for a nonfunctional allele of BACE-1. These animals show normal development indicating that BACE-1 is not necessary for development and hence is an appropriate therapeutic target. The tran... | 12/18/2007 |
| 7297837 | Method for generating hypermutable organisms Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more... | 11/20/2007 |
| 7291764 | Cloning pigs using non-quiescent differentiated donor cells or nuclei An improved method of nuclear transfer involving the transplantation of donor differentiated pig cell nuclei into enucleated pig oocytes is provided. The resultant nuclear transfer units are useful for multiplication of genotypes and transgenic genotypes by the prod... | 11/06/2007 |
