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Felix Hoffmann, a German chemist, was searching for something to relieve his father's arthritis. In doing so, he "rediscovered" acetylsalicylic acid and in 1900, patented a stable process for developing it. Hence, we have aspirin.
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| Number | Title | Issue Date |
| 8030538 | Cattle beta-casein gene targeting vector using homologous recombination The present invention relates to a bovine beta-casein gene targeting vector comprising (1) a first region having a length of 5 to 12 kb which is homologous to the promoter and its flanking nucleic acid sequences of bovine beta-casein gene, and comprising exon 1, int... | 10/04/2011 |
| RE42704 | Production of fibrinogen in transgenic animals Materials and methods for producing fibrinogen in transgenic non-human mammals are disclosed. DNA segments encoding Aα, Bβ and γ chains of fibrinogen are introduced into the germ line of a non-human mammal, and the mammal or its female progeny produces milk conta... | 09/13/2011 |
| 7718845 | Production of growth hormone in the milk of a transgenic bovine and methods of purification of the growth hormone from the milk The invention relates to a method of producing a protein of interest, comprising making a non-human transgenic mammal that produces said protein in its milk, obtaining said milk from the non-human transgenic mammal and purifying said protein of interest from the mil... | 05/18/2010 |
| 7632980 | Modified nucleic acid sequences and methods for increasing mRNA levels and protein expression in cell systems The invention provides modified recombinant nucleic acid sequences (preferably DNA) and methods for increasing the mRNA levels and protein expression of proteins which are known to be, or are likely to be, difficult to express in cell culture systems, mammalian cell... | 12/15/2009 |
| 7544853 | C1 inhibitor with short half-life transient treatment The present invention relates to the use of a C1 inhibitor (C1INH) with shorter half-life than plasma-derived C1INH for the preparation of a medicament for the transient treatment of an individual. It relates to both therapeutic and prophylactic treatment. The metho... | 06/09/2009 |
| 7435869 | Transgenic nonhuman mammals producing fibrinogen in milk and methods of producing fibrin A transgenic, non-human mammalian animal is capable of expressing a heterologous gene for human or other recombinant physiologically functional fibrinogen holoprotein or individual subunit chain polypeptides thereof or a modified or fusion fibrinogen in mammary glan... | 10/14/2008 |
| 7419948 | Treatment of hemophilia with human Factor IX produced in mammary tissue of transgenic mammals Recombinant Factor IX characterized by a high percentage of active protein can be obtained in the milk of transgenic animals that incorporate chimeric DNA molecules according to the present invention. Transgenic animals of the present invention are produced by intro... | 09/02/2008 |
| 7381712 | In vivo transfection in avians The present invention provides for methods of producing transgenic avians which may include delivering a heterologous nucleic acid to oviduct tissue of an avian wherein the nucleic acid enters a cell of the oviduct tissue and is expressed. ... | 06/03/2008 |
| 7354594 | Merozoite surface protein 1 lacking glycosylation sites The invention provides modified recombinant nucleic acid sequences (preferably DNA) and methods for increasing the mRNA levels and protein expression of malarial surface protein MSP-1 which is known to be difficult to express in cell culture systems, mammalian cell ... | 04/08/2008 |
| 7332646 | Transgenic animal model for degenerative diseases of cartilage The present invention provides animal model systems for cartilage-degenerative disease, which comprise transgenic animals which can express recombinant matrix-degrading enzymes (MDEs), particularly matrix metalloproteinases (MMPs), in a temporally and spatially regu... | 02/19/2008 |
| 7271312 | Modified nucleic acid sequences and methods for increasing mRNA levels and protein expression in cell systems The invention provides modified recombinant nucleic acid sequences (preferably DNA) and methods for increasing the mRNA levels and protein expression of proteins which are known to be, or are likely to be, difficult to express in cell culture systems, mammalian cell... | 09/18/2007 |
| 7244874 | Stearoyl CoA desaturase transgenic non-human animals The present invention provides transgenic, non-human animals that include a transgene that encodes a fatty acid desaturase, e.g., stearoyl-CoA desaturase, and methods for producing such animals. The invention further provides an expression cassette that includes a c... | 07/17/2007 |
| 7220718 | Oral treatment of hemophilia Disclosed herein is a simple method for the treatment of antigen-deficiency diseases, by orally administering to a subject a therapeutically effective amount of the deficient antigen, wherein the antigen is not present in a liposome. In one embodiment, the method in... | 05/22/2007 |
| 7211650 | Purification of fibrinogen from fluids by precipitation and hydrophoic chromatography The present invention provides a method for the part purification of fibrinogen from milk, the method comprising the transfer of protease enzyme which is present in the milk, into the whey phase with the removal or partition if fibrinogen into another phase of the m... | 05/01/2007 |
| 7208576 | Non-glycosylated human alpha-fetoprotein, methods of production, and uses thereof The invention features non-glycosylated human alpha-fetoprotein, methods of production, and uses thereof. ... | 04/24/2007 |
| 7176278 | Modified transferrin fusion proteins The present invention discloses fusion proteins comprising transferrin, lactoferrin or melanotransferrin fused to glucagon-like peptide 1 (GLP-1). In one embodiment of the invention, the fusion protein displays increased serum half-life as compared to a GLP-1 peptid... | 02/13/2007 |
| 7169963 | Mammals expressing IGF-1 and alpha-lactalbumin in their milk The present invention relates to animals that express exogenous growth factors in their milk, and in particular to pigs that express exogenous IGF-I in their milk. The present invention also relates to methods for increasing piglet weight gain and intestinal lactase... | 01/30/2007 |
| 7157615 | Production of biofilaments in transgenic animals Disclosed is a method for the recombinant production of biofilaments, such as spider silk or insect fibroins, using transgenic animals which secrete the biofilaments in their milk and/or urine, and transgenic cells which secrete the biofilaments into culture media. ... | 01/02/2007 |
| 7074983 | Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin The present invention relates to the production of a transgenic bovine which comprises a genetic modification that results in inactivation and loss of expression of its endogenous antibodies, and the expression of xenogenous antibodies, preferably human antibodies. ... | 07/11/2006 |
| 7067713 | C1 Inhibitor produced in the milk of transgenic non-human mammals The invention provides transgenic nonhuman mammals expressing C1 inhibitor in their milk. The C1 inhibitor is useful in treating patients with hereditary angioedema or patients requiring immunosuppression. ... | 06/27/2006 |
| 7067127 | GIcNAc phosphotransferase of the lysosomal targeting pathway The present invention provides nucleotide and amino sequences of the lysosomal targeting pathway enzyme GlcNAc-phosphotransferase, methods of producing and methods of purifying this enzyme. ... | 06/27/2006 |
| 7045676 | Transgenic animals secreting proteins into milk A DNA sequence containing a gene encoding a protein, the gene being under the transcriptional control in the DNA sequence of a mammalian milk protein promoter which does not naturally control the transcription of the gene, such DNA sequence including DNA enabling se... | 05/16/2006 |
| 7045677 | Fusion proteins incorporating lysozyme A process for the production of a peptide is disclosed, the process comprising expressing in the milk of a transgenic, non-human, placental mammal a fusion protein which comprises the peptide to be expressed linked to a fusion partner protein which is lysozyme. The ... | 05/16/2006 |
| 7030289 | Stabilization of milk from transgenic animals The present invention relates to the stabilization of milk from transgenic animals. In particular, the invention relates to the protection of proteins (e.g. fibrinogen) expressed in milk from transgenic animals by co-expression of a serine proteinase inhibitor (e.g.... | 04/18/2006 |
| 7019193 | Treatments using transgenic goat produced antithrombin III This invention relates to transgenically produced human Antithrombin III (tgATIII). The human ATIII produced by the transgenic process of the present invention has a monosaccharide composition which comprises N-acetylgalactosamine (GalNAc) along with fucose, N-acety... | 03/28/2006 |
| 6987211 | Transgenic non-human mammals producing a cholinesterase in their milk The present invention relates to novel alternative forms of human acetylcholinesterase (AChE) and nucleotide sequences encoding the same. The genes encoding the novel forms of human AChE have been identified in various malignant tumor cells. In a further aspect, the... | 01/17/2006 |
| 6984772 | Transgenic non-human mammals producing fibrinogen in their milk A transgenic, non-human mammalian animal is capable of expressing a heterologous gene for human or other recombinant physiologically functional fibrinogen holoprotein or individual subunit chain polypeptides thereof or a modified or fusion fibrinogen in mammary glan... | 01/10/2006 |
| 6924412 | Means and methods for raising antibody concentration in compartments of the body of a non-human animal Methods and processes for raising the concentration of a first class of immunoglobulin relative to at least a second class of immunoglobulin in a compartment of the body of a non-human animal or the progeny thereof, as well as the animals produced by such methods an... | 08/02/2005 |
| 6905856 | Soluble GlcNAc phosphotransferase The present invention relates to a soluble GlcNAc phosphotransferase, a method of making the same and a method of phosphorylating with the same. ... | 06/14/2005 |
| 6727405 | Transgenic animals secreting desired proteins into milk A DNA sequence containing a gene encoding a protein, the gene being under the transcriptional control in the DNA sequence of a mammalian milk protein promoter which does not naturally control the transcription of the gene, such DNA sequence including DNA enabling se... | 04/27/2004 |
| 6713662 | Production of collagen in the milk of transgenic mammals The invention provides transgenic nonhuman mammals capable secreting exogenous procollagen or collagen into their milk. The mammals are healthy and capable of producing procollagen or collagen at high levels, usually in trimeric form. Suitable transgenes for incorpo... | 03/30/2004 |
| 6677500 | Ungulates expressing exogenous IGF-I in their milk The present invention relates to animals that express exogenous growth factors in their milk, and in particular to pigs that express exogenous IGF-I in their milk. The present invention also relates to methods for increasing piglet weight gain and intesti... | 01/13/2004 |
| 6548735 | Production of heterologous protein in milk of transgenic non-human mammals comprising a construct with an intron Proteinaceous products can be produced by transgenic animals having genetic constructs integrated into their genome. The construct comprises a 5'-flanking sequence from a mammalian milk protein gene (such as beta-lactoglobulin) and DNA coding for a hetero... | 04/15/2003 |
| 6545198 | Transgenically produced prolactin Transgenically produced prolactin and methods of making and using transgenically produced prolactin.... | 04/08/2003 |
| 6528699 | Transgenically produced non-secreted proteins The invention provides a method of making and secreting a non-secreted protein. The method includes expressing the protein from a nucleic acid construct which includes: (a) a mammary epithelial specific promoter; (b) a milk protein specific signal sequenc... | 03/04/2003 |
| 6525241 | Expression methods The present invention relates to human bile salt-stimulated lipase (BSSL) obtainable from transgenic sheep. The invention further relates to transgenic sheep whose germ cells and somatic cells contain a recombinant nucleotide molecule comprising a nucleot... | 02/25/2003 |
| 6518482 | Transgenic non-human mammals expressing human coagulation factor VIII and von Willebrand factor A non-human transgenic mammalian animal, as described above, contains an exogenous double stranded DNA sequence stably integrated into the genome of the animal, which comprises cis-acting regulatory units operably linked to a DNA sequence encoding human F... | 02/11/2003 |
| 6472584 | Production of membrane proteins in the milk of transgenic mammals Production of proteins not normally secreted through conventional pathways such as membrane proteins including, for example, CFTR associated with cystic fibrosis, is now made possible by collection of such protein from the milk of lactating transgenic ani... | 10/29/2002 |
| 6448469 | Production of membrane proteins in the milk of transgenic nonhuman mammals Production of proteins not normally secreted through conventional pathways such as membrane proteins including, for example, CFTR associated with cystic fibrosis, is now made possible by collection of such protein from the milk of lactating transgenic ani... | 09/10/2002 |
| 6441145 | Transgenically produced Antithrombin III This invention relates to transgenically produced human Antithrombin III (tgATIII). The human ATIII produced by the transgenic process of the present invention has a monosaccharide composition which comprises N-acetylgalactosamine (GaINAc) along with fuco... | 08/27/2002 |
