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| Number | Title | Issue Date |
| 7414170 | Transgenic bovines capable of human antibody production The invention features novel methods for the production of large quantities of xenogenous antibodies, such as human antibodies. Preferably, this result is effected by inactivation of IgM heavy chain expression and, optionally, by inactivation of Ig light chain expre... | 08/19/2008 |
| 7294753 | Method for preparing anti-MIF antibodies The specification provides methods of preparing high-affinity antibodies to a macrophage migration inhibitory factor (MIF) in animals in which the MIF gene has been homozygously knocked-out (MIF−/−). Also provided are methods of preparing hybridomas w... | 11/13/2007 |
| 7208576 | Non-glycosylated human alpha-fetoprotein, methods of production, and uses thereof The invention features non-glycosylated human alpha-fetoprotein, methods of production, and uses thereof. ... | 04/24/2007 |
| 7132586 | Protein production system The invention relates to a method for producing a protein of interest comprising transforming a target insect with a non-viral expression system that expresses the protein in the insect larvae, breeding the insect to produce larvae, culturing the larvae and isolatin... | 11/07/2006 |
| 6921846 | Antibody production methods relating to disruption of peripheral tolerance in B lympho-cytes The subject invention relates a method for the production of monoclonal antibodies. The method utilizes an immunized animal having antibody-producing cells with disrupted peripheral tolerance. The invention also provides a method for the use of such monoclonal antib... | 07/26/2005 |
| 6800462 | Production of recombinant proteins in vivo and use for generating antibodies The invention is directed to methods of producing a protein by administering a nucleic acid encoding the protein to an animal. Following the administration of the nucleic acid to the animal, the protein is produced in vivo and is isolated by removing a biological sa... | 10/05/2004 |
| 6632976 | Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene A chimeric, non-human animal can be produced by a method that entails providing a microcell that contains one or more foreign chromosomes or fragment(s) thereof and then fusing the microcell with a pluripotent cell, thereby introducing the foreign chromos... | 10/14/2003 |
| 6613957 | Synthesis of functional human hemoglobin and other proteins in erythroid tissues of transgenic non-human mammals The present invention relates to the synthesis of functional human hemoglobin and other proteins in erythroid tissues of transgenic non-human animals and erythroid cell lines. It is based on the discovery that two of the five hypersensitivity sites of the... | 09/02/2003 |
| 6570061 | Targeted replacement of an immunoglobulin gene without endogenous and selectable residual sequences in mice Transgenic mice that produce high levels of humanized antibodies are described. Targeted gene replacement exchanges constant regions of the mouse immunoglobulin heavy and light chain genes with human genes, either through conventional gene targeting, or b... | 05/27/2003 |
| 6372955 | Methods for Producing B cells and antibodies from H2-O modified transgenic mice A transgenic animal with alterations in an H2-O gene is prepared by introduction of an altered H2-O gene into a host animal. The resulting transgenic animals produce a substantially greater frequency of high affinity antibodies compared to H2-O wild type ... | 04/16/2002 |
| 6022736 | Nucleic acid vectors comprising DNase I hypersensitive sites The present invention provides novel recombinant nucleic acid vectors which may be used to produce -globin as well as other proteins of interest in quantity in the red blood cells of transgenic animals or cell cultures of erythroid lineage. The pre... | 02/08/2000 |
| 6013857 | Transgenic bovines and milk from transgenic bovines Transgenes for producing recombinant polypeptides transgenic bovine species. A transgene for producing recombinant polypeptides in the milk of transgenic bovine species comprises at least one expression regulation sequence, a secretory DNA sequence encodi... | 01/11/2000 |
| 5766884 | Synthesis of functional human hemoglobin and other proteins in erythroid tissues of transgenic animals The present invention relates to the synthesis of functional human hemoglobin and other proteins in erythroid tissues of transgenic non-human animals and erythroid cell lines. It is based on the discovery that two of the five hypersensitivity sites of the... | 06/16/1998 |
| 5602306 | Synthesis of functional human hemoglobin and other proteins in erythroid tissues of transgenic animals The present invention relates to the synthesis of functional human hemoglobin and other proteins in erythroid tissues of transgenic non-human animals and erythroid cell lines. It is based on the discovery that two of the five hypersensitivity sites of the... | 02/11/1997 |
| 4870009 | Method of obtaining gene product through the generation of transgenic animals Mammalian genes that encode hormones are cloned and linked to strong promoter DNA sequences. The linked sequences are inserted in plasmids for amplification in prokaryotic cells, and multiple copies of the linked sequences are excised therefrom. Linked se... | 09/26/1989 |
