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| Number | Title | Issue Date |
| 8030537 | Somatic cloning gene transfer for the production of recombinant proteins, cells and organs The present invention relates to a method for recombinant manufacturing of substances, wherein cells are transformed suing a nucleotide sequence coding for the substance, the transformed cells are subjected to a cloning process, and the cells obtained in this fashio... | 10/04/2011 |
| 7928285 | Method of producing xenogenous antibodies using a bovine In general, the invention features genetically modified non-human mammals (e.g., bovines and other ungulates), and methods of making these mammals. In particular, the invention features transgenic ungulates having reduced levels of endogenous IgM heavy chain and/or ... | 04/19/2011 |
| 7875762 | Method of producing an exogenous protein in the egg of a chicken This invention provides for proteins which are expressed in the avian oviduct, packaged into eggs laid by the avian and removed from the eggs. ... | 01/25/2011 |
| 7812215 | Methods and protein production using ovomucoid promoters Methods of producing protein using a recombinant ovomucoid gene expression controlling region operably linked to one or more useful amino acid coding sequences. ... | 10/12/2010 |
| 7772459 | Transgenic production in saliva The invention relates to the production of proteins and other substances of interest in saliva of transgenic animals, particularly in mammals that produce large quantities of saliva, particularly monogastric ruminants, and ovine, caprine and bovine mammals. Preferre... | 08/10/2010 |
| 7723563 | Transgenic proteins from multi-gene systems, methods, compositions, uses and the like relating thereto A non-human transgenic mammalian animal, as described above, contains one or more exogenous double stranded DNA sequence(s) stably integrated into the genome of the animal, which comprises trans-acting regulatory units controlling expression of DNA sequences encodin... | 05/25/2010 |
| 7692059 | Method for generating overexpression of alleles in genes of unknown function Methods for generating and using novel overexpression activity alleles of a gene in any organism, especially Drosophilia, are provided. Such alleles may be utilized in screening assays, and used to generate dominant-negative forms of bacterial toxins. ... | 04/06/2010 |
| 7459599 | Methods for producing proteins using silkworm middle silk gland-specific gene expression system Transgenic silkworms comprising GFP whose expression is regulated by the sericin gene promoter were produced. Observation of the silk glands of the last instar larvae of the silkworms showed fluorescence only in the middle silk glands. GFP was secreted from middle s... | 12/02/2008 |
| 7435871 | Transgenic animals bearing human Igλ light chain genes The invention relates to transgenic animals bearing one or more human λ light chain loci. The invention also relates to methods and compositions for making transgenic animals that have incorporated human λ light chain loci. The invention further relates to methods... | 10/14/2008 |
| 7416886 | Porcine uroplakin II promoter and the production method of useful proteins using said promoter The present invention relates to a porcine uroplakin II gene promoter, an expression vector containing the promoter, and a method for producing useful proteins using the vector. The promoter of the present invention promotes the bladder-specific expression of a targ... | 08/26/2008 |
| 7402729 | Human artificial chromosome containing human antibody λ light chain gene and non-human animal containing the human artificial chromosome capable of genetic transmission The present invention relates to a human artificial chromosome which is genetically transmissible to the next generation with high efficiency and the method for using the same. More specifically, the present invention relates to: a human artificial chromosome in whi... | 07/22/2008 |
| 7381712 | In vivo transfection in avians The present invention provides for methods of producing transgenic avians which may include delivering a heterologous nucleic acid to oviduct tissue of an avian wherein the nucleic acid enters a cell of the oviduct tissue and is expressed. ... | 06/03/2008 |
| 7355092 | Genetic vaccines for the production of chicken egg-yolk antibodies against enterotoxigenic and other pathogens Genetic vaccine which comprises plasmid(s) containing genes coding for antigens of enterotoxigenic Escherichia coli (ETEC) strains is disclosed. Additionally, plasmids may consist of multiple copies of the same antigen (i.e. K88 or K99 fimbrial antigen) or mu... | 04/08/2008 |
| 7294753 | Method for preparing anti-MIF antibodies The specification provides methods of preparing high-affinity antibodies to a macrophage migration inhibitory factor (MIF) in animals in which the MIF gene has been homozygously knocked-out (MIF−/−). Also provided are methods of preparing hybridomas w... | 11/13/2007 |
| 7253334 | Methods for cloning non-human mammals using reprogrammed donor chromatin or donor cells The invention provides methods for cloning mammals that allow the donor chromosomes or donor cells to be reprogrammed prior to insertion into an enucleated oocyte. The invention also features methods of inserting chromosomes or nuclei into recipient cells. ... | 08/07/2007 |
| 7220718 | Oral treatment of hemophilia Disclosed herein is a simple method for the treatment of antigen-deficiency diseases, by orally administering to a subject a therapeutically effective amount of the deficient antigen, wherein the antigen is not present in a liposome. In one embodiment, the method in... | 05/22/2007 |
| 7157615 | Production of biofilaments in transgenic animals Disclosed is a method for the recombinant production of biofilaments, such as spider silk or insect fibroins, using transgenic animals which secrete the biofilaments in their milk and/or urine, and transgenic cells which secrete the biofilaments into culture media. ... | 01/02/2007 |
| 7132586 | Protein production system The invention relates to a method for producing a protein of interest comprising transforming a target insect with a non-viral expression system that expresses the protein in the insect larvae, breeding the insect to produce larvae, culturing the larvae and isolatin... | 11/07/2006 |
| 7119248 | Antibodies against epitopes with homology to self antigens, methods of preparation and applications thereof This invention provides novel methods of obtaining autologous monoclonal antibodies (AMABs) to self-antigens or homologs thereof. The method involves obtaining a genetically engineered host animal that does not biosynthesize at least one epitope of the antigen and u... | 10/10/2006 |
| 7115795 | Transgenic animals expressing salivary proteins The invention provides a transgenic animal having within its genome a transgene construct for gastrointestinal tract specific expression of a protein. In a preferred embodiment, the protein is a phytase or a homologue thereof. Such proteins may be heterologous and m... | 10/03/2006 |
| 7112554 | Substituted arylketones The invention relates to novel aryl ketones of the formula (I) in which A1, A2, Q, R1, R2, X, Y and Z are as defined in the descripti... | 09/26/2006 |
| RE39270 | Process for continuous optimized protein production in insect larvae The present invention provides for a recombinant insect larvae and a process of manufacturing proteins utilizing insect larvae that allows for the selection of individual larvae for harvest at the point of their optimal expression of a protein of interest. This inve... | 09/05/2006 |
| 7087808 | Method for expressing multiple recombinant proteins in milk of transgenic non-human mammals The present invention discloses a method for expressing multiple recombinant proteins in transgenic non-human mammalian milk, characterized in which human clotting factor IX gene and porcine lactoferrin gene are transferred into the mammal by gene injection and embr... | 08/08/2006 |
| 7074983 | Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin The present invention relates to the production of a transgenic bovine which comprises a genetic modification that results in inactivation and loss of expression of its endogenous antibodies, and the expression of xenogenous antibodies, preferably human antibodies. ... | 07/11/2006 |
| 7071373 | Transgenic ungulate compositions and methods Transgenic ungulates and compositions and methods for making and using same, are provided. Central to the invention are porcine, bovine, ovine and caprine embryonic stem cell lines and methods for establishing them. Cells of such lines are transformed with exogenous... | 07/04/2006 |
| 7053262 | Mammary gland tissue-specific expression system using β-casein promoter site of Korean native goat The mammary gland-specific expression systems developed by the present inventors, named pGbc, pGbc_L and pGbc_S were deposited under the Budapest Treaty on the International Recognition of the Deposit of Microorganisms for the Purpose of Patent Procedure in the Kore... | 05/30/2006 |
| 7034109 | Intracellular delivery of biological effectors The invention relates to a sequence of amino acids with the capacity to facilitate transport of an effector across a biological membrane. More specifically, the present invention relates to novelpeptide transporters that specifically target certain cell types for th... | 04/25/2006 |
| 6962975 | Prion protein standard and method of making the same The invention provides prion protein standards for use as reference materials for prion detection. The standard may be species specific, i.e. the standard is comprised of a preparation for detection of a single strain prion or it may be prepared to allow detection o... | 11/08/2005 |
| 6946266 | Gene transfer in chicken bursal stem cells The invention relates to a method of expressing proteins in higher eukaryotes in vitro. In general, the invention sets forth a method of expressing exogenous proteins as fusion partners with the immunoglobulin molecules of avian species specifically chickens. The te... | 09/20/2005 |
| 6924412 | Means and methods for raising antibody concentration in compartments of the body of a non-human animal Methods and processes for raising the concentration of a first class of immunoglobulin relative to at least a second class of immunoglobulin in a compartment of the body of a non-human animal or the progeny thereof, as well as the animals produced by such methods an... | 08/02/2005 |
| 6921846 | Antibody production methods relating to disruption of peripheral tolerance in B lympho-cytes The subject invention relates a method for the production of monoclonal antibodies. The method utilizes an immunized animal having antibody-producing cells with disrupted peripheral tolerance. The invention also provides a method for the use of such monoclonal antib... | 07/26/2005 |
| 6888047 | Transgenic animals as urinary bioreactors for the production of polypeptide in the urine, recombinant DNA construct for kidney-specific expression, and method of using same The invention relates to recombinant DNA constructs, a method for producing a recombinant biologically active protein in vivo in the urine of a non-human mammal using a kidney-specific promoter, such as the uromodulin promoter, and the transgenic non-human mammals t... | 05/03/2005 |
| 6872869 | Method for establishing an expression system of spider dragline silk gene in bombyx mori The present invention provides a method for establishing an expression system of spider dragline silk gene in Bombyx mori. The rate of transformation is about 0.5-1%. In the silk protein produced by the transgenic Bombyx mori obtained by the method of the present in... | 03/29/2005 |
| 6835866 | Compositions and methods of modulating cholesterol metabolism The present invention relates to compositions and methods for reducing cholesterolemia and its effects. More specifically, the invention is directed, in one embodiment, to methods for screening for compounds that affect cholesterol levels generally, and in particula... | 12/28/2004 |
| 6800462 | Production of recombinant proteins in vivo and use for generating antibodies The invention is directed to methods of producing a protein by administering a nucleic acid encoding the protein to an animal. Following the administration of the nucleic acid to the animal, the protein is produced in vivo and is isolated by removing a biological sa... | 10/05/2004 |
| 6800790 | Method for maintenance and propagation of germline stem cells using members of the TFG-β family of growth factors The TGF-β family of growth factors, particularly the bone morphogenetic protein (BMP)-2/4 homolog decapentaplegic (dpp), are specifically required to maintain germline stem cells and promote their division. Overexpression of dpp blocks germline stem cell differenti... | 10/05/2004 |
| 6734338 | Transfection, storage and transfer of male germ cells for generation of transgenic species and genetic therapies A composition for in vitro and in vivo transfection of vertebrate male germ cells comprises a nucleic acid or transgene, and a gene delivery system, and optionally a protective internalizing agent, such as an endosomal lytic agent, a virus or a viral component, whic... | 05/11/2004 |
| 6730822 | Vectors in avian transgenesis This invention provides vectors and methods for the stable introduction of exogenous nucleic acid sequences into the genome of a bird and for expressing said exogenous sequences to alter the phenotype of the bird or to produce desired proteins. In particular, transg... | 05/04/2004 |
| 6673987 | Strategy for maintaining pregnancy Pregnancy in animals such as the pig usually does not continue to term when there are only a few embryos in the uterus. Currently available technology for maintaining pregnancy involves a series of hormone injections, and the failure rate is high. It has ... | 01/06/2004 |
| 6664443 | Pathogenic Tau mutations in transgenic mice Isolated nucleic acid molecules that include a tau gene sequence are described. The tau gene sequences have a mutation linked to a Tau pathology. Transgenic non-human mammals that develop a Tau pathology also are described.... | 12/16/2003 |
