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| Number | Title | Issue Date |
| 8445745 | Animal model having a chimeric human liver and susceptible to human hepatitis C virus infection The present invention features a non-human animal model that is susceptible to infection by human hepatotrophic pathogens, particularly human hepatitis C virus (HCV). The model is based on a non-human, immunocompromised transgenic animal having a human-mouse chimeri... | 05/21/2013 |
| 8436224 | Methods for testing for caloric restriction (CR) mimetics Methods for treating neurological diseases and for testing Caloric Restriction (CR) mimetics or CR mimetic candidates. In one exemplary method, a CR mimetic candidate is administered to a transgenic animal and the effects of the administering are determined; the tra... | 05/07/2013 |
| 8431768 | Targeted and regional cellular ablation in zebrafish A system including: (i) a methodology for targeted cellular ablation in zebrafish; (ii) a methodology for regional cellular ablation in zebrafish. These methodologies are used to identify drug compounds that influence cellular regeneration for the purpose of develop... | 04/30/2013 |
| 8431767 | Transgenic non-human animal and methods for stem cell engraftment Transgenic immunodeficient non-human animals according to embodiments of the present invention are described which include in their genome a nucleic acid encoding xenogeneic Stem Cell Factor operably linked to a promoter. Administration of xenogeneic hematopoetic st... | 04/30/2013 |
| 8420884 | Models of malignant brain cancer, and therapeutic siRNAs against oncogenic signaling pathways, and methods and kits for uses therefor Methods for screening compounds to treat an oncological disorder regulated through a tumor-inducing pathway are provided. The compounds are administered to non-human animal subjects having a disease model, so that the subjects display pathology symptoms that corresp... | 04/16/2013 |
| 8420885 | Determining the capability of a test compound to affect solid tumor stem cells A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation an... | 04/16/2013 |
| 8389792 | Compositions and methods for the treatment and prevention of ulcerative colitis and colon cancer and screening methods to identify same The instant invention is based, at least in part, on the discovery that T-bet maintains host commensal relationships in the gastrointestinal tract. Accordingly, this invention provides methods of treating and/or preventing ulcerative colitis, and/or colon cancer, an... | 03/05/2013 |
| 8367887 | Normal-tension glaucoma model and method for evaluation of test substances by using same It is intended to provide a simple normal-tension glaucoma model capable of spontaneously, age-dependently and surly developing conditions similar to symptoms of normal-tension glaucoma which occurs more frequently in elder people, and a method of evaluating therape... | 02/05/2013 |
| 8357832 | F1B-TMIR plasmid vector and transgenic mouse A trifusion reporter plasmid is described that comprises a plasmid operably coupled to a mammalian FGF1B promoter that is operably coupled to a bioluminescence gene fused to a fluorescence gene fused to a nuclear medical imaging gene. The new reporter allows in vivo... | 01/22/2013 |
| 8319007 | Mouse models with enhanced essential tremor and preparation method thereof Disclosed herein are an α1/CaV3.1 double knockout mouse or α1−/−; Emx1-Cre mouse with enhanced essential tremor and a screening method of therapeutic agents for essential tremor by using the same. The α1/CaV3.1 double knockout mouse or α1−/... | 11/27/2012 |
| 8309790 | Animal models for demyelination disorders This invention is in the field of neurology. Specifically, the invention relates to the discovery and characterization of molecular components that play a role in neuronal demyelination or remyelination. In addition, the invention relates to the generation of an ani... | 11/13/2012 |
| 8304601 | Mouse model for eye disease It is intended to provide an animal model which shows a naturally occurring eye disease symptom, particularly ocular hypertension and/or retinal degeneration. The invention relates to a non-human animal for eye disease model in which the function of Vav2 gene and/or... | 11/06/2012 |
| 8263822 | TREM-2 gene and protein as inhibitors of expression of GA733-2, and transgenic animals comprising the same and uses thereof Disclosed are a composition for inhibiting the expression of GA733-2 or for detecting GA733-2, which comprises TREM-2 gene or protein, a transgenic animal containing same, and a method using the same. ... | 09/11/2012 |
| 8263821 | Non-invasive real-time in vivo bioluminescence imaging of local CaÂ2+ dynamics in living organisms The invention relates to a method for optical detection of the dynamics of Ca2+ in a biological system, said method comprising monitoring the photons emitted by a recombinant Ca2+-sensitive polypeptide, which comprises or consists of a chemilum... | 09/11/2012 |
| 8232446 | Non-human animal model for lung carcinoma A transgenic mouse expressing JSRV Env transgene that is operably linked to a surfactant protein C promoter (SPCp) is disclosed. The transgenic mouse is prone to developing a lung tumor and serves as an animal model for human lung carcinoma. ... | 07/31/2012 |
| 8227661 | Methods of identifying agents that ameliorate or modulate effects of PRO1328 gene disruptions The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO227, PRO233, PRO238, PRO1328, PRO434... | 07/24/2012 |
| 8217222 | Methods for identifying markers for early-stage human cancer, cancer progression and recurrence A method is described to identify secreted proteins identified with stages of malignancy of cancer. The proteins are initially identified by trapping them with a fluorescent protein containing vector that can insert in any gene. The secreted proteins are initially i... | 07/10/2012 |
| 8207396 | Gene disruptions, compositions and methods relating thereto The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO3600... | 06/26/2012 |
| 8168854 | Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression Transgenic animals containing a nucleic acid sequence encoding TCL1 operably linked to transcriptional control sequences directing expression to B cells are described. Such transgenic animals provide a useful animal model system for human B cell chronic lymphocytic ... | 05/01/2012 |
| 8148599 | Transgenic non-human animals for pharmacological and toxicological studies The present invention is directed to the production, breeding and use of transgenic non-human animals such as mice in which specific genes or portions of genes have been replaced by homologues from another animal to make the physiology of the animals so modified mor... | 04/03/2012 |
| 8124829 | Transgenic mice over-expressing receptor for advanced glycation endproduct (RAGE) in brain and uses thereof The present invention provides for a transgenic non-human animal whose cells contain a DNA sequence comprising: (a) a nerve tissue specific promoter; and (b) a DNA sequence which encodes a receptor for advanced glycation endproducts (RAGE), wherein the promoter and ... | 02/28/2012 |
| 8088968 | Transgenic animals for analyzing CYP3A4 cytochrome P450 gene regulation The invention relates to the generation of non-human transgenic animals comprising a reporter construct for producing a detectable amount of a reporter molecule operably linked to a transcriptional regulatory nucleic acid molecule from the human CYP3A4 gene located ... | 01/03/2012 |
| 8071838 | Targeted and regional cellular ablation in zebrafish A system including: (i) a methodology for targeted cellular ablation in zebrafish; (ii) a methodology for regional cellular ablation in zebrafish. These methodologies are used to identify genetic components that regulate cellular regeneration and to identify drug co... | 12/06/2011 |
| 8067664 | PRO224 gene disruptions, and methods related thereto The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO224, PRO9783, PRO1108, PRO34000, PRO... | 11/29/2011 |
| 8058502 | Increasing lifespan by modulation of WWP-1 and UBC-18 Ubiquitin ligase wwp-1 and ubiquitin conjugating enzyme ubc-18 are identified in nematodes as mediators of dietary restriction induced longevity and therefore as targets for modulation of lifespan in animals. Methods of screening for compounds that modulate longevit... | 11/15/2011 |
| 8053627 | Methods for treating demyelination disorders This invention is in the field of neurology. Specifically, the invention relates to the discovery and characterization of molecular components that play a role in neuronal demyelination or remyelination. In addition, the invention relates to the generation of an ani... | 11/08/2011 |
| 8044259 | Determining the capability of a test compound to affect solid tumor stem cells A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation an... | 10/25/2011 |
| 7989675 | Method of identifying compounds using a transgenic pig model of cystic fibrosis The present invention provides transgenic, large non-human animal models of diseases and conditions, as well as methods of using such animal models in the identification and characterization of therapies for the diseases and conditions. ... | 08/02/2011 |
| 7960605 | Methods for testing for caloric restriction (CR) mimetics Methods for treating neurological diseases and for testing Caloric Restriction (CR) mimetics or CR mimetic candidates. In one exemplary method, a CR mimetic candidate is administered to a transgenic animal and the effects of the administering are determined; the tra... | 06/14/2011 |
| 7956237 | Gene disruptions, compositions and methods relating thereto The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO196, PRO217, PRO231, PRO236, PRO245,... | 06/07/2011 |
| 7947866 | Gene disruptions, compositions and methods relating thereto The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO194, PRO220, PRO241, PRO284, PRO331,... | 05/24/2011 |
| 7928284 | Methods and animal model for analyzing age-related macular degeneration Methods for testing candidate drugs for treatment of age-related macular degeneration are provided. Ccl2-deficient, and Ccr2-deficient mice are used to determine the effect of candidate drugs and treatments on development of age-related macular degeneration. Also pr... | 04/19/2011 |
| 7928283 | Transgenic reporter system that reveals expression profiles and regulation mechanisms of alternative splicing in nematodes An object of the present invention is to develop a new alternative splicing reporter system and to provide a method for detecting alternative splicing patterns in a multicellular organism more precisely, a method for identifying efficiently substances and gene regio... | 04/19/2011 |
| 7919671 | Method for testing a compound for a therapeutic effect and a diagnostic method A method for testing compound for a therapeutic effect utilizing a non-human animal or cell having disruption in the prostatic acid phosphatase gene resulting in a decrease or absence in the activity or the level of prostatic acid phosphatase. The compound may be us... | 04/05/2011 |
| 7919670 | Transgenic mice over-expressing receptor for advanced glycation endproduct (RAGE) in brain and uses thereof The present invention provides for a transgenic non-human animal whose cells contain a DNA sequence comprising: (a) a nerve tissue specific promoter; and (b) a DNA sequence which encodes a receptor for advanced glycation endproducts (RAGE), wherein the promoter and ... | 04/05/2011 |
| 7906701 | p300 transgenic animal The present invention relates to a transgenic animal wherein DNA encoding p300 and a promoter exerting its activity in myocardial cells are introduced, and a screening method using the same. ... | 03/15/2011 |
| 7884260 | Cell-based screen for agents useful for reducing neuronal demyelination or promoting neuronal remyelination This invention is in the field of neurology. Specifically, the invention relates to the discovery and characterization of molecular components that play a role in neuronal demyelination or remyelination. In addition, the invention relates to the generation of an ani... | 02/08/2011 |
| 7858843 | Gene disruptions, compositions and methods relating thereto The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO69122, PRO204, PRO214, PRO222, PRO23... | 12/28/2010 |
| 7847146 | Model for neurodegenerative disorders The present invention discloses a double transgenic fly that expresses both Tau protein and the human Aβ42 peptide of human amyloid-β precursor protein (APP). The double transgenic flies of the present invention display a synergistic altered phenotype as compared ... | 12/07/2010 |
| 7838726 | Methods for introducing heterologous cells into fish The invention provides methods of introducing heterologous cells into fish. After introduction cells remain viable, and in some instances proliferate, for sufficient time to conduct a variety of analyses on the heterologous cells or the fish or both. Such methods ar... | 11/23/2010 |
