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...Daniel Webster invented a "bull plow" to pull out tree stumps. It didn't catch on because it was huge and required four oxen to pull it!
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| Number | Title | Issue Date |
| 8124832 | Method for producing cloned dog Provided is a method for producing a cloned dog by enucleating an oocyte of a dog to produce an enucleated oocyte, transferring a somatic cell of the dog into the enucleated oocyte, carrying out electrofusion under optimized conditions to produce a nuclear transfer ... | 02/28/2012 |
| 7893316 | Method for reconstructing a non-human mammal embryo with foetal adult differentiated cells The invention concerns the reconstruction in vitro of non-human mammal embryos by a method which consists in treating the nucleus of a somatic donor cell prior to its transfer into a receiver cytoplasm, said treatment comprising controlled proteolysis of non-histone... | 02/22/2011 |
| 7820878 | Production of ungulates, preferably bovines that produce human immunoglobulins The present invention relates to a method of producing an ungulate having both copies of the IgM heavy chain (mu) rag-1 and/or rag-2 gene eliminated from its genome. Animals which have IgM, rag-1 and/or rag-2 eliminated from their genome are unable to conduct the ge... | 10/26/2010 |
| 7696404 | Embryonic or stem-like cell lines produced by cross species nuclear transplantation and methods for enhancing embryonic development by genetic alteration of donor cells or by tissue culture conditions An improved method of nuclear transfer involving the transplantation of differentiated donor cell nuclei into enucleated oocytes of a species different from the donor cell is provided. The resultant nuclear transfer units are useful for the production of isogenic em... | 04/13/2010 |
| 7683236 | Enhanced production of cloned mammals by zona pellucida-free homologous mammalian embryo aggregation Compositions and methods are provided for the efficient and reproducible generation of clone animals of all developmental stages. Also provided are methods of use of the same in reproductive and therapeutic cloning protocols. ... | 03/23/2010 |
| 7659443 | Method of constructing nucleus-implanted egg, parthenogenetic embryo and parthenogenetic mammal Disclosed is a method for constructing a nucleus-implanted egg, a parthenogenetic embryo and for producing a parthenogenetic mammal each having 2 haploid genome sets originating in mammalian ova, and provides methods of constructing a nucleus-implanted egg having a ... | 02/09/2010 |
| 7652192 | Cloning of transgenic unglulates comprising artificial chromosomes The invention is directed in part to totipotent cells that have one or more artificial chromosomes; processes for producing such cells; processes for using such cells (e.g., nuclear transfer); transgenic embryos and transgenic animals cloned from such cells; and pro... | 01/26/2010 |
| 7615677 | Assessment method A method of assessing the viability of a cell comprises incubating the cell in a culture medium. The culture medium includes a plurality of amino acids and the change in concentration in the medium of at least one amino acid is determined. ... | 11/10/2009 |
| 7612250 | Nuclear transfer embryo formation method A nuclear transfer embryo is formed by destabilizing microtubules of an oocyte, whereby essentially all endogenous chromatin collects at a second polar body during meiosis of an oocyte. The oocyte is fused with the nucleus of a donor somatic cell of the same species... | 11/03/2009 |
| 7601884 | Method of producing cloned animals by demecolcine treatment A cloned animal is produced by demecolcine treatment characterized by culturing the nuclear transfer embryo in vitro and transferring the embryo in vivo. This significantly improves in vitro development of somatic cell nuclear transfer embryos and maintenance of pre... | 10/13/2009 |
| 7592503 | Mammalian telophase oocyte enucleation The present invention pertains to methods for cloning animals. In particular, the invention includes methods of cloning an animal by combining a genome from an activated donor cell with an activated enucleated oocyte to thereby obtain a nuclear transfer embryo, and ... | 09/22/2009 |
| 7547818 | Metaphase donor cells for effective nuclear reprogramming in mammals The present invention provides methods of producing a clone non-human mammalian nuclear transfer (NT) embryo and methods for producing a cloned non-human mammal. Embodiments of the methods include introducing doner genetic material into a metaphase I oocyte; introdu... | 06/16/2009 |
| 7531715 | Double nuclear transfer method and results thereof A method is described for the production of an animal (offspring) by the process of nuclear transfer. The animal may be produced using donor genetic material in cells taken directly from any stage of an animal, such as an embryo, foetus or adult or from cell culture... | 05/12/2009 |
| 7446240 | Method for the production of porcine nuclear transfer embryos Methods for the production of nuclear transfer embryos, nuclear transfer embryos and animals derived therefrom are described. The method generally comprises at least the steps of: providing at least one enucleated recipient cell; providing at least one donor cell or... | 11/04/2008 |
| 7432415 | Unactivated oocytes as cytoplast recipients for nonprimate mammalian and pig nuclear transfer A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to th... | 10/07/2008 |
| 7429690 | Transgenic bovines having reduced prion protein production The invention provides cloned transgenic ungulates (e.g., bovines) in which prion protein activity is reduced by one or more genetically engineered mutations. Desirably, these transgenic bovines are also genetically modified to express xenogenous (e.g., human) antib... | 09/30/2008 |
| 7411111 | Method for cloning of the rat by nuclear transfer The invention relates to a method for cloning in the rat by nuclear transfer. The invention further relates to the rats obtained thus, in the foetal or adult state, as well as use thereof for the production of molecules of interest or as study models. ... | 08/12/2008 |
| 7371922 | Nuclear transfer with porcine embryonic stem cells Provided is a method for the production of transgenic animals, especially pigs, by the use of nuclear transfer from genetically modified or other embryonic stem cells to either enucleated oocytes which were matured in vivo or in vitro and activated or to enucleated ... | 05/13/2008 |
| 7361804 | Unactivated oocytes in nuclear transfer to produce ungulates A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to th... | 04/22/2008 |
| 7358416 | Transgenic mouse expressing human FcRn protein Disclosed is a transgenic knockout mouse whose genome comprises a homozygous disruption in its endogenous FcRn gene. The homozygous RcRn disruption prevents the expression of a functional FcRn protein, resulting in a transgenic knockout mouse in which exogenously ad... | 04/15/2008 |
| 7355094 | Methods of ungulate nuclear transfer A method of reconstituting an animal embryo involves transferring the nucleus from a quiescent donor cell into a suitable recipient cell. The donor cell is quiescent, in that it is caused to exit from the growth and division cycle at G1 and to arrest in the G0 state... | 04/08/2008 |
| 7351876 | Efficient nuclear transfer with primordial gametes This invention relates to a method for breeding animals via cloning and the animals obtainable by the method, in particular a method for reproducing animal embryos via efficient nuclear transfer with primordial gametes. ... | 04/01/2008 |
| 7335811 | Method for collecting cells in M phase or Gphase and method for nuclear transplantation using the cells Methods for collecting cells in M phase or G1 phase, by which the percentage of M phase or G1 phase cells is higher than that attained by the conventional methods are disclosed. ... | 02/26/2008 |
| 7332648 | Unactivated oocytes in nuclear transfer to produce cultured inner cell mass cells and ungulates A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to th... | 02/19/2008 |
| 7332647 | Fish produced by nuclear transfer from cultured cells The disclosure provided herein teaches that fertile transgenic fish can be generated by nuclear transfer using cultured cells as embryonic fibroblasts. ... | 02/19/2008 |
| 7329796 | Serial nuclear transfer of ungulate embryos A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to th... | 02/12/2008 |
| 7326824 | Unactivated ungulate oocytes to produce a transgenic ungulate by nuclear transfer A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to th... | 02/05/2008 |
| 7326825 | Methods of ungulate nuclear transfer A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to th... | 02/05/2008 |
| 7323619 | Method for producing transgenic birds and fish The present invention relates to methods for producing transgenic animals, particularly transgenic birds and fish, using retroviral constructs engineered to carry the transgene(s) of interest. ... | 01/29/2008 |
| 7323620 | Activation of equine oocytes A method for activating an equine oocyte comprising exposing oocyte to a medium containing a concentration of calcium of at least about 4 mM. Preferably the oocyte is exposed to this concentration of calcium during activation. ... | 01/29/2008 |
| 7321076 | Unactivated ungulate oocytes to produce a cloned ungulate by nuclear transfer A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to th... | 01/22/2008 |
| 7321075 | Serial nuclear transfer of ungulate embryos A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to th... | 01/22/2008 |
| 7316896 | Egg freezing and storing tool and method An egg freezing and storing instrument has an egg freezing and storing tube made of a liquid nitrogen-resistant material; and a metal cylindrical protection member for protecting the tube. The tube has a body part; and an egg-storing small-diameter part having an in... | 01/08/2008 |
| 7307198 | Ungulates produced by nuclear transfer of G1 cells A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to th... | 12/11/2007 |
| 7304204 | Ungulates produced by nuclear transfer of G1 cells A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to th... | 12/04/2007 |
| 7297837 | Method for generating hypermutable organisms Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more... | 11/20/2007 |
| 7294508 | Isolation of inner cell mass for the establishment of human embryonic stem cell (hESC) lines A method for isolating an inner cell mass comprising the steps of immobilizing a blastocyst stage embryo having a zona pellucida, trophectoderm, and inner cell mass, creating an aperture in the blastocyst stage embryo by laser ablation, and removing the inner cell m... | 11/13/2007 |
| 7291764 | Cloning pigs using non-quiescent differentiated donor cells or nuclei An improved method of nuclear transfer involving the transplantation of donor differentiated pig cell nuclei into enucleated pig oocytes is provided. The resultant nuclear transfer units are useful for multiplication of genotypes and transgenic genotypes by the prod... | 11/06/2007 |
| 7265262 | Telomerizing nuclear donor cells and improving the efficiency on nuclear transfer This disclosure provides a system for creating cloned cells and embryos that are genetically modified. Cells are treated to increase expression of telomerase and potentially extend replicative capacity. One or more genetic modifications is made to inactivate a gene ... | 09/04/2007 |
| 7259291 | Enucleation of avian eggs by gamma irradiation A method of enucleating an egg by exposing the egg to gamma irradiation. The dose of gamma irradiation used is sufficiently high to halt development of the egg or embryo derived therefrom directed by the nucleus of the irradiated egg, but sufficiently low to enable ... | 08/21/2007 |
