Class 800/23 - Via retrovirus

Subclass of Class 800 - Multicellular living organisms and unmodified parts thereof and related processes
Definition: Method wherein the nucleic acid is or is carried by
No. of patents: 33
Last issue date: 02/19/2008

Number	Title	Issue Date
7332333	Host cells containing multiple integrating vectors The present invention relates to the production of proteins in host cells, and more particularly to host cells containing multiple integrated copies of an integrating vector. Suitable integrating vectors for use in the present invention include retrovirus vec...	02/19/2008
7323619	Method for producing transgenic birds and fish The present invention relates to methods for producing transgenic animals, particularly transgenic birds and fish, using retroviral constructs engineered to carry the transgene(s) of interest. ...	01/29/2008
7294755	Genetic modification of male germ cells for generation of transgenic species and genetic therapies Disclosed is an in vivo method of incorporating exogenous genetic material into the genome of a vertebrate, which involves administering to a male vertebrate's testis a gene delivery mixture comprising a viral vector, such as a retroviral vector, to deliver a polynu...	11/13/2007
7282620	Type III allergic inflammation model animal The present invention provides an experimental model animal which does not develop anaphylaxis, a type I allergy, can specifically induce Arthus reaction, a type III allergy, is not affected by type I allergy and evaluates type III allergy inflammation individually,...	10/16/2007
7189553	Modified subtilisins and detergent, compositions containing same The present invention relates to enzymes produced by mutating the genes for a number of subtilisin proteases and expressing the mutated genes in suitable hosts are presented. The enzymes exhibit improved wash performance in comparison to their wild type parent enzym...	03/13/2007
7173010	Orphanin FQ receptor The present invention provides Orphanin FQ receptor nucleic acids and polypeptides and uses thereof. In particular, the present invention provides nucleic acid sequences of differentially expressed splice variants of the Orphanin FQ receptor. The present invention a...	02/06/2007
7169963	Mammals expressing IGF-1 and alpha-lactalbumin in their milk The present invention relates to animals that express exogenous growth factors in their milk, and in particular to pigs that express exogenous IGF-I in their milk. The present invention also relates to methods for increasing piglet weight gain and intestinal lactase...	01/30/2007
7138562	Transgenic animals The present invention provides improved methods and compositions for the generation of transgenic non-human animals. The present invention permits the introduction of exogenous nucleic acid sequences into the genome of unfertilized eggs (e.g., pre-maturation oocytes...	11/21/2006
7094569	Hair follicle growth factor proteins The present invention relates to novel hair follicle growth factor (HFGF) proteins, genes encoding HFGFs, methods for preparing HFGF proteins and therapeutic uses of HFGF proteins. The HFGF proteins of the present invention have a characteristic reduced expression i...	08/22/2006
7045201	Starch-modified aqueous adhesive dip, treated yarns therewith and tire having component of rubber composition containing such treated yarns The invention relates to treatment of yarns for use in reinforcement of rubber products. Such treatment comprises application to the yarn of an aqueous emulsion of polyester and/or epoxy adhesive, or an aqueous alkaline dispersion of rubber latex and resorcinol-form...	05/16/2006
7041870	Transgenic transchromosomal rodents for making human antibodies The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies. ...	05/09/2006
6946266	Gene transfer in chicken bursal stem cells The invention relates to a method of expressing proteins in higher eukaryotes in vitro. In general, the invention sets forth a method of expressing exogenous proteins as fusion partners with the immunoglobulin molecules of avian species specifically chickens. The te...	09/20/2005
6822137	Nucleotide sequence encoding the enzyme I-SCEI and the uses thereof An isolated DNA encoding the enzyme I-SceI is provided. The DNA sequence can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful in gene mapping and site-directed insertion of genes. ...	11/23/2004
6734338	Transfection, storage and transfer of male germ cells for generation of transgenic species and genetic therapies A composition for in vitro and in vivo transfection of vertebrate male germ cells comprises a nucleic acid or transgene, and a gene delivery system, and optionally a protective internalizing agent, such as an endosomal lytic agent, a virus or a viral component, whic...	05/11/2004
6730822	Vectors in avian transgenesis This invention provides vectors and methods for the stable introduction of exogenous nucleic acid sequences into the genome of a bird and for expressing said exogenous sequences to alter the phenotype of the bird or to produce desired proteins. In particular, transg...	05/04/2004
6548740	Methods for creating transgenic animals The present invention provides improved methods and compositions for the generation of transgenic non-human animals. The present invention permits the introduction of exogenous nucleic acid sequences into the genome of unfertilized eggs (e.g., pre-maturat...	04/15/2003
6512161	Transgenic rabbit that expresses a functional human lipoprotein (a) A transgenic rabbit which has in its genomic DNA sequences that encode apolipoprotein (a) and apolipoprotein B polypeptides which are capable of combining to produce lipoprotein (a), a process for creating such a rabbit, and the use of the rabbit to ident...	01/28/2003
6479285	p53 as a regulator of cell differentiation The present invention involves the role of p53 in the differentiation of embryonic tissues. More particularly, the present invention provides methods of the blocking of p53 function in embryonic tissues, and the use of these tissues as screening tools for...	11/12/2002
6395961	Gene transfer in chickens by introduction of DNA into muscle in ovo A method of altering the phenotype of a bird comprises introducing a DNA molecule into the muscle tissue of a bird contained within an egg during in ovo incubation. The DNA molecule is selected to be effective to cause a change in phenotype, such as an in...	05/28/2002
6291740	Transgenic animals The present invention provides improved methods and compositions for the generation of transgenic non-human animals. The present invention permits the introduction of exogenous nucleic acid sequences into the genome of unfertilized eggs (e.g., pre-maturat...	09/18/2001
6287863	Method of transferring a DNA sequence to a cell in vitro Improved recombinant retrotransposon vectors for gene transfer are disclosed. The synthetic vectors are truncated so as to reduce or altogether eliminate homologous recombination with retroviral helper sequences found in helper cells used to propagate the...	09/11/2001
6100444	Prostate specific regulatory nucleic acid sequences and transgenic non-human animals expressing prostate specific antigen The non-coding regulatory sequences of the prostate specific antigen (PSA) are described. Non-human transgenic animals are also provided which express human PSA, which is non-naturally occurring in non-human animals....	08/08/2000
6080912	Methods for creating transgenic animals The present invention provides improved methods and compositions for the generation of transgenic non-human animals. The present invention permits the introduction of exogenous nucleic acid sequences into the genome of unfertilized eggs (e.g., pre-maturat...	06/27/2000
6028244	Defective platelet activation in G଱_q deficient mice The invention provides a nonhuman transgenic animal having a transgene disrupting or interfering with expression of G଱q chromosomally integrated into the germ cells of the animal. Cells and cell lines derived from these nonhuman transgeni...	02/22/2000
6025540	Transgenic non-human mammals producing EC-SOD protein in their milk The present invention relates to a transgenic non-human mammal comprising a DNA sequence encoding human extracellular superoxide dismutase (human EC-SOD) or a variant thereof which is expressed in the milk. Transgenic mice containing a chimeric whey acidi...	02/15/2000
5969211	Pantropic retroviral vectors for gene transfer in mollusks A method for introducing foreign nucleic acid sequences into marine mollusks. A pantropic retroviral vector containing a foreign gene sequence is introduced into fertilized mollusk embryos by electroporation. The gene sequence becomes integrated into the ...	10/19/1999
5907080	Method for development of transgenic dwarf goats The invention features a method which includes the following steps: (a) introducing a transgene into a zygote of a dwarf goat, (b) transplanting the zygote into a pseudopregnant non-dwarf goat, and (c) allowing the zygote to develop to term. In another as...	05/25/1999
5530179	Transgenic immunodeficient animal models The invention features a transgenic mouse having a substantial deficiency in functionally active natural killer cells and T lymphocytes which is useful as a model system for immune diseases, tumorigenesis and transplant rejection....	06/25/1996
5434340	Transgenic mice depleted in mature T-cells and methods for making transgenic mice Transgenic mice having a phenotype characterized by the substantial absence of mature T lymphocytes otherwise naturally occurring in said mice. The phenotype is conferred in the transgenic mouse by a transgene contained in at least the precursor stem cell...	07/18/1995
5175384	Transgenic mice depleted in mature T-cells and methods for making transgenic mice Transgenic mice having a phenotype characterized by the substantial absence of mature T lymphocytes otherwise naturally occurring in said mice. The phenotype is conferred in the transgenic mouse by a transgene contained in at least the precursor stem cell...	12/29/1992
5162215	Method of gene transfer into chickens and other avian species A method for introducing a replication-defective retroviral vector into pluripotent stem cells of embryos of an avian species, including chickens, turkeys, quails or ducks. The method is useful for transferring nucleic acid sequences into embryonic avian ...	11/10/1992
5032407	Gene transfer using transformed, neodetermined, embryonic cells This invention is directed to a method for the preparation of carrier cells capable of delivering exogenous genetic material to a particular tissue of the body by means of embryonic cells competent to develop into that tissue, and essentially only that ti...	07/16/1991
4997763	Vectors for gene insertion into avian germ line A stable, substantially nononcogenic vector having a cloning site for the convenient insertion of a gene of interest has been constructed by recombinant technology from an avian retrovirus. The construct is derived from Rous sarcoma virus and the cloning ...	03/05/1991

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Class 800/23 - Via retrovirus