Quotables
"The production of too many useful things results in too many useless people."
Karl Marx
PatentStorm News
Make the Most of PatentStorm
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest patents by subscribing to an RSS feed.
Got questions? Ask a Patent Expert!
Registered users: Manage your profile, comments and alerts.
| Number | Title | Issue Date |
| 7541513 | Mouse λ light chain locus The present invention provides in a first aspect a mouse in which the λ(lambda) light chain locus has been functionally silenced. In one embodiment, the mouse λ light chain locus was functional silenced by deletion of gene segments coding for the λ light chain lo... | 06/02/2009 |
| 7405342 | Transgenic mice expressing heterologous complement receptor type 1 (CR1) molecules on erythrocytes and uses therefor The present invention is directed, at least in part, to mice which express exogenous complement receptor type 1 (CR1) on red blood cells. The invention also pertains to genetic constructs encoding heterologous CR1 for expression on red blood cells. Methods of using ... | 07/29/2008 |
| 7399901 | Mutated gene coding for a lat protein and the biological applications thereof The present invention relates to a mutated gene coding for a mutant LAT protein leading to exaggerated TH2 differentiation. The invention relates to biological structures containing the mutant, particularly non-human LAT gene, mutated animals, plasmids, c... | 07/15/2008 |
| 7358416 | Transgenic mouse expressing human FcRn protein Disclosed is a transgenic knockout mouse whose genome comprises a homozygous disruption in its endogenous FcRn gene. The homozygous RcRn disruption prevents the expression of a functional FcRn protein, resulting in a transgenic knockout mouse in which exogenously ad... | 04/15/2008 |
| 7309812 | Perlecan transgenic animals and methods of identifying compounds for the treatment of amyloidoses The invention provides a transgenic non-human animal expressing a perlecan encoding transgene. Also provided is a double-transgenic non-human animal expressing a perlecan and an amyloid encoding transgene. A method of screening for a compound which alters the rate o... | 12/18/2007 |
| 7294755 | Genetic modification of male germ cells for generation of transgenic species and genetic therapies Disclosed is an in vivo method of incorporating exogenous genetic material into the genome of a vertebrate, which involves administering to a male vertebrate's testis a gene delivery mixture comprising a viral vector, such as a retroviral vector, to deliver a polynu... | 11/13/2007 |
| 7285699 | Ends-out gene targeting method A gene targeting method for use in a host organism whereby the host organism is transfected with an ends-out donor construct. Further transfecting the host organism with two transgenes expressing endonuclease and recombinase enzymes. The endonuclease and recombinase... | 10/23/2007 |
| 7271313 | Presenilin-deficient mouse model of age-dependent neurodegeneration and cognitive loss The present invention is directed to recombinantly engineered mice that are deficient in the expression of both presenilin-1 and presenilin-2. The mice exhibit characteristics of age-dependent cognitive impairments and neurodegeneration similar to those seen in Alzh... | 09/18/2007 |
| 7247766 | Double transgenic mice overexressing human beta secretase and human APP-London The present invention relates to a novel animal model for amyloidopathies, especially Alzheimer' disease overexpressing human BACE and human APP London. This novel animal model exhibits several aspects of amyloidopathy. The present invention also relates to a method... | 07/24/2007 |
| 7193126 | Method for generating overexpression of alleles in genes of unknown function Methods for generating and using novel overexpression activity alleles of a gene in any organism, especially Drosophilia, are provided. Such alleles may be utilized in screening assays, and used to generate dominant-negative forms of bacterial toxins. ... | 03/20/2007 |
| 7166763 | Mouse model of myxomatous valvular disease An animal selected for lacking heparan sulfate 3-O-sulfotransferase-1 activity is provided. This animal exhibits characteristics associated with myxomatous valvular disease and is useful for identifying agents which prevent, delay or treat myxomatous valvular diseas... | 01/23/2007 |
| 7145055 | Method of producing a mouse suitable for the engraftment, differentiation and proliferation of heterologous cells, mouse produced by this method and use of the mouse The present invention provides an immunodeficient mouse (NOG mouse) suitable for engraftment, differentiation and proliferation of heterologous cells, and a method of producing such a mouse. This mouse is obtained by backcrossing a C.B-17-scid mouse with an NOD/Shi ... | 12/05/2006 |
| 7094949 | Breeding and milking cows for milk free of β-casein A A milk or other dairy product, capable of minimizing the onset of disease such as coronary heart disease or enhancing the immune response is derived from animals which are substantially free of the β-casein A1 allele. Bulk milk can be produced by testing... | 08/22/2006 |
| 7087808 | Method for expressing multiple recombinant proteins in milk of transgenic non-human mammals The present invention discloses a method for expressing multiple recombinant proteins in transgenic non-human mammalian milk, characterized in which human clotting factor IX gene and porcine lactoferrin gene are transferred into the mammal by gene injection and embr... | 08/08/2006 |
| 7081561 | Gene-targeted animal model of apolipoprotein E4 domain interaction and uses thereof The invention provides gene-targeted non-human animals comprising a genetically modified apoE gene encodes a recombinant apoE polypeptide displaying domain interaction. The invention further provides cells isolated from the gene-targeted animals, which cells produce... | 07/25/2006 |
| 7041870 | Transgenic transchromosomal rodents for making human antibodies The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies. ... | 05/09/2006 |
| 7026525 | Vector for gene trap, and a method for gene trapping by using the vector The present application provides a vector for trapping an unknown gene of Drosophila melanogaster, which is a recombinant plasmid comprising the following nucleotide sequences in this order: an artificial consensus splicing acceptor site; a synthetic “stop/... | 04/11/2006 |
| 6998514 | Murine expression of a human IgA lambda locus In humans, approximately 60% of expressed immunoglobulin light chains are of the Kappa type and 40% of the Lambda type. In mice, there is almost no expression from the Lambda locus and over 95% of light chains are of Kappa type. The present invention discloses, amon... | 02/14/2006 |
| 6995298 | Transgenic mammals expressing mutant GP IIIa The present invention relates to mammals into which foreign DNA has been introduced or in which various modifications or substitutions have been made to an integrin β subunit, thereby generating transgenic or genetically-engineered non-human mammals. In particular,... | 02/07/2006 |
| 6965022 | Methods to identify swine genetically resistant to F18 E. coli associated diseases The present invention provides non-invasive methods and compositions to differentiate, with a high level of sensitivity and specificity, swine that are genetically susceptible to diseases associated with F18 E. coli infection, from resistant swine. DNA polymo... | 11/15/2005 |
| 6949692 | Method for identifying mutants and molecules Methods for breeding mutagenized mice permit detection of genetic loci that in heterozygous mutated form can modify a known index phenotype involves crossing a mutagenized founder strain and a second strain of mice carrying an allele at a locus that confers the inde... | 09/27/2005 |
| 6943025 | Method for identifying genes involved in cell proliferation The present invention provides fish system as a powerful forward genetic tool to directly identify a number of novel genes involved in cell proliferation in vertebrates without the time consuming and costly maintenance of animals. The invention provides a tool to id... | 09/13/2005 |
| 6933422 | Nav2 channel gene-deficient mice An object of the present invention is to provide a null mutant non-human animal showing salt intake behavior similar to that of wild-type animals under water-sufficient conditions and showing much more intakes of hypertonic saline compared with wild-type animals und... | 08/23/2005 |
| 6927318 | WIP, a WASP-associated protein Described herein is a novel gene and its product, WIP, which associates with WASP. The subject invention relates to the isolated WIP gene or cDNA and transgenic mammals that have the WIP gene disrupted in their genome. Also the subject of this invention are methods ... | 08/09/2005 |
| 6852906 | Assay for measuring enzyme activity in vivo A method is provided for measuring in vivo in a transgenic non-human multicellular organism the activity of a cellular enzyme, which organism is transgenic by virtue of comprising one or more nucleic acid constructs encoding a binding domain and a binding partner th... | 02/08/2005 |
| 6835867 | Allelic series of genomic modifications in cells The present invention relates to methods of producing an allelic series of modifications in genes of interest in a cell. In particular, the invention provides methods for using nucleic acid sequence-modifying agents (e.g., chemicals, electromagnetic radiation, etc.)... | 12/28/2004 |
| 6791006 | LKB1 gene knockout mice A mammal is provided, in which the LKB1 gene can be deleted phase-specifically and tissue-specifically. These mammals are highly useful as tools to reveal the onset mechanism for diseases caused by LKB1 gene deficiency, such as Peutz-Jeghers syndrome and cancers, as... | 09/14/2004 |
| 6762038 | Mutant cell lines and methods for producing enhanced levels of recombinant proteins Mammalian somatic cells having a homozygous disruption in the gene which encodes the endonbonuclease RNase L and a homyzgous disruption in the gene which encodes the double-stranded RNA dependent kinase PKR are provided. Methods for producing enhanced levels of reco... | 07/13/2004 |
| 6762342 | Transgenic mice containing intestinal alkaline phosphatase gene disruptions The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in an intestinal alkaline phosphatase gene. ... | 07/13/2004 |
| 6740794 | Methods of isolating the androgenic sex hormone from crustacean prawn and marine shrimp and methods of use This work constitutes a novel approach and methodology, e.g., the in vitro secretion method to isolate the androgenic polypeptide hormone (AH) from the androgenic gland of shrimp or prawns. Alternatively, the AH can be obtained recombinantly by cloning and expressin... | 05/25/2004 |
| 6720472 | HMGI proteins in cancer and obesity The present invention relates to HMGI genes and proteins and methods of using the same. Embodiments of the invention pertain to methods for treating obesity, methods for treating a tumor, methods for producing a transgenic non-human mammal, methods for screening can... | 04/13/2004 |
| 6677501 | P2X7 receptor-deficient mice and uses thereof The invention provides non-human, genetically-modified mammals and genetically modified animals cells having a functionally disrupted P2×7 receptor gene. Also provided are methods for producing genetically modified mice in which one or both P | 01/13/2004 |
| 6664443 | Pathogenic Tau mutations in transgenic mice Isolated nucleic acid molecules that include a tau gene sequence are described. The tau gene sequences have a mutation linked to a Tau pathology. Transgenic non-human mammals that develop a Tau pathology also are described.... | 12/16/2003 |
| 6653113 | High efficiency gene targeting in mouse embryonic stem cells The present invention provides novel methods for modifying the genome of an animal cell which typically comprise the steps of: constructing a DNA molecule in which desired sequence modifications are contained in a segment of DNA (a "targeting DNA") that i... | 11/25/2003 |
| 6642433 | Fgl-2 knockout mice A knockout mouse in which the Fgl-2 gene has been suppressed is described. The mouse is useful in studying the role of Fgl-2 in normal and disease states including viral hepatitis, allograph rejection, fetal loss, inflammatory bowel disease, lupus glomeru... | 11/04/2003 |
| 6617491 | Use of drosophila melanogaster as a model for screening psychostimulant plant materials The invention provides a method for screening of plant materials as CNS stimulant/depressant using Drosophila melanogaster as a model.... | 09/09/2003 |
| 6613957 | Synthesis of functional human hemoglobin and other proteins in erythroid tissues of transgenic non-human mammals The present invention relates to the synthesis of functional human hemoglobin and other proteins in erythroid tissues of transgenic non-human animals and erythroid cell lines. It is based on the discovery that two of the five hypersensitivity sites of the... | 09/02/2003 |
| 6605753 | Protein tyrosine phosphate-1B (PTP-1B) deficient mice and uses thereof The present invention provides mice that have had their PTP-1B genes disrupted by targeted homologous recombination. The mice have no detectable PTP-1B protein, yet appear to be physiologically normal. However, in the fed state on a normal diet, the mice ... | 08/12/2003 |
| 6603058 | Non-human animal model for obesity and uses thereof Described is a genetically modified non-human animal model for studying the peripheral and central pathways of energy homeostasis. Also disclosed are methods of identifying compounds for regulating such pathways and a Pomc mutant mouse.... | 08/05/2003 |
| 6593512 | Transgenic mouse expressing human tau gene A bigenic mouse is provided whose germ cells and somatic cells contain (i) inactive mouse TAU genes, and/or (ii) a transgene encoding the human TAU gene, with the transgene including all regulatory elements of the human TAU gene necessary for neuronal exp... | 07/15/2003 |