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| Number | Title | Issue Date |
| 8373018 | Process for generating transgenic animals using recombinant lentiviruses A process for generating transgenic animals using recombinant lentiviruses. The process comprises injecting recombinant lentiviruses into the interstituim of the testis of a male to produce mature spermatozoa within a few days. The male with transgene expressing len... | 02/12/2013 |
| 8354568 | Suppression of B-cell apoptosis in transgenic animals expressing humanized immunoglobulin The invention provides a novel approach to increase immunoglobulin expression in non-human transgenic animals. For instance, the invention provides a method to increase humanized immunoglobulin production in animals genetically engineered to express one or several h... | 01/15/2013 |
| 8283518 | Administration of transposon-based vectors to reproductive organs Methods and compositions for the administration of transposon-based vectors to the reproductive organs of animals and the creation of transgenic animals. Preferred methods involve administration of the transposon-based vectors to the lumen of the oviduct of an avian... | 10/09/2012 |
| 7893315 | Derivation of embryonic stem cells and embryo-derived cells This present invention provides novel methods for deriving embryonic stem cells and embryo-derived cells from an embryo without requiring destruction of the embryo. The invention further provides cells and cell lines derived without embryo destruction, and the use o... | 02/22/2011 |
| 7838727 | Derivation of embryonic stem cells This present invention provides novel methods for deriving embryonic stem cells, those cells and cell lines, and the use of the cells for therapeutic and research purposes without the destruction of the embryo. It also relates to novel methods of establishing and st... | 11/23/2010 |
| 7718847 | Method of gene introduction in in-vivo spermatogenic cell The present invention provides a method of producing a non-human vertebrate that harbours germ cells having a desired gene transferred thereto, comprising injecting the desired gene to the testis of a non-human vertebrate wherein no tight junction exists between Ser... | 05/18/2010 |
| 7709696 | Transgenic mice generated by transposition and uses thereof A method of inducing transposition in a transgenic embryo, sperm and egg is described, comprising the steps of (a) generating a first adult transgenic organism comprising within its genome one or more copies of a transposon; (b) generating a second adult transgenic ... | 05/04/2010 |
| 7667091 | Method of encoding information in nucleic acids of a genetically engineered organism The present invention provides a method of producing a genetically engineered transgenic organism, by (a) incorporating into the organism a functional DNA sequence that confers a trait on an organism and (b) incorporating into the organism a non-functional DNA seque... | 02/23/2010 |
| 7659442 | Method for making homozygous genetic modifications Methods of generating modified embryos and mammals by introduction of donor cells into an early stage embryo are provided, such that the resulting embryo and animal generated therefrom has a significant contribution to all tissues from the donor cells and is capable... | 02/09/2010 |
| 7652191 | Nonhuman mammals exhibiting PTSD-like behavior The invention relates to production of maladapted animals characterized by PTSD like behavior from a population by behavioral conditioning. The method includes determining a baseline behavioral level for individual under defined conditions; exposing each individual ... | 01/26/2010 |
| 7642402 | Human photoaged skin model The invention provides a human photoaged skin model and an animal model which are useful for evaluating cosmetics and similar products in terms of their anti-aging or rejuvenating effect, as well as a method for producing such a skin model and such an animal model. ... | 01/05/2010 |
| 7638679 | Tolerance and chronic hepatitis C virus This invention provides a model for the induction of immunological tolerance to antigens. The tolerance model of the invention can be used for screening candidate drugs effective in modulating tolerance. The invention also provides the use of such tolerance-modulati... | 12/29/2009 |
| 7576259 | Method for making genetic modifications Methods of generating modified embryos and mammals by introduction of donor cells into an early stage embryo are provided, such that the resulting embryo and animal generated therefrom has a significant contribution to all tissues from the donor cells and is capable... | 08/18/2009 |
| 7554004 | Allelic series of genomic modifications in cells The present invention relates to methods of producing an allelic series of modifications in genes of interest in a cell. In particular, the invention provides methods for using nucleic acid sequence-modifying agents (e.g., chemicals, electromagnetic radiation, etc.)... | 06/30/2009 |
| 7550650 | Production of a transgenic avian by cytoplasmic injection This invention provides methods for the stable introduction of heterologous coding sequences into the genome of a bird and expressing the coding sequences to produce desired proteins or to alter the phenotype of the bird. The present invention provides preferred met... | 06/23/2009 |
| 7518033 | Methods for the production of cells and mammals with desired genetic modifications The present invention features novel methods for generating cell lines and mammals with site-specific genetic modifications of interest. The methods involve homologous recombination between an artificial chromosome having a modification of interest and an endogenous... | 04/14/2009 |
| 7416886 | Porcine uroplakin II promoter and the production method of useful proteins using said promoter The present invention relates to a porcine uroplakin II gene promoter, an expression vector containing the promoter, and a method for producing useful proteins using the vector. The promoter of the present invention promotes the bladder-specific expression of a targ... | 08/26/2008 |
| 7402728 | Transgenic mice expressing human CD20 and/or CD16 The present invention generally relates to non-human transgenic animals expressing human cellular markers, including CD20 and/or preferably CD16. ... | 07/22/2008 |
| 7402730 | Knockout animals manifesting hyperlipidemia Genetically engineered cells and animals are described that incorporate a mutated GHP1 allele. Animals that are homozygous for the mutated GHP1 allele are useful for the production of monoclonal antibodies against GHP1. ... | 07/22/2008 |
| 7399900 | Nematodes as model organisms for the investigation of neurodegenerative diseases, in particular parkinsons disease, uses and methods for the discovery of substances and genes which can used in the treatment of the above disease states and identification of anematode gene The invention relates to nematodes as model organisms for the investigation of neurodegenerative diseases in particular. Parkinsons disease, uses and methods for the discovery of substances and genes which can be used in the treatment of the above disease states and... | 07/15/2008 |
| 7399901 | Mutated gene coding for a lat protein and the biological applications thereof The present invention relates to a mutated gene coding for a mutant LAT protein leading to exaggerated TH2 differentiation. The invention relates to biological structures containing the mutant, particularly non-human LAT gene, mutated animals, plasmids, c... | 07/15/2008 |
| 7381712 | In vivo transfection in avians The present invention provides for methods of producing transgenic avians which may include delivering a heterologous nucleic acid to oviduct tissue of an avian wherein the nucleic acid enters a cell of the oviduct tissue and is expressed. ... | 06/03/2008 |
| 7375258 | Transgenic avians with an ovomucoid gene expression control region linked to a nucleotide sequence encoding a heterologous polypeptide The present invention provides novel isolated nucleic acids that comprise an avian nucleic acid sequence comprising a ovomucoid gene expression control region. The ovomucoid promoter region of the present invention will allow expression of an operably linked heterol... | 05/20/2008 |
| 7371920 | Transgenic mouse model of neurodegenerative disorders The present invention provides a transgenic animal model of Alzheimer's Disease designated TgCRND8 as well as a method for making such model, which allows for the characterization of the etiology of the disease as well as for provide a system for the development and... | 05/13/2008 |
| 7358416 | Transgenic mouse expressing human FcRn protein Disclosed is a transgenic knockout mouse whose genome comprises a homozygous disruption in its endogenous FcRn gene. The homozygous RcRn disruption prevents the expression of a functional FcRn protein, resulting in a transgenic knockout mouse in which exogenously ad... | 04/15/2008 |
| 7355092 | Genetic vaccines for the production of chicken egg-yolk antibodies against enterotoxigenic and other pathogens Genetic vaccine which comprises plasmid(s) containing genes coding for antigens of enterotoxigenic Escherichia coli (ETEC) strains is disclosed. Additionally, plasmids may consist of multiple copies of the same antigen (i.e. K88 or K99 fimbrial antigen) or mu... | 04/08/2008 |
| 7351876 | Efficient nuclear transfer with primordial gametes This invention relates to a method for breeding animals via cloning and the animals obtainable by the method, in particular a method for reproducing animal embryos via efficient nuclear transfer with primordial gametes. ... | 04/01/2008 |
| 7351875 | FcγRIIa transgenic animal model for autoimmune disease The present invention provides a FcγRIIa transgenic non-human animal model for autoimmune disease, particularly arthritis. This invention also provides a method of using this model to screen compounds that can reduce aberrant immune activity including aberrant immu... | 04/01/2008 |
| 7339090 | Microinjection devices and methods of use The present invention provides for microinjection devices comprising a needle and a viewing instrument wherein the viewing instrument provides magnified viewing of an object to an operator from an angle other than a right angle to the object. ... | 03/04/2008 |
| 7335811 | Method for collecting cells in M phase or Gphase and method for nuclear transplantation using the cells Methods for collecting cells in M phase or G1 phase, by which the percentage of M phase or G1 phase cells is higher than that attained by the conventional methods are disclosed. ... | 02/26/2008 |
| 7332646 | Transgenic animal model for degenerative diseases of cartilage The present invention provides animal model systems for cartilage-degenerative disease, which comprise transgenic animals which can express recombinant matrix-degrading enzymes (MDEs), particularly matrix metalloproteinases (MMPs), in a temporally and spatially regu... | 02/19/2008 |
| 7323618 | Tissue specific expression of exogenous proteins in transgenic chickens Transgenes encoding exogenous proteins are stably integrated into embryonic stem cells and are present in the somatic tissue of transgenic or chimeric birds. The transgenes encode exogenous proteins and are expressed in any of endodermal, ectodermal, mesodermal, or ... | 01/29/2008 |
| 7314968 | Transgenic fish and β-catenin signaling pathway model The present invention is directed a Lef1/β-catenin-dependent reporter and to transgenic fish containing this reporter. The present invention is also directed to the use of the reporter and the transgenic fish as a model for the β-catenin signaling pathway. The mod... | 01/01/2008 |
| 7312374 | Production of a transgenic avian by cytoplasmic injection This invention provides methods for the stable introduction of heterologous coding sequences into the genome of a bird and expressing the coding sequences to produce desired proteins or to alter the phenotype of the bird. The present invention provides preferred met... | 12/25/2007 |
| 7309812 | Perlecan transgenic animals and methods of identifying compounds for the treatment of amyloidoses The invention provides a transgenic non-human animal expressing a perlecan encoding transgene. Also provided is a double-transgenic non-human animal expressing a perlecan and an amyloid encoding transgene. A method of screening for a compound which alters the rate o... | 12/18/2007 |
| 7304757 | System and method for secure printing The present disclosure relates to a system and method for secure printing. In one arrangement, the system and method pertain to receiving a document to be printed, determining that the document cannot be printed in its present form, transmitting the document to a co... | 12/04/2007 |
| 7301068 | Nonhuman model animal of Th2-mediated hyperimmune response An object of the present invention is to provide a nonhuman model animal of Th2-mediated hyperimmune response lacking PIR-B gene function on its chromosome by which the Th2-mediated immune response mechanism and allergy onset mechanism in vivo can be analyzed and wh... | 11/27/2007 |
| 7297836 | Methods of detecting neurological disorders The present invention provides methods of detecting an amyloid peptide-related neurological disorder in an individual; and methods for staging an amyloid peptide-related neurological disorder in an individual. The methods involve detecting a level of a calcium-respo... | 11/20/2007 |
| 7294753 | Method for preparing anti-MIF antibodies The specification provides methods of preparing high-affinity antibodies to a macrophage migration inhibitory factor (MIF) in animals in which the MIF gene has been homozygously knocked-out (MIF−/−). Also provided are methods of preparing hybridomas w... | 11/13/2007 |
| 7294754 | Method for generating an animal homozygous for a genetic modification Methods of generating modified embryos and mammals by introduction of donor cells into an early stage embryo are provided, such that the resulting embryo and animal generated therefrom has a significant or complete contribution to all tissues from the donor cells an... | 11/13/2007 |
