Class 800/20 - Fish

Subclass of Class 800 - Multicellular living organisms and unmodified parts thereof and related processes
Definition: Subject matter wherein the transgenic nonhuman animal
No. of patents: 38
Last issue date: 05/31/2011

Number	Title	Issue Date
7951989	Methods of screening agents for activity using teleosts The present invention provides methods of screening an agent for activity using teleosts. Methods of screening an agent for angiogenesis activity, toxic activity and an effect cell death activity in teleosts are provided. Methods of screening an agent for an activit...	05/31/2011
7834239	Sale of transgenic fish that express gene encoding fluorescent protein Four zebrafish gene promoters, which are skin specific, muscle specific, skeletal muscle specific and ubiquitously expressed respectively, were isolated and ligated to the 5′ end of the EGFP gene. When the resulting chimeric gene constructs were introduced into ze...	11/16/2010
7700825	Recombinant constructs and transgenic fluorescent ornamental fish therefrom The present invention relates to the method and use of reef coral fluorescent proteins in making transgenic red, green and yellow fluorescent zebrafish. Preferably, such fluorescent zebrafish are fertile and used to establish a population of transgenic zebrafish and...	04/20/2010
7687682	Methods of screening agents for activity using teleosts The present invention provides methods of screening an agent for activity using teleosts. Methods of screening an agent for angiogenesis activity, toxic activity and an effect cell death activity in teleosts are provided. The invention further provides high throughp...	03/30/2010
7671251	In vivo assay for neurite outgrowth in zebrafish and its application in drug screening A genetically modified zebrafish embryo, comprising a HBNF cDNA or a NGF cDNA or a GDNF cDNA together with a cDNA encoding green fluorescent protein (GFP) so as to induce neurite outgrowth during said zebrafish embryonic development, and a method of using such genet...	03/02/2010
7525011	Transgenic cancer models in fish The present invention provides transgenic fish whose genome has stably-integrated therein an oncogene operably linked to a promoter. Methods of making the transgenic fish and methods for their use are also provided. In one embodiment, the transgenic fish may advanta...	04/28/2009
7514595	Targeted and regional cellular ablation in zebrafish A system including: (i) a methodology for targeted cellular ablation in zebrafish; (ii) a methodology for regional cellular ablation in zebrafish. These methodologies are used to identify genetic components that regulate cellular regeneration and to identify drug co...	04/07/2009
7435870	Methods of screening agents for activity using teleosts The present invention provides methods of screening an agent for activity using teleosts. Methods of screening an agent for angiogenesis activity, toxic activity and an effect cell death activity in teleosts are provided. ...	10/14/2008
7427677	Expression of zebrafish bone morphogenetic protein 4 Embodiments of the invention generally provide isolated DNA molecules, tissue-specific expression sequences, and promoter and regulatory DNA sequences involved in the regulation of bone morphogenetic protein 4 (BMP4). More specifically, the invention relates to regu...	09/23/2008
7408095	Methods for introducing heterologous cells into fish to determine if the heterologous cells contain cancer cells or a pathogen Methods of introducing heterologous cells into fish are provided. After introduction cells remain viable, and in some instances proliferate, for sufficient time to conduct a variety of analyses on the heterologous cells or the fish or both. Such methods are also use...	08/05/2008
7365177	Recombinant plasmid expressing two fluorescence genes Recombinant plasmids comprising (a) a ubiquitous promoter, (b) one fluorescent gene, the gene being operably liked to and inserted downstream of the ubiquitous promoter, (c) a skin-specific or muscle-specific promoter, and (d) another fluorescent gene, the gene bein...	04/29/2008
7355095	Method for producing heart-specific fluorescence of non-human eukaryotic animals A method of expressing in vivo heart-specific fluorescence in transgenic line of zebrafish is developed, which provides a research model for studying heart-related gene functions and performing gene therapies in the future. The method comprises the following steps. ...	04/08/2008
7332647	Fish produced by nuclear transfer from cultured cells The disclosure provided herein teaches that fertile transgenic fish can be generated by nuclear transfer using cultured cells as embryonic fibroblasts. ...	02/19/2008
7314968	Transgenic fish and β-catenin signaling pathway model The present invention is directed a Lef1/β-catenin-dependent reporter and to transgenic fish containing this reporter. The present invention is also directed to the use of the reporter and the transgenic fish as a model for the β-catenin signaling pathway. The mod...	01/01/2008
7230156	Method for preparing a sterile transgenic carp The present application disclosed a method for preparing a sterile transgenic fish, comprising constructing antisense RNA expression vector of salmon-type gonadotropin-releasing hormone, introducing the recombinant DNA fragment into carp oosperm by microinjection, a...	06/12/2007
7194978	Inducing sterility in fish by disrupting the development of the GnRH system The present invention provides for a method for inducing sterility in fish by administering at least one compound that disrupts the establishment of the gonadotropin-releasing hormone system during early development thereby inhibiting sexual maturity in the treated ...	03/27/2007
7183079	Compositions and methods for enhancing disease resistance in fish Compositions and methods for conferring enhanced disease resistance in a fish are provided. Compositions include novel recombinant constructs that induce transgenic expression of anti-pathogenic polypeptides, including cecropin proteins or biologically active varian...	02/27/2007
7135613	Chimeric gene constructs for generation of fluorescent transgenic ornamental fish Four zebrafish gene promoters, which are skin specific, muscle specific, skeletal muscle specific and ubiquitously expressed, respectively, were isolated and ligated to the 5′ end of the EGFP gene. When the resulting chimeric gene constructs were introduced into z...	11/14/2006
7041870	Transgenic transchromosomal rodents for making human antibodies The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies. ...	05/09/2006
7041276	Methods of screening agents for activity using teleosts The present invention provides methods of screening an agent for activity using teleosts. Methods of screening an agent for angiogenesis activity, toxic activity and an effect cell death activity in teleosts are provided. ...	05/09/2006
6959663	Rearing of aquatic species with DHA-rich prey organisms A method of rearing aquatic species is provided, comprising feeding the aquatic species during at least part of the larval and/or post-larval state with prey organisms, such as Artemia or rotifers, having in their total lipid content a DHA content of at least...	11/01/2005
6953875	Transgenic zebra fish embryo model for hematopoiesis and lymphoproliferative disorders A transgenic zebrafish animal model is disclosed. The model can be used for study of hematopoetic cell differentiation, control, and screening of therapeutic agents and can include a transgenic zebrafish expressing a heterologous Ikaros protein. ...	10/11/2005
6951739	Polyvalent cation-sensing receptor in atlantic salmon The present invention encompasses three full length nucleic acid and amino acid sequences for PolyValent Cation-Sensing Receptors (PVCR) in Atlantic Salmon. These PVCR have been named SalmoKCaR#1, SalmoKCaR#2, and SalmoKCaR#3. The present invention includes homologs...	10/04/2005
6943025	Method for identifying genes involved in cell proliferation The present invention provides fish system as a powerful forward genetic tool to directly identify a number of novel genes involved in cell proliferation in vertebrates without the time consuming and costly maintenance of animals. The invention provides a tool to id...	09/13/2005
6867349	Inhibition of gene expression using polynucleotide analogues The invention provides sequence specific polynucleotide analogues and methods for determining the function of a nucleic acid of known sequence. ...	03/15/2005
6835867	Allelic series of genomic modifications in cells The present invention relates to methods of producing an allelic series of modifications in genes of interest in a cell. In particular, the invention provides methods for using nucleic acid sequence-modifying agents (e.g., chemicals, electromagnetic radiation, etc.)...	12/28/2004
6759568	High estrogen-sensitive medaka fish (1) Transgenic medaka fish into which a polynucleotide having the nucleotide sequence from 211 to 1935 position represented by Sequence ID No: 1 is introduced, (2) A method of producing medaka fish having one or more thrombi, comprising the step of raising the trans...	07/06/2004
6737559	See-through medaka This invention relates to a see-through medaka deficient in iridophores, melanophores, xanthophores and leucophores; a see-through medaka deficient in iridophores, melanophores and xanthophores, and whose sex can be identified by the presence or absence of leucophor...	05/18/2004
6476290	Transgenic tilapia comprising a humanized insulin gene In accordance with the present invention, there are provided humanized fish insulin genes. Humanized insulin the present invention encode human insulin alpha and/or beta chains while using fish-preferred codons and regulatory sequences. These humanized ge...	11/05/2002
6472583	Plasmid-based mutation detection system in transgenic fish The present invention provides transgenic fish whose somatic and germ cells contain a genomically integrated plasmid containing a heterologous mutation target nucleic acid sequence that is detectable via bioassay in a bacterial cell into which the target ...	10/29/2002
6380458	Cell-lineage specific expression in transgenic zebrafish Disclosed are transgenic fish, and a method of making transgenic fish, which express transgenes in stable and predictable tissue- or developmentally-specific patterns. The transgenic fish contain transgene constructs with homologous expression sequences. ...	04/30/2002
6372959	Expression vector of a mud loach growth hormone gene Disclosed herein are an expression vector of mud loach growth hormone gene and a fast-growing transgenic mud loach transformed with the expression vector. Also disclosed herein is an expression vector containing ଲ-actin gene regulation site of mud l...	04/16/2002
6307121	Bacteriophage-based transgenic fish for mutation detection The present invention provides transgenic fish whose somatic and germ cells contain a genomically integrated bacteriophage lambda-derived transgene construct. The transgene construct can include an excisable test nucleic acid sequence containing a heterol...	10/23/2001
6015713	Transgenic fish and a method of harvesting islet cells therefrom This invention relates to transgenic fish containing a humanized insulin gene which has been altered to secrete human insulin and its use in the treatment of diabetes. In the transgenic fish of the present invention, the fish insulin gene has been modifie...	01/18/2000
5998697	Transgenic fish and vectors therefor Sockeye salmon growth hormone genes Types 1 and 2, and sockeye histone and metallothionein gene promoters have been isolated and sequenced. Terminator sequences for the growth hormone gene have been found. Vectors containing these promoter and terminator ...	12/07/1999
5998698	Transgenic fish capable of expressing exogenous lytic peptides Novel means have been discovered for increasing the resistance of an animal host (including humans) to diseases caused by intracellular bacteria, protozoa, and viruses. The infection treated may, for example, be equine infectious anemia, or infection by t...	12/07/1999
5545808	Transgenic salmonid fish expressing exogenous salmonid growth hormone An "all fish" chimeric gene construct suitable for gene transfer for commercially important fish comprises the antifreeze gene (AFP) promoter fused to the desired gene sequence which is incorporated into fish embryos. The desired gene sequence is expresse...	08/13/1996

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Class 800/20 - Fish