Did You Know...
...that to encourage use of his new invention, the shopping cart, market owner Sylvan Goldman hired fake shoppers to push the carts around his store in Oklahoma City? Seems his customers were reluctant to give up their hand-carried baskets.
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| Number | Title | Issue Date |
| 8106251 | Tissue products derived from porcine animals lacking any expression of functional alpha 1,3 galactosyltransferase The present invention provides tissues derived from animals, which lack any expression of functional alpha 1,3 galactosyltransferase (alpha-1,3-GT). Such tissues can be used in the field of xenotransplantation, such as orthopedic reconstruction and repair, skin repa... | 01/31/2012 |
| 7956238 | Porcine pancreatic amylase gene promoter and transgenic pigs expressing heterologous digestive enzymes The present invention relates to a novel promoter and its use in driving expression of foreign genes in transgenic animals (especially pigs). Accordingly, the present invention provides a method for producing transgenic animals harboring heterologous genes regulated... | 06/07/2011 |
| 7919673 | Transgenic pig with altered incretin function The present invention relates to transgenic pigs containing a dominant-negative incretin hormone receptor, namely the dominant-negative human glucose-dependent insulinotropic polypeptide receptor. The present invention furthermore relates to uses of these transgenic... | 04/05/2011 |
| 7795493 | Porcine animals lacking any expression of functional alpha 1, 3 galactosyltransferase The present invention is a porcine animal, tissue, organ, cells and cell lines, which lack any expression of functional alpha 1,3 galactosyltransferase (alpha1,3GT). These animals, tissues, organs and cells can be used in xenotransplantation and for other medical pu... | 09/14/2010 |
| 7547816 | α(1,3)-galactosyltransferase knockout swine, tissues and organs The invention relates to the genetic manipulation of non-human animals. More particularly, the invention relates to genetic manipulation of non-human animals to be used for xenotransplantation. The invention provides viable gene knockout swine including swine in whi... | 06/16/2009 |
| 7491867 | Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates The present invention relates to the production of a transgenic bovine which comprises a genetic modification that results in inactivation and loss of expression of its endogenous antibodies, and the expression of xenogenous antibodies, preferably human antibodies. ... | 02/17/2009 |
| 7485769 | Transgenic mammals This invention provides a nonhuman transgenic mammal carrying transgene comprising the regulatory genes capable of functioning in the hyperacute rejection-occurring local cells and gene encoding human N-acetylglucosaminyltransferase III (GnT-III), or a nonhuman tran... | 02/03/2009 |
| 7435869 | Transgenic nonhuman mammals producing fibrinogen in milk and methods of producing fibrin A transgenic, non-human mammalian animal is capable of expressing a heterologous gene for human or other recombinant physiologically functional fibrinogen holoprotein or individual subunit chain polypeptides thereof or a modified or fusion fibrinogen in mammary glan... | 10/14/2008 |
| 7378569 | Transgenic pigs carrying both hHO-1 and hDAF transgenes for xenotransplantation The invention provides a transgenic animal carrying two transgenes, one encoding a human decay accelerating factor (hDAF) and the other encoding a human heme oxygenase-1 (hHO)-1, which are useful for providing cells, tissues or organs therefrom for xenotransplantati... | 05/27/2008 |
| 7371922 | Nuclear transfer with porcine embryonic stem cells Provided is a method for the production of transgenic animals, especially pigs, by the use of nuclear transfer from genetically modified or other embryonic stem cells to either enucleated oocytes which were matured in vivo or in vitro and activated or to enucleated ... | 05/13/2008 |
| 7361804 | Unactivated oocytes in nuclear transfer to produce ungulates A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to th... | 04/22/2008 |
| 7354594 | Merozoite surface protein 1 lacking glycosylation sites The invention provides modified recombinant nucleic acid sequences (preferably DNA) and methods for increasing the mRNA levels and protein expression of malarial surface protein MSP-1 which is known to be difficult to express in cell culture systems, mammalian cell ... | 04/08/2008 |
| 7355094 | Methods of ungulate nuclear transfer A method of reconstituting an animal embryo involves transferring the nucleus from a quiescent donor cell into a suitable recipient cell. The donor cell is quiescent, in that it is caused to exit from the growth and division cycle at G1 and to arrest in the G0 state... | 04/08/2008 |
| 7332646 | Transgenic animal model for degenerative diseases of cartilage The present invention provides animal model systems for cartilage-degenerative disease, which comprise transgenic animals which can express recombinant matrix-degrading enzymes (MDEs), particularly matrix metalloproteinases (MMPs), in a temporally and spatially regu... | 02/19/2008 |
| 7326825 | Methods of ungulate nuclear transfer A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to th... | 02/05/2008 |
| 7326824 | Unactivated ungulate oocytes to produce a transgenic ungulate by nuclear transfer A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to th... | 02/05/2008 |
| 7321076 | Unactivated ungulate oocytes to produce a cloned ungulate by nuclear transfer A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to th... | 01/22/2008 |
| 7307198 | Ungulates produced by nuclear transfer of G1 cells A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to th... | 12/11/2007 |
| 7304204 | Ungulates produced by nuclear transfer of G1 cells A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to th... | 12/04/2007 |
| 7291764 | Cloning pigs using non-quiescent differentiated donor cells or nuclei An improved method of nuclear transfer involving the transplantation of donor differentiated pig cell nuclei into enucleated pig oocytes is provided. The resultant nuclear transfer units are useful for multiplication of genotypes and transgenic genotypes by the prod... | 11/06/2007 |
| 7238797 | Nucleic acid encoding a pig heat shock protein 70 The invention provides a transgenic pig having incorporated into its genome a HSP70 gene or fragment thereof, whereby the transgenic pig overexpresses HSP70. The transgenic pig of the invention can be used in the production of HSP in large quantities, as a xenograft... | 07/03/2007 |
| 7238851 | Non-human transgenic mammals expressing an n-3 desaturase gene The present invention features compositions (e.g, nucleic acids encoding fat-1, optionally and operably linked to a constitutively active or tissue-specific promoter or other regulatory sequence and pharmaceutically acceptable formulations including that nucleic aci... | 07/03/2007 |
| 7232938 | Cloning ungulates from a quiescent donor cell A method of reconstituting an animal embryo involves transferring the nucleus from a quiescent donor cell into a suitable recipient cell. The donor cell is quiescent, in that it is caused to exit from the growth and division cycle at G1 and to arrest in the G0 state... | 06/19/2007 |
| 7220718 | Oral treatment of hemophilia Disclosed herein is a simple method for the treatment of antigen-deficiency diseases, by orally administering to a subject a therapeutically effective amount of the deficient antigen, wherein the antigen is not present in a liposome. In one embodiment, the method in... | 05/22/2007 |
| 7199281 | Method of generating a transgenic livestock animal The present invention provides methods of producing transgenic livestock animals. The methods generally involve first introducing a nucleoprotein made up of nucleic acid and a recombinase into a totipotent or pluripotent cell to produce a recombinant totipotent or p... | 04/03/2007 |
| 7169963 | Mammals expressing IGF-1 and alpha-lactalbumin in their milk The present invention relates to animals that express exogenous growth factors in their milk, and in particular to pigs that express exogenous IGF-I in their milk. The present invention also relates to methods for increasing piglet weight gain and intestinal lactase... | 01/30/2007 |
| 7166278 | Modified organs and cells for xenotransplantation It has been discovered that there are at least two significant antigens present on the cells of animal species such as pigs that elicit an immune or inflammatory response immediately upon implantation into humans or contact with human serum. The first is an α-galac... | 01/23/2007 |
| 7141716 | Inbred miniature swine and uses thereof The invention provides a swine which is homozygous for a major histocompatibility complex haplotype and at least 60% homozygous at all other genetic loci and such animal is propagatable, and a cell or an organ derived therefrom. The invention also provides a method ... | 11/28/2006 |
| 7126039 | Animal tissue with carbohydrate antigens compatible for human transplantation This disclosure provides a system for generating animal tissue with carbohydrate antigens that are compatible for transplantation into human patients. The tissue is inactivated homozygously for expression of α(1,3)galactosyltransferase, and comprises a transgene fo... | 10/24/2006 |
| 7115795 | Transgenic animals expressing salivary proteins The invention provides a transgenic animal having within its genome a transgene construct for gastrointestinal tract specific expression of a protein. In a preferred embodiment, the protein is a phytase or a homologue thereof. Such proteins may be heterologous and m... | 10/03/2006 |
| 7115796 | Transgenic pig containing heat shock protein 70 transgene The invention provides a transgenic pig having incorporated into its genome a HSP70 gene or fragment thereof, whereby the transgenic pig overexpresses HSP70. The transgenic pig of the invention can be used in the production of HSP in large quantities, as a xenograft... | 10/03/2006 |
| 7087808 | Method for expressing multiple recombinant proteins in milk of transgenic non-human mammals The present invention discloses a method for expressing multiple recombinant proteins in transgenic non-human mammalian milk, characterized in which human clotting factor IX gene and porcine lactoferrin gene are transferred into the mammal by gene injection and embr... | 08/08/2006 |
| 7074983 | Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin The present invention relates to the production of a transgenic bovine which comprises a genetic modification that results in inactivation and loss of expression of its endogenous antibodies, and the expression of xenogenous antibodies, preferably human antibodies. ... | 07/11/2006 |
| 7067713 | C1 Inhibitor produced in the milk of transgenic non-human mammals The invention provides transgenic nonhuman mammals expressing C1 inhibitor in their milk. The C1 inhibitor is useful in treating patients with hereditary angioedema or patients requiring immunosuppression. ... | 06/27/2006 |
| 7045677 | Fusion proteins incorporating lysozyme A process for the production of a peptide is disclosed, the process comprising expressing in the milk of a transgenic, non-human, placental mammal a fusion protein which comprises the peptide to be expressed linked to a fusion partner protein which is lysozyme. The ... | 05/16/2006 |
| 7041870 | Transgenic transchromosomal rodents for making human antibodies The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies. ... | 05/09/2006 |
| 7038107 | Elimination of endogenous porcine retrovirus Porcine nucleic acid sequences flanking potentially infectious porcine endogenous retroviral (PERV) insertion sites have been identified and isolated. The unique flanking sequences include porcine nucleic acid sequences that flank the 3′ end and porcine nucleic ac... | 05/02/2006 |
| 7030289 | Stabilization of milk from transgenic animals The present invention relates to the stabilization of milk from transgenic animals. In particular, the invention relates to the protection of proteins (e.g. fibrinogen) expressed in milk from transgenic animals by co-expression of a serine proteinase inhibitor (e.g.... | 04/18/2006 |
| 6987211 | Transgenic non-human mammals producing a cholinesterase in their milk The present invention relates to novel alternative forms of human acetylcholinesterase (AChE) and nucleotide sequences encoding the same. The genes encoding the novel forms of human AChE have been identified in various malignant tumor cells. In a further aspect, the... | 01/17/2006 |
| 6984772 | Transgenic non-human mammals producing fibrinogen in their milk A transgenic, non-human mammalian animal is capable of expressing a heterologous gene for human or other recombinant physiologically functional fibrinogen holoprotein or individual subunit chain polypeptides thereof or a modified or fusion fibrinogen in mammary glan... | 01/10/2006 |
