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| Number | Title | Issue Date |
| 7435869 | Transgenic nonhuman mammals producing fibrinogen in milk and methods of producing fibrin A transgenic, non-human mammalian animal is capable of expressing a heterologous gene for human or other recombinant physiologically functional fibrinogen holoprotein or individual subunit chain polypeptides thereof or a modified or fusion fibrinogen in mammary glan... | 10/14/2008 |
| 7361804 | Unactivated oocytes in nuclear transfer to produce ungulates A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to th... | 04/22/2008 |
| 7355094 | Methods of ungulate nuclear transfer A method of reconstituting an animal embryo involves transferring the nucleus from a quiescent donor cell into a suitable recipient cell. The donor cell is quiescent, in that it is caused to exit from the growth and division cycle at G1 and to arrest in the G0 state... | 04/08/2008 |
| 7354594 | Merozoite surface protein 1 lacking glycosylation sites The invention provides modified recombinant nucleic acid sequences (preferably DNA) and methods for increasing the mRNA levels and protein expression of malarial surface protein MSP-1 which is known to be difficult to express in cell culture systems, mammalian cell ... | 04/08/2008 |
| 7332646 | Transgenic animal model for degenerative diseases of cartilage The present invention provides animal model systems for cartilage-degenerative disease, which comprise transgenic animals which can express recombinant matrix-degrading enzymes (MDEs), particularly matrix metalloproteinases (MMPs), in a temporally and spatially regu... | 02/19/2008 |
| 7326824 | Unactivated ungulate oocytes to produce a transgenic ungulate by nuclear transfer A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to th... | 02/05/2008 |
| 7326825 | Methods of ungulate nuclear transfer A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to th... | 02/05/2008 |
| 7321076 | Unactivated ungulate oocytes to produce a cloned ungulate by nuclear transfer A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to th... | 01/22/2008 |
| 7307198 | Ungulates produced by nuclear transfer of G1 cells A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to th... | 12/11/2007 |
| 7304204 | Ungulates produced by nuclear transfer of G1 cells A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to th... | 12/04/2007 |
| 7238851 | Non-human transgenic mammals expressing an n-3 desaturase gene The present invention features compositions (e.g, nucleic acids encoding fat-1, optionally and operably linked to a constitutively active or tissue-specific promoter or other regulatory sequence and pharmaceutically acceptable formulations including that nucleic aci... | 07/03/2007 |
| 7232938 | Cloning ungulates from a quiescent donor cell A method of reconstituting an animal embryo involves transferring the nucleus from a quiescent donor cell into a suitable recipient cell. The donor cell is quiescent, in that it is caused to exit from the growth and division cycle at G1 and to arrest in the G0 state... | 06/19/2007 |
| 7199281 | Method of generating a transgenic livestock animal The present invention provides methods of producing transgenic livestock animals. The methods generally involve first introducing a nucleoprotein made up of nucleic acid and a recombinase into a totipotent or pluripotent cell to produce a recombinant totipotent or p... | 04/03/2007 |
| 7169963 | Mammals expressing IGF-1 and alpha-lactalbumin in their milk The present invention relates to animals that express exogenous growth factors in their milk, and in particular to pigs that express exogenous IGF-I in their milk. The present invention also relates to methods for increasing piglet weight gain and intestinal lactase... | 01/30/2007 |
| 7157615 | Production of biofilaments in transgenic animals Disclosed is a method for the recombinant production of biofilaments, such as spider silk or insect fibroins, using transgenic animals which secrete the biofilaments in their milk and/or urine, and transgenic cells which secrete the biofilaments into culture media. ... | 01/02/2007 |
| 7067713 | C1 Inhibitor produced in the milk of transgenic non-human mammals The invention provides transgenic nonhuman mammals expressing C1 inhibitor in their milk. The C1 inhibitor is useful in treating patients with hereditary angioedema or patients requiring immunosuppression. ... | 06/27/2006 |
| 7045677 | Fusion proteins incorporating lysozyme A process for the production of a peptide is disclosed, the process comprising expressing in the milk of a transgenic, non-human, placental mammal a fusion protein which comprises the peptide to be expressed linked to a fusion partner protein which is lysozyme. The ... | 05/16/2006 |
| 7045676 | Transgenic animals secreting proteins into milk A DNA sequence containing a gene encoding a protein, the gene being under the transcriptional control in the DNA sequence of a mammalian milk protein promoter which does not naturally control the transcription of the gene, such DNA sequence including DNA enabling se... | 05/16/2006 |
| 7041870 | Transgenic transchromosomal rodents for making human antibodies The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies. ... | 05/09/2006 |
| 7030289 | Stabilization of milk from transgenic animals The present invention relates to the stabilization of milk from transgenic animals. In particular, the invention relates to the protection of proteins (e.g. fibrinogen) expressed in milk from transgenic animals by co-expression of a serine proteinase inhibitor (e.g.... | 04/18/2006 |
| 6987211 | Transgenic non-human mammals producing a cholinesterase in their milk The present invention relates to novel alternative forms of human acetylcholinesterase (AChE) and nucleotide sequences encoding the same. The genes encoding the novel forms of human AChE have been identified in various malignant tumor cells. In a further aspect, the... | 01/17/2006 |
| 6984772 | Transgenic non-human mammals producing fibrinogen in their milk A transgenic, non-human mammalian animal is capable of expressing a heterologous gene for human or other recombinant physiologically functional fibrinogen holoprotein or individual subunit chain polypeptides thereof or a modified or fusion fibrinogen in mammary glan... | 01/10/2006 |
| 6906238 | Effective nuclear reprogramming in mammals using CDK2 inhibitors The present invention provides methods of producing a cloned non-human mammalian nuclear transfer (NT) embryo and methods for producing a cloned non-human mammal. Embodiments of the methods include introducing donor genetic material into a metaphase I oocyte; introd... | 06/14/2005 |
| 6891082 | Transgenic non-human animals expressing a truncated activintype II receptor The present invention provides a substantially purified growth differentiation factor (GDF) receptor, including a GDF-8 (myostatin) receptor, as well as functional peptide portions thereof. In addition, the invention provides a virtual representation of a GDF recept... | 05/10/2005 |
| 6888047 | Transgenic animals as urinary bioreactors for the production of polypeptide in the urine, recombinant DNA construct for kidney-specific expression, and method of using same The invention relates to recombinant DNA constructs, a method for producing a recombinant biologically active protein in vivo in the urine of a non-human mammal using a kidney-specific promoter, such as the uromodulin promoter, and the transgenic non-human mammals t... | 05/03/2005 |
| 6872868 | Transgenic mammals Genetic transformation of a zygote and the embryo and mature organism which result therefrom is obtained by placing or inserting exogenous genetic material into the nucleus of the zygote or into any genetic material which ultimately forms at least a part of the nucl... | 03/29/2005 |
| 6743966 | Production of membrane proteins in the milk of transgenic mammals Production of proteins not normally secreted through conventional pathways such as membrane proteins including, for example, CFTR associated with cystic fibrosis, is now made possible by collection of such protein from the milk of lactating transgenic animals. ... | 06/01/2004 |
| 6727405 | Transgenic animals secreting desired proteins into milk A DNA sequence containing a gene encoding a protein, the gene being under the transcriptional control in the DNA sequence of a mammalian milk protein promoter which does not naturally control the transcription of the gene, such DNA sequence including DNA enabling se... | 04/27/2004 |
| 6706947 | Method for screening for agents against cancer using an immunosuppression animal model The invention relates to an animal model of cancer. The animal carries a tumour xenograft and is immunosuppressed by administration of cyclosporin and ketoconazole. The model is useful for studying cancer and treatment thereof. ... | 03/16/2004 |
| 6677500 | Ungulates expressing exogenous IGF-I in their milk The present invention relates to animals that express exogenous growth factors in their milk, and in particular to pigs that express exogenous IGF-I in their milk. The present invention also relates to methods for increasing piglet weight gain and intesti... | 01/13/2004 |
| 6603059 | Method of cloning animals The present invention relates to cloning technologies. The invention relates in part to immortalized and totipotent cells useful for cloning animals, the embryos produced from these cells using nuclear transfer techniques, animals that arise from these ce... | 08/05/2003 |
| 6538174 | Animal model for transplantation The invention relates to an animal model of cancer. The animal carries a tumor xenograft and is immunosuppressed by administration of cyclosporin and ketoconazole. The model is useful for studying cancer and treatment thereof.... | 03/25/2003 |
| 6525241 | Expression methods The present invention relates to human bile salt-stimulated lipase (BSSL) obtainable from transgenic sheep. The invention further relates to transgenic sheep whose germ cells and somatic cells contain a recombinant nucleotide molecule comprising a nucleot... | 02/25/2003 |
| 6525243 | Unactivated oocytes as cytoplast recipients of quiescent cell nuclei while maintaining correct ploidy A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept ex... | 02/25/2003 |
| 6518482 | Transgenic non-human mammals expressing human coagulation factor VIII and von Willebrand factor A non-human transgenic mammalian animal, as described above, contains an exogenous double stranded DNA sequence stably integrated into the genome of the animal, which comprises cis-acting regulatory units operably linked to a DNA sequence encoding human F... | 02/11/2003 |
| 6448469 | Production of membrane proteins in the milk of transgenic nonhuman mammals Production of proteins not normally secreted through conventional pathways such as membrane proteins including, for example, CFTR associated with cystic fibrosis, is now made possible by collection of such protein from the milk of lactating transgenic ani... | 09/10/2002 |
| 6395958 | Method of producing a polypeptide in an ungulate The present invention relates to cloning technologies. The invention relates in part to immortalized and totipotent cells useful for cloning animals, the embryos produced from these cells using nuclear transfer techniques, animals that arise from these ce... | 05/28/2002 |
| 6344596 | Expression of active human factor IX in mammary tissue and of milk non human transgenic mammals Recombinant Factor IX characterized by a high percentage of active protein can be obtained in the milk of transgenic animals that incorporate chimeric DNA molecules according to the present invention. Transgenic animals of the present invention are produc... | 02/05/2002 |
| 6339183 | Transgenic mammals expressing heterologous DNA in urothelium and isolation of biologically active molecules from urine A vector is provided which contains a promoter construct linked to a heterologous gene encoding a selected biologically active molecule or oncogene wherein the promoter construct is capable of directing urothelial expression of the heterologous gene. Meth... | 01/15/2002 |
| 6271436 | Cells and methods for the generation of transgenic pigs Disclosed are methods for the isolation of primordial germ cells, culturing these cells to produce primordial germ cell-derived cell lines, methods for transforming both the primordial germ cells and the cultured cell lines, and using these transformed ce... | 08/07/2001 |
