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| Number | Title | Issue Date |
| 8134044 | Transgenic reptiles A transgenic animal such as a transgenic snake or other reptile that expresses a heterologous expression product is described, along with methods of making the same. In general, the animal comprises cells containing a sequence encoding the heterologous expression pr... | 03/13/2012 |
| 8124830 | Transgenic non-human animals expressing a truncated activin type II receptor The present invention provides a substantially purified growth differentiation factor (GDF) receptor, including a GDF-8 (myostatin) receptor, as well as functional peptide portions thereof. In addition, the invention provides a virtual representation of a GDF recept... | 02/28/2012 |
| 8093450 | Non-aggregating fluorescent proteins and methods for using the same Nucleic acid compositions encoding non-aggregating chromo/fluoroproteins and mutants thereof, as well as the proteins encoded by the same, are provided. The proteins of interest are polypeptides that are non-aggregating colored and/or fluorescent proteins, where the... | 01/10/2012 |
| 8076531 | Transgenic animal with monocyte chemotactic protein 1 promoter The present invention relates to a transgenic animal, which comprises in its genome a recombinant polynucleotide encoding one or more reporter proteins and a monocyte chemotactic protein-1 (MCP-1) promoter, wherein the one or more reporter proteins are expressed und... | 12/13/2011 |
| 7932430 | Development of a simple animal model for infection by viruses and other obligate intracellular parasites The present invention provides methods for studying pathogenesis of mammalian viruses. In particular, the present invention provides a nonhuman animal model system for studying disease mechanisms wherein the nonhuman animal model is infected with an animal virus. In... | 04/26/2011 |
| 7868222 | Transfected mosquito vectors A method is provided for producing an artificial infection in a Culicidae (mosquito) species. The mosquitoes include species within the subfamilies Culicinae and Anophelinae, and the species include Aedes albopictus, Aedes aegypti and Aedes polynesiensis | 01/11/2011 |
| 7858844 | Non aggregating fluorescent proteins and methods for using the same Nucleic acid compositions encoding non-aggregating chromo/fluoroproteins and mutants thereof, as well as the proteins encoded by the same, are provided. The proteins of interest are polypeptides that are non-aggregating colored and/or fluorescent proteins, where the... | 12/28/2010 |
| 7816578 | Transgenic transchromosomal rodents for making human antibodies The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies. ... | 10/19/2010 |
| 7767880 | Methods of screening agents for activity using teleosts The present invention provides methods of screening an agent for activity using teleosts. Methods of screening an agent for angiogenesis activity, toxic activity and an effect cell death activity in teleosts are provided. Methods of screening an agent for an activit... | 08/03/2010 |
| 7663019 | Transgenic snakes and methods of making A transgenic animal such as a transgenic snake or other reptile that expresses a heterologous expression product is described, along with methods of making the same. In general, the animal comprises cells containing a sequence encoding the heterologous expression pr... | 02/16/2010 |
| 7572949 | SKN-1 and GSK-3 genes and proteins The present invention relates, in part, to the C. elegans SKN-1 gene and protein (a transcription factor), and target genes thereof. The invention includes various therapeutic methods and screening methods for identifying antioxidants. ... | 08/11/2009 |
| 7498479 | Animal model having a chimeric human liver The present invention features a non-human animal model that is susceptible to infection by human hepatotrophic pathogens, particularly human hepatitis C virus (HCV). The model is based on a non-human, immunocompromised transgenic animal having a human-mouse chimeri... | 03/03/2009 |
| 7491866 | Transgenic rats and spermatogonial stem cells A transgenic rat expresses a gene of interest, such as EGFP, exclusively in the germ cells of both males and females. From such a transgenic rat one can isolate a line of spermatogonial stem cells, which can renew and proliferate in culture. ... | 02/17/2009 |
| 7482507 | Methods of screening agents for activity using teleosts The present invention provides methods of screening an agent for activity using teleosts. Methods of screening an agent for angiogenesis activity, toxic activity and an effect cell death activity in teleosts are provided. The invention further provides high throughp... | 01/27/2009 |
| 7465848 | Zebrafish assay The invention includes a zebrafish assay for cardiac response. ... | 12/16/2008 |
| 7435870 | Methods of screening agents for activity using teleosts The present invention provides methods of screening an agent for activity using teleosts. Methods of screening an agent for angiogenesis activity, toxic activity and an effect cell death activity in teleosts are provided. ... | 10/14/2008 |
| 7435872 | Role of p62 in aging-related disease The application discloses a role of p62 in aging-related disease, such as development of obesity, type 2 diabetes mellitus, non-alcoholic fatty liver, various tumors, increased male mortality, intracellular inclusion named sequestosome, and redox regulation. In part... | 10/14/2008 |
| 7435868 | Screening assay based on the forkhead transcription factor-dependent promoter The invention relates to the identification and use of the DAF-2/IR responsive sod-3 promoter. Transgenic C. elegans containing sod-3 reporter gene constructs are described which are useful for, among other things, the identification of genes or compounds cap... | 10/14/2008 |
| 7420100 | Methods and compositions relating to HDAC 4 and 5 regulation of cardiac gene expression The present invention relates to cardiac hypertrophy. More particularly, the present invention defines the molecular events linking calcium stimulation to cardiac hypertrophy. More specifically, the present invention shows that Ca2+ stimulation of the hyp... | 09/02/2008 |
| 7414171 | PD-1-lacking mouse and use thereof The invention relates to BALB/c mice that are deficient in the programmed cell death-1 receptor (PD-1), a screening method for autoimmune disease medicine using these mice, an IgG self-reactive antibody that the mice produce, a protein that specifically reacts to th... | 08/19/2008 |
| 7402728 | Transgenic mice expressing human CD20 and/or CD16 The present invention generally relates to non-human transgenic animals expressing human cellular markers, including CD20 and/or preferably CD16. ... | 07/22/2008 |
| 7402726 | Methods and compositions for screening for modulators of Parkinson's disease Methods and compositions for identifying an agent (e.g., a gene product or small molecule compound) that modulates a Parkinson's disease phenotype are provided. In practicing the subject methods, a non-mammalian animal model, such as Drosophila melanogaster, ... | 07/22/2008 |
| 7402729 | Human artificial chromosome containing human antibody λ light chain gene and non-human animal containing the human artificial chromosome capable of genetic transmission The present invention relates to a human artificial chromosome which is genetically transmissible to the next generation with high efficiency and the method for using the same. More specifically, the present invention relates to: a human artificial chromosome in whi... | 07/22/2008 |
| 7399902 | Mouse cardiac conduction system model The present invention relates to a transgenic mouse which has integrated a reporter gene in the locus of the Cx40 gene, wherein said reporter gene is expressed in the different components of the cardiac conduction system (CCS) including the atrio-ventricular node (A... | 07/15/2008 |
| 7399900 | Nematodes as model organisms for the investigation of neurodegenerative diseases, in particular parkinsons disease, uses and methods for the discovery of substances and genes which can used in the treatment of the above disease states and identification of anematode gene The invention relates to nematodes as model organisms for the investigation of neurodegenerative diseases in particular. Parkinsons disease, uses and methods for the discovery of substances and genes which can be used in the treatment of the above disease states and... | 07/15/2008 |
| 7371920 | Transgenic mouse model of neurodegenerative disorders The present invention provides a transgenic animal model of Alzheimer's Disease designated TgCRND8 as well as a method for making such model, which allows for the characterization of the etiology of the disease as well as for provide a system for the development and... | 05/13/2008 |
| 7368536 | Alzheimer's disease secretase, APP substrates therefor, and uses therefor The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP prote... | 05/06/2008 |
| 7365239 | In vivo models for rabGEF1-dependent signaling and functions Non-human transgenic animal models and cells derived therefrom are provided for RabGEF1 function. RabGEF1 is a negative regulator of FcεRI-dependent mast cell activation and T cell activation via the T cell receptor and a lack of RabGEF1 results in the development ... | 04/29/2008 |
| 7358416 | Transgenic mouse expressing human FcRn protein Disclosed is a transgenic knockout mouse whose genome comprises a homozygous disruption in its endogenous FcRn gene. The homozygous RcRn disruption prevents the expression of a functional FcRn protein, resulting in a transgenic knockout mouse in which exogenously ad... | 04/15/2008 |
| 7332643 | Ferritin light subunit variant-encoding nucleic acids, polypeptides, transgenic animals comprising the same, antibodies thereto, and methods of use thereof Nucleic acids encoding a novel ferritin light chain variant, a ferritin light chain variant polypeptide, ferritin light chain variant polypeptide-specific antibodies, and methods of use thereof are provided herein. Also provided are methods to screen and identify ag... | 02/19/2008 |
| 7332645 | IL-21 as a regulator of immunoglobin production A transgenic mouse is disclosed herein whose somatic and germ cells comprise a disrupted IL-21 receptor gene, the disruption being sufficient to inhibit the binding of IL-21 to an IL-21 receptor, and a disrupted IL-4 gene, the disruption being sufficient to inhibit ... | 02/19/2008 |
| 7323619 | Method for producing transgenic birds and fish The present invention relates to methods for producing transgenic animals, particularly transgenic birds and fish, using retroviral constructs engineered to carry the transgene(s) of interest. ... | 01/29/2008 |
| 7304203 | Transgenic TIEG non-human animals Materials and methods related to a transgenic non-human animal (e.g., a transgenic non-human mammal) whose genome comprises a disrupted TIEG allele are provided. Methods for making such transgenic non-human animals, and using them to identify and characterize agents... | 12/04/2007 |
| 7301068 | Nonhuman model animal of Th2-mediated hyperimmune response An object of the present invention is to provide a nonhuman model animal of Th2-mediated hyperimmune response lacking PIR-B gene function on its chromosome by which the Th2-mediated immune response mechanism and allergy onset mechanism in vivo can be analyzed and wh... | 11/27/2007 |
| 7273963 | Malarial animal model having a chimeric human liver The present invention features a non-human animal model of malaria, e.g., Plasmodium, particularly Plasmodium falciparum. The model is based on a non-human, immunocompromised transgenic animal having a human-mouse chimeric liver, where the transgene pr... | 09/25/2007 |
| 7271312 | Modified nucleic acid sequences and methods for increasing mRNA levels and protein expression in cell systems The invention provides modified recombinant nucleic acid sequences (preferably DNA) and methods for increasing the mRNA levels and protein expression of proteins which are known to be, or are likely to be, difficult to express in cell culture systems, mammalian cell... | 09/18/2007 |
| 7265260 | Transgenic non-human mammals expressing constitutively activated tyrosine kinase receptors A transgenic non-human mammal whose germ cells and somatic cells contain a constructively activated tyrosine kinase receptor introduced into the mammal, or an ancestor of the mammal, at an embryonic stage. The transgenic non-human mammals can be used as ligand-indep... | 09/04/2007 |
| 7256321 | Intracellular modulators of apoptopic cell death pathways A DNA sequence encoding a glucocorticoid-induced leucine-zipper family related protein (GILR), isoforms, fragments or analogs thereof, said GILR, isoforms, fragments or analogs thereof capable of inhibiting apoptosis and stimulating lymphocyte activity, GILR protein... | 08/14/2007 |
| 7238797 | Nucleic acid encoding a pig heat shock protein 70 The invention provides a transgenic pig having incorporated into its genome a HSP70 gene or fragment thereof, whereby the transgenic pig overexpresses HSP70. The transgenic pig of the invention can be used in the production of HSP in large quantities, as a xenograft... | 07/03/2007 |
| 7230155 | Method for identifying an agonist of neuronal calcium sensor-1 (NCS-1), for therapy of CNS disorders Provided is a method for determining whether an agent is an agonist of the neuron-specific calcium sensor-1 (NCS-1), for consideration of an agonist of NCS-1 as a drug candidate for therapy of a behavioral disorder or for improving learning and/or memory of a subjec... | 06/12/2007 |
