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| Number | Title | Issue Date |
| 7897834 | Mutation in the rat adenomatous polyposis coli gene within the human mutation hotspot region A rat with a disrupted Apc (adenomatous polyposis coli) gene is provided. The mutation can include an A to T transversion changing a lysine to a stop codon at codon 1137. Methods of generating the knockout rat are provided. Also provided is the offspring or progeny ... | 03/01/2011 |
| 7402728 | Transgenic mice expressing human CD20 and/or CD16 The present invention generally relates to non-human transgenic animals expressing human cellular markers, including CD20 and/or preferably CD16. ... | 07/22/2008 |
| 7402727 | Non-human animal exhibiting bone metastasis of tumor cells The present invention provides a non-human bone metastasis model animal in which tumor cells capable of inducing bone metastasis by peripheral administration have been introduced, and a method for producing the animal. The bone metastasis model animal in the ... | 07/22/2008 |
| 7371515 | Identifying and characterizing genes The invention provides methods and materials for identifying and characterizing genes related to phenotypes such as cancer and cell survivability. Also provided in the invention are cells and transgenic, non-human mammals that can be used in these methods. ... | 05/13/2008 |
| 7341871 | Nucleotide sequences for gene regulation and methods of use thereof The invention provides nucleic acid sequences which regulate expression of a nucleotide sequence of interest. In particular, the invention provides nucleic acid sequences which regulate expression of a nucleotide sequence of interest in an age-related manner and/or ... | 03/11/2008 |
| 7291597 | Growth factor therapy mobilization of stem cells into the peripheral blood Stem cells are mobilized into the peripheral blood by a method comprising the steps of: (i) administering to an individual at least one of the following: FGF1 and FGF2, and also at least one of the following: VEGF, VEGFA and VEGF165; (ii) isolating the peripheral bl... | 11/06/2007 |
| 7288521 | Growth factor therapy mobilization of stem cells into the peripheral blood Stem cells are mobilized into the peripheral blood by a method comprising the steps of: (i) administering to an individual at least one of the following: FGF1 and FGF2, and also at least one of the following: VEGF, VEGFA, VEGFB, PLGF, VEGF121, VEGF145, VEGF165, VEGF... | 10/30/2007 |
| 7279553 | PRO1083 polypeptides The present invention is directed to novel seven transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising ... | 10/09/2007 |
| 7253333 | Drosophila strain carrying bradeion gene(s) transferred thereinto Provided is a special Drosophila strain having a Bradeion gene artificially incorporated therein to exclusively express the gene in the compound eyes and thus to exhibit rough eye. The Drosophila strain has the following properties: (a) a ... | 08/07/2007 |
| 7220891 | Feline bronchioloalveolar lung carcinoma xenograft and cell line The present invention provides feline transplantable lung carcinoma xenografts and cell lines. Such xenografts and cell lines exhibit a number of unique characteristics which allows their use in experimental models of carcinoma in order to dissect out the molecular ... | 05/22/2007 |
| 7186880 | Adult T cell leukemia model animal The present invention provides an adult T cell leukemia model animal, which is a T cell function deficient animal to which a cell line infected with human T cell leukemia virus-1 is transplanted. This model animal allows the HTLV-1 infected cell line to proliferate ... | 03/06/2007 |
| 7186883 | In vitro propagation of embryonic stem cells The present invention relates to the use of leukemia inhibitory factor (LIF) in the isolation and propagation of embryonic stem cells in vitro. ... | 03/06/2007 |
| 7135609 | Non-human animal exhibiting bone metastasis of tumor cells and method of screening for bone metastasis inhibitors The present invention provides a non-human bone metastasis model animal in which tumor cells capable of inducing bone metastasis by peripheral administration have been introduced, and a method for producing the animal. The bone metastasis model animal in the present... | 11/14/2006 |
| 7129062 | Matrix attachment regions and methods for use thereof The present invention relates to compositions and methods for transfecting eukaryotic cells with nucleic acid vectors. In particular, the invention relates to the uses of Matrix Attachment Region (MAR) elements to increase stable and transient transfection efficienc... | 10/31/2006 |
| 7122714 | Mouse models of human prostate cancer The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof. ... | 10/17/2006 |
| 7105717 | Model rat with the onset of prostatic cancer To provide a rat model with the onset of prostate cancer in which the prostate cancer including an invasive cancer can be developed and can be bred for generations stably. A rat model with the onset of prostate cancer which can develop prostate cancer including inva... | 09/12/2006 |
| 7087371 | Material and methods for the production of sperm and analysis thereof Provided herein are methods of producing viable sperm from neonatal mammalian testes which have been engrafted in mice. ... | 08/08/2006 |
| 7053263 | Mouse models of human prostate cancer progression The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof. ... | 05/30/2006 |
| 6998513 | Human inflammatory breast carcinoma xenograft capable of lymphovascular invasion and methods for its use The present invention provides human transplantable inflammatory breast carcinoma xenografts. Such xenografts exhibit a number of unique characteristics which allows their use in experimental models of inflammatory carcinoma in order to dissect out the molecular bas... | 02/14/2006 |
| 6956145 | Mice models of human prostate cancer progression The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof. ... | 10/18/2005 |
| 6953875 | Transgenic zebra fish embryo model for hematopoiesis and lymphoproliferative disorders A transgenic zebrafish animal model is disclosed. The model can be used for study of hematopoetic cell differentiation, control, and screening of therapeutic agents and can include a transgenic zebrafish expressing a heterologous Ikaros protein. ... | 10/11/2005 |
| 6949692 | Method for identifying mutants and molecules Methods for breeding mutagenized mice permit detection of genetic loci that in heterozygous mutated form can modify a known index phenotype involves crossing a mutagenized founder strain and a second strain of mice carrying an allele at a locus that confers the inde... | 09/27/2005 |
| 6943025 | Method for identifying genes involved in cell proliferation The present invention provides fish system as a powerful forward genetic tool to directly identify a number of novel genes involved in cell proliferation in vertebrates without the time consuming and costly maintenance of animals. The invention provides a tool to id... | 09/13/2005 |
| 6930222 | In vivo animal model of human leukemia The present invention provides a process for making an in vivo model of human leukemia. The process includes the steps of: pre-conditioning an immunodeficient rodent by administering to the rodent a sub-lethal dose of irradiation and injecting the rodent with an eff... | 08/16/2005 |
| 6828471 | Mice models of human prostate cancer The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof. ... | 12/07/2004 |
| 6825394 | Conditionally immortalized cell lines derived from transgenic animals The invention relates to mammalian cell lines and transgenic mammals. More particularly, it relates to a method for producing a rat cell line, a method for producing a transgenic rat, a transgenic rat, a rat cell line, cells and tissue obtained therefrom and uses th... | 11/30/2004 |
| 6815574 | Methods of simulating human prostate cancer progression The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof. ... | 11/09/2004 |
| 6797721 | Phorboxazole derivatives for treating cancer Synthetic Phorboxazole A and derivatives thereof for the treatment of cancer, including inhibition of cancer cell growth, induction of apoptosis, and inhibition of metastises. ... | 09/28/2004 |
| 6759038 | Metastasis models using green fluorescent protein (GFP) as a marker A method to follow the progression of metastasis of a primary tumor, which method comprises removing fresh organ tissues from a vertebrate subject which has been modified to contain tumor cells that express GFP and observing the excised tissues for the presence of f... | 07/06/2004 |
| 6747187 | Knockout mouse for the tumor suppressor gene ANX7 A knockout transgenic mouse containing a nonfunctional allele of the tumor suppressing gene, annexin VII. This mouse is used as a screening model for potential therapeutic agents useful in the treatment of tumors resulting from an annexin tumor suppressor disease. | 06/08/2004 |
| 6706947 | Method for screening for agents against cancer using an immunosuppression animal model The invention relates to an animal model of cancer. The animal carries a tumour xenograft and is immunosuppressed by administration of cyclosporin and ketoconazole. The model is useful for studying cancer and treatment thereof. ... | 03/16/2004 |
| 6639121 | Inducible cancer model to study the molecular basis of host tumor cell interactions in vivo A non-human mammal having incorporated into its genome an expression construct in which nucleic acid encoding an oncogene is operably linked to an inducible promoter; the mammal further has a genetic mutation that causes it to have an increased susceptibi... | 10/28/2003 |
| 6632979 | Rodent HER2 tumor model The invention concerns HER2-transgenic non-human mammals, animal models for screening drug candidates for the treatment of diseases and disorders associated with the overexpression of HER2. In particular, the invention concerns animal models designed to t... | 10/14/2003 |
| 6632975 | Method for the production of in vivo model of hepatocellular carcinoma without lung metastasis The present invention provides a method for producing an in vivo model of hepatocellular carcinoma without lung metastasis in an animal by injecting diethylnitrosamine and administering nitrosomorpholine in the drinking water of the animal, as well as, me... | 10/14/2003 |
| 6576811 | Transgenic rat with human normal type c-Ha-ras gene The present invention provides a human c-Ha-ras proto-oncogene transgenic rat and the methods of the screening of many carcinogens and the screenings of promoters of carcinogenesis and preventive and inhibitory agents of tumors, and additionally enables t... | 06/10/2003 |
| 6541680 | Nutritional methyl supplements change DNA methylation and related characteristics of mammalian offspring Increasing methylation of DNA in an unborn offspring of a pregnant mammal results in changing the epigenetically determined phenotype of the unborn offspring, inhibiting parasitic DNA sequences in the unborn offspring, and/or reducing susceptibility to tu... | 04/01/2003 |
| 6538174 | Animal model for transplantation The invention relates to an animal model of cancer. The animal carries a tumor xenograft and is immunosuppressed by administration of cyclosporin and ketoconazole. The model is useful for studying cancer and treatment thereof.... | 03/25/2003 |
| 6531645 | RAS/P21 transgenic mouse A transgenic rodent that constitutively expresses a ras protein in at least one tissue, is p21 null in at least one chromosome, and exhibits enhanced and accelerated ras-dependent tumorigenesis, together with methods for using said rodent, or cells derive... | 03/11/2003 |
| 6521815 | Animal model system for squamous cell carcinoma Non-human mammalian animals having a higher epidermal expression level of protein kinase C&3xb5; than their wild-type counterparts are phenotypically distinguished from wild-type animals in that the animals induced to develop tumors in a chemical initiati... | 02/18/2003 |
| 6455756 | Long term xenogeneic myeloid and lymphoid cell production in chimeric immunocompromised mice Immunocompromised mammalian hosts are sub-cutaneously implanted with a combination of human fetal bone and spleen. The chimeric animals can produce human B-cells, myeloid cells and T-cells for up to 9 months in vivo when supplied with an allogeneic human ... | 09/24/2002 |
