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| Number | Title | Issue Date |
| 8020433 | Systems and methods for a sample fluid collection device A fluid collection device comprising a body comprising a capsule interface, and a capsule configured to interface with the body via the capsule interface and configured to hold a sample receiving chip. The sample receiving chip comprises a substrate that receives an... | 09/20/2011 |
| 7987702 | Tear film osmometry Osmolarity measurement of a sample fluid, such as tear film, is achieved by depositing an aliquot-sized sample on a sample receiving substrate. The sample fluid is placed on a sample region of the substrate. Energy is imparted to the sample fluid and energy properti... | 08/02/2011 |
| 7908906 | Fluidic test apparatus and method An apparatus, system and method for determining the osmolarity of a fluid. The system includes an apparatus having: a chip with a substantially planar top surface; a first circuit portion and a second circuit portion, each having a plurality of redundant electricall... | 03/22/2011 |
| 7905134 | Biomarker normalization In accordance with the invention, a fluid sample is measured with a tear film measuring system that includes a processing device that receives a sample chip comprising a sample region configured to contain an aliquot volume of sample fluid, the processing device con... | 03/15/2011 |
| 7886582 | Device for measuring load loss in reverse osmosis membrane containers An interconnector coupled to a permeate water collection tube, establishing first and second groups of membranes, has open and closed ends, and orifices arranged circumferentially and located at a peripheral area in an intermediate section of the interconnector. The... | 02/15/2011 |
| 7810380 | Systems and methods for collecting tear film and measuring tear film osmolarity A sample receiving chip comprising a substrate that receives an aliquot volume of a sample fluid and a sample region of the substrate, sized such that the volume of the sample fluid is sufficient to operatively cover a portion of the sample region. The energy impart... | 10/12/2010 |
| 7574902 | Tear film osmometry Osmolarity measurement of a sample fluid, such as tear film, is achieved by depositing an aliquot-sized sample on a sample receiving substrate. The sample fluid is placed on a sample region of the substrate. Energy is imparted to the sample fluid and energy properti... | 08/18/2009 |
| 7380477 | Method for tissue osmometry A measurement system including a staging unit including a substrate having piezoelectric properties and a conductive electrode formed on the substrate, the conductive electrode including an area adapted to receive a sample, and an oscillator coupled to the conductiv... | 06/03/2008 |
| 7282362 | Tray with protrusions A feeding tray for retaining a liquid nutrient liquid is provided for use with a multiwell filter plate. The feeding tray includes a flat support surface surrounded by walls which retain liquid on the support surface. The flat support surface includes protrusions po... | 10/16/2007 |
| 7276028 | Sensor in vivo measurement of osmotic changes The present invention teaches a method, system and units for measuring changes in blood during a longer period of time in vivo with a patient by measuring diffusivity of solvent. A differential pressure sensor is arranged on a silicon wafer or beam comprising resist... | 10/02/2007 |
| 7233865 | Method for determining diffusivity and molecular weight in a microfluidic device The present invention is directed to a method for determining the molecular weight and diffusivity of a sample solute by providing a plus shaped microchannel network on a microfluidic chip, having at least four microchannels intersecting at a cross point; flowing a ... | 06/19/2007 |
| 7229593 | Portable vapor diffusion coefficient meter An apparatus for measuring the effective vapor diffusion coefficient of a test vapor diffusing through a sample of porous media contained within a test chamber. A chemical sensor measures the time-varying concentration of vapor that has diffused a known distance thr... | 06/12/2007 |
| 7219534 | Method and apparatus for determining transpiration characteristics of a permeable membrane A system and method for measuring the transpirational characteristics of a permeable polymeric membrane, particularly polymeric membranes used for bandages. The polymeric membrane is placed against a moisture source. A probe is applied to the other side. Signals fro... | 05/22/2007 |
| 7189579 | Zero headspace extractor and method for determining partitioning and contaminant release rates of volatile and semi-volatile compounds A method and device for measuring release rates of contaminants in at least one of a fast release mode and a slow release mode in which a volatile liquid sample is introduced into a sealed transparent reactor vessel having at least one sorbent contained within the t... | 03/13/2007 |
| 7182509 | Nanoliter osmometer and method of operation The invention is an apparatus for determining a temperature at which a phase change occurs in a fluid sample, a method for measuring a temperature at which a phase change occurs in a sample and a sample cell. An apparatus for determining a temperature at which a pha... | 02/27/2007 |
| 7179637 | Apparatus and method for using intestinal segments or their substitutes in high-throughput analysis of compound absorption An apparatus for high-throughput analysis of compound absorption in a controlled environment that closely resembles in-vivo conditions. The apparatus includes at least one tissue-receiving enclosure that is capable of interfacing (e.g., via transfer of fluids, elect... | 02/20/2007 |
| 7172859 | System and method for optimizing tissue barrier transfer of compounds The present invention relates to high-throughput systems and methods to prepare a large number of component combinations, at varying concentrations and identities, at the same time, and high-throughput methods to test tissue barrier transfer, such as transdermal tra... | 02/06/2007 |
| 7148060 | Feeding tray for multiwell test apparatus A feeding tray for retaining a nutrient medium is provided for use with a multiwell filter plate. The feeding tray includes an inclined support surface surrounded by walls that retain nutrient medium on the support surface. The support surface is inclined away from ... | 12/12/2006 |
| 7146848 | Testing device for seal bodies A device for measuring the permeability of fluids and/or vapors through elastomeric seal bodies comprising a container incorporating a recess for holding a test medium, the recess being covered and closed off by a lid by way of screws fastening the lid to said conta... | 12/12/2006 |
| 7129717 | Systems and methods for measuring tear film osmolarity An osmolarity measuring system is configured to receive a contact lens in a measurement chamber. The measurement chamber includes a volume of fluid, and a series of electrodes are configured to measure the electrical properties of the fluid. A processing device corr... | 10/31/2006 |
| 7111502 | Systems and methods for reducing the effect of corruptive signals during nanoliter osmometry An osmolarity measuring system includes the ability to recognize patterns within the electrical profile of nanoliters of fluid an account for corruptive signals in the electrical profile. These corruptive signals are mainly caused by the mechanical relaxation of the... | 09/26/2006 |
| 7039527 | Method for measuring diffusivities of compounds using microchips A method for determining the molecular diffusivity of a solute in a microchannel where a solute is introduced into a first end of a microchannel and a first concentration profile is measured at first and second locations along the microchannel. A theoretical concent... | 05/02/2006 |
| 7017394 | Tear film osmometry Osmolarity measurement of a sample fluid, such as tear film, is achieved by depositing an aliquot-sized sample on a sample receiving substrate. The sample fluid is placed on a sample region of the substrate. Energy is imparted to the sample fluid and energy properti... | 03/28/2006 |
| 6941825 | Analytical devices based on diffusion boundary layer calibration and quantitative sorption A method and device for determining the concentration of analytes in a sample. The device has a surface with an extraction coating thereon. The method is carried out while the sample is highly agitated to maintain a substantially constant boundary layer. The sample ... | 09/13/2005 |
| 6928893 | Method of making a gas diffusion media and quality controls for same The present invention discloses various methods in which a quality of a diffusion media for use in a fuel cell assembly can be qualitatively evaluated. The material constant, an internal contact angle, a ratio of high and low energy pores, and an external contact an... | 08/16/2005 |
| 6779384 | Device and method for measuring a diffusion coefficient of nano-particle fluid through hollow-fiber micropores A particle diffusion coefficient measuring device is provided with a hollow-fiber including micropores on its surface. The hollow-fiber provides a passage for particle suspension to transport through. The device is also provided with a fluid passage formed outside t... | 08/24/2004 |
| 6595042 | Method for demonstrating breathability A method for demonstrating breathability by providing an aliquot of liquid in a container having an opening; forming a closed system by securing a film about the opening; imparting evaporation on the closed system; and measuring or observing the remaining... | 07/22/2003 |
| 6588255 | Analytical devices based on diffusion boundary layer calibration and quantitative sorption A method and device for determining the concentration of analytes in a sample. The device has a surface with an extraction coating thereon. The method is carried out while the sample is highly agitated to maintain a substantially constant boundary layer. ... | 07/08/2003 |
| 6450014 | Method and apparatus for measuring osmotic pressure A method and apparatus are provided for the measuring osmotic pressure of a solution. A sample of a solution is placed into a sample cell above a membrane supported in the sample cell and the sample cell is sealed. Gas at an elevated pressure is introduce... | 09/17/2002 |
| 6422066 | Sensor capsule for CO2 sensor A sensor capsule to facilitate positioning of an analyte sensitive element such as a CO2 sensor at the end of a fiber optic probe, which discloses a dye layer defined by a dye well, fluorescent dye solution and apertures formed in a silicone se... | 07/23/2002 |
| 6397666 | Method for generating a solution with a predetermined osmotic pressure A method is provided for determining the concentration of a solution having a predetermined osmotic pressure and/or for generating a solution with a predetermined osmotic pressure. The method is performed by placing a sample of a solution into a sample ce... | 06/04/2002 |
| 6360588 | Materials and methods for the analysis of substances passing through a membrane The subject invention pertains to the efficient and accurate detection and analysis of materials passing through a membrane. In a specific example the transport of materials through skin is analyzed. The subject method can allow accurate, precise, and spe... | 03/26/2002 |
| 6335202 | Method and apparatus for on-line measurement of the permeation characteristics of a permeant through dense nonporous membrane This invention relates to a method and apparatus for on-line measurement of permeation characteristics (transmitting chemicals) through dense nonporous membrane. This invention is intended to facilitate various research activities, such as simultaneous an... | 01/01/2002 |
| 6298713 | Method for determination of water transport in biocompatible materials A method is provided for determining the water diffusion coefficient of a biocompatible material. The method measures water diffusion through the biocompatible material by detecting the presence of hydrogen ions in D2 O by NMR analysis.... | 10/09/2001 |
| 6269679 | System and method to characterize gas transport properties An artificial capillary testing apparatus (ACTA) is provided for evaluation of gas transport/exchange properties of a fluid. A sample fluid, having a known of measured partial gas pressure, is introduced from a gas-tight dispenser into an artificial capil... | 08/07/2001 |
| 6267003 | Method for measuring changes in osmotic pressure A method is provided which allows for monitoring changes in osmotic pressure of a sample as a function of time and/or temperature. This is accomplished by placing a sample of a solution at an initial temperature into the sample cell above the membrane sup... | 07/31/2001 |
| 6251859 | Deepithelialized skin diffusion cell system A deepithelialized skin cell diffusion system which can be used to select topical gel and cream formulations containing human other wound healing promoters such as plasma fibronectin. The formulations provide slow release and increased contact time of fib... | 06/26/2001 |
| 6234004 | Method for measurement of flow velocity or diffusivity, microsensor and application of such microsensor The invention relates to a method and a microsensor for measurement of transport coefficients like diffusivity or flow velocity. The microsensor has a reservoir provided with a mouth and a transducer. The transducer has a tip placed in the mouth, which ca... | 05/22/2001 |
| 6202475 | Predicting logarithmic reduction values A method of predicting logarithmic reduction values for a membrane filtration system having a filtrate flow portion and a bypass flow portion relative to a filtrate permeable membrane with stable input gas flow comprising: determining the filtrate flow ra... | 03/20/2001 |
| 6119506 | Apparatus and method for determining transport properties of porous materials An apparatus and method for measuring the mass transport properties of pos materials. The apparatus is a permeation or diffusion cell that comprises two outer portions with longitudinal channels therein, two clamping plates with openings therein, two flo... | 09/19/2000 |
