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| Number | Title | Issue Date |
| 8088160 | Drug-eluting intravascular prostheses and methods of use The present invention provides intravascular prostheses and methods of production and use. An implantable device for treating a vascular disease or disorder includes an intravascular prosthesis containing an inhibitor of smooth muscle cell proliferation and a growth... | 01/03/2012 |
| 8057535 | Implantable medical device The invention provides an implantable medical device comprising a fibrous polymer body comprising a plurality of electrospun poly(urethane) fibers, a support filament wrapped around the body, an outer layer around the filament for adhering the filament to the body, ... | 11/15/2011 |
| 8029562 | Wettable ePTFE medical devices Methods are provided for surface modifying a hydrophobic polymer substrate to increase wettability comprising the steps of pre-treating the hydrophobic polymer substrate with a radio frequency (RF)-generated first plasma and a RF-generated second plasma wherein the ... | 10/04/2011 |
| 7563279 | Stent having an ultrasonic emitter A system and method that minimizes plaque accumulation on a stent and thereby restenosis that could require a subsequent invasive medical procedure following stent implantation. The stent, essentially an expandable wire mesh tube comprised of a plurality of integral... | 07/21/2009 |
| 7452373 | Stent coated with magnesium-based compound for reducing thrombosis Treatment with magnesium produces a inhibition of acute stent thrombosis under high-shear flow conditions without any hemostatic or significant hemodynamic complications. ... | 11/18/2008 |
| 7364585 | Medical devices comprising drug-loaded capsules for localized drug delivery A medical device comprising a plurality of capsules, and a method of administering therapeutic agent to a patient using the same. The capsules further comprise a therapeutic agent and a multilayer polyelectrolyte shell. The medical device is adapted to apply a press... | 04/29/2008 |
| 7363074 | Coatings comprising self-assembled molecular structures and a method of delivering a drug using the same A coating for an implantable medical device is disclosed, the coating including a self-assembled molecular structure. The coating can be used for altering the release rate of a therapeutic substance from the implantable device. ... | 04/22/2008 |
| 7351421 | Drug-eluting stent having collagen drug carrier chemically treated with genipin A method for treating vulnerable plaques of a patient, comprising: providing a biodegradable stent comprising a first supporting zone made of a first biodegradable material, wherein the supporting zone comprises at least a portion of continuous circumference of the ... | 04/01/2008 |
| 7351257 | Vascular graft device A vascular graft device includes a semipermeable inner wall surrounding a passage. A nonpermeable outer wall surrounds the inner wall. A biological agent is disposed between the inner and outer walls for release through the inner wall. ... | 04/01/2008 |
| 7335391 | Method for coating implantable devices A method of forming a coating for an implantable medical device, such as a stent, is provided which includes applying a composition to the device in an environment having a selected pressure. ... | 02/26/2008 |
| 7329413 | Coatings for drug delivery devices having gradient of hydration and methods for fabricating thereof Coatings for implantable medical devices, and methods for fabricating thereof, are provided. The coatings include a first polymer layer and a second polymer layer, where the second polymer has a higher degree of hydration than the first polymer. ... | 02/12/2008 |
| 7326240 | Stents for blood vessels A stent for supporting part of a blood vessel includes a supporting portion around which or within which part of an intact blood vessel, other than a graft, can be placed so that the stent internally or externally supports that part of the blood vessel. The supporti... | 02/05/2008 |
| 7323209 | Apparatus and method for coating stents An apparatus and method is provided for forming coatings on stents. The apparatus includes a temperature adjusting element that can increase or decrease the temperature of the stent. The apparatus can support a stent during the application of a coating composition t... | 01/29/2008 |
| 7323189 | Liquid and low melting coatings for stents A method for forming liquid coatings for medical devices such as stents and angioplasty balloons is provided. The liquid coatings can be made from biodegradable materials in liquid, low melting solid, or wax forms, which preferably degrade in the body without produc... | 01/29/2008 |
| 7318932 | Coatings for drug delivery devices comprising hydrolitically stable adducts of poly(ethylene-co-vinyl alcohol) and methods for fabricating the same A polymer coating for medical devices based on a derivatized poly(ethylene-co-vinyl alcohol) is disclosed. A variety of polymers are described to make coatings for medical devices, particularly, for drug delivery stents. The polymers include poly(ethylene-co-vinyl a... | 01/15/2008 |
| 7314860 | Heparin-like compounds, their preparation and use to prevent arterial thrombosis associated with vascular injury and interventions The present invention is related to heparin-like compounds characterized by their capacity of inhibiting collagen-induced platelet aggregation in flowing whole blood and their use for prophylactic treatment of arterial thrombosis associated with vascular or microvas... | 01/01/2008 |
| 7311980 | Polyactive/polylactic acid coatings for an implantable device A polymeric coating for a medical device that comprises poly(lactic acid) and a block copolymer including blocks of poly(ethylene glycol) and poly(butylene terephthalate) is provided. ... | 12/25/2007 |
| 7300662 | Drug/drug delivery systems for the prevention and treatment of vascular disease A drug and drug delivery system may be utilized in the treatment of vascular disease. A local delivery system is coated with rapamycin or other suitable drug, agent or compound and delivered intraluminally for the treatment and prevention of neointimal hyperplasia f... | 11/27/2007 |
| 7294329 | Poly(vinyl acetal) coatings for implantable medical devices A coating for a medical device, particularly for a drug eluting stent, is described. The coating includes a polyacetal-based polymer. ... | 11/13/2007 |
| 7288609 | Coatings for drug delivery devices based on poly (orthoesters) A polymer coating for implantable medical devices based on polyorthoesters and methods for fabricating the coating are disclosed. The implantable medical devices made of polyorthoesters and methods for fabricating thereof are also disclosed. ... | 10/30/2007 |
| 7288084 | Drug-loaded medical device A medical device is designed to be placed in a patient's body and release one or more therapeutic agents therefrom. The medical device includes an elongated member defining a passage for passing bodily fluids therethrough and at least one enclosed internal space for... | 10/30/2007 |
| 7279004 | Expandable medical device with curved hinge An expandable tissue supporting device of the present invention employs ductile hinges at selected points in the expandable device. When expansion forces are applied to the device as a whole, the ductile hinges concentrate expansion stresses and strains in small wel... | 10/09/2007 |
| 7279183 | Method of reducing thrombosis and complications after arterial angioplasty using stent coated with magnesium-based compound Treatment with magnesium produces a inhibition of acute stent thrombosis under high-shear flow conditions without any hemostatic or significant hemodynamic complications. ... | 10/09/2007 |
| 7279174 | Stent coatings comprising hydrophilic additives A coating for implantable medical devices and a method for fabricating thereof are disclosed. The coating includes a mixture of a hydrophobic polymer and a polymeric hydrophilic additive, wherein the hydrophobic polymer and the hydrophilic additive form a physically... | 10/09/2007 |
| 7268134 | Medical devices employing triazine compounds and compositions thereof The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced... | 09/11/2007 |
| 7261735 | Local drug delivery devices and methods for maintaining the drug coatings thereon Local drug delivery medical devices are utilized to deliver therapeutic dosages of drugs, agents or compounds directly to the site where needed. The local drug delivery medical devices utilize various materials and coating methodologies to maintain the drugs, agents... | 08/28/2007 |
| 7261946 | Block copolymers of acrylates and methacrylates with fluoroalkenes A block copolymer comprising a fluorinated block and a non-fluorinated block and method of making the block copolymer are provided. Also provided herein are a coating on an implantable device comprising the block copolymer and method of using the implantable device.... | 08/28/2007 |
| 7247313 | Polyacrylates coatings for implantable medical devices A coating for a medical device, particularly for a drug eluting stent, is described. The coating can include a polyacrylate, a blend of polyacrylates, or a blend of the polyacrylate with other polymers, for example, poly(ethylene-co-vinyl alcohol). ... | 07/24/2007 |
| 7244443 | Polymers of fluorinated monomers and hydrophilic monomers A polymer of fluorinated monomers and hydrophilic monomers is provided. It is also provided a polymer blend that contains a polymer of fluorinated monomers and another biocompatible polymer. The polymer of fluorinated monomers or polymer blend described herein and o... | 07/17/2007 |
| 7238199 | Method and apparatus for stent deployment with enhanced delivery of bioactive agents A stent for use in animals including humans is disclosed which includes unprotected and protected regions, each protected regions including a bioactive or biopenetrating agent containing therein where the protected regions are protected by the unprotected regions wh... | 07/03/2007 |
| 7232573 | Stent coatings containing self-assembled monolayers A coating for a medical device, particularly for a drug eluting stent, is described. The coating includes a self-assembled monolayer. ... | 06/19/2007 |
| 7229473 | Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent Methods of preparing intravascular stents with a polymeric coating containing macrocyclic lactone (such as rapamycin or its analogs), stents and stent graphs with such coatings, and methods of treating a coronary artery with such devices. The macrocyclic lactone-bas... | 06/12/2007 |
| 7223282 | Remote activation of an implantable device The invention is directed to an implantable device, such as a stent, for delivering a therapeutic substance. The device includes a reservoir containing a therapeutic substance and an energy converter to cause the release of the substance. ... | 05/29/2007 |
| 7223571 | Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same The present invention relates to methodology for polymer grafting by a polysaccharide synthase and, more particularly, polymer grafting using the hyaluronate or chondroitin or heparin/heparosan synthases from Pasteurella, in order to create a variety of glyco... | 05/29/2007 |
| 7223286 | Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent Methods of preparing intravascular stents with a polymeric coating containing macrocyclic lactone (such as rapamycin or its analogs), stents and stent graphs with such coatings, and methods of treating a coronary artery with such devices. The macrocyclic lactone-bas... | 05/29/2007 |
| 7220816 | Biologically absorbable coatings for implantable devices based on poly(ester amides) and methods for fabricating the same Coatings for an implantable medical devices such as stents and methods of fabricating thereof are disclosed. The coatings comprise a biologically absorbable poly(ester amide), which is a polymeric product of a reaction between a diol-diamine and a dicarboxylic acid.... | 05/22/2007 |
| 7217426 | Coatings containing polycationic peptides for cardiovascular therapy Coatings for implantable medical devices and methods for fabricating the same are disclosed. The coatings include a region containing a polycationic peptide, such as, for example, the polycationic peptide known as R7. ... | 05/15/2007 |
| 7217286 | Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent Methods of preparing intravascular stents with a polymeric coating containing macrocyclic lactone (such as rapamycin or its analogs), stents and stent graphs with such coatings, and methods of treating a coronary artery with such devices. The macrocyclic lactone-bas... | 05/15/2007 |
| 7214242 | Bioengineered tubular graft prostheses The invention is directed to bioengineered tubular graft prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bior... | 05/08/2007 |
| 7214383 | Stent for delivery of drugs to the endothelium The present invention provides for a stent for treatment and prevention of arterial stenosis and re-stenosis. The stent for intraluminal placement within an artery and subsequent expansion for implantation in a patient comprises of a main body portion having a first... | 05/08/2007 |
