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| Number | Title | Issue Date |
| 7887581 | Methods of hemodialysis utilizing grafts coated with cells expressing human fibulin-5 The present relates to artificial vascular grafts and for methods for performing hemodialysis with the same. The grafts comprise an inner surface on which cells genetically altered to express or over-express one or more cell adhesion factors, such as fibulin-5, or o... | 02/15/2011 |
| 7875072 | Cellular transplant stent A cellular stent carries living therapeutic cellular material for implantation into a human or animal body and allows either localized or systemic delivery of the therapeutic products, while promoting engraftment, either on a tissue surface or its interior. The cell... | 01/25/2011 |
| 7758635 | Medical device including cylindrical micelles An endovascular stent comprising an expandable framework including a plurality of interconnected segments, and a plurality of entangled cylindrical micelles disposed on the expandable framework. Each of the plurality of cylindrical micelles may be loaded with a ther... | 07/20/2010 |
| 7563278 | Drug-eluting intravascular prostheses and methods of use The present invention provides intravascular prostheses and methods of production and use. An implantable device for treating a vascular disease or disorder includes an intravascular prosthesis containing an inhibitor of smooth muscle cell proliferation and a growth... | 07/21/2009 |
| 7357812 | Apparatus and methods for delivery of braided prostheses Blood vessels and other body lumens are expanded using an evertible braided prosthesis. The braided prosthesis is delivered to the blood vessel in a radially collapsed configuration. A leading edge of the braided prosthesis is then everted so that it expands as it i... | 04/15/2008 |
| 7326238 | Method and apparatus for treating vulnerable plaque An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has a medical device to treat an occlusive plaque, and is also adapted to release a biologically active agent to treat vulnerable plaque located downstream from the occlusive plaque... | 02/05/2008 |
| 7326564 | Flow system for medical device evaluation and production In some embodiments, a flow system includes a medical device mount, fluid and a conduit containing the fluid and medical device mount. The conduit is mounted on an assembly that moves the conduit along with the medical device mount to induce relative motion of the f... | 02/05/2008 |
| 7311904 | Tissue matrices comprising placental stem cells, and methods of making the same A method of manufacturing a tissue matrix for implantation into a patient is disclosed. The method sets forth collecting embryonic stem cells from a placenta which has been treated to remove residual cord blood and seeding the collected stem cells onto or into a tis... | 12/25/2007 |
| 7299805 | Scaffold and method for implanting cells An improved method of implanting cells in the body of a patient includes positioning viable cells on a support structure. One or more blood vessels may be connected with the support structure to provide a flow of blood through the support structure. A support struct... | 11/27/2007 |
| 7267686 | Implantable prosthetic valve A prosthetic valve for implantation within a fluid conducting lumen within a body includes an elongate generally cylindrical radially collapsible valve body scaffold defining a fluid passageway therethrough for retentive positioning within the lumen. A radially coll... | 09/11/2007 |
| 7244242 | Valve treatment catheter and methods The invention provides a catheter for insertion into a biological passage which contains a first flowing fluid, the catheter including a tubular member having a proximal end and a distal end; a fluid delivery lumen contained within the tubular member; an inflatable ... | 07/17/2007 |
| 7235096 | Implantable device for promoting repair of a body lumen An implantable stent having surface features adapted to promote an organized growth pattern of infiltrating cells when implanted in a tubular organ is provided. The surface features comprise depressions, pores, projections, pleats, channels or grooves in the stent b... | 06/26/2007 |
| 7186267 | Porous and/or polycrystalline silicon orthopaedic implant The invention relates to orthopaedic implant materials and devices comprising porous and or polycrystalline silicon. Such materials and devices may be used in the treatment of one or more of the following conditions: hip fracture, arthrosis of the hip and knee, vert... | 03/06/2007 |
| 7179287 | Bioreactor mediated recellularization of natural and tissue engineered vascular grafts Processes for producing a tissue graft comprising acellularizing or devitalizing a tubular tissue to produce a tissue matrix. The tissue matrix is then populated with at least some viable cells. The processing and the populating steps are performed in a closed syste... | 02/20/2007 |
| 7175658 | Artificial vascular grafts, their construction and use The present invention relates to artificial vascular grafts, methods for manufacturing and uses for them. The grafts are coated on their lumen with UP50. The grafts comprise an inner surface on which cells genetically altered to express or over-express one or more c... | 02/13/2007 |
| 7169764 | Promoter for smooth muscle cell expression Disclosed is a smooth muscle cell specific promoter, the SM22α gene promoter as well as the murine cDNA and genomic SM22α nucleic acid sequences. Also disclosed are methods of preventing restenosis following balloon angioplasty and methods of treating asthma based... | 01/30/2007 |
| 7156872 | Implantable valve system An implantable valve having a valve element or leaflet and a base that is attachable to a vessel wall using a connector such as a screw, pin or a staple. The valve can be implanted using a catheter to position the valve in a desired location and drive the connector ... | 01/02/2007 |
| 7147846 | Prosthetic grafts An improved prosthetic graft for the bypass, replacement or repair of vessels and organs that are in contact with blood flow is disclosed. The prosthetic graft includes a porous prosthetic implant and adherent cells adhered to the outer surface of the implant. The a... | 12/12/2006 |
| 7112218 | Tissue engineered blood vessels and apparatus for their manufacture The invention is a tissue engineered blood vessel (TEBV) made from a cultured fibroblast sheet rolled into a multilayer vessel which has sufficient burst strength to withstand physiological blood pressure without the inclusion of smooth muscle cells or synthetic sca... | 09/26/2006 |
| 7108717 | Stent covered with heterologous tissue A covered stent assembly comprising a tubular, expandable stent having a metallic framework covered with a cylinder of biocompatible, non-thrombogenic expandable material, such as heterologous tissue. In a preferred embodiment, the metallic framework is positioned c... | 09/19/2006 |
| 7087089 | Graft prosthesis devices containing renal capsule collagen The invention provides tissue graft compositions comprising collagen-based extracellular matrices derived from renal capsules of warm-blooded vertebrates. The invention further provides a process of harvesting and purifying a renal capsule to provide an extracellula... | 08/08/2006 |
| 7081131 | Artificial valve Method and apparatus implementing and using techniques for controlling flow in a body lumen, including use of an implantable medical device. The device includes a membrane implantable in a body lumen and invertibly deformable between a first position and a second po... | 07/25/2006 |
| 7073456 | Method for manufacturing stent-grafts A sewing machine is provided which is capable of sewing reinforcing wire to tubular grafts in order to form stent grafts. A bobbin (which may be seated in a shuttle) carries a bottom thread through the bore of the tubular graft and forms a stitch in combination with... | 07/11/2006 |
| 7056337 | Natural tissue stent A medical implant made from multiple layers of non-synthetic, natural tissues is provided. The medical device includes openings that extend radially through the wall of the medical implant. One advantage of the medical implant is that a synthetic support structure i... | 06/06/2006 |
| 7007698 | Body lumen closure Method and apparatus implementing and using techniques for body lumen closure, including use of an implantable medical closure device. The device includes a flexible strand defining an arcuate form. The strand is deformable upon implantation from a large cross-secti... | 03/07/2006 |
| 6945957 | Valve treatment catheter and methods The invention provides a catheter for insertion into a biological passage which contains a first flowing fluid, the catheter including a tubular member having a proximal end and a distal end; a fluid delivery lumen contained within the tubular member; an inflatable ... | 09/20/2005 |
| 6926743 | Biological stent-graft A biological stent-graft and a method of making the same wherein a stent is surgically implanted in the lumen of an artery of a mammal, harvesting the stent-graft precursor after the stent has been incorporated into artery wall, fixing the harvested stent-graft prec... | 08/09/2005 |
| 6733747 | Prosthetic grafts An improved prosthetic graft for the bypass, replacement or repair of vessels and organs that are in contact with blood flow is disclosed. The prosthetic graft includes a porous prosthetic implant and adherent cells adhered to the outer surface of the implant. The a... | 05/11/2004 |
| 6630000 | Method of using body tissue A method of using body tissue includes obtaining graft tissue. A medicinal substance is added to the graft tissue. The graft tissue is shaped to a predetermined configuration while the graft tissue is outside of a patient's body. The graft tissue is moved... | 10/07/2003 |
| 6579313 | Methods for implanting cells A method for implanting cells onto a prosthesis includes the steps of: (a) providing a prosthesis including a porous tube, where at least 25% of the pores on the inner surface of the tube have diameters of more than about 40 μm, at least 25% of the pores... | 06/17/2003 |
| 6544249 | Biological microfistula tube and implantation method and apparatus The present invention provides a microfistula tube including a soluble duct, defining a drainage canal having an inner surface, the duct being biocompatible, wherein the microfistula tube is coated with and/or incorporates biological for forming a basemen... | 04/08/2003 |
| 6503273 | Tissue engineered blood vessels and methods and apparatus for their manufacture The invention is a tissue engineered blood vessel (TEBV) made from a cultured fibroblast sheet rolled into a multilayer vessel which has sufficient burst strength to withstand physiological blood pressure without the inclusion of smooth muscle cells or sy... | 01/07/2003 |
| 6443941 | Biodegradable polymeric endoluminal sealing process, apparatus and polymeric products for use therein A novel process for paving or sealing the interior surface of a tissue lumen by entering the interior of the tissue lumen and applying a polymer to the interior surface of the tissue lumen. This is accomplished using a catheter which delivers the polymer ... | 09/03/2002 |
| 6355055 | Endovascular support device and method of use An endovascular support device adapted for local delivery of a therapeutic agent and for minimizing the rate of restinosis having a cylindrical support body with an inside surface and an opposite outside surface, and at least one layer of pericardial tiss... | 03/12/2002 |
| 6352555 | Methods for implanting cells Disclosed herein is a method for implanting cells onto a prosthesis, including the steps of: (a) providing a prosthesis including a porous tube, where at least 25% of the pores on the inner surface of the tube have diameters of more than about 40 μm, at ... | 03/05/2002 |
| 6331527 | Promoter smooth muscle cell expression Disclosed is a smooth muscle cell specific promoter, the SM22 gene promoter as well as the murine cDNA and genomic SM22 nucleic acid sequences. Also disclosed are methods of preventing restenosis following balloon angioplasty and methods of ... | 12/18/2001 |
| 6328762 | Prosthetic grafts An improved prosthetic graft for the bypass, replacement or repair of vessels and organs that are in contact with blood flow is disclosed. The prosthetic graft includes a porous prosthetic implant and adherent cells adhered to the outer surface of the imp... | 12/11/2001 |
| 6210436 | Implantable members for receiving therapeutically useful compositions An implantable prosthesis includes a porous polymeric member having pores present in its wall structure wherein these pores contain a variety of therapeutically useful compositions including, collagen, genetically altered cells and piezoelectric materials... | 04/03/2001 |
| 6176874 | Vascularized tissue regeneration matrices formed by solid free form fabrication techniques Solid free-form fabrication (SFF) methods are used to manufacture devices for allowing tissue regeneration and for seeding and implanting cells to form organ and structural components, which can additionally provide controlled release of bioactive agents,... | 01/23/2001 |
| 6139574 | Vascularized tissue regeneration matrices formed by solid free form fabrication techniques Solid free-form fabrication (SFF) methods are used to manufacture devices for allowing tissue regeneration and for seeding and implanting cells to form organ and structural components, which can additionally provide controlled release of bioactive agents,... | 10/31/2000 |
