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| Number | Title | Issue Date |
| 8175712 | Homotopic conditioning of the brain stem baroreflex of a subject Disclosed are methods for regulating blood pressure in a subject which include administering a first induction stimulus effective to sensitize brainstem baroreflex neurons of a subject for a period of time in the range of about 10-15 hours thereby producing an enhan... | 05/08/2012 |
| 8175711 | Methods for treating a condition or disease associated with cardio-renal function Methods and apparatus are provided for treating congestive heart failure, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuat... | 05/08/2012 |
| 8150521 | Methods and devices for controlling battery life in an implantable pulse generator Methods, devices, and systems for controlling an implantable pulse generator for activation of a nerve or receptor are provided. In particular, the method, devices, and systems embodying features of the present invention control the energy output of a battery in an ... | 04/03/2012 |
| 8150519 | Methods and apparatus for bilateral renal neuromodulation Methods and apparatus are provided for bilateral renal neuromodulation, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate ... | 04/03/2012 |
| 8150520 | Methods for catheter-based renal denervation Methods and apparatus are provided for treating end-stage renal disease, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate... | 04/03/2012 |
| 8150518 | Renal nerve stimulation method and apparatus for treatment of patients A method and apparatus for treatment of heart failure, hypertension and renal failure by stimulating the renal nerve. The goal of therapy is to reduce sympathetic activity of the renal nerve. Therapy is accomplished by at least partially blocking the nerve with drug... | 04/03/2012 |
| 8145317 | Methods for renal neuromodulation Methods and apparatus are provided for treating hypertension, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversib... | 03/27/2012 |
| 8145316 | Methods and apparatus for renal neuromodulation Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial ... | 03/27/2012 |
| 8131371 | Methods and apparatus for monopolar renal neuromodulation Methods and apparatus are provided for monopolar neuromodulation, e.g., via a pulsed electric field. Such monopolar neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, ... | 03/06/2012 |
| 8131372 | Renal nerve stimulation method for treatment of patients A method and apparatus for treatment of heart failure, hypertension and renal failure by stimulating the renal nerve. The goal of therapy is to reduce sympathetic activity of the renal nerve. Therapy is accomplished by at least partially blocking the nerve with drug... | 03/06/2012 |
| 8131373 | Baroreflex stimulation synchronized to circadian rhythm An embodiment of a baroreflex stimulator comprises a pulse generator to provide a baroreflex stimulation signal through an electrode, and a modulator to modulate the baroreflex stimulation signal based on a circadian rhythm template. According to an embodiment of a ... | 03/06/2012 |
| 8126561 | Implantable and rechargeable neural stimulator One aspect of the present subject matter relates to an implantable medical device. An embodiment of the device comprises a rechargeable power supply adapted to be recharged through an ultrasound signal, a neural stimulator connected to the rechargeable power supply,... | 02/28/2012 |
| 8126560 | Stimulation lead for stimulating the baroreceptors in the pulmonary artery An apparatus includes a flexible lead body extending from a proximal end to a distal end, the distal end having a biased portion having an outer diameter dimensioned to abut a wall of a pulmonary artery, an electrode coupled proximate the distal end, and an implanta... | 02/28/2012 |
| 8121693 | Baroreflex stimulation to treat acute myocardial infarction An aspect of the present subject relates to an implantable medical system. An embodiment of the system includes a baroreflex stimulator, a myocardial infarction detector, and a controller. The baroreflex stimulator applies a baroreflex stimulation signal through an ... | 02/21/2012 |
| 8116873 | Measurement of patient physiological parameters A method of determining one or more physiological parameter of a patient by providing a plurality of implantable electrodes proximate a blood vessel of the patient, applying a measurement signal through the plurality of electrodes, the measurement signal having a kn... | 02/14/2012 |
| 8086315 | Cardiac stimulation apparatus and method for the control of hypertension A method that electrically stimulates a heart muscle to alter the ejection profile of the heart, to control the mechanical function of the heart and reduce the observed blood pressure of the patient. The therapy may be invoked by an implantable blood pressure sensor... | 12/27/2011 |
| 8086314 | Devices and methods for cardiovascular reflex control Devices, systems and methods are described which control blood pressure, nervous system activity, and neurohormonal activity by activating baroreceptors. By selectively and controllably activating baroreceptors, the present invention reduces excessive blood pressure... | 12/27/2011 |
| 8060206 | Baroreflex modulation to gradually decrease blood pressure The present invention is a baroreceptor stimulator, including, a pulse generator to provide a baroreceptor stimulation signal through an electrode and a modulator to modulate the baroreceptor stimulation signal to increase the baroreceptor stimulation therapy by a p... | 11/15/2011 |
| 8041428 | Electrical stimulation treatment of hypotension The present invention includes methods and devices for treating hypotension, such as in cases of shock, including septic shock, anaphylactic shock and hypovolemia. The method includes the step of applying at least one electrical impulse to at least one selected regi... | 10/18/2011 |
| 8010199 | Blood pressure regulating system by substituting native biological regulatory function A blood pressure regulating system uses a native regulation rule to estimate at least one nerve activity in response to blood pressure changes, comprising at least one blood pressure sensing means which senses blood pressure and outputs a input blood pressure signal... | 08/30/2011 |
| 8010198 | Systems and methods for avoiding neural stimulation habituation An embodiment relates to a method for delivering a vagal stimulation therapy to a vagus nerve, including delivering a neural stimulation signal to non-selectively stimulate both afferent axons and efferent axons in the vagus nerve according to a predetermined schedu... | 08/30/2011 |
| 8000793 | Automatic baroreflex modulation based on cardiac activity An aspect relates to a system for providing baroreflex stimulation. An embodiment of the system comprises a cardiac activity monitor to sense cardiac activity and provide a signal indicative of the cardiac activity, and a baroreflex stimulator. The stimulator includ... | 08/16/2011 |
| 7962216 | Cardiac pacing system, blood pressure regulating system, and cardiac disease treatment system by substituting native biological regulatory function A medical treating system based on biological activities characterized by biological activity sensing means for sensing biological activity information produced by biological activities and outputting a biological activity signal, calculating means for receiving, an... | 06/14/2011 |
| 7949400 | Devices and methods for cardiovascular reflex control via coupled electrodes Devices, systems and methods are disclosed by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, p... | 05/24/2011 |
| 7925352 | System and method for transvascularly stimulating contents of the carotid sheath Methods and systems are disclosed for stimulating contents of the carotid sheath using an intravascular pulse generator and lead. The lead carries an energy delivery device such as an electrode, which is anchor within the portion of the internal jugular vein that is... | 04/12/2011 |
| 7869881 | Baroreflex stimulator with integrated pressure sensor An aspect relates to an implantable medical device. An embodiment of the device comprises a pulse generator, sensor circuitry, a lead, and a controller. The pulse generator generates baroreflex stimulation pulses. The lead is adapted to be electrically connected to ... | 01/11/2011 |
| 7840271 | Stimulus regimens for cardiovascular reflex control Devices, systems and methods by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, for example a b... | 11/23/2010 |
| 7835797 | Method and system for implantable pressure transducer for regulating blood pressure An apparatus and a system can chronically and automatically measure a physiologic parameter associated with the high pressure side of the vasculature and/or regulate blood pressure based upon the measured parameter. The apparatus may be made up of a transducer, a ba... | 11/16/2010 |
| 7801614 | Stimulus regimens for cardiovascular reflex control Baroreflex activation is achieved by providing suitable control signals to a baroreflex activation device. A method comprises establishing a therapy interval (possibly on the order of minutes to hours, or possibly of indefinite duration), within the therapy interval... | 09/21/2010 |
| 7765008 | Method of controlling blood pressure A method of promoting the healing of a lesion in a smooth muscle (200), comprises selecting a smooth muscle portion having a lesion, and applying a non-excitory electric field (210) to the portion, which reduces the mechanical activity of the portion. | 07/27/2010 |
| 7756583 | Methods and apparatus for intravascularly-induced neuromodulation Methods and apparatus are provided for intravascularly-induced neuromodulation using a pulsed electric field, e.g., to effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, changes in cytoki... | 07/13/2010 |
| 7706884 | Baroreflex stimulation synchronized to circadian rhythm An aspect relates to a baroreflex stimulator. An embodiment of the stimulator comprises a pulse generator to provide a baroreflex stimulation signal through an electrode, and a modulator to modulate the baroreflex stimulation signal based on a circadian rhythm templ... | 04/27/2010 |
| 7653438 | Methods and apparatus for renal neuromodulation Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial ... | 01/26/2010 |
| 7650190 | Methods and apparatus for the regulation of hormone release A method and apparatus for delivering corrective therapy through hormone regulation is provided. Inhibition of sympathetic fibers by spinal cord stimulation is used to regulate the levels of hormones such as catecholamines, renin, and calcitonin gene-related peptide... | 01/19/2010 |
| 7647114 | Baroreflex modulation based on monitored cardiovascular parameter An aspect relates to a system for providing baroreflex stimulation. An embodiment of the system comprises a heart rate monitor to sense a heart rate and provide a signal indicative of the heart rate, and a baroreflex stimulator. The stimulator includes a pulse gener... | 01/12/2010 |
| 7647115 | Renal nerve stimulation method and apparatus for treatment of patients A method and apparatus for treatment of heart failure, hypertension and renal failure by stimulating the renal nerve. The goal of therapy is to reduce sympathetic activity of the renal nerve. Therapy is accomplished by at least partially blocking the nerve with drug... | 01/12/2010 |
| 7623926 | Stimulus regimens for cardiovascular reflex control Baroreflex activation is achieved by providing suitable control signals to a baroreflex activation device. A method comprises establishing a therapy interval (possibly on the order of minutes to hours, or possibly of indefinite duration), within the therapy interval... | 11/24/2009 |
| 7616997 | Devices and methods for cardiovascular reflex control via coupled electrodes Devices, systems and methods are disclosed by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, p... | 11/10/2009 |
| 7486991 | Baroreflex modulation to gradually decrease blood pressure An aspect of the present subject matter relates to a baroreflex stimulator. An embodiment of the stimulator includes a pulse generator to provide a baroreflex stimulation signal through an electrode, and a modulator. The modulator modulates the baroreflex stimulatio... | 02/03/2009 |
| 7409241 | Monitoring the sympathico-vagal activity by analysis of endocardiac acceleration in an active implantable medical device An active implantable medical device having a function for monitoring the sympathico-vagal activity by an analysis of endocardiac acceleration. The device collects at least one physiological parameter of the patient, analyzes that collected parameter and delivers at... | 08/05/2008 |
