Felix Hoffmann, a German chemist, was searching for something to relieve his father's arthritis. In doing so, he "rediscovered" acetylsalicylic acid and in 1900, patented a stable process for developing it. Hence, we have aspirin.
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| Number | Title | Issue Date |
| 7792584 | System and method for characterization of atrial wall using digital signal processing A system and method for characterizing the atrial wall of the heart is provided. The characterization of the atrial wall can be used for a variety of diagnostic and therapeutic purposes. For example, it can be used to detect precursors to various types of hear disea... | 09/07/2010 |
| 7319900 | Cardiac response classification using multiple classification windows Methods and devices for classifying a cardiac response to pacing involve establishing a plurality of classification windows relative to and following a pacing pulse. One or more characteristics of a cardiac signal sensed following the pacing pulse are detected withi... | 01/15/2008 |
| 7248921 | Method and devices for performing cardiac waveform appraisal The present invention is directed toward a sensing architecture for use in cardiac rhythm management devices. The sensing architecture of the present invention provides a method and means for certifying detected events by the cardiac rhythm management device. Moreov... | 07/24/2007 |
| 7215993 | Cardiac rhythm management systems and methods for detecting or validating cardiac beats in the presence of noise This document describes systems, devices, and methods for detecting or validating cardiac beats, such as in the presence of myopotential or other noise. In one example, an amplitude peak, which is a candidate for a detected cardiac beat, is used in a weighted averag... | 05/08/2007 |
| 7212862 | Cardiac stimulation device including sleep apnea prevention and treatment An implantable cardiac stimulation device comprises a physiologic sensor and one or more pulse generators. The physiologic sensor is capable of sensing a physiologic parameter. The pulse generators can generate cardiac pacing pulses with a timing based on the physio... | 05/01/2007 |
| 7130686 | Selection of preventative arrhythmia therapy based on patient specific histogram data Methods and systems for providing cardiac therapy are described. In some embodiments, methods and systems are configured to deliver atrial tachyarrhythmia therapy by confirming that a patient is asleep and thereafter administering the therapy. Sleep can be confirmed... | 10/31/2006 |
| 7027867 | Implantable cardiac device having a system for detecting T wave alternan patterns and method A system and method for use in an implantable cardiac device that delivers electrical therapy to a patient's heart determines if a T wave alternan pattern of the patient's heart exists. The system includes a sensing circuit that generates an electrical signal repres... | 04/11/2006 |
| 7019716 | Driving method for PDPs with variable vertical frequency A driving method for PDPs with variable vertical frequency. The method increases the sum of the sustain periods to obtain high brightness, by adjusting vertical frequency of a PDP through an image loading such that each image frame time displayed on the PDP is adjus... | 03/28/2006 |
| 6999817 | Cardiac stimulation device including sleep apnea prevention and treatment An implantable cardiac stimulation device comprises a physiologic sensor and one or more pulse generators. The physiologic sensor is capable of sensing a physiologic parameter. The pulse generators can generate cardiac pacing pulses with a timing based on the physio... | 02/14/2006 |
| 6950702 | Use of curvature based features for beat detection A cardiac rhythm management system includes a sensing circuit to sense a cardiac signal and a sensing processor to detect cardiac depolarizations (beats) by utilizing certain morphological context of the sensed cardiac signal. The sensing processor samples the sense... | 09/27/2005 |
| 6928324 | Stimulation device for sleep apnea prevention, detection and treatment An implantable cardiac stimulation device comprises a metabolic demand sensor, an activity sensor, and one or more pulse generators. The metabolic demand sensor and activity sensor can sense metabolic demand and physical activity parameters, respectively. The pulse ... | 08/09/2005 |
| 6925330 | Implantable medical device and method for detecting cardiac events without using of refractory or blanking periods Cardiac electrical events are detected by comparing signal vectors with pre-determined classification zones representative of different cardiac events. The signal vector is generated by sensing the voltages between various combinations of electrodes, such as A-tip t... | 08/02/2005 |
| 6917830 | Method and system for noise measurement in an implantable cardiac device An implantable cardiac rhythm management device is configured to estimating the noise level and noise floor in a sensing channel by measuring the magnitude of signal in the sensing channel when noise is determined to be present or absent, respectively. The presence ... | 07/12/2005 |
| 6904320 | Sleep apnea therapy device using dynamic overdrive pacing A cardiac stimulation device uses dynamic overdrive pacing to prevent sleep apnea. In another aspect, the device can use dynamic overdrive pacing to terminate sleep apnea after detection. An implantable cardiac stimulation device comprises a sensor and one or more p... | 06/07/2005 |
| 6836682 | Rate responsive pacing system with QT sensor based on intrinsic QT data There is provided a system and method of rate responsive pacing, having an intrinsic QT rate sensor. The system has the capability of sensing the QT interval of intrinsic cardiac signals and constructing from such intrinsic QT data a QT reference curve. The QT refer... | 12/28/2004 |
| 6269268 | Rate-responsive pacemaker with closed-loop control A rate-responsive pacemaker which is provided with a closed-loop control system whose rate control parameter is the depolarization gradient. Any difference between the measured value of the rate control parameter and a target value is used to change the p... | 07/31/2001 |
| 6029087 | Cardiac pacing system with improved physiological event classification based on DSP There is provided an implantable cardiac pacing system or other cardiac monitoring system, having an enhanced capability of classifying intracardiac signals through a combination of DSP techniques and software algorithms. The implantable device has one or... | 02/22/2000 |
| 5571144 | Method of verifying capture of the atrium by a cardiac stimulator A method of verifying whether an atrium of the heart has been captured by an atrial cardiac stimulation pulse. An atrial signal is sensed via an electrode located in the atrium during a period of time from before delivery of the stimulation pulse to after... | 11/05/1996 |
| 5456263 | Detector for detecting heart depolarizations A compact, power-sparing detector for detecting heart polarizations is described. The detector has a first operational amplifier which uses sensed heart signals from a heart as an input signal. By means of feedback coupling via a second operational amplif... | 10/10/1995 |
| 5431693 | Method of verifying capture of the heart by a pacemaker A method of verifying cardiac capture. A cardiac signal evoked in response to a cardiac stimulation pulse is sensed via an electrode. The sensed signal is lowpass filtered to remove noise and to pass frequencies characteristic of the evoked cardiac signal... | 07/11/1995 |
| 5312455 | Programmable window reference generator for use in an implantable cardiac pacemaker A sense amplifier adapted for use with a cardiac pacer or the like includes a constant gain filter, a window comparator circuit and a programmable threshold reference generator circuit. The reference generator circuit generates a programmable window (refe... | 05/17/1994 |
| 5309919 | Method and system for recording, reporting, and displaying the distribution of pacing events over time and for using same to optimize programming A method and system for monitoring the behavior of an implanted pacemaker counts (records) the number of times that a given internal event or state change of the pacemaker occurs, and also determines the rate at which each event or state change thus count... | 05/10/1994 |
| 5306293 | Device for the prevention of cardiac failures The implantable device, of the Holter intervention type, permits the detection and the polygraphic analysis (ECG, TA, haemodynamics, resonant frequencies), of the cardiovascular parameters, especially in the active sequence of current cycles, permitting t... | 04/26/1994 |
| 5271393 | Pacemaker employing antitachyarrhythmia prevention based on ventricular gradient An anti-tachyarrythmia pacing system is disclosed which utilizes an intra-cardiac electrode to obtain a gradient for each cardiac cycle. When the gradient increases beyond a predetermined value, it is determined that tachyarrythmia is imminent and the pac... | 12/21/1993 |
| 5085215 | Metabolic demand driven rate-responsive pacemaker A rate-responsive dual-chamber pacemaker and pacing method for supporting the heart with electrical stimulation at a pacing rate driven by the heart's sinus node or, alternatively, by a sensor adapted to determine the patient's metabolic demand (a metabol... | 02/04/1992 |
| 4969461 | Pacemaker with improved automatic output regulation A pacemaker which is provided with an improved automatic regulation circuit which is capable of distinguishing between a fusion beat and loss of capture. The failure to sense an evoked potential following a stimulus may be due to either. The cause is dete... | 11/13/1990 |
| 4969460 | Pacemaker with improved automatic output regulation A pacemaker which is provided with an improved automatic regulation circuit which is capable of distinguishing between a fusion beat and loss of capture. The failure to sense an evoked potential following a stimulus may be due to either. The cause is dete... | 11/13/1990 |
| 4969467 | Pacemaker with improved automatic output regulation A pacemaker which is provided with an improved automatic regulation circuit which is capable of distinguishing between a fashion beat and loss of capture. The failure to sense an evoked potential following a stimulus may be due to either. The cause is det... | 11/13/1990 |
| 4969464 | Pacemaker with improved automatic output regulation A pacemaker which is provided with an improved automatic regulation circuit which is capable of distinguishing between a fusion beat and loss of capture. The failure to sense an evoked potential following a stimulus may be due to either. The cause is dete... | 11/13/1990 |
| 4969462 | Pacemaker with improved automatic output regulation A pacemaker which is provided with an improved automatic regulation circuit which is capable of distinguishing between a fusion beat and loss of capture. The failure to sense an evoked potential following a stimulus may be due to either. The cause is dete... | 11/13/1990 |
| 4955376 | Pacemaker with improved automatic output regulation A pacemaker which is provided with an improved automatic regulation circuit which is capable of distinguishing between a fusion beat and loss of capture. The failure to sense an evoked potential following a stimulus may be due to either. The cause is dete... | 09/11/1990 |
| 4895150 | Implanted power source A housing for enclosing a power source for operating an implanted artificial organ is provided. The housing has an annular rim defining an aperture and is mounted in the human body such that replacement of the power source through the aperture is effected... | 01/23/1990 |
| 4878497 | Pacemaker with improved automatic output regulation A pacemaker which is provided with an improved automatic regulation circuit which is capable of distinguishing between a fusion beat and loss of capture. The failure to sense an evoked potential following a stimulus may be due to either. The cause is dete... | 11/07/1989 |
| 4766900 | Rate responsive pacing system using the integrated cardiac event potential A rate responsive cardiac pacing system is provided. In the illustrative embodiment, electrical stimulus pulses are applied to the heart ventricle and the evoked potential of the applied electrical stimulus pulses is detected. The detected potential is in... | 08/30/1988 |
| 4766901 | Rate responsive pacing system using the integrated evoked potential A rate responsive cardiac pacing system is provided. In the illustrative embodiment, electrical stimulus pulses are applied to the heart ventricle and the evoked potential of the applied electrical stimulus pulses is detected. The detected potential is in... | 08/30/1988 |
| 4759367 | Rate responsive pacing using the magnitude of the repolarization gradient of the ventricular gradient A rate responsive cardiac pacing system is provided. In the illustrative embodiment, electrical stimulus pulses are applied to the heart ventricle and the evoked potential of the applied electrical stimulus pulses is detected. The detected potential is in... | 07/26/1988 |
| 4759366 | Rate responsive pacing using the ventricular gradient A rate responsive cardiac pacing system is provided. In the illustrative embodiment, electrical stimulus pulses are applied to the heart ventricle and the evoked potential of the applied electrical stimulus pulses is detected. The detected potential is in... | 07/26/1988 |
| 4556062 | Cardiac stimulator with frequency self-regulation through the electrocardiographic T wave A pacemaker used for cardiac stimulation has its stimulation frequency varied according to the changing metabolic requirements of a subject pacemaker user due to stress, emotion and the like. Control of the stimulation frequency is based essentially on th... | 12/03/1985 |