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| Number | Title | Issue Date |
| 8116851 | Living body measurement apparatus with waveguide light source and light extracting pattern Disclosed is a living body measurement apparatus including: a first light source placed on the surface of the skin in a living body and radiating a first light in a visible light wavelength range onto the surface of the skin; a second light source placed on the surf... | 02/14/2012 |
| 8090432 | Implantable tissue perfusion sensing system and method A medical device for sensing cardiac events that includes a plurality of electrodes sensing cardiac signals utilized to identify a cardiac event, a plurality of light sources capable of emitting light at a plurality of wavelengths, and a detector to detect the emitt... | 01/03/2012 |
| 8090431 | Systems and methods for bioluminescent computed tomographic reconstruction An image of an object is synergistically reconstructed using two or multiple imaging modalities. A first reconstructed image, showing structural information of the object is produced using a first imaging modality. The first reconstructed image is segmented, and kno... | 01/03/2012 |
| 8078262 | Method for imaging and spectroscopy of tumors and determination of the efficacy of anti-tumor drug therapies The present invention relates to methods of passive infrared imaging and dynamic infrared imaging of a tumor or lesion (“DIR”) where multiple images are taken before, during and after heating or cooling the tumor or lesion. Patterns of intensity of infrared emis... | 12/13/2011 |
| 8078264 | Intra-operative molecular imaging A system for imaging an abnormal cell and or diseased tissue after topical application of a near infrared protease-specific probe is disclosed. The system includes a protease-specific near infrared (NIRF) imaging probe, means for topically administering the protease... | 12/13/2011 |
| 8078263 | Projection of subsurface structure onto an object's surface An imaging system illuminates an object with infrared light to enhance visibility of buried structure beneath the surface of the object, and projects a visible light image of the buried structure onto the surface of the object. The system may include an infrared lig... | 12/13/2011 |
| 8073531 | Micro vein enhancer The present invention is a Miniature Vein Enhancer that includes a Miniature Projection Head. The Miniature Projection Head may be operated in one of three modes, AFM, DBM, and RTM. The Miniature Projection Head of the present invention projects an image of the vein... | 12/06/2011 |
| 8060187 | Near-infrared spectroscopic analysis of blood vessel walls The invention relates to methods and devices for characterizing tissue in vivo, e.g., in walls of blood vessels, to determine whether the tissue is healthy or diseased, and include methods of displaying results with or without thresholds. ... | 11/15/2011 |
| 8060188 | Method for imaging variations in tissue viability Prolonged and severe tissue hypoxia results in tissue necrosis in pedicled flaps. We demonstrate the potential of near-infrared spectroscopy for predicting viability of compromised tissue portions. This approach clearly identifies tissue regions with low oxygen supp... | 11/15/2011 |
| 8055330 | Sensing gas bubbles in a living body A method of detecting gas bubbles in a living body, comprising: transmitting at least one original electromagnetic signal to a body portion; detecting a signal modulated by a flow of blood in said body portion; and analyzing a perturbation in said signal to determin... | 11/08/2011 |
| 8050744 | Optical system for measuring metabolism in a body and imaging method In an optical measurement system and imaging method adapted to measure in vivo information in a living body without harming the living body, light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irrad... | 11/01/2011 |
| 8050745 | Methods and systems for enhanced medical procedure visualization The present invention employs image intensification for medical procedures within the human body. Methods and systems of the invention utilize infrared radiation (e.g. greater than about 750 nm) illumination and visualization of a surgical treatment area. Preferred ... | 11/01/2011 |
| 8024027 | Infrared endoscopic balloon probes Balloon probes, adapted for use in endoscopy and other medical procedures, are useful to obtain spectroscopic information reflected or emitted from a tissue of interest in the infrared spectral region. The information collected by the probe is useful in the diagnosi... | 09/20/2011 |
| 8010185 | Method of diagnosing a lower urinary tract disorder A method for sensitively diagnosing lower urinary tract disorders, particularly interstitial cystitis, is provided. The method can visually, simply, and clearly diagnose bladder ulcer without requirement of bladder hydrodistention under anesthesia. In the method, lo... | 08/30/2011 |
| 8000775 | Systems and methods for tomographic image reconstruction Optical tomography systems that provide light of multiple distinct wavelengths from a plurality of sources are described. The systems direct light into mammalian tissue, and light from the mammalian tissue is collected at a plurality of reception points. Collected l... | 08/16/2011 |
| 8000774 | Method and system for intra luminal thrombus detection A method for detecting a complete or partial obstruction in a vessel through an intervening fluid includes receiving spectroscopic responses at different locations of a vessel wall, e.g., a vein or artery, through an intervening fluid, preferably blood. Spectroscopi... | 08/16/2011 |
| 7991455 | Systems and methods for dynamic optical imaging A medical system includes a catheter having an elongated tubular member and an inner core slideably received within the elongated member. The inner core includes an imager on a distal end and is coupled with a control system and an imaging system. The inner core is ... | 08/02/2011 |
| 7983736 | Methods and compositions to reduce scattering of light during therapeutic and diagnostic imaging procedures Disclosed are improved methods and compositions for use in light-based in vivo imaging and treatment. The techniques described involve the use of low-scattering, oxygen-carrying blood substitutes in imaging and treatment methods, including OCT imaging. The invention... | 07/19/2011 |
| 7974683 | Method and system for characterization and mapping of tissue lesions via light and special chemical agents A method and an apparatus for the in vivo, non-invasive, early detection of alterations and mapping of the grade of these alterations, causing in the biochemical and/or in the functional characteristics of the epithelial tissues during the development of tissue atyp... | 07/05/2011 |
| 7970456 | Method and apparatus for detecting the presence of dermal melanin in epithelial tissue An image of an individual (2) is obtained using a digital camera (1). The image data is then processed by ratio determination module (10) and an image conversion module (12) to analyze the image and determine data representative of the di... | 06/28/2011 |
| 7962198 | System and method for spectral-encoded high-rate hemodynamic tomography An optical tomography system has a group of lasers for generating light of multiple distinct wavelengths within a first wavelength band. Light from these lasers is directed into mammalian tissue at laser-specific locations on the tissue, and light from the mammalian... | 06/14/2011 |
| 7962199 | Method and apparatus for determination of bone fracture risk using raman spectroscopy A method is disclosed for analyzing keratinized tissue, particularly fingernails, of a subject to diagnose osteoporosis and bone fracture risk. A Raman spectrum of a sample of keratinized tissue is generated. Broad spectral background features of the spectrum are re... | 06/14/2011 |
| 7953473 | Method of identifying a lesion inside patient'S tubular organ A lesion identification system for surgical operations has a light marker adapted for placement in the vicinity of a lesion inside an organ of an organism, and a location-identifying device detecting a light emitted from the light marker at an outside of the organ f... | 05/31/2011 |
| 7925331 | Apparatus for displaying a tissue containing a fluorescent dye An apparatus is disclosed for displaying a tissue containing a fluorescent dye at least in sections. It is proposed for the purpose of simplification to record the tissue with a number of cameras from different observation angles while omitting a beam splitter, and ... | 04/12/2011 |
| 7904138 | Micro vein enhancer The present invention is a Miniature Vein Enhancer that includes a Miniature Projection Head. The Miniature Projection Head may be operated in one of three modes, AFM, DBM, and RTM. The Miniature Projection Head of the present invention projects an image of the vein... | 03/08/2011 |
| 7899518 | Non-invasive tissue glucose level monitoring Instruments and methods are described for performing non-invasive measurements of analyte levels and for monitoring, analyzing and regulating tissue status, such as tissue glucose levels. ... | 03/01/2011 |
| 7890157 | Method for fluorescence lifetime imaging microscopy and spectroscopy A method and system for analysis of fluorescence emission spectroscopy data and fluorescence lifetime imaging microscopy data are described. A unique Laguerre expansion can be found for fluorescence intensity decays of arbitrary form with convergence to a correct so... | 02/15/2011 |
| 7873406 | Spectroscope for recovering light from re-entrant zone of arterial wall A spectroscope includes an optical fiber extending through a catheter, and in communication with an optical system. The optical system has a finite focal length. ... | 01/18/2011 |
| 7865230 | Method and system for detecting sentinel lymph nodes According to one embodiment of the present invention, a method for detecting lymph nodes in a human includes introducing a fluorescent contrast agent into a lymph node system of a body, directing near-infrared time-varying excitation light into the tissue of the bod... | 01/04/2011 |
| 7860554 | Visible-near infrared spectroscopy in burn injury assessment A non-invasive method of characterizing burn injuries using near infrared spectroscopy is described. In the method, a beam of light is emitted into the burnt tissue portion at two or more different tissue depths. The spectra are then compared using multivariate anal... | 12/28/2010 |
| 7840257 | Examination of biological tissue using non-contact optical probes An optical system for examination of biological tissue includes a light source, a light detector, optics and electronics. The light source generates a light beam to be transmitted to the biological tissue spaced apart from the source. The light detector is located a... | 11/23/2010 |
| 7831298 | Mapping physiological functions of tissues in lungs and other organs Systems, apparatus and techniques for non-invasive optical probing of various substances, and systems, apparatus and techniques for detecting, diagnosing and treating a disease in lungs and other organs using the non-invasive optical probing, including mapping physi... | 11/09/2010 |
| 7809429 | Imaging apparatus To improve usability. This invention provides an imaging apparatus that operates in a first mode to image a subject as an imaging target and in a second mode to image an inside of a body as an imaging target. This imaging apparatus comprises: an irradiation means fo... | 10/05/2010 |
| 7797034 | 3-D in-vivo imaging and topography using structured light The present invention provides systems and methods for obtaining a three-dimensional (3D) representation of one or more light sources inside a sample, such as a mammal. Mammalian tissue is a turbid medium, meaning that photons are both absorbed and scattered as they... | 09/14/2010 |
| 7778694 | Biological optical measurement instrument A biological optical measurement instrument including: a measurement probe positionable to a surface of a subject, which irradiates light beams having a plurality of wavelengths from a light beam source through optical fibers onto the subject, and collects the light... | 08/17/2010 |
| 7778693 | System and method for quantifying the dynamic response of a target system A time series of optical tomography data is obtained for a target tissue site in a human (or animal), using an optical wavelength, such as near infrared, at which hemoglobin is absorptive, to observe properties of the vasculature of the human. The data may be compar... | 08/17/2010 |
| 7769432 | Minimally invasive diagnosis and treatment for breast cancer The present invention provides a treatment method to excise a cancerous lesion, such as in the breast, with subsequent ablation of the margin. The method provides for location and excision with ablation under open guidance or guided imaging and for diagnosis by cyto... | 08/03/2010 |
| 7764986 | Method and apparatus for determining target depth, brightness and size within a body region A method of investigating the location and size of a light-emitting source in a subject is disclosed. In practicing the method, one first obtains a light intensity profile by measuring, from a first perspective with a photodetector device, photons which (i) originat... | 07/27/2010 |
| 7761139 | System and method for identifying tissue using low-coherence interferometry An apparatus for needle biopsy with real time tissue differentiation using one dimensional interferometric ranging imaging, comprising a biopsy device having a barrel and a needle, an optical fiber inserted in the needle, and a fiber optic imaging system connected t... | 07/20/2010 |
| 7747315 | Methods and compositions to reduce scattering of light during therapeutic and diagnostic imaging procedures Disclosed are improved methods and compositions for use in light-based in vivo imaging and treatment. The techniques described involve the use of low-scattering, oxygen-carrying blood substitutes in imaging and treatment methods, including OCT imaging. The invention... | 06/29/2010 |
