Did You Know...
...that the x-ray was discovered purely by accident? When German physicist Wilhelm Konrad von Roentgen was experimenting with cathode rays in 1895, he put an activated Crookes tube in a book and went out to lunch. When he returned, he discovered that a key that had also been placed in the book showed up as an image on the developed film!
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| Number | Title | Issue Date |
| 7863488 | Synthesis of acenes and hydroxy-acenes A method comprising reducing an acenequinone to form an acenepolyhydrodiol by exposing the acenequinone to a reducing environment comprising an alkoxyaluminate. ... | 01/04/2011 |
| 7132294 | Functionalized small molecules for use in chemical sensors The invention provides a device for selective molecular recognition, the device comprising a sensing portion, wherein said sensing portion includes a substrate having coated thereon a layer comprising a non-volatile, small molecule compound having at least two penda... | 11/07/2006 |
| 7087798 | Process for preparation of spirofluorenols A spirofluorenol such as 3′,9′-dimethoxy-5′-hydroxyspiro[(1H-cyclopent[d,e,f]phenanthrene)-1,7′-benzo[c]fluorene] is produced by protecting a hydroxyl group bonded to a particular fluorenone compound such as 3,9-dimethoxy-5-hydroxybenzo[c]fluorene-7-one with... | 08/08/2006 |
| 6924400 | Triaromatic vitamin D analogues The invention relates, as novel and useful industrial products, to triaromatic compounds, which are vitamin D analogues, of general formula (I): and also to a method for preparing them and to their use in pharmaceutica... | 08/02/2005 |
| 6787676 | Process for the preparation of non-chiral and optically active organic compounds containing hydroxyl groups Non-chiral and, in particular, optically active alcohols are prepared from a carbonyl compound with hydrogen in the presence of a catalyst, a base and optionally a diamine in an advantageous manner by using a catalyst that contains both a support-bonded Ru(II) compl... | 09/07/2004 |
| 6727392 | Process for the preparation of non-steroidal glucocorticoid receptor modulators A process for preparing a compound of the formula useful as a non-steroidal glucocorticoid receptor modulator. ... | 04/27/2004 |
| 6700025 | Process for stereoselective synthesis of prostacyclin derivatives An improved method is described for making 9-deoxy-PGF1 -type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.... | 03/02/2004 |
| 6610889 | Catalytic compositions and methods for asymmetric aldol reactions Methods and compositions are provided for the direct catalytic asymmetric aldol reaction of aldehydes with donor molecules selected from ketones and nitroalkyl compounds. The reactions employ as catalyst a Group 2A or Group 2B metal complex of a ligand of... | 08/26/2003 |
| 6586613 | Substituted tetrahydronaphthaline and analogous compounds Substituted tetrahydro-naphthalenes and analogous compounds are prepared by reducing or condensing appropriate functional substituents in substituted tetrahydro-naphthalenes and analogous compounds by customary methods and converting functional groups in ... | 07/01/2003 |
| 6566537 | Process and intermediates The invention relates to a process for the enantioselective preparation of tolterodine and analogues and salts thereof comprises the steps of: a) enantioselectively reducing the carbonyl function in a compound of formula (II): ##STR1## wherein R1 | 05/20/2003 |
| 6521755 | Process for preparing 10,11-methanobenzosuberane derivatives This invention provides a process to prepare 10,11-(optionally substituted)methanodibenzosuberane derivatives. The invention also provides an intermediate in this process.... | 02/18/2003 |
| 6465700 | Coupling reactions of 2-substituted, 7-haloindenes with aryl substituents to produce metallocene catalyst ligands Novel 2-substituted 7-haloindenes and methods for synthesizing such indenes are described. The 2-substituted 7-haloindenes may be coupled with any aryl group to produce a metallocene catalyst intermediate.... | 10/15/2002 |
| 6448412 | Methods for the preparation and characterization of multi-substituted fullerenes The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a library of fullerene derivatives and comprises the steps of fo... | 09/10/2002 |
| 6399785 | Multiply-substituted fullerenes The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a library of fullerene derivatives and comprises the steps of fo... | 06/04/2002 |
| 6342642 | 1,4-diaryl-2-fluoro-1-buten-3-ol compounds and their use in the preparation of 1,4-diaryl-2-fluoro-1,3-butadiene and 1,4-diaryl-2-fluoro-2-butene compounds The present invention provides novel 1,4-diaryl-2-fluoro-1-buten-3-ol compounds of the structural formula I ##STR1## a method for the preparation of those formula I compounds, and the use of those formula I compounds in the preparation of 1,4-diaryl-... | 01/29/2002 |
| 6333435 | Process of synthesizing binaphthyl derivatives A process of synthesizing a compound of the formula 1: ##STR1## is disclosed, which comprises reacting a compound of the formula 2: ##STR2## with diphenylphosphine in the presence of an amine base and a nickel catalyst to produce a compound of formula 1.... | 12/25/2001 |
| 6323173 | 2-indanmethanol derivatives and their use in perfumery The compounds of the formula ##STR1## wherein the symbols R1, R2, R3 and R4 represent, independently of one another, a hydrogen atom or a linear or branched, saturated or unsaturated C1 to C3 | 11/27/2001 |
| 6306899 | Inhibition and treatment of Hepatitis B virus and Flavivirus by Helioxanthin and its analogs This invention relates to anti-viral drugs such as Helioxanthin and its analogs. The present compounds may be used alone or in combination with other drugs for the treatment of Hepatitis B virus (HBV), Hepatitis C virus (HCV), Yellow Fever, Dengue Virus, ... | 10/23/2001 |
| 6297399 | Indane compounds with smooth muscle relaxing and/or mast cell stabilizing and/or anti-inflammatory activity Indane compounds of general formulas (7) and (8) and their pharmaceutical use particularly to achieve smooth muscle relaxing activity and/or mast cell stabilizing activity and/or anti-inflammatory activity as described, wherein in formula (7) R2 | 10/02/2001 |
| 6207865 | Method for the hydrogenation of carbonyl compounds A carbonyl compound or a mixture of two or more carbonyl compounds is catalytically hydrogenated in the presence of a Raney copper catalyst in the form of nuggets.... | 03/27/2001 |
| 6184381 | Process for preparing optically active compounds This document describes a novel and practically excellent process for the preparation of optically active compounds, such as optically active alcohols or amines which are useful for various applications, for example, as synthetic intermediates of pharmace... | 02/06/2001 |
| 6162926 | Multi-substituted fullerenes and methods for their preparation and characterization The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a library of fullerene derivatives and comprises the steps of fo... | 12/19/2000 |
| 6156940 | Process for producing optically active carbinols The present invention relates to a process for producing optically active halomethyl phenyl carbinols of the formula (1), comprising reducing halomethyl phenyl ketones of the formula (2) using an asymmetric reducing agent obtained from boranes and optical... | 12/05/2000 |
| 6147224 | 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors Compounds of Formula 1, Formula 2 or Formula 3 where X is O, S, or (CR1 R1)n where n is 0, 1 or 2; Y is a bivalent radical having Formula 4 or Formula 5 where o is an integer from 1 to 4 ##STR1## or Y is a bivalent ar... | 11/14/2000 |
| 6133488 | Processes for separating adamantanols With the use of an aqueous solvent containing at least water (e.g. water), and at least one organic solvent selected from esters or ketones and separable from the aqueous solvent, the processes of the invention separate (1) an adamantanediol and an adaman... | 10/17/2000 |
| 6103688 | Aromatic compounds, processes for their preparation and their use in perfumery Compounds consisting of indan derivatives of the formula: ##STR1## Wherein X or Y represents an aldehyde or an acetal group and the other represents a hydrogen, and R represents a hydrogen or a methyl group and the t-butyl group is at the 5 or 6 posi... | 08/15/2000 |
| 6037505 | Enantioselective oxazaborolidine catalysts The anantoselective borane reduction of prochiral ketones to optically pure alcohols is effectively achieved by performing the reduction in the precence of catalytic amounts of the new and valuable oxazaborolidine compounds of formulas (I) and (II). The c... | 03/14/2000 |
| 6025531 | Processes for preparing optically active alcohols and optically active amines A process for preparing an optically active alcohol by reacting a prochiral ketone corresponding to the optically active alcohol and an acid with a mixture of (1) a boron-containing compound selected from the group consisting of i) a borane compound which... | 02/15/2000 |
| 6005133 | Enantioselective oxazaborolidine catalysts The enantioselective borane reduction of prochiral ketones to optically pure alcohols is effectively achieved by performing the reduction in the presence of catalytic amounts of the new and valuable oxazaborolidine compounds of formulae (I) and (II). The ... | 12/21/1999 |
| 5990172 | Peptidomimetics for the treatment of HIV infection This invention provides peptidomimetics which bind to T4 or CD4 cell receptors and are useful in inhibiting viral infectivity by viruses which bind to T4 cell receptors. More specifically, peptidomimetics of this invention can alleviate symptoms of AIDS b... | 11/23/1999 |
| 5968908 | Restricted 9-cis retinoids The invention is novel analogs of 9-cis-retinoic acid which are useful for the treatment and prevention of coronary artery disease and to protect against premature atherosclerosis by increasing HDL levels. The invention includes processes for preparing th... | 10/19/1999 |
| 5948933 | Tropane analogs and methods for inhibition of monoamine transport New tropane analogs that bind to monoamine transporters are described, particularly, 8-aza, 8carbo and 8-oxo tropanes having 6- or 7-substituents. The compounds of the present invention can be racemic, pure R-enantiomers, or pure S-enantiomers. Certain pr... | 09/07/1999 |
| 5876631 | Fluorinated organic gelation agents The present invention generally relates to the formation of organic gels by dissolving organic gelling agents in organic solvents. The aryl cyclohexanol gelling agents employed in this invention are not structurally related to previously known gellation a... | 03/02/1999 |
| 5861385 | Substituted triols Substituted triols are prepared by reducing appropriately substituted carboxylic esters. The substituted triols can be used as active substances in medicaments.... | 01/19/1999 |
| 5852221 | Optically active ଲ-aminoalkoxyborane complex An optically active ଲ-aminoalkoxyborane complex of the formula (I): ##STR1## wherein R1 is C1 -C8 alkyl, C3 -C7 cycloalkyl, C7 -C11 aralkyl or C6 -C10... | 12/22/1998 |
| 5841000 | Process for producing Trans-2 bromoindan-1-ol A cheap industrial method for making trans-2-bromoindan-1-ol. Trans-2-bromoindan-1-ol represented by Formula (II) is made by hydrolysing 1,2-dibromoindane represented by General Formula (I) (where the configuration of the bromine atoms on position 1 and p... | 11/24/1998 |
| 5834521 | Substituted dibenz (A F)azulenes and methods of preparation Tetracyclic compounds having the following structure are described: ##STR1## wherein R1 -R10 are as defined. The tetracyclic compounds are capable of potent effects on steroid sensitive tissues and have demonstrated increased ut... | 11/10/1998 |
| 5830920 | Sulfuric acid esters of sugar alcohols Compounds of the formula ##STR1## wherein n1 -n9 are each independently 0 or 1; m1 -m9 are each independently 0 or 1, but with the proviso that at least one of m1, m2 and m3, at ... | 11/03/1998 |
| 5792876 | Process for producing acetals A process is described for producing acetals comprising reacting an aldehyde or a ketone with an alcohol in the presence of a titanium compound having an acetylacetone as a ligand, or in the presence of a compound selected from the group consisting of sta... | 08/11/1998 |
| 5750794 | Process for preparing chiral tetralone A process for preparing the chiral (4S)-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone is disclosed wherein racemic 4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone is asymmetrically reduced by contacting the racemic tetralone with an asy... | 05/12/1998 |
