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| Number | Title | Issue Date |
| 7432399 | Diols formed by ring-opening of epoxies A polyol monomer comprising the formula: R1 and R3 are —H, aliphatic, aromatic, or ether; R2 is aliphatic, aromatic, ester, ether, or acrylic, and R1 contains a hydroxyl group, ... | 10/07/2008 |
| 7420003 | Compounds and a novel process for their preparation The present invention is directed to a procedure for making an enantiomerically enriched compound containing a hydronaphthalene ring structure. The process involves reacting oxabenzonorbornadienes with nucleophiles using rhodium as a catalyst and in the presence of ... | 09/02/2008 |
| 7309803 | Clean, High-yield preparation of S,S and R,S amino acid isosteres The present invention provides compounds and methods that can be used to convert the intermmediate halomethyl ketones (HMKs), e.g., chloromethyl ketones, to the corresponding S,S- and R,S-diastereomers. More particularly, the present invention provides: (1) reductio... | 12/18/2007 |
| 7223803 | Polyethylene (glycol) derivatives with proximal reactive groups An activated, substantially water soluble poly(ethylene glycol) is provided having of a linear or branched poly(ethylene glycol) backbone and at least one terminus linked to the backbone through a hydrolytically stable linkage, wherein the terminus is branched and h... | 05/29/2007 |
| 7183443 | Process for the preparation of enantiomerically enriched compounds Process for the preparation of enantiomerically enriched amino aldehydes and amino alcohols, wherein a corresponding enantiomerically enriched amino nitrile is subjected to hydrogenation in the presence of hydrogen, a hydrogenation catalyst, preferably a Pd-catalyst... | 02/27/2007 |
| 7030278 | Polyethylene(Glycol) derivatives with proximal reactive groups An activated, substantially water soluble poly(ethylene glycol) is provided having of a linear or branched poly(ethylene glycol) backbone and at least one terminus linked to the backbone through a hydrolytically stable linkage, wherein the terminus is branched and h... | 04/18/2006 |
| 7009079 | Chiral copper complex and production processes thereof and using the same There is disclosed an optically active salicylideneaminoalcohol compound of formula (1): wherein R1 represents an alkyl group or the like, R2 represents an aryl g... | 03/07/2006 |
| 6977315 | Process for producing optically active nitroalcohols The present invention relates to a process for producing optically active β-nitroalcohols wherein nitroaldol reactions of aldehydes and nitroalkanes are carried out in the presence of a base and an optically active metal complex catalyst represented by the followin... | 12/20/2005 |
| 6924400 | Triaromatic vitamin D analogues The invention relates, as novel and useful industrial products, to triaromatic compounds, which are vitamin D analogues, of general formula (I): and also to a method for preparing them and to their use in pharmaceutica... | 08/02/2005 |
| 6916961 | β2-adrenergic receptor agonists Disclosed are multibinding compounds which are β2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.... | 07/12/2005 |
| 6815443 | 5-Amino-1-pentene-3-ol substituted derivatives The invention relates to 5-amino-1-pentene-3-ol substituted derivatives, a method for the production thereof, medicaments containing said compounds, the use of substituted 5-amino-1-pentene-3-ol derivatives for the production of medicaments, and methods of treatment... | 11/09/2004 |
| 6670500 | Chiral copper complex and production processes thereof and using the same There is disclosed an optically active salicylideneaminoalcohol compound of formula (1): ##STR1## wherein R1 represents an alkyl group or the like, R2 represents an aryl group and the like, and when X1 represents a nitr... | 12/30/2003 |
| 6599952 | Polyether polyols with increased functionality This invention relates to a process for the preparation an epoxide-reactive compound having a functionality of at least 3, a molecular weight of from about 250 to about 1,900, and an OH number of from about 85 to about 1,400. This process comprises reacti... | 07/29/2003 |
| 6548564 | Polyether polyols with increased functionality This invention relates to a process for the preparation of a polyether polyol having a functionality of at least about 3, a molecular weight of from about 560 to about 35,000 and an OH number of from about 10 to about 1,100. This process comprises reactin... | 04/15/2003 |
| 6515050 | Comb-shaped diol, water-soluble polyurethane, and application thereof A water-soluble polyurethane obtained from water-soluble polyalkylene glycol, polydiisocyanate, and comb-shaped hydrophobic diol represented by the following general formula: ##STR1## wherein R1 is a hydrocarbon group of 1 to 20 carbon atoms; e... | 02/04/2003 |
| 6437025 | Poly(ethylene glycol) derivatives with proximal reactive groups An activated, substantially water soluble poly(ethylene glycol) is provided having of a linear or branched poly(ethylene glycol) backbone and at least one terminus linked to the backbone through a hydrolytically stable linkage, wherein the terminus is bra... | 08/20/2002 |
| 6362254 | Poly(ethylene glycol) derivatives with proximal reactive groups An activated, substantially water soluble poly(ethylene glycol) is provided having of a linear or branched poly(ethylene glycol) backbone and at least one terminus linked to the backbone through a hydrolytically stable linkage, wherein the terminus is bra... | 03/26/2002 |
| 6348629 | Free radical inhibitors for quenching aqueous phase polymer growth and related methods An aqueous phase inhibitor for quenching free radical polymerization comprising a free radical quenching agent having a hydrophilic tail is disclosed, as well as a coating and related methods. In one embodiment, the free radical quenching agent can either... | 02/19/2002 |
| 6255522 | Process for reducing -amino ketones The present invention has its objects to provide a method for reducing -aminoketone derivatives under mild conditions with high stereoselectivity. This invention is a method for reducing -aminoketone which comprises reacting an a-aminoketone... | 07/03/2001 |
| 5895824 | Preparation of polyether polyols containing aromatics In a process for preparing polyether polyols containing aromatics by molecular addition of alkylene oxides to H-functional initiators at from 70° C. to 135° C. and pressures of from 0.1 MPa to 1.0 MPa, the alkoxylation is carried out using at least one ... | 04/20/1999 |
| 5831102 | Chemiluminescent 3-(substituted adamant-2'-ylidene) 1,2-dioxetanes Enzymatically cleavable chemiluminescent 1,2-dioxetane compounds capable of producing light energy when decomposed, substantially stable at room temperature before a bond by which an enzymatically cleavable labile substituent thereof is intentionally clea... | 11/03/1998 |
| 5801260 | Carbonothioate phospholipid analogs as substrate of phospholipases and lipases Novel substrates of phospholipases, lysophospholipases and lipases are disclosed.... | 09/01/1998 |
| 5773625 | Process for the preparation of disubstituted carbonates The present invention relates to a process for the preparation of cabonate compounds useful for the preparation of compounds which are human immunodeficiency virus (HIV) protease inhibitors. The compounds have formula I: ##STR1## wherein R9 | 06/30/1998 |
| 5756306 | Process for producing a-hydroxy acid or a-hydroxyamide by microorganism A process for producing an -hydroxy acid or an -hydroxyamide which comprises treating an aldehyde and prussic acid or an -hydroxynitrile with a microorganism having nitrilase or nitrile hydratase activity in an aqueous medium and main... | 05/26/1998 |
| 5410033 | Deoxygenation of cis vicinal diols to make didehydro dideoxy nucleosidies and synthetic intermediates Cis vicinal diols are converted to olefins using tellurides or selenide reagents. The diol is reacted to convert the hydroxyl groups into good leaving groups for nucleophilic substitution. Alkyl and aryl sulfonate groups such as mesylate or tosylate are p... | 04/25/1995 |
| 5399790 | Non-steroid and non-prostanoid inhibitors of steroid and prostaglandin transforming enzymes Compounds such as 1-(4'-nitrophenyl)-2-propen-1-ol are disclosed which are non-steroidal mechanism-based inactivators of rat liver 3-hydroxysteroid dehydrogenase. The corresponding ketones are time dependent inactivators of cyclooxygenase (PGH... | 03/21/1995 |
| 5382709 | Alpha-mannosidase and fucosidase inhibitors Substituted (1, 2ଲ, 3 or ଲ,4,5 or ଲ)-2,3,4-trihydroxy-5-(hydroxymethyl)cyclopentylamines are inhibitors of alphamannosidase and alpha-fucosidase and are useful immunostimulants, antiviral and antimetastatic ag... | 01/17/1995 |
| 5338768 | Substantially closed cell rigid polyurethane foams Substantially closed cell rigid polyurethane foam cores of laminates are disclosed which are scorch-free, have a density of 50 kg/m3 and are made using water as the sole or main blowing agent and without the need to use a CFC. The foams are pre... | 08/16/1994 |
| 5328933 | Cyclopentane heptenylnitro and heptanylnitro-2-aliphatic or aryl aliphatic derivatives and homologues The present invention relates to cyclopentane heptenylnitro and heptanylnitro-2-aliphatic or arylaliphatic derivatives. In particular, heptenylnitrate and heptanylnitrate 2-aliphatic or arylaliphatic derivatives, substituted at the 3 and/or 5 position of ... | 07/12/1994 |
| 5296620 | Intermediates in the asymmetric synthesis of 3-substituted furanoside compounds Novel processes, intermediates and reagents for the preparation of 3-substituted furanose or furanoside compounds of Formula I: ##STR1## wherein M is hydrogen or alkyl (C1 -C3), A is halogen or A may be selected from a moiety of... | 03/22/1994 |
| 5273686 | Soluble magnesium hydrides, method of preparing them, and use thereof Organic-solvent soluble magnesium hydrides or formulas ##STR1## are prepared by catalytically hydrogenating finely powdered magnesium, optionally in the presence of a magnesium halide, in an organic solvent in the presence of their MgH2 -f... | 12/28/1993 |
| 5254747 | Fluorine-containing chiral smectic liquid crystals Compounds are provided which comprise a fluorocarbon terminal portion and a chiral hydrocarbon terminal portion, said terminal portions being connected by a central core, said compounds having tilted smectic mesophases or having latent tilted smectic meso... | 10/19/1993 |
| 5232836 | Vitamin D derivatives: therapeutic applications and applications to assays of metabolites of vitamin D Vitamin D derivatives corresponding to the following formula I ##STR1## in which R1 denotes a substituted alkyl group having 1 to 15 carbon atoms, in particular the side chains of vitamin D2 (C20 to C28) or... | 08/03/1993 |
| 5218073 | Polyhydroxy urethanes formed by reaction of reduced sugars and organic diisocyanates Polyhydroxy urethanes prepared from reduced sugars of the formula Cx H2(x+1) Ox where x is 4, 5 and 6 and diisocyanates are disclosed. There is a molar excess of 1.5 and preferably 2.0 of the reduced sugar in the polyhydro... | 06/08/1993 |
| 5144087 | Process for the preparation of dibromonitro-alcohols and blends with dibromonitro-alcohols A process for preparing dibromonitro-alcohols, and mixtures thereof with bromonitro-alcohols, is disclosed in which dibromonitromethane, and optionally bromonitroethane, is reacted with a C1 -C3 aldehyde in aqueous solution at an aci... | 09/01/1992 |
| 5141676 | Soluble magnesium hydrides, method of preparing them, and use thereof Organic-solvent soluble magnesium hydrides of the formulas (MgH2)n. MgQ2 (II) (MgH2)n. RMgX (III) ##STR1## are prepared by catalytically hyd... | 08/25/1992 |
| 5110961 | Catalytic process for the synthesis of an alcohol, new metal complexes and process for the synthesis of these complexes The invention relates to a catalytic process for the synthesis of an alcohol by reaction of an epoxide with a nucleophilic compound containing a labile hydrogen, such as an alcohol, a phenol, a primary amine or a carboxylic acid. The catalyst is a metal c... | 05/05/1992 |
| 5093519 | Vitamin D derivatives: therapeutic applications and applications to assays of metabolities of vitamin D Vitamin D derivatives corresponding to the following formula I ##STR1## in which R1 denotes a substituted alkyl group having 1 to 15 carbon atoms, in particular the side chains of vitamin D2 (C20 to C28) or... | 03/03/1992 |
| 5091536 | Soluble magnesium hydrides, method of preparing them, and use thereof Organic-solvent soluble magnesium hydrides of the formulas ##STR1## are prepared by catalytically hydrogenating finely powdered magnesium, optionally in the presence of a magnesium halide, in an organic solvent in the presence of their MgH2 | 02/25/1992 |
| 5075510 | Process for the preparation of bromonitro-alcohols A process for preparing bromonitro-alcohols is disclosed in which bromonitromethane is reacted with a C1 -C3 aldehyde in aqueous solution at an acid pH, preferably between about 4.0 and about 7.0. An aqueous solution of the aldehyde ... | 12/24/1991 |
