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3M employee and church chorister Art Fry needed something to temporarily mark pages in his hymnal. He was in luck because his colleague, Spencer Silver, accidentally developed a glue that was too weak for other purposes. After initially discouraging consumer response, Post-it Notes became a hit in 1979.
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| Number | Title | Issue Date |
| 8168834 | 4-alkyl 1-(3-methoxy-2-propen-1-yl) benzene compounds and their use in perfume compositions The present invention is directed to novel 4-alkyl 1-(3-methoxy-2-propen-1-yl)benzene compounds and a method of improving, enhancing or modifying a fragrance formulation through the addition of an olfactory acceptable amount of the novel compounds. ... | 05/01/2012 |
| 7420003 | Compounds and a novel process for their preparation The present invention is directed to a procedure for making an enantiomerically enriched compound containing a hydronaphthalene ring structure. The process involves reacting oxabenzonorbornadienes with nucleophiles using rhodium as a catalyst and in the presence of ... | 09/02/2008 |
| 7354942 | Benzylether and benzylamino beta-secretase inhibitors for the treatment of Alzheimer's disease The present invention is directed to benzylether and benzylamino derivative compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secre... | 04/08/2008 |
| 7288237 | Epoxidation catalyst Titanium or vanadium zeolite catalysts are prepared by reacting a titanium or vanadium compound, a silicon source, a templating agent, a hydrocarbon, and a surfactant at a temperature and for a time sufficient to form a molecular sieve. The catalyst is useful in ole... | 10/30/2007 |
| 7268242 | Chelating carbene ligand precursors and their use in the synthesis of metathesis catalysts Chelating ligand precursors for the preparation of olefin metathesis catalysts are disclosed. The resulting catalysts are air stable monomeric species capable of promoting various metathesis reactions efficiently, which can be recovered from the reaction mixture and... | 09/11/2007 |
| 7238832 | Production method of a coupling compound There is provided a method for producing a coupling compound of formula (1): (Y—)(n−1)R1—R2—(R1)(n′−1) (1) wherein R1, R2 n and n′ are as defined belo... | 07/03/2007 |
| 7220784 | Substituted stilbenes and their reactions The present invention relates to stilbene and quinone compounds related to combretastatin A-4 and their use as anticancer compounds and prodrugs. The compounds include those with an alkyl group on the double bond of cis or trans-stilbenes, compounds with one or more... | 05/22/2007 |
| 7148386 | Processes for preparing benzoquinones and hydroquinones A process for the preparation of hydroquinone compounds comprising, reacting an aromatic hydroxy compound with an oxidizing agent in a biphasic solvent system. The reaction is carried out in the presence of a transition metal hydroxy phosphate catalyst to produce th... | 12/12/2006 |
| 7135600 | Phenethanolamine derivatives for treatment of respiratory diseases The present invention relates to novel compounds of Formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases. ... | 11/14/2006 |
| 7126023 | Method for deuteration of an inert methylene The present invention relates to a method for deuteration of an inert alkane using activated palladium carbon. The present invention discloses “A method for deuteration of a hydrogen atom of a methyl group or a hydrogen atom bonded to a carbon atom at benzy... | 10/24/2006 |
| 7109164 | Aniline-derived ligands for the thyroid receptor New thyroid receptor ligands are provided which have the general formula in which: X is —O—, —S—, —CH2—, —CO—, or —NH—; Y is —(... | 09/19/2006 |
| 7026516 | Compounds with high monoamine transporter affinity Featured compounds have high monoamine transport affinity and are characterized by one of the following two general formulas set out above. The compounds bind selectively or non-selectively to monoamine transporters. The compounds are useful to treat various medical... | 04/11/2006 |
| 7015189 | Oxime methyl ethers The use of various novel oxime ethers are described as fragrance chemicals. These chemicals are suitable for use in creating fragrance, and scents in items such as perfumes, colognes and personal care products is disclosed. ... | 03/21/2006 |
| 6989466 | Reversible crosslinked polymers, benzylic hydroxyl crosslinkers and method A polymer having a crosslinked structure made from a polyol and an isocyanate where the crosslinks contain urethane and/or ester bonds made from the reaction of a benzylic hydroxyl group and an isocyanate group. ... | 01/24/2006 |
| 6939845 | Fragrance precursors The present invention provides a fragrance precursor of formula I: that is capable of forming a fragrant ketone of formula II: and a fragrant lactone of formula III: | 09/06/2005 |
| 6933063 | Spirobifluorene compounds, electroluminescence polymer and electroluminescence element having the same Provided are spirobifluorene compounds which can provide excellent processibility with improved solubility in organic solvents, an electroluminescence (EL) polymer obtained therefrom and an EL element having the same. The EL polymer comprising repeating units of the... | 08/23/2005 |
| 6924263 | Oxime methyl ethers The use of various oxime ethers are described as fragrance chemicals, suitable for use in creating fragrance, and scents in items such as perfumes, colognes and personal care products is disclosed. Novel compounds are also disclosed. ... | 08/02/2005 |
| 6890619 | Optical systems and refractive index-matching compositions Optical systems such as, for example, optical switches, are disclosed comprising a solid component and a refractive index-matching liquid composition interfaced with the solid component. The liquid composition has a refractive-index that is substantially equal to th... | 05/10/2005 |
| 6891071 | Halogenated styrene compounds and very low-loss polymers made therefrom The invention is directed to polymerizable vinyl compounds having halogenated aromatic groups and to a method of synthesizing such compounds. In particular, the invention is directed to polymerizable aromatic vinyl compounds wherein, except for the vinylic hydrogen ... | 05/10/2005 |
| 6881869 | Method for preparing substituted mixed alkynyl ethers The present invention relates to a process for preparing mixed substituted alkynyl ethers. More particularly, the invention concerns the preparation of mixed ethers derived from a benzyl type alcohol and a substituted alkynyl alcohol. The process of the invention fo... | 04/19/2005 |
| 6870058 | Compounds which mimic the chemical and biological properties of discodermolide Compounds which mimic the chemical and/or biological activity of discodermolide are provided and intermediates useful in their preparation. ... | 03/22/2005 |
| 6852895 | Practical, cost-effective synthesis of CoQ10 The present invention provides a convergent method for the synthesis of ubiquinones and ubiquinone analogues. Also provided are precursors of ubiquinones and their analogues that are useful in the methods of the invention. ... | 02/08/2005 |
| 6844461 | Synthesis of A-ring synthon of 19-NOR-1α,25-dihydroxyvitamin D3 from (D)-glucose The present invention provides a method for the synthesis of an A-ring synthon phosphine oxide used in the preparation of 19-nor vitamin D compounds, and to novel synthetic intermediates formed during the synthesis. The new method prepares the phosphine oxide from (... | 01/18/2005 |
| 6800605 | Aniline-derived ligands for the thyroid receptor New thyroid receptor ligands are provided which have the general formula in which: X is —O—, —S—, —CH2—, —CO—, or —NH—; Y is —(CH2)n— where n is an i... | 10/05/2004 |
| 6740678 | Method of treatment of cardiovascular injuries The present invention provides a method for treating cardiovascular ailments. The method involves first screening an individual to determine their risk of having the potential for unstable plaques. Such individuals can be selected by looking at one of the following ... | 05/25/2004 |
| 6720463 | Process for the production of alkanediol derivative The present invention provides a process for producing an alkanediol derivative represented by the general formula (II) from an ester compound represented by the general formula (I), safely without giving rise to racemization. The present invention lies in a ... | 04/13/2004 |
| 6683219 | Synthesis of A-ring synthon of 19-nor-1,25-dihydroxyvitamin D3 from (D)-glucose The present invention provides a method for the synthesis of an A-ring synthon phosphine oxide used in the preparation of 19-nor vitamin D compounds, and to novel synthetic intermediates formed during the synthesis. The new method prepares the phosphine o... | 01/27/2004 |
| 6608232 | Method for preparing a benzylic-type ether The invention concerns a method for preparing a benzylic-type ether from an aromatic compound. The inventive method for preparing a benzylic-type ether from an aromatic compound is characterised in that it consists in: in a first step, acylating an aromat... | 08/19/2003 |
| 6444709 | Heteroethylene compounds and pharmaceutical and cosmetic compositions containing same The invention relates to novel heteroethynylenic compounds having the general formula (I): ##STR1## as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumatic, r... | 09/03/2002 |
| 6444858 | Method of reducing flock during alkoxylation The present invention provides a method for alkoxylating organic compounds comprising contacting an organic compound adapted to be alkoxylated with an alkylene oxide in a reaction vessel under conditions effective to alkoxylate the organic compound. The a... | 09/03/2002 |
| 6433227 | USE OF TRIS (TRIFLUORO METHYLSULFONYL) METHANE, IN ADDITION TO ALKALINE METAL SALTS AND ALKALINE-EARTH METAL SALTS THEREOF AS CATALYSTS DURING C-C BONDING SYNTHESES AND THE NOVEL MG SALT OF TRIS (TRIFLUORO METHYLSULFONYL) METHANE Compounds are used as catalysts according to general formula (1) M+x (C(SO2 CF3)3)x, whereby x is equal to 1 or 2; M represents one hydrogen or alkaline metal atom when x equals 1; and M represents on... | 08/13/2002 |
| 6388146 | Polymerizable compound, polymerizable resin composition, cured polymer and liquid crystal display device The polymerizable compound of this invention is represented by general formula (I): ##STR1## where R is H, R', R'O, R'COO, or R'OCO, R' is a linear or branched alkyl group or alkenyl group having 1 to about 15 carbon atoms, A1 and A2 | 05/14/2002 |
| 6326520 | Optically active compound and method for producing same The invention relates to a method for producing a novel optically active compound represented by the general formula [IV]. This method includes the step of reacting a vinyl ether with a halogenated acetaldehyde in the presence of an optically active binap... | 12/04/2001 |
| 6326499 | Omega chain modified 15-hydroxyeicosatetraenoic acid derivatives and methods of their use for the treatment of dry eye Omega chain modified 15-HETE derivatives and methods of their use for treating dry eye are disclosed.... | 12/04/2001 |
| 6323376 | Process for preparing alkoxy or arylmethoxy aroxyethanes The present invention is a novel process, with or without solvent, for manufacture of compounds of the formula ##STR1## wherein P is selected from phenyl and naphthyl; wherein R1 and R2 and R3 are each independently selected ... | 11/27/2001 |
| 6320085 | Process for the preparation of benzyl-ethers ##STR1## The subject matter of the invention is the process for the preparation of mixed ethers of formula I, wherein Ar represents an aromatic or one or more heteroatom-containing moiety, optionally substituted by one or more C1-4 alkoxy, meth... | 11/20/2001 |
| 6291721 | Processes for the preparation of 2-arylvinyl alkyl ether and 1,4-diaryl-2-fluoro-2-butene compounds An improved process for the preparation of 2-arylvinyl alkyl ether compounds of the structural formula I ##STR1## In addition, the present invention provides an improved process for the preparation of 1,4-diaryl-2-fluoro-2-butene compounds of the structur... | 09/18/2001 |
| 6288271 | Process for the preparation of (2,2,2-trifluoroethoxy)benzoic acids A process for producing trifluoroethoxybenzoic acids or salts thereof by reaction of halobenzoic acids or salts thereof with 2,2,2-trifluoroethanol in the presence of a strong base and copper containing materials. The compounds obtained by the process of ... | 09/11/2001 |
| 6287829 | Process for the selective enzymatic hydroxylation of aldehydes and ketones A process for the selective enzymatic hydroxylation of aldehydes and ketones using chiral anchor-protective groups.... | 09/11/2001 |
| 6274635 | Alkylated resorcinol derivatives for the treatment of immune diseases The present invention provides a method, compounds, and compositions for treating a disease associated with immune dysfunction. In accordance with the method, a pharmacologically-acceptable composition including at least one compound selected from the gro... | 08/14/2001 |
