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| Number | Title | Issue Date |
| 7157419 | Growth factor binding molecules Growth factor binding molecules having a plurality of peptide loops attached to a non-peptide organic scaffold, preferably having pseudo-six amino acid peptide loops with four amino acid sidechains. The growth factor binding molecules specifically bind various growt... | 01/02/2007 |
| 7115743 | Metabolites of ecteinascidin 743 The purification and structure elucidation of several products of the metabolism of Et 743 by human cytochrome CYP3A4 have been accomplished. These compounds are abbreviated herein as “ETM” followed by a numeric value which represents the approximate molecular w... | 10/03/2006 |
| 7011925 | Three-dimensional optical memory The present invention is directed to a three-dimensional memory apparatus for storing information in a volume comprising of an active medium. The active medium is capable of changing from a first to a second isomeric form as a response to radiation of a light beam h... | 03/14/2006 |
| 6867334 | Metabolites of ecteinascidin 743 formed by human cytochrome CYP3A4 The purification and structure elucidation of several products of the metabolism of Et 743 by human cytochrome CYP3A4 have been accomplished. These compounds are abbreviated herein as “ETM” followed by a numeric value which represents the approximate molecular w... | 03/15/2005 |
| 6462044 | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use The present invention describes novel nitrosated and/or nitrosylated phosphodiesterase inhibitors, and novel compositions containing at least one nitrosated and/or nitrosylated phosphodiesterase inhibitor, and, optionally, one or more compounds that donat... | 10/08/2002 |
| 6451904 | Preparing sterile articles from polymers containing a stabilizer based on a poly (oxyalkylene) Novel polymer stabilizers are disclosed. The novel stabilizers have the general formula (R)q Sn-(MR"-OCH2 -R'CH]m -OT)4-q, P-[(OCH2 -R'CH)m OT]3' ##STR1## wherein M is O or S and... | 09/17/2002 |
| 6379590 | Method for making unsymmetrically substituted fluorenyl compounds for nonlinear optical applications A new method for producing unsymmetrically substituted fluorenyl compounds, one step of which is the preparation of 2,7-disubstituted fluoren-9-one derivatives via the nucleophilic substitution of a compound of the formula D ##STR1## wherein A' is se... | 04/30/2002 |
| 6331543 | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use The present invention describes novel nitrosated and/or nitrosylated phosphodiesterase inhibitors, and novel compositions containing at least one nitrosated and/or nitrosylated phosphodiesterase inhibitor, and, optionally, one or more compounds that donat... | 12/18/2001 |
| 6284894 | Preparation of allylic aromatic compounds A process for the preparation of an allylic aromatic compound in which an aromatic amine is reacted first with a nitrite and then with an allylic olefin having an eliminatable terminal substituent. Novel allylic derivatives of disubstituted benzene compou... | 09/04/2001 |
| 6281393 | Polyols useful for preparing water blown rigid polyurethane foam Mannich polyols having a viscosity of from 300 to 3,500 cps (0.3 to 3.5 Pa*s) at 25° C. are prepared by admixing a phenol, an alkanolamines, and formaldehyde mixed in molar ratios of from 1:1:1 to 1:2.2:2.2 resulting in an initiator which can be alkoxyla... | 08/28/2001 |
| 6277897 | Photoinitiators and applications therefor The present invention is directed to new, energy-efficient photoinitiators in the form of -amino enol ether compounds. The present invention is also directed to a method of generating reactive species, which includes exposing one or more photoiniti... | 08/21/2001 |
| 6274775 | Process for the preparation of nitrosobenzenes The invention relates to a process for the preparation of nitrosobenzene from aromatic amines by oxidation with hydrogen peroxide in the presence of a catalyst based on compounds of tungsten and/or molybdenum without the addition of the organic solvents c... | 08/14/2001 |
| 6198007 | Process for the preparation of 1-substituted 2,4-dinitrobenzenes Provided is a process for the preparation of specific 1-substituted 2,4-dinitrobenzenes by reaction of 1-halogeno-2,4-dinitrobenzenes with mono-alkali metal salts of specific diols, in which the 1-halogeno-2,4-dinitrobenzene and the mono-alkali metal salt... | 03/06/2001 |
| 5998636 | Carbamate herbicides Substituted N-phenyl- and N-heteroarylalkylcarbamates of the formula I ##STR1## in which Q is a group ##STR2## R is halogen, trifluoromethyl, cyano, nitro or C1 -C3 haloalkoxy; Z is hydrogen or halogen; or Z and R together ... | 12/07/1999 |
| 5831114 | Carbamate herbicides Substituted N-phenyl- and N-heteroarylalkylcarbamates of formula (I), in which Q is a group (1), (2) or (3); R is halogen, trifluoromethyl, cyano, nitro or C1 -C3 haloalkoxy; Z is hydrogen or halogen; or Z and R together in the 2- an... | 11/03/1998 |
| 5602283 | Multi-stage process for preparing N-alkyl-3,4-dialkyl-2,6-dinitroanilines A multistage process of preparing N-alkyl-3,4-dialkyl-2,6-dinitroanilines starts from 3,4-dialkyl phenol and goes through the stages of 3,4-dialkyl-2,6-dinitrophenol and 3,4-dialkyl-2,6-ditro alkoxybenzene, wherein the latter are new compounds.... | 02/11/1997 |
| 5474716 | Process for the preparation of bridged cyclopentadienylmagnesium compounds and use thereof for preparing metallocenes Disclosed are processes for the preparation of new bridged cyclopentadienylmagnesium compounds of the general formula Q(CpRa)(Cp'R'a ')Mg, and the use thereof for preparing bridged metallocenes.... | 12/12/1995 |
| 5475148 | Process and intermediate to prepare N-alkyl-3,4-dialkyl-2,6-dinitro-anilines The intermediate ##STR1## wherein R is a lower alkyl group, is used to prepare a N-alkyl-3,4-dialkyl-2,6,-dinitro-aniline in a relatively simple, inexpensive and safe fashion, and with a high yield.... | 12/12/1995 |
| 5453221 | Bridged cyclopentadienylmagnesium compounds and use thereof for preparing metallocenes Disclosed are new bridged cyclopentadienylmagnesium compounds of the general formula Q(CpRa) (Cp'R'a')Mg, processes for the preparation thereof, and the use thereof for preparing bridged metallocenes.... | 09/26/1995 |
| 5446186 | Structure and synthesis of nitrophenyl-EGTA, a caged calcium, intermediates thereof and a method of producing a high photochemical yield of liberated calcium The synthesis and compound of a new caged calcium which is an ortho-nitrophenyl derivative of EGTA and various intermediates. It is synthesized in ten steps and 24% overall yield. The photosensitive chelator, nitrophenyl-EGTA, has a Kd for Ca | 08/29/1995 |
| 5434304 | Process for preparing formoterol and related compounds The present invention is directed to a process for preparing formoterol and related compounds and derivatives thereof and their pharmacologically and pharmaceutically acceptable fumarate salts and/or solvates. The present invention is also directed to cer... | 07/18/1995 |
| 5393776 | Tocotrienol analogs in the treatment of hypercholesterolemia and hyperlipidemia This invention relates to structurally novel acyclic tocotrienol analogs, which are useful for cholesterol/lipid lowering in cases of hypercholesterolemia and hyperlipidemia, and for atherosclerosis. Also provided are pharmaceutical compositions and a met... | 02/28/1995 |
| 5387718 | Method of manufacturing alkylphenyl alkyl ethers or alkylphenyl alkyl thioethers Alkylphenyl alkyl ethers or alkylphenyl alkyl thioethers, of the formula ##STR1## where U represents O or S; and R1 -R6 each independently represent an alkyl or aryl group with 1-6 C atoms, but R1 -R5 may e... | 02/07/1995 |
| 5382702 | Process for the production of 5-alkoxy-2,4-dinitro-alkylbenzenes Process for producing 5-alkoxy-2,4-dinitroalkylbenzenes of the general formula (I) ##STR1## R1 =C1 to C4 alkyl; R=C1 to C6 alkyl group, C2 to C4 hydroxyalkyl, C3 ... | 01/17/1995 |
| 5347050 | 3-aminopropoxyphenyl derivatives, their preparation and pharmaceutical compositions containing them The compounds of formula I, ##STR1## wherein the substituents have various significances, and physiologically acceptable hydrolyzable derivatives thereof having the hydroxy group in the 2 position of the 3-aminopropoxy side chain in esterified form, ... | 09/13/1994 |
| 5281742 | Bis(fluorophenyl) carbonate derivatives Disclosed are fluorobenzene derivatives, which are important intermediates for producing herbicidal oxazolidinedione derivatives, and methods of producing them. The fluorobenzene derivatives include compounds of a formula (11): ##STR1## where X ... | 01/25/1994 |
| 5258544 | Synthesis of aldehydes useful in the preparations of HMG-CoA reductase inhibitors Disclosed is a process for the preparation of 2-aryl-1-cyclohexene-1-carboxaldehydes from 1-arylcyclohexenes which are intermediates for trans-6-[(2-arylsubstituted cycloalkenyl and substituted cycloalkyl)alkenyl and alkyl]-3,4,5,6-tetrahydro-2H-pyran-2-o... | 11/02/1993 |
| 5136114 | Process for the preparation of geminal diarylalkanes, new geminal diarylalkanes and alk(en)ylated aromatic compounds The invention relates to a new process for the preparation of geminal diarylalkanes of the formula ##STR1## by Friedel-Crafts alkylation of aromatic compounds with specific aliphatic halogen compounds (addition compounds of CCl4 , to ... | 08/04/1992 |
| 4987266 | Process for the manufacture of nitrophenetole A process is provided for producing nitrophenetole where nitrochlorobenzene is reacted in a cosolvent of a monohydric alcohol and N-alkylpyrrolidone with aqueous alkali metal hydroxide.... | 01/22/1991 |
| 4963576 | Dithioacetal compounds, processes for preparation thereof and pharmaceutical composition comprising the same The invention relates to dithioacetal compounds having 5-lipoxygenase-inhibiting activity, of the formula: ##STR1## wherein R1 is lower alkyl, di-(lower)alkylamino, aryl, or heterocyclic group which may have one or more substituents select... | 10/16/1990 |
| 4960950 | Formation of nitrophenyl ethers from polyols and nitroanisoles Disclosed is a novel process for effecting an ether interchange reaction by heating together in the presence of a basic catalyst, a nitroaromatic ether or thioether and an organic compound containing at least one hydroxyl or mercapto group. The novelty re... | 10/02/1990 |
| 4954657 | Process for the preparation of o-nitrophenetole A process for the preparation of o-nitrophenetole by allowing about 1.05 to about 1.4 mole of ethanol to act on 1 mole of o-nitrochlorobenzene in the presence of a phase-transfer catalyst in approximately 40 to approximately 70 percent by weight alkali me... | 09/04/1990 |
| 4948794 | Cycloalkyl or benzyl-6-substituted-quinoxalinediones Heterocyclic dihydroxyquinoxaline compounds having the formula ##STR1## wherein R1 is C1-12 -alkyl, which may optionally be substituted by hydroxy, formyl, carboxy, carboxylic esters, amides or amines, C3-8 -cycloalky... | 08/14/1990 |
| 4876376 | Process for the halogenation, nitration and fluorination of aromatic derivatives A process for the halogenation (bromination or chlorination)/nitration/fluorination of aromatic derivatives substituted by at least one group containing a halogenoalkyl unit. The aromatic derivative is reacted with a halogen and a nitrating agent in liqui... | 10/24/1989 |
| 4847426 | Process for the preparation of 2,4-dinitrophenyl ethers A process for the preparation of 2,4-dinitrophenyl ethers of the general formula (1) ##STR1## in which R denotes an alkyl(C1 -C6) or alkoxy(C1 -C4)alky(C1 -C4) group by reacting 1 mole... | 07/11/1989 |
| 4782190 | Process for the preparation of 4-nitrophenetol 4-Nitrophenetol is prepared by reaction of 4-chloronitrobenzene with ethanol and alkali metal hydroxides in the presence of phase-transfer catalysts by carrying out the reaction at temperatures from 60° to 95° C. and under pressure in the presence of ox... | 11/01/1988 |
| 4613682 | Ether synthesis The vapor phase reaction of phenolic compounds with organic halides to form aromatic ethers is catalyzed by metal oxides. The halide value of the organic halide is retained as hydrogen halide which can be reacted with a halide acceptor such as methanol to... | 09/23/1986 |
| 4605745 | N-neopentyl-4-diorganoamino pyridinium compounds A method is provided for making aromatic ethers by effecting the displacement of reactive radicals on an activated aromatic nucleus such as a phthalimide with a mono or bisalkali metal phenoxide in the presence of an organic solvent and a dialkylamino bra... | 08/12/1986 |
| 4595763 | Process for preparing methyl ethers or thioethers of aryl compounds Aromatic hydroxyl- or thiol-containing compounds are methylated by contacting with methyl trichloroacetate at elevated temperatures in the presence of an initiator.... | 06/17/1986 |
| 4537999 | Process for a production of dinitrophenyl ethers A process for the production of dinitrophenyl ethers having the general formula [III]: ##STR1## wherein, one of R1 and R2 is a nitro radical, and the other is a hydrogen atom or a straight-chain, branched-chain or cyclic, satura... | 08/27/1985 |
