The invention provides a selective Sigma 1 or Dopamine D3 receptor agonist or a 5HT2c receptor ligand for use in the treatment of symptoms of anxiety and/or depression associated with an affective disorder and/or symptoms associated with cognitive impairment disorde...
|7126028||Process for preparing chiral compounds|
Process for the preparation of chiral compounds of formula (I) comprising contacting a compound of formula (II) with a source of hydrogen or halide; wherein A is a chiral center; X is selected from oxygen, sulphur and nitrogen; n is selected from 0 and 1 and is equa...
Substituted 3-amino-2-benzyl-1-phenlypropane derivatives, methods for preparing them, pharmaceutical compositions containing them, and methods of using them to treat various medical conditions....
|6599921||Non-steroidal estrogen receptor ligands|
Novel non-steroidal estrogen receptor ligands and methods of synthesis are disclosed. The novel molecules are intended for use in therapeutic preparations for the treatment of estrogen receptor related disease states. The compounds specified are tetra-cyc...
|6518314||Pharmaceutical agents that impede the initiation and progression of primary and secondary DMS disruptions|
Compositions comprising a pharmaceutically effective amount of a compound that impedes disruption of intact dense microspheres (DMS) by acting on DMS either to prevent disruption, or if disrupted, act on pre-disrupted DMS in such a way that, when the comp...
|6414179||Alpha-and beta-substituted trifluoromethyl ketones as phospholipase inhibitors|
Inhibitors of the cytosolic phospholipase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula ##STR1## where X, Z, R1, R2, ...
|6191165||Pharmaceutical for treatment of neurological and neuropsychiatric disorders|
The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof....
|6172263||Tamoxifen and analogues thereof|
A method of preparing a first geometric isomer of tamoxifen or an analogue comprises allowing the first isomer to crystallize in hexanol and the product thereof to crystallize in methanol and then derivatising the product of the methanol crystallization t...
|6143933||Process for the preparation of optically active methadones in high enantiomeric purity|
A method of preparing optically active methadones comprises an enzymatic process for the resolution of 1-dialkyl-amino-2-propanol and conversion of the enantiomers to the optically active methadones in high enantiomeric purity....
|6117911||Compounds and therapies for the prevention of vascular and non-vascular pathologies|
The invention provides a method of treating a mammal having, or at risk of, an indication associated with a TGF-beta deficiency comprising administering one or more agents that is effective to elevate the level of TGF-beta. The invention also provides nov...
|5773469||Diaryl antimicrobial agents|
The invention relates to diaryl antimicrobial compounds of the general formula: ##STR1## where G, E L, J, q, m, X, Ar, W, p, n and A are as described herein, pharmaceutical compositions containing the compounds, methods for their production and ...
|5610183||Phenylglycine derivatives pharmaceutical compositions containing them and their use in therapy|
Compounds of Formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein Q is optionally substituted phenyl or naphthyl; X and Y are each H, C1-6 alkyl, C2-6 alkenyl or X and Y are together .dbd.O; Z is O or S; R...
|5521220||Acyclic ethylenediamine derivatives|
The present invention relates to novel acyclic ethylenediamine derivatives of nitrogen containing heterocyclic compounds, and specifically, to compounds of the formula ##STR1## wherein R1, R2, R3, R4, R
|5426229||Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes, 3-aminochromanes, and 3-aminothiochromanes|
The present invention provides novel ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes, 3-aminochromanes, and 3-aminothiochromanes, including their corresponding sulfoxides and sulfones, which ring-substituted compounds exhibit agonist activity at t...
|5192765||Certain amines which are muscarinic receptor antagonists|
Amines of the following formula: ##STR1## where the variables are defined in the specification are useful in the treatment of diseases associated with altered motility and/or tone of smooth muscle....
|5171752||Benzhydryl derivatives having calmodulin inhibitor properties|
The invention relates to a benzhydryl derivative having the formula ##STR1## wherein each of the groups R1, R2, and R3 represents one to four substituents independently selected from the group consisting of hydrogen, ...
|4857313||Transdermal drug delivery device comprising copolymers of N-morpholinoethyl methacrylate and 2-hydroxylmethacrylate|
The invention concerns a novel copolymer of N-morpholinoethyl methacrylate and 2-hydroxyethyl methacrylate which can be used in transdermal delivery systems or in oral controlled release products. The invention also concerns a process for preparing the co...
|4429162||Perfluoroalkyl phenols and naphthols|
The instant invention relates to compounds of the formula ##STR1## wherein each Rf is independently straight or branched chain perfluoroalkyl of 2 to 18 carbon atoms or perfluoroalkoxy-perfluoroalkyl of 4 to 18 carbon atoms; each R1
|4246201||Substituted N-(3-phenylthiopropyl)-3,3-diphenyl-propylamines possessing pharmacological activity|
Compound of formula: ##STR1## wherein R represents hydrogen or an alkyl group having from 1 to 4 carbon atoms; R', R", R'" and R"", equal or different from each other represent hydrogen atoms or OH groups, with the limitation that when R', R", R'" an...
A new compound [N-(2-diphenylmethoxyethyl)-N-(1-methyl-2-phenoxyethyl)-N-methyl] amine, its pharmaceutically acceptable salts and its processes of preparation are disclosed. Such salts have a muscle relaxing and vasodilating activity....
|4066686||New benzhydrysulphinyl derivatives|
The invention provides the benzhydrylsulphinyl derivatives of the formula: where n is 1, 2 or 3 and R is C(.dbd.O)NHOH, C(.dbd.NH)NH2, C(.dbd.NH)NHOH, 2-Ɗ2 -imidazolinyl or NR1 R2 (where R1 is H or C...
Diphenylmethoxyethylamines of the general formula ##STR1## in which R1 represents a fluorine, bromine or chlorine atom, R2 represents a hydrogen or fluorine atom and R3 represents a hydrogen, fluorine or chlorine atom...