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| Number | Title | Issue Date |
| 8053603 | Tetralone-based monoamine reuptake inhibitors The invention relates to novel tetralone based amines and their use in the treatment of central nervous system (CNS) disorders, such as depression, attention deficit hyperactivity disorder (ADHD) and Parkinson's disease. The invention further relates to pharmaceutic... | 11/08/2011 |
| 8026397 | Method for obtaining an aminoindan mesylate derivative The invention relates to processes for preparing rasagiline mesylate that avoid the use of alcohol solvents, thereby producing rasagiline mesylate free of any alkyl mesylates, including isopropyl mesylate. The invention further relates to processes for purifying ras... | 09/27/2011 |
| 7968749 | Process for preparing and drying solid rasagiline base Disclosed is crystalline R(+)-N-propargyl-l-aminoindan containing water at an amount of less than 0.5% by weight and a pharmaceutical composition comprising the same, and the process for the manufacture and the validation thereof. Also disclosed is a process for the... | 06/28/2011 |
| 7781615 | Process for the preparation of amines The present invention relates to a novel a process for the preparation of the compound of the general formula (I), wherein R1 and R2 are independently H or C1-6 alkyl, which comprises treating with a reducing agent either a compound ... | 08/24/2010 |
| 7781616 | Method for obtaining an aminoindan mesylate derivative The invention relates to processes for preparing rasagiline mesylate that avoid the use of alcohol solvents, thereby producing rasagiline mesylate free of any alkyl mesylates, including isopropyl mesylate. The invention further relates to processes for purifying ras... | 08/24/2010 |
| 7705183 | Aromatic amine derivative and organic electroluminescence device employing the same An aromatic amine derivative with a special structure bonding to a fused polycyclic hydrocarbon group having silyl group. An organic electroluminescence device which comprises one or more organic thin film layers comprising at least a light emitting layer sandwiched... | 04/27/2010 |
| 7642380 | Aromatic amine derivative and organic electroluminescence device using the same The present invention relates to aromatic amine derivatives having a specific structure; and organic electroluminescent devices comprising a cathode, an anode and one or plural organic thin film layers including at least a light emitting layer which are sandwiched b... | 01/05/2010 |
| 7589237 | Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine Treatment of CNS disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is disclosed. A process for preparing 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-n... | 09/15/2009 |
| 7518018 | Processes for preparing sertraline Provided are processes for the preparation of sertraline and sertraline hydrochloride. ... | 04/14/2009 |
| 7491847 | Methods for isolating propargylated aminoindans A process for isolating from a reaction mixture a salt of a mono-propargylated aminoindan, a process for isolating from a reaction mixture a crystalline diastereomeric salt of a mono-propargylated aminoindan, and a process for isolating from a reaction mixture a sal... | 02/17/2009 |
| 7482490 | Amine compound having fluorene group as framework, process for producing the amine compound, and use of the amine compound Novel amine compounds that can be utilized as hole transport materials, hole injection materials or the like of organic electroluminescence devices, electrophotographic receptors or the like, and their production processes are provided. The novel amine compou... | 01/27/2009 |
| 7442838 | Polymorphic forms of sertraline hydrochloride Sertraline hydrochloride polymorphic form II is conveniently prepared by adding hydrogen chloride to solution of sertraline free amine in a ketone. In preferred processes, the solution of sertraline free amine seeded with some crystals of polymorphic form II and/or ... | 10/28/2008 |
| 7423179 | Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine Treatment of CNS disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)- 1,2,3,4-tetrahydro-1-napthalenamine is disclosed. A process for preparing 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-... | 09/09/2008 |
| 7413682 | Antioxidants and methods of making antioxidants Antioxidants for industrial, automotive, and aviation lubricants and methods of making the same are provided. A process using alkylated diphenylamines; alkylated phenyl-α-naphthyl amines; and a metal catalyst to form oxidates is provided. The metal catalyst is a co... | 08/19/2008 |
| 7375250 | Aminoanthryl derivative substitution compound and organic electroluminescence device using the same There is provided an aminoanthryl derivative substitution compound represented by the following general formula (1). The compound according to the present invention can provide an organic electroluminescence device showing an extremely pure luminescence hue, and an ... | 05/20/2008 |
| 7345201 | Processes for preparing sertraline Provided are processes for the preparation of sertraline and sertraline hydrochloride. ... | 03/18/2008 |
| 7319171 | Sertraline hydrochloride form II and methods for the preparation thereof The present invention is directed to Form II of sertraline hydrochloride and novel methods for its preparation. According to the present invention, sertraline hydrochloride Form II may be produced directly form sertraline base or sertraline mandelate. It may also be... | 01/15/2008 |
| 7276629 | Hydrogenation of imine intermediates of sertraline with catalysts Provided are hydrogenation processes of sertraline imine intermediates with catalysts in various reactors. ... | 10/02/2007 |
| 7262327 | Recycling process for preparing sertraline Provided is a recycling process for preparing sertraline, which may be carried out on an industrial scale. ... | 08/28/2007 |
| 7259271 | Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation Compounds of formula I: where R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, alkylaryl, alkyloxy, hydroxy, nitro, amino, alkylcarbonylamino, alkyl... | 08/21/2007 |
| 7253320 | Process for preparing polymorphic form II of sertraline hydrochloride The present invention relates to a new process for preparing sertraline hydrochloride form II. ... | 08/07/2007 |
| 7250532 | Method for producing aromatic amino compound A method for producing aromatic amino compound (V): by synthesizing intermediate compound (IV): by the reaction of compound (I): H2N—R1 | 07/31/2007 |
| 7235194 | Two-photon or higher-order absorbing optical materials for generation of reactive species Disclosed are highly efficient multiphoton absorbing compounds and methods of their use. The compounds generally include a bridge of pi-conjugated bonds connecting electron donating groups or electron accepting groups. The bridge may be substituted with a variety of... | 06/26/2007 |
| 7202384 | Process for producing 5-nitro-3,4-dihydro-1(2H)-naphthalinone, 1,5-naphthalenediamine and 1,5-naphthalene diisocyanate The present invention relates to a process for producing 5-nitro-3,4-dihydro-1(2H)-naphthalinone, 1,5-naphthalenediamine and 1,5-naphthalene diisocyanate, in which 4-(2-nitrophenyl)-n-butyronitrile is converted to 4-(2-nitrophenyl)-n-butyric acid. ... | 04/10/2007 |
| 7202378 | Process for producing 5-nitro-3,4-dihydro-1(H)-naphthalinone, 1,5-naphthalenediamine and 1,5-naphthalene diisocyanate The present invention relates to a process for producing 5-nitro-3,4-dihydro-1(2H)-naphthalinone, 1,5-naphthalenediamine and 1,5-naphthalene diisocyanate, in which 4-(2-nitrophenyl)-n-butyronitrile is converted to 4-(2-nitrophenyl)-n-butyric acid. ... | 04/10/2007 |
| 7196222 | Sertraline hydrochloride form II and methods for the preparation thereof The present invention is directed to Form II of sertraline hydrochloride and novel methods for its preparation. According to the present invention, sertraline hydrochloride Form II may be produced directly form sertraline base or sertraline mandelate. It may also be... | 03/27/2007 |
| RE39532 | Metallocenes containing ligands of 2-substituted indenyl derivatives, process for their preparation, and their use as catalysts The novel metallocenes of the formula I in which, preferably, M1 is Zr or Hf, R1 and R2 are alkyl or halogen, R3 and R4 are hydrogen, R5 and R6 are alky... | 03/27/2007 |
| 7189876 | Methods for preparing sertraline hydrochloride polymorphs This invention relates to crystalline polymorphs of sertraline hydrocloride, i.e. (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtalenamine hydrochloride, denominated form I, II and V, and methods for their preparation. ... | 03/13/2007 |
| 7186863 | Sertraline compositions An acid salt of sertraline, wherein the acid is citric acid, fumaric acid, malic acid, maleic acid, malonic acid, phosphoric acid, succinic acid, sulfuric acid, L-tartaric acid, HBr, acetic acid, benzoic acid, benzenesulfonic acid, ethanesulfonic acid, lactic acid, ... | 03/06/2007 |
| 7173153 | Sertraline hydrochloride form II and methods for the preparation thereof This invention relates to a method for the preparation of sertraline hydrochloride, (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtalenamine hydrochloride, in its crystalline form II. ... | 02/06/2007 |
| 7157604 | Selective estrogen receptor modulators The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a v... | 01/02/2007 |
| 7154007 | Luminous compounds and labeling reagents using the same This invention provides: a compound represented by formula (I): R—Y—(—X-Phe-COCH2COCnF2n+1)m (I) wherein R denotes hydrogen, alkyl, phenyl, or a group capable of binding to a protein, peptid... | 12/26/2006 |
| 7132571 | Self-assembled calixarene-based guest-host assemblies for guest storage by van der Waals confinement A guest-host assembly having a generally spheroidal host assembly formed of trimers of calixarene molecules in a hexagonal close-packed assembly and its preparation. The calixarene trimers are associated together predominantly by van der Waals forces to provide dila... | 11/07/2006 |
| 7115780 | Propanolaminomethyltetralines, their preparation and pharmaceutical composition comprising same The invention concerns compounds of formula (I), wherein A is a group of formula (a) or (b), wherein: R represents a hydrogen or halogen atom, a —S(O)z(C1–C4)Alk wherein z is 0, 1 or 2, a —NHSO2(C1–C | 10/03/2006 |
| 7105699 | Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine and its formamide Treatment of CNS disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is disclosed. A process for preparing 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-n... | 09/12/2006 |
| 7094930 | Pharmaceutically acceptable salts of sertraline and pharmaceutical compositions thereof The present invention is directed to certain pharmaceutically acceptable salts of the therapeutically potent selective serotonin reuptake inhibitor, sertraline: and pharmaceutical compositions thereof, wherein sa... | 08/22/2006 |
| 7094929 | Water-soluble distyrylbenzene chromophores for applications in optoelectronic technologies Two-photon or multi-photon chromophores having a conjugated pi-electron system with donating groups at each end of the pi-electron system providing charge-transfer properties, and having quaternary amine groups that can enhance the solubility of the chromophore in w... | 08/22/2006 |
| 7087785 | Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine and its formamide Treatment of CNS disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is disclosed. A process for preparing 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-n... | 08/08/2006 |
| 7081550 | Arylamine compound and organic electroluminescence device A novel arylamine compound represented by the following general formula (1): wherein R1 and R2 each independently represent an alkyl group, an alkoxyl group, an aryl group, an arylalkyl group or an aryloxyl group, Ar1 to Ar | 07/25/2006 |
| 7074840 | Light adjustable lenses capable of post-fabrication power modification via multi-photon processes The invention relates to novel photoinitiators and their use in light adjustable compositions. The initiatives comprise two or more multiphoton chromophores linked by a bridging compound. The bridging compound consists of a material that is compatible with the base ... | 07/11/2006 |
