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| Number | Title | Issue Date |
| 7423177 | Carboxamide derivatives as therapeutic agents This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the... | 09/09/2008 |
| 7402697 | Antibacterial agents D-(threo)-1-aryl-2-disubstitutedacylamido-3-fluoro-1-propanol compounds compounds and analogues thereof (“Fenicol Compounds”), compositions comprising an effective amount of a Fenicol Compound, and methods for treating or preventing a bacterial infection in an a... | 07/22/2008 |
| 7358396 | Preparation of optically active amines A process for preparing optically active amines, a process for preparing racemic amines which can be resolved using optically active carboxylic acids or enzymes, and racemic and optically active amines and optically active amides are described. ... | 04/15/2008 |
| 7217409 | Alkanoic acid derivatives A method for treating respiratory disorders comprises administering to a patient a pharmaceutical aerosol formulation comprising: (i) a compound of formula (I) or a salt or solvate thereo... | 05/15/2007 |
| 7102026 | Process for preparing and isolating -bicalutamide and its intermediates The present invention relates to a new process for the synthesis of racemic and optically active bicalutamide starting from ethyl pyruvate and methyl methacrylate. The present invention discloses processes of preparing bicalutamide intermediates including ethyl-[2-{... | 09/05/2006 |
| 6960688 | Use of compounds for the elevation of pyruvate dehydrogenase activity The use of compounds of formula (I), and salts thereof; and pharmaceutically acceptable in vivo cleavable prodrugs of said compound of formula (I); and pharmaceutically acceptable salts of said compound or said prodrugs; in formula (I), Ring C is phenyl or a carbon ... | 11/01/2005 |
| 6770784 | Use of γ-hydroxybutyric acid amides in the treatment of drug addiction and in particular of alcoholism Gamma-hydroxybutryic acid amides are used in the treatment of drug addiction and especially in the treatment of alcoholism. ... | 08/03/2004 |
| RE38506 | Potent inducers of terminal differentiation and methods of use thereof The present invention provides the compound having the structure: wherein each of R1 and R2 are independently the same as or different from each other; when R1 and R2 are the same, each i... | 04/20/2004 |
| 6689909 | Substituted N-phenyl 2-hydroxy-2-methyl-3,3,3-trifluoropropanamide derivatives which elevate pyruvate dehydrogenase activity A compound of formula (I) wherein: n is 1 or 2; R1 is chloro, fluoro, bromo, methyl or methoxy; R2 is as defined within; R3 is as defined within; and R4 is hydrogen or fluoro; or a pharmaceutically acceptable sa... | 02/10/2004 |
| 6593315 | Salicylic acid derivatives, processes for their preparation, compositions comprising them, and their use Salicylic acid derivatives of the formula I, ##STR1## where the index and the substituents have the following meanings: X is halogen, NO2, cyano, alkyl or alkoxy; m is 0, 1, 2 or 3, it being possible for the substituents X to be different from each ... | 07/15/2003 |
| 6548534 | Nonsteroidal gestagens This invention describes the new, nonsteroidal gestagens of general formula I ##STR1## in which A, B, Ar1, R1, R2 and R3 have the meanings that are indicated in more detail in the description. The new compounds ... | 04/15/2003 |
| 6498275 | Use of compounds for the elevation of pyruvate dehydrogenase activity The use of compounds of the formula (I), and salts thereof; and pharmaceutically acceptable in vivo cleavable prodrugs of said compound of formula (I); and pharmaceutically acceptable salts of said compound or said prodrugs: ##STR1## wherein: Ring C ... | 12/24/2002 |
| 6482985 | 2-benzyloxy-5-halo-acylanilide compounds and method of using them Disclosed is a compound comprising a 2-benzyloxy-5-haloacylanilide having the structural formula I: ##STR1## wherein R is hydrogen or an alkyl group, RA is a substituent and n is 0-5; and X is a halogen. Also disclosed is a method for preparing a co... | 11/19/2002 |
| 6462234 | Process to prepare (2S)-2-(dipropylamino)-6-ethoxy-2, 3-dihydro-1H-indene-5-carboxamide The present invention is a process, including intermediates, to produce (2S)-2-dipropylamino)-6-ethoxy-2,3-dihydro-1H-indene-5-carboxamide ##STR1## which is a useful pharmaceutical agent.... | 10/08/2002 |
| 6452052 | Aniline disulfide derivatives for treating allergic diseases Methods and compositions for preventing or treating allergic diseases of the eye, nose, skin, ear, gastrointestinal tract, airways or lung and preventing or treating manifestations of systemic mastocytosis are disclosed. The compositions contain a mast ce... | 09/17/2002 |
| 6369273 | Chemical compounds and their use to elevate pyruvate dehydrogenase activity The use of a compound of the formula (I): ##STR1## wherein: ring C is phenyl or carbon-linked heteroaryl selected from pyridyl, pyrazinyl, pyrimidinyl and pyridazinyl; and wherein said phenyl or heteroaryl is substituted as defined herein; A--B is selecte... | 04/09/2002 |
| 6271005 | Enzymatic resolution of aminotetralins Stereoisomers of carbocyclic amine compounds such as amino tetralins are separated by subjecting a mixture of the stereoisomers to reaction with an acylating agent in the presence of the enzyme Pseudomonas capacia lipase which effect selective acylation o... | 08/07/2001 |
| 6019957 | Non-steroidal radiolabeled agonist/antagonist compounds and their use in prostate cancer imaging The present invention relates to a radiolabeled non-steroidal compound having the formula: ##STR1## where R1, R2, and R3, are the same or different and are a radioactive or nonradioactive halogen, a nitro, a cyano, a ... | 02/01/2000 |
| 5922771 | Benzocycloalkene compounds, their production and use A compound of the formula ##STR1## wherein R1 and R2 independently represent H or an optionally substituted hydrocarbon group; R3 represents an optionally substituted hydrocarbon group; R4 represents H or a... | 07/13/1999 |
| 5880158 | Propionamide anticonvulsants The present invention is directed to a compound of the following formula: ##STR1## pharmaceutical compositions containing the same and the use thereof as an anticonvulsant.... | 03/09/1999 |
| 5874617 | Process of producing anilide compound A process of producing an anilide compound, including reacting an acid fluoride with an N-silylaniline compound in the presence of a basic compound, is provided. According to the process, a desired anilide compound can be produced in a high yield without ... | 02/23/1999 |
| 5849945 | Aminotetralone derivatives and preparation process thereof The present invention pertains to a process for the preparation of Compound (4) through the below-described reaction route: ##STR1## wherein R1 and R2 each represents H, halogen, OH or C1-6 alkyl group; X and Y each r... | 12/15/1998 |
| 5808152 | Synthesis of N-(4-fluorophenyl)-2-hydroxy-N-(1-methylethyl)acetamide using sodium formate The present invention relates to a process for making N-(4-fluorophenyl)-2-hydroxy-N-(1-methylethyl)acetamide. The process includes the steps of (a) reacting 2-chloro-N-(4-fluorophenyl)-N-(1-methylethyl)acetamide with sodium formate to form a reactio... | 09/15/1998 |
| 5753652 | Antiretroviral hydrazine derivatives The invention relates to compounds of formula ##STR1## and salts, pharmaceutical compositions, intermediates and processes of preparation thereof.... | 05/19/1998 |
| 5728869 | Processes for the preparation of pesticides and intermediates There is disclosed a process for the preparation of an indanylamine compound of general formula ##STR1## wherein R1 represents an optionally substituted alkyl group, and R2, R3 and R4 independently represen... | 03/17/1998 |
| 5684198 | Method of preparing therapeutic amides Amides having formula I: ##STR1## wherein E, X, R2 and R3 have the meanings given in the specification, and pharmaceutically acceptable salts and pharmaceutically acceptable in vivo hydrolysable esters thereof, which are useful ... | 11/04/1997 |
| 5670650 | Fatty acid analogs and prodrugs Novel derivatives of fatty acid analogs that have from one to three heteroatoms in the fatty acid moiety which can be oxygen, sulfur or nitrogen, are disclosed in which the carboxy-terminus has been modified to form various amides, esters, ketones, alcoho... | 09/23/1997 |
| 5631403 | Process for the preparation of hydroxycarboxanilides The present invention relates to a process for the preparation of hydroxycarboxanilides of the formula (1) ##STR1## in which R1 and R2 are identical or different and are hydrogen, halogen, a nitro group, a cyano group, a straigh... | 05/20/1997 |
| 5616799 | Process for the preparation of glycoloylanilides A process for the preparation of glycoloylanilide of the formula (G) ##STR1## is recited that involves reacting a nitrobenzene with hydrogen and, if desired, with a carbonyl compound, in the presence of a noble metal catalyst and a solvent, reacting ... | 04/01/1997 |
| 5541228 | Melatonergic agents New melatonergic agents are phenyl alkanyl or phenyl alkyl substituted carboxamides and ureas of Formula I: ##STR1## wherein: R1 =C1-3 alkyl, allyl, C3-6 cycloalkyl substituted C1-4 alkyl; R2 =hy... | 07/30/1996 |
| 5523320 | N-methyldeacetylcolchiceinamide derivatives N-methyldeacetylcolchiceinamide derivatives represented by the formula ##STR1## wherein R denotes a residue obtained by removing COOH from a C3 -C7 sugar carboxylic acid, and hydroxyl groups present in the residue may properly b... | 06/04/1996 |
| 5488131 | Synthesis of compounds with predetermined chirality A method for synthesizing enantiomerically enriched chemical intermediates with predetermined chirality is described. The method comprises formation of a pseudoephedrine amide, followed by stereoselective alkylation at the alpha carbon. The chiral auxilia... | 01/30/1996 |
| 5416118 | Bicyclic amides as inhibitors of acyl-coenzyme A: cholesterol acyl transferase Novel bicyclic amides of the formula ##STR1## wherein Ar1 and Ar2 are phenyl, R2 -substituted phenyl, heteroaryl or R2 -substituted heteroaryl, wherein R2 is 1 to 3 substituents independently sel... | 05/16/1995 |
| 5391476 | Non-ionic surface active compounds Water-soluble, non-ionic surface active compounds are provided having the formula ##STR1## wherein R1 and R2 are each independently hydrogen or an alkyl group having from 1 to 4 carbon atoms; X is a hydrophobic substituted or un... | 02/21/1995 |
| 5382598 | Therapeutic amides Amides having formula I: ##STR1## wherein E, X, R2 and R3 have the meanings given in the specification, and pharmaceutically acceptable salts and pharmaceutically acceptable in vivo hydrolyzable esters thereof, which are useful ... | 01/17/1995 |
| 5369108 | Potent inducers of terminal differentiation and methods of use thereof The present invention provides the compound having the structure: ##STR1## wherein each of R1 and R2 are independently the same as or different from each other; when R1 and R2 are the same, each is a substi... | 11/29/1994 |
| 5319004 | Hardener for epoxy resins comprising reaction products of polyamidoamines, secondary polyamines and epoxy-polyol adducts Hardeners for epoxy resins, comprising reaction products of (A) polyamidoamines that were obtained by polycondensation of (a) dicarboxylic acids containing oxyalkylene groups, or their derivatives, with (b) polyamines containing at least two amino groups capab... | 06/07/1994 |
| 5103039 | Activated polymers and conjugates thereof Macromolecular species such as enzymes, proteins, drugs, and solid supports which contain reactive carbonyl groups or groups which are readily converted to reactive carbonyl groups are modified by reaction with a compound of the formula ##STR1## ... | 04/07/1992 |
| 5064827 | Polyhydroxybenzyloxpropanolamines Compounds of the present invention, are represented by the general formula ##STR1## wherein R1 group which may be alkyl of from 1 to about 6 carbon atoms, alkenyl of from 2 to about 6 carbon atoms, alkynyl of from 2 to about 10 carbon atom... | 11/12/1991 |
| 5021414 | Phenol derivatives A phenol derivative of the formula NU--A--X--R1 wherein NU is a defined bis-phenolic nucleus including a hydroxyphenyl-hydroxynaphthyl; hydroxyphenyl-hydroxyindanyl, hydroxyphenyl-hydroxybenzothienyl or di-hydroxyphenyl-ethylene or vinylene nuc... | 06/04/1991 |
