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| Number | Title | Issue Date |
| 8030519 | Method for producing acetoacetic acid arylamides Acetoacetic acid arylamides are continuously produced from diketene and primary or secondary aromatic amines under the conditions of a reactive distillation in the presence of water. The continuous method provides a high purity of the products, nearly quantitative y... | 10/04/2011 |
| 7423177 | Carboxamide derivatives as therapeutic agents This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the... | 09/09/2008 |
| 7297200 | Water-soluble yellow azo dyes A dye of the formula (2) and a process for preparing the same, wherein the radicals are as defined in the specification ... | 11/20/2007 |
| 7144993 | Process for the preparation of 4-methyl-7-aminoquinolones The present invention relates to a process for the preparation of a compound of the general formula (I), which comprises converting a compound of the general formula (II), in an aprotic organic solvent in the presence of a catalytically active amount of a strong aci... | 12/05/2006 |
| 7034015 | Aminobenzoephenones The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating patients comprising administering said compounds, and to the use of said ... | 04/25/2006 |
| 6960581 | Glucocorticoid mimetics, methods of making them, pharmaceutical formulations, and uses thereof A compound of Formula (I) wherein R1, R2, R3, R4, R5, and R6 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof, pharmaceutical com... | 11/01/2005 |
| 6949677 | Acetoacetylated N-phenyl-p-phenylenediamines Compounds of the general Formula: in which R1 and R2 are at each occurrence independently hydroxyl, C1-6-alkyl, C1-6-alkoxy, halogen, phenyl or phenoxy; ... | 09/27/2005 |
| 6916767 | Antioxidant amines based on n-(4aniliophenyl) amides antioxidant amines based on n-(4-anilinophenyl) amides A composition of matter is disclosed wherein the composition comprises an N-aromatic substituted acid amide compound selected from the group consisting of compounds of formula (I) wherein A and B are independently selected alkylene groups; R1 is selected ... | 07/12/2005 |
| 6734324 | Method for producing acetoacetylated aromatic amines A method for producing compounds of general formula (I): wherein R1 and R2, each time they occur and independently of each other, mean hydroxyl, C1-6-alkyl, C1-6-alkoxy, haloge... | 05/11/2004 |
| RE38506 | Potent inducers of terminal differentiation and methods of use thereof The present invention provides the compound having the structure: wherein each of R1 and R2 are independently the same as or different from each other; when R1 and R2 are the same, each i... | 04/20/2004 |
| 6686503 | Methods for the synthesis of highly substituted 2,4-dioxopiperidine libraries The invention relates to methods of synthesizing libraries of diverse and complex highly substituted 2,4-dioxopiperidine compounds of the general formula: ##STR1## wherein R1, R2 and R3 are as herein described, novel ... | 02/03/2004 |
| 6586631 | Acetoacetarylamides Novel acetoacetarylamides in the form of a solidified melt which are in a form which can be used in industry and is easy to handle and which has a water content of from 3 to 15 percent by weight. These novel acetoacetarylamides have been used for the prep... | 07/01/2003 |
| 6552206 | Compositions and methods for their preparation from lepidium The invention relates to compositions that can be isolated from Lepidium plant material and to methods for their isolation. The compositions are useful for treating and preventing cancer and sexual dysfunction.... | 04/22/2003 |
| 6462234 | Process to prepare (2S)-2-(dipropylamino)-6-ethoxy-2, 3-dihydro-1H-indene-5-carboxamide The present invention is a process, including intermediates, to produce (2S)-2-dipropylamino)-6-ethoxy-2,3-dihydro-1H-indene-5-carboxamide ##STR1## which is a useful pharmaceutical agent.... | 10/08/2002 |
| 6388133 | Fluorination of ketoamides A process for the preparation of an N,N-disubstituted-2-fluoro-1,3-ketoamide having the formula RCO.CFR'CONR2 " comprises treating an N,N-disubstituted-1,3-ketoamide having the formula RCO.CHR'CONR2 " with elemental fluorine. The ... | 05/14/2002 |
| 6384278 | Boron-mediated amidation of carboxylic acids The present invention provides an inexpensive one-step method for preparing an aromatic carboxamide, such as a phenyl substituted carboxamide) by reacting an aromatic amine (e.g. a phenylamine) and a carboxylic acid (e.g. an alkanoic acid or ester thereof... | 05/07/2002 |
| 6242609 | Method for manufacturing a color coupler used in a silver halide photographic light-sensitive material A method for manufacturing a color coupler used in a silver halide photographic light-sensitive material using an ammonium trihalide. Said method for manufacturing the color coupler comprising the following step: a step for halogenating a coupling position of ... | 06/05/2001 |
| 6194612 | Template for solution phase synthesis of combination libraries This invention features a template for synthesizing combinatorial libraries, methods of synthesizing combiatorial libraries of chemical compounds utilizing the template, and combinatorial libraries of chemical compounds formed by the methods of this inven... | 02/27/2001 |
| 6090840 | Peptidyl compounds having MMP and TNF inhibitory activity The subject invention concerns mercaptoalkylacyl compounds of formula (I): ##STR1## The compounds of the subject invention can be used to inhibit matrix metalloproteinases and/or TNF- and L-selectin sheddase-mediated diseases including degener... | 07/18/2000 |
| 5959146 | Tricyclic compounds Novel tricyclic compounds of formula I as defined in the specification, a process for their preparation and their use for the preparation of optically active or racemic colchicine and thiocolchicine derivatives.... | 09/28/1999 |
| 5922716 | 5H-indeno1,2-b!pyrazine-2,3-dione derivatives, their preparation and medicinal products containing them Compounds of formula (I): ##STR1## wherein R represents a CR4 R5, CHR6, or C.dbd.R7 radical and R3 represents an oxygen atom, salts thereof, the preparation thereof and drugs containing same. The... | 07/13/1999 |
| 5922771 | Benzocycloalkene compounds, their production and use A compound of the formula ##STR1## wherein R1 and R2 independently represent H or an optionally substituted hydrocarbon group; R3 represents an optionally substituted hydrocarbon group; R4 represents H or a... | 07/13/1999 |
| 5886223 | Process for the preparation of substituted ଲ-ketoanilide compounds There is provided a process for the preparation of substituted ଲ-ketoanilide compounds having the structural formula I ##STR1## The substituted ଲ-ketoanilide compounds are useful for the control of insect pests.... | 03/23/1999 |
| 5808153 | Conversion of N-(4-fluorophenyl)-2-hydroxy-N-(1-methylethyl) acetamide acetate to N-4-fluorophenyl)-2-hydroxy-N-(1-methylethyl) acetamide The present invention provides a process for converting N-(4-fluorophenyl)-2-hydroxy-N-(1-methylethyl)acetamide acetate to N-(4-fluorophenyl)-2-hydroxy-N-(1-methylethyl)acetamide. The process includes the step of hydrolyzing N-(4-fluorophenyl)-2-hydr... | 09/15/1998 |
| 5728869 | Processes for the preparation of pesticides and intermediates There is disclosed a process for the preparation of an indanylamine compound of general formula ##STR1## wherein R1 represents an optionally substituted alkyl group, and R2, R3 and R4 independently represen... | 03/17/1998 |
| 5631394 | Pharmaceutically active ceramide-related compounds This invention provides a compound having the formula R1 --Y1 --CHZ1 --CH(NY2 Y3)--CH2 --Z2, wherein: R1 is a straight-chained alkyl, alkenyl or alkynyl group having from 8... | 05/20/1997 |
| 5616799 | Process for the preparation of glycoloylanilides A process for the preparation of glycoloylanilide of the formula (G) ##STR1## is recited that involves reacting a nitrobenzene with hydrogen and, if desired, with a carbonyl compound, in the presence of a noble metal catalyst and a solvent, reacting ... | 04/01/1997 |
| 5523486 | Preparation of acetoacetarylamides A process for preparing acetoacetarylamides of the formula I ##STR1## where R1 and R2 are identical or different alkyl radicals, l and m are each 0, 1 or 2, and is 0 or 1, by addition of diketene to the appropriate arylamine by continuous... | 06/04/1996 |
| 5488131 | Synthesis of compounds with predetermined chirality A method for synthesizing enantiomerically enriched chemical intermediates with predetermined chirality is described. The method comprises formation of a pseudoephedrine amide, followed by stereoselective alkylation at the alpha carbon. The chiral auxilia... | 01/30/1996 |
| 5475130 | Anilide derivative An anilide derivative useful as an atherosclerosis treating drug, represented by the following formula (I): ##STR1## wherein X is an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms; Y is a hydrogen atom or an alko... | 12/12/1995 |
| 5442115 | Preparation of alpha-chloroacetoacetanilide compounds A process for the preparation of -chloroacetoacetanilide compounds (-Cl AAA) which comprises the steps of: (a) reacting an acetoacetanilide compound (AAA) with chlorine in the presence of a solvent mixture consisting essentially of an organic sol... | 08/15/1995 |
| 5416118 | Bicyclic amides as inhibitors of acyl-coenzyme A: cholesterol acyl transferase Novel bicyclic amides of the formula ##STR1## wherein Ar1 and Ar2 are phenyl, R2 -substituted phenyl, heteroaryl or R2 -substituted heteroaryl, wherein R2 is 1 to 3 substituents independently sel... | 05/16/1995 |
| 5414017 | Trifluoromethyl mercaptan and mercaptoacyl derivatives and method of using same Compounds of the formula ##STR1## wherein m is zero or 1; n is zero, 1 or 2; p is zero or 1 to 6 provided that m and p are not both zero; R3 is hydrogen, acyl, or benzyl; and R1 is hydrogen, alkyl, phenyl, substituted phenyl, ph... | 05/09/1995 |
| 5391811 | Process for the preparation of -fluoro-ଲ-dicarbonyl compounds -fluoro-ଲ-dicarbonyl compounds are prepared by reacting a halogenated dicarbonyl compound at temperatures of 20° to 100° C. with an addition product of hydrogen fluoride and a trialkylamine. This process is easy to carry out in technical te... | 02/21/1995 |
| 5369108 | Potent inducers of terminal differentiation and methods of use thereof The present invention provides the compound having the structure: ##STR1## wherein each of R1 and R2 are independently the same as or different from each other; when R1 and R2 are the same, each is a substi... | 11/29/1994 |
| 5219988 | Gem-diamino derivatives and their use in the synthesis of retro-inverso peptides This invention relates to new gem-diamino derivatives of general formula (I) ##STR1## where R is the side chain of an amino acid, of which any functional groups are suitably protected, and X is an acyl group chosen from the group consisting of 2-nitr... | 06/15/1993 |
| 5145997 | Poly (alkylene oxide) substituted acetoacetanilides Poly (alkylene oxide) substituted acetoacetanilides of the formula: ##STR1## wherein B comprises a divalent bridging moiety selected from the group consisting of C1 -C6 alkylene, --NHSO2 --, --O--, --CO--, --COO--, an... | 09/08/1992 |
| 5108890 | Chromogenic compounds, processes for the preparation thereof and use thereof as enzyme substrates The present invention provides compounds of the general formula: ##STR1## wherein R1 is an amino acid residue or a residue of an oligopeptide in which the amino groups are optionally substituted by protective groups, R2 and R | 04/28/1992 |
| 5049698 | Process for manufacturing 2-chloro-1,3-diketo compounds A novel process for producing 2-chloro-1,3-diketo compounds of the formula ##STR1## wherein Q is an amino, substituted amino or hydrocarbyloxy group, e.g., --OCH3, wherein the 1,3-diketo precursor in solution in a low boiling alcohol is ne... | 09/17/1991 |
| 5023275 | S-substituted beta-thioacrylamide biocides and fungicides S-substituted beta-thioacrylamide compounds have been discovered to be useful as biocides and fungicides. Compositions comprising the compound and isothiazolin-3-ones and/or carriers, methods of preparation of the compounds and methods of using the compou... | 06/11/1991 |
