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| Number | Title | Issue Date |
| 7317023 | Diaryl ether β2 adrenergic receptor agonists The invention provides novel β2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with β2 adrenergic receptor... | 01/08/2008 |
| 7256204 | Amine compounds, their production and use A compound of the formula: wherein Ar is an aromatic ring assembly group which may be substituted or a fused aromatic group which may be substituted; X is (i) a bond, (ii) —S—, —SO— or —SO2â€... | 08/14/2007 |
| 7094928 | Process for the synthesis of (±) 2-Amino-N-[2,(2,5-dimethoxy phenyl)-2-hydroxyethyl] acetamide monohydrochloride This invention relates to an improved process for synthesizing (±)-2-Amino-N-[2-(2,5-dimethoxyphenyl]-2-hydroxyethyl acetamide monohydrochloride in good yield and in a cost effective manner from 1-(2,5-dimethoxyphenyl)-2-bromoethanone by reacting the same with hexa... | 08/22/2006 |
| 7022880 | Piperidine derivatives and process for their production The present invention relates to substantially pure piperidine derivative compounds of the formulae: wherein R1 is hydrogen or hydroxy; | 04/04/2006 |
| 6916767 | Antioxidant amines based on n-(4aniliophenyl) amides antioxidant amines based on n-(4-anilinophenyl) amides A composition of matter is disclosed wherein the composition comprises an N-aromatic substituted acid amide compound selected from the group consisting of compounds of formula (I) wherein A and B are independently selected alkylene groups; R1 is selected ... | 07/12/2005 |
| 6734324 | Method for producing acetoacetylated aromatic amines A method for producing compounds of general formula (I): wherein R1 and R2, each time they occur and independently of each other, mean hydroxyl, C1-6-alkyl, C1-6-alkoxy, haloge... | 05/11/2004 |
| 6518458 | (Aminoiminomethyl) amino) alkane-carboxamides and their applications in therapy The invention to a pharmaceutical composition comprising as active principle a compound of general formula (I), in which R1, R2, R3, and A are as defined in claim 1. These compositions can be used in the treatment of patho... | 02/11/2003 |
| 6482859 | Microbicidal N-sulfonylglycin alkynyloxyphenethyl amide derivatives The invention relates to novel pesticidally active compounds of the general formula I ##STR1## as well as possible isomers and mixtures of isomers thereof, wherein n is a number zero or one; and R1 is C1 -C12 alkyl that is unsu... | 11/19/2002 |
| 6444851 | Process for the preparation of Midodrine The invention provides a process for the preparation of 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide of the formula 1 by hydrogenolysis of substituted 2-dibenzylamino-N-[2-(2',5'-dimethoxyphenyl)-2-hydroxy-ethyl]acetamide having the fo... | 09/03/2002 |
| 6277849 | N-sulphonyl and N-sulphinyl amino acid amides as microbiocides The invention relates to novel pesticidally active compounds of the general formula I ##STR1## as well as possible isomers and isomeric mixtures thereof, wherein n is a number zero or one; and R1 is C1 -C12 alkyl that is unsubs... | 08/21/2001 |
| 6255285 | Phenethylamine derivatives The present invention has as its object providing phenethylamine derivatives that typically function as a motilin receptor antagonist and which are useful as medicines. The invention provides compounds represented by the general formula (1): ##STR1##... | 07/03/2001 |
| 6242494 | Substituted ଲ-amino acid inhibitors of methionine aminopeptidase-2 A class of substituted b-amino acids are potent inhibitor of methionine aminopeptidase type 2 (MetAP2) and are thus useful in inhibiting angiogenesis and disease conditions which depend upon angiogenesis for their development such as diabetic retinopathy,... | 06/05/2001 |
| 6201153 | Synthesis of midodrine HCI from a novel intermediate 1-(2',5'-dimethoxyphenyl)-2-azidoethanone Midodrine hydrochloride, &#b1;1-(2',5'-dimethoxyphenyl)-2-glycineamido-ethanol-(1)-HCl, is prepared from a novel intermediate, 1-(2',5'-dimethoxyphenyl)-2-azidoethanone.... | 03/13/2001 |
| 6194611 | N-sulphonyl and N-sulphinyl amino acid derivatives as microbicides -Amino acid amides of formula (I) wherein the substituents are defined as follows: n is the number zero or one; R1 to R7 are as herein defined; R8 is C1 -C6 alkyl, C3 -C6 ... | 02/27/2001 |
| 6194612 | Template for solution phase synthesis of combination libraries This invention features a template for synthesizing combinatorial libraries, methods of synthesizing combiatorial libraries of chemical compounds utilizing the template, and combinatorial libraries of chemical compounds formed by the methods of this inven... | 02/27/2001 |
| 6096925 | Quaternary ammonium salt for photo-curable antifogging composition, method for preparing the same, and photo-curable antifogging composition Disclosed is a photo-curable antifogging composition which may be applied to substrates such as glass, various plastic materials and the like to give antifogging property on the surface of these substrates. The main ingredient of the composition is a quat... | 08/01/2000 |
| 6063962 | Process for the preparation of NMDA antagonists This invention relates to an improved process for the production of known amine compounds which are useful as medicaments.... | 05/16/2000 |
| 6048899 | Anticonvulsant enantiomeric amino acid derivatives The present invention is directed to N-benzyl-2-amino-3-methoxypropionamide and stereoisomers the use thereof anti-convulsant and an intermediate in the preparation of other anti-convulsants.... | 04/11/2000 |
| 5981600 | Hydroxyanthraquinone derivatives A compound selected from the group having the general formula ##STR1## wherein Z is a divalent moiety selected from linear or branched, saturated or unsaturated alkylene group, and the O.dbd.C(R) group contains one of a quaternary ammonium group and ... | 11/09/1999 |
| 5922771 | Benzocycloalkene compounds, their production and use A compound of the formula ##STR1## wherein R1 and R2 independently represent H or an optionally substituted hydrocarbon group; R3 represents an optionally substituted hydrocarbon group; R4 represents H or a... | 07/13/1999 |
| 5880158 | Propionamide anticonvulsants The present invention is directed to a compound of the following formula: ##STR1## pharmaceutical compositions containing the same and the use thereof as an anticonvulsant.... | 03/09/1999 |
| 5856479 | Fluorescent group-containing carbodiimide compound Using the fluorescent group-containing carbodiimide compound represented-by the following formula (I) as the label and the like in the nucleic acid detection method, immunoassay, or chemiluminescence assay, labeling can be made efficiently for a short tim... | 01/05/1999 |
| 5814669 | Amino acid derivatives and their use as pesticides The invention relates to novel amino acid derivatives, to a process for their preparation and to their use as pesticides, in particular as fungicides, and as intermediates for preparing known substituted amino acid derivatives with fungicidal activity.... | 09/29/1998 |
| 5808003 | Polyaminocarboxylate chelators A compound according to the formula: ##STR1## and conjugates thereof.... | 09/15/1998 |
| 5736578 | Ethylamido fluorenes and improved method of making same Novel substituted fluorene compunds of Formula I are active as melatonergic agents: ##STR1## wherein: X=H, halogen, OH or OZ; Z=C1-6 alkyl; --(CH2)m --CF3 (m=0-2); CD3 ; or ##STR2## n=1 or 2... | 04/07/1998 |
| 5728875 | Microbicides -Amino acid amides of the formula I ##STR1## in which n is the number zero or one; R1 is C1 -C12 alkyl, which is unsubstituted or can be substituted by C1 -C4 alkoxy, C1 -C4 | 03/17/1998 |
| 5679857 | Method of preparing D-amino acid-N-(S)--alkylbenzylamide L-amino acid amides are converted to the corresponding D-amino acid amides. An amide formed from an L-amino acid and an optically active (S)--alkylbenzylamine is subjected to dehydration condensation with an aryl aldehyde to form a Schiff's base, w... | 10/21/1997 |
| 5585519 | Microbicides -Amino acid amides of the formula I ##STR1## in which n is the number zero or one; R1 is C1 -C12 alkyl, which is unsubstituted or can be substituted by C1 -C4 alkoxy, C1 -C4 | 12/17/1996 |
| 5532259 | Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides, pharmaceuticals containing these compounds and their use Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides, pharmaceuticals containing these compounds and their use Isoxazole-4-carboxamide derivatives and hydroxyalkylidene-cyanoacetamide derivatives are suitable for the treatment of carcinoses. These com... | 07/02/1996 |
| 5504115 | Inhibitors of farnesyl protein transferase The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invent... | 04/02/1996 |
| 5494911 | Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides, pharmaceuticals containing these compounds and their use Isoxazole-4-carboxamide derivatives and hydroxyalkylidene-cyanoacetamide derivatives are suitable for the treatment of carcinoses. These compounds can be prepared by known processes. Some of the compounds are novel and are additionally suitable for the tr... | 02/27/1996 |
| 5383942 | Fuel composition An amido alkanolamine composition obtained by reacting, at a temperature of 10° C.-200° C.: (a) a 4-alkyl-2-morpholinone represented by the formula: ##STR1## in which R represents a monovalent aliphatic radical having from 1 to 10 carbon atoms; and... | 01/24/1995 |
| 5382683 | 2-aminopropanamide derivatives Compounds are provided of the following general structure: ##STR1## wherein B is hydrogen or lower alkyl (C1 -C4), R1 is hydrogen or methyl, R2 is lower alkyl (C1 -C4), phenylmethyl or... | 01/17/1995 |
| 5352705 | Inhibitors of farnesyl protein transferase The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invent... | 10/04/1994 |
| 5331007 | Arylalkyl-amines and -amides having anticonvulsant and neuroprotective properties There is provided a method of treatment of neurological disorders, such as epilepsy, stroke and cerebral ischaemia, which comprises the administration of a compound of Formula I: ##STR1## wherein, Ar1 and Ar2, which may be the s... | 07/19/1994 |
| 5318994 | N-[2-(7-lower-alkoxynaphth-1-yl)ethyl]benzamides Compounds of the formula: ##STR1## in which: A represents ##STR2## R represents linear or branched lower alkyl, R1 represents hydrogen or linear or branched lower alkyl, and R2 represents aryl or lower arylalkyl or aryl or ... | 06/07/1994 |
| 5286264 | Gasoline detergent additive composition and motor fuel composition A gasoline detergent additive composition comprising a) the reaction product of a 4-alkyl-2-morpholinone and an alkylphenoxypolyoxyalkylene amine; b) the reaction product of a polyalkenyl succinic acid anhydride and a polyethylene polyamine; and c) a poly... | 02/15/1994 |
| 5278148 | Amino acid derivatives useful for treating high blood pressure Compounds of the formula ##STR1## wherein R1 is hydrogen or methyl, R2 is ethyl, propyl, isopropyl, imidazol-2-yl, imidazol-4-yl, pyrazol-3-yl, thiazol-4-yl, thien-2-yl, ethoxycarbonyl, t-butylcarbonylmethyl, benzyloxycarbonylme... | 01/11/1994 |
| 5234478 | Fuel additive method of preparation and motor fuel composition An amido alkanolamine composition obtained by reacting, at a temperature of 10° C.-200° C.: (a) a 4-alkyl-2-morpholinone represented by the formula: ##STR1## in which R represents a monovalent aliphatic radical having from 1 to 10 carbon atoms, and... | 08/10/1993 |
| 5190974 | N-substituted derivatives of -mercapto alkylamines, their preparation process and the intermediates obtained, their use as medicaments and the compositions containing them Novel -mercapto-alkylamines in all possible racemic, enantiomeric and diastereoisomeric forms of the formula ##STR1## wherein n, R1, R2, X, A, R3A and R4A are set forth in the claims and their non-to... | 03/02/1993 |
