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| Number | Title | Issue Date |
| 7902401 | Fluorinated compounds Compounds of Formula I are useful in the treatment of epilepsy, neuropathic pain, acute and chronic inflammatory pain, migraine, tardive dyskinesia and other related CNS disorders. wherein: A and R1 ... | 03/08/2011 |
| 7868206 | Trihalomethionine derivative and pharmaceutical product containing the same A compound represented by the formula (I) is used as an active ingredient in a medicament for treatment or prevention of infectious diseases caused by protozoa or bacterium. X represents halogen, Z ... | 01/11/2011 |
| 7439393 | Phenethanolamine derivatives for treatment of respiratory diseases The invention relates to 4-{(1R)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol; and salts and solvates thereof, including those which are pharmaceutically acceptable, along with formulations thereof, combinations there... | 10/21/2008 |
| 7423177 | Carboxamide derivatives as therapeutic agents This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the... | 09/09/2008 |
| 7361787 | Phenethanolamine derivatives for treatment of respiratory diseases The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases ... | 04/22/2008 |
| 7241812 | Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity The present invention relates to compounds which modulate the activity of the S1P1 receptor, the use of these compounds for treating conditions associated with signaling through the S1P1 receptor, and pharmaceutical compositions comprising these compounds. ... | 07/10/2007 |
| 7223859 | Method for producing (R)-3-[4-(trifluoromethyl) phenylamino]-pentanoic acid amide derivative The present invention provides a method for easily producing an (R)-3-[4-(trifluoromethyl)phenylamino]-pentanoic acid amide derivative useful for an intermediate for pharmaceutical products, particularly an inhibitor of a cholesteryl ester transfer protein (CETP) fr... | 05/29/2007 |
| 7166641 | Pharmaceutically acceptable salts containing local anesthetic and anti-inflammatory activities and methods for preparing the same The present invention provides pharmaceutically acceptable salts having local anesthetic and anti-inflammatory activities. The preferred pharmaceutically acceptable salt is a diclofenac salt of lidocaine. Diclofenac is a non-steroidal anti-inflammatory drug (“NSAI... | 01/23/2007 |
| 7094928 | Process for the synthesis of (±) 2-Amino-N-[2,(2,5-dimethoxy phenyl)-2-hydroxyethyl] acetamide monohydrochloride This invention relates to an improved process for synthesizing (±)-2-Amino-N-[2-(2,5-dimethoxyphenyl]-2-hydroxyethyl acetamide monohydrochloride in good yield and in a cost effective manner from 1-(2,5-dimethoxyphenyl)-2-bromoethanone by reacting the same with hexa... | 08/22/2006 |
| 7053211 | Process for the preparation of α-aminosubstituted carboxylic acid amides The invention relates to a process for the preparation of α-aminosubstituted carboxylic acid amide compounds and/or their salts comprising reacting a carboxylic acid amide of a primary amine with a nitrosylating agent in the presence of a base followed by hydrolysi... | 05/30/2006 |
| 6916767 | Antioxidant amines based on n-(4aniliophenyl) amides antioxidant amines based on n-(4-anilinophenyl) amides A composition of matter is disclosed wherein the composition comprises an N-aromatic substituted acid amide compound selected from the group consisting of compounds of formula (I) wherein A and B are independently selected alkylene groups; R1 is selected ... | 07/12/2005 |
| 6784315 | Stilbene derivative crystal and method for producing the same A Type IV crystal of (Z)-N-[2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)vinyl]phenyl]-L-serinamide hydrochloride, which can be produced by crystallization using a solvent containing water at 2% by weight at the maximum and which has a X ray powder diffraction pattern con... | 08/31/2004 |
| 6770754 | Universal supports for oligonucleotide synthesis Universal supports for oligonucleotide synthesis include a support material represented by the following formula: In this formula, substituent A is selected from H, alkyl, aryl, or a polymeric or silica base material; su... | 08/03/2004 |
| 6734324 | Method for producing acetoacetylated aromatic amines A method for producing compounds of general formula (I): wherein R1 and R2, each time they occur and independently of each other, mean hydroxyl, C1-6-alkyl, C1-6-alkoxy, haloge... | 05/11/2004 |
| RE38506 | Potent inducers of terminal differentiation and methods of use thereof The present invention provides the compound having the structure: wherein each of R1 and R2 are independently the same as or different from each other; when R1 and R2 are the same, each i... | 04/20/2004 |
| 6699904 | PPAR agonists PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-c... | 03/02/2004 |
| 6686503 | Methods for the synthesis of highly substituted 2,4-dioxopiperidine libraries The invention relates to methods of synthesizing libraries of diverse and complex highly substituted 2,4-dioxopiperidine compounds of the general formula: ##STR1## wherein R1, R2 and R3 are as herein described, novel ... | 02/03/2004 |
| 6608196 | Process for solid supported synthesis of pyruvate-derived compounds Provided are processes for synthesizing structurally diverse pyruvate-derived compounds using a parallel approach on a solid phase support. Examples of such a solid phase support include resins which have also been used in solid phase peptide synthesis.... | 08/19/2003 |
| 6551761 | Photoactivatable nitrogen-containing bases based on -ammonium ketones, iminium ketones or amidinium ketones and aryl borates This invention relates to -ammonium ketones, iminium ketones or amidinium ketones in the form of their tetraaryl- or triarylalkylborate salts which can be photochemically converted into amines, imines or amidines as well as to a process for their p... | 04/22/2003 |
| 6548523 | Process for the preparation of arylethanolamine derivatives having an anti-obesity and anti-diabetic properties The present invention is a process for the preparation of a compound of Formula (IA) or a pharmaceutically acceptable salt thereof: ##STR1## that includes preparing a diamide of Formula (II) or a pharmaceutically acceptable salt thereof: ##STR2##... | 04/15/2003 |
| 6518458 | (Aminoiminomethyl) amino) alkane-carboxamides and their applications in therapy The invention to a pharmaceutical composition comprising as active principle a compound of general formula (I), in which R1, R2, R3, and A are as defined in claim 1. These compositions can be used in the treatment of patho... | 02/11/2003 |
| 6489119 | Analgesic screening method and composition Disclosed is a method of selecting analgesic agents based on their selective ability to block tetrodotoxin-insensitive sodium channels, particularly in comparison to blocking tetrodotoxin-sensitive sodium channels. Also disclosed is a novel class of compo... | 12/03/2002 |
| 6444851 | Process for the preparation of Midodrine The invention provides a process for the preparation of 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide of the formula 1 by hydrogenolysis of substituted 2-dibenzylamino-N-[2-(2',5'-dimethoxyphenyl)-2-hydroxy-ethyl]acetamide having the fo... | 09/03/2002 |
| 6413987 | Dermal anesthetic agents The present invention relates to new aminoindane piperidine compounds, the method of using aminoindane compounds as local anesthetics, said compounds having particularly valuable properties as dermal and topical anesthetics in mammals, including man, as w... | 07/02/2002 |
| 6242494 | Substituted ଲ-amino acid inhibitors of methionine aminopeptidase-2 A class of substituted b-amino acids are potent inhibitor of methionine aminopeptidase type 2 (MetAP2) and are thus useful in inhibiting angiogenesis and disease conditions which depend upon angiogenesis for their development such as diabetic retinopathy,... | 06/05/2001 |
| 6197987 | Polyfunctional perhalogenated polyorganosiloxanes and the processes for their preparation The present invention relates to chemically stable, polyfunctional, perfluorinated polyorganosiloxanes (POS) comprising on the one hand fluorinated lateral grafts resulting from the hydrosilylation of perfluorinated olefins with SiH units and having alkyl... | 03/06/2001 |
| 6194612 | Template for solution phase synthesis of combination libraries This invention features a template for synthesizing combinatorial libraries, methods of synthesizing combiatorial libraries of chemical compounds utilizing the template, and combinatorial libraries of chemical compounds formed by the methods of this inven... | 02/27/2001 |
| 6140372 | Acyl derivatives of melatonin and of melatoninergic analogues and their use as medicinal products The invention relates to derivatives of general formula I ##STR1## as defined in the description. The invention also relates to a process for their preparation and to their therapeutic use, in particular for the treatment of complaints associated wit... | 10/31/2000 |
| 6077877 | Reactive amine catalysts for use in polyurethane polymers The present invention provides amine/amide catalysts for use in catalyzing the formation of polyurethane. The amine/amide catalysts, which have low fugitivity due to their reactivity with isocyanates, and good catalytic activity, have the structure #... | 06/20/2000 |
| 6048899 | Anticonvulsant enantiomeric amino acid derivatives The present invention is directed to N-benzyl-2-amino-3-methoxypropionamide and stereoisomers the use thereof anti-convulsant and an intermediate in the preparation of other anti-convulsants.... | 04/11/2000 |
| 5998653 | 1-(substituted phenyl)-2,3-disubstituted propane-1,3-diones as intermediates to 4-benzoylisoxazoles Compounds of the formula ##STR1## are useful as intermediates to new herbicidal 4-benzoylisoxazoles.... | 12/07/1999 |
| 5990179 | Composition and method of enhancing electrotransport agent delivery A composition suitable for transdermal electrotransport delivery of an agent through a body surface comprises a free acid/base form of an agent to be delivered by transdermal electrotransport, and a salt form of the agent, and optionally a permeation enha... | 11/23/1999 |
| 5929242 | Manufacture of levobupivacaine and analogues thereof from L-lysine The subject invention concerns a compound of formula (X), ##STR1## which can be prepared from the starting material L-lysine, and converted to levobupivacaine by cyclization.... | 07/27/1999 |
| 5880158 | Propionamide anticonvulsants The present invention is directed to a compound of the following formula: ##STR1## pharmaceutical compositions containing the same and the use thereof as an anticonvulsant.... | 03/09/1999 |
| 5814669 | Amino acid derivatives and their use as pesticides The invention relates to novel amino acid derivatives, to a process for their preparation and to their use as pesticides, in particular as fungicides, and as intermediates for preparing known substituted amino acid derivatives with fungicidal activity.... | 09/29/1998 |
| 5753652 | Antiretroviral hydrazine derivatives The invention relates to compounds of formula ##STR1## and salts, pharmaceutical compositions, intermediates and processes of preparation thereof.... | 05/19/1998 |
| 5736578 | Ethylamido fluorenes and improved method of making same Novel substituted fluorene compunds of Formula I are active as melatonergic agents: ##STR1## wherein: X=H, halogen, OH or OZ; Z=C1-6 alkyl; --(CH2)m --CF3 (m=0-2); CD3 ; or ##STR2## n=1 or 2... | 04/07/1998 |
| 5679857 | Method of preparing D-amino acid-N-(S)--alkylbenzylamide L-amino acid amides are converted to the corresponding D-amino acid amides. An amide formed from an L-amino acid and an optically active (S)--alkylbenzylamine is subjected to dehydration condensation with an aryl aldehyde to form a Schiff's base, w... | 10/21/1997 |
| 5674906 | Stilbene compounds and pharmaceutical compositions containing them Stilbene compounds of the following formula (I) or their pharmaceutically acceptable salts are effective as carcinostatics and of low toxicity: ##STR1## wherein X represents a hydrogen atom or a nitrile group, and Y represents an amino acid acyl grou... | 10/07/1997 |
| 5616312 | Thiol ligands and complexes for X-ray imaging The present invention provides new and structurally diverse compositions comprising compounds of the general formula: ##STR1## Wherein R1, R2, R3, R4, and R5 are the same or different and are --C... | 04/01/1997 |
